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Novel methods in Magnetic Resonance Spectroscopy to investigate mechanisms underlying metabolic disease

Publications

Effects of dietary macronutrients on liver fat content in adults: a systematic review and meta-analysis of randomized controlled trials

Author(s): Esther Winters-van Eekelen, Inge Verkouter, Harry P. F. Peters, Marjan Alssema, Babette G. de Roos, Vera B. Schrauwen-Hinderling, Kay H. M. Roumans, Jan W. Schoones, Peter L. Zock, Patrick Schrauwen, Frits R. Rosendaal, Olaf M. Dekkers, Renée de Mutsert
Published in: European Journal of Clinical Nutrition, 2020, ISSN 0954-3007
Publisher: Nature Publishing Group
DOI: 10.1038/s41430-020-00778-1

An Empirical Approach to Derive Water T(1) from Multiparametric MR Images Using an Automated Pipeline and Comparison With Liver Stiffness

Author(s): Michelotti, F. C., Kupriyanova, Y., Mori, T., Kustner, T., Heilmann, G., Bombrich, M., Moser, C. Schon, M., Kuss, O., Roden, M., Schrauwen-Hinderling, V. B.
Published in: J Magn Reson Imaging, 2023, ISSN 1522-2586
Publisher: J Magn Reson Imaging
DOI: 10.1002/jmri.28906

Replacing Foods with a High-Glycemic Index and High in Saturated Fat by Alternatives with a Low Glycemic Index and Low Saturated Fat Reduces Hepatic Fat, Even in Isocaloric and Macronutrient Matched Conditions

Author(s): Basset-Sagarminaga, J., Roumans, K. H. M., Havekes, B., Mensink, R. P., Peters, H. P. F., Zock, P. L., Mutsert, R., Boren, J., Lindeboom, L., Schrauwen, P., Schrauwen-Hinderling, V. B.
Published in: Nutrients, 2023, ISSN 2072-6643
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/nu15030735

Application of Magnetic Resonance Spectroscopy in metabolic research

Author(s): Tineke van de Weijer, Vera B. Schrauwen-Hinderling
Published in: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Issue 1865/4, 2019, Page(s) 741-748, ISSN 0925-4439
Publisher: Elsevier BV
DOI: 10.1016/j.bbadis.2018.09.013

A randomized, double-blind crossover trial

Author(s): Anna Veelen; Charlotte Andriessen; Yvo Op den Kamp; Edmundo Erazo-Tapia; Marlies de Ligt; Julian Mevenkamp; Johanna A. Jörgensen; Esther Moonen-Kornips; Gert Schaart; Russell Esterline; Bas Havekes; Jan Oscarsson; Vera B. Schrauwen-Hinderling; Esther Phielix; Patrick Schrauwen
Published in: ISSN=0026-0495;TITLE=Metabolism-Clinical and Experimental, Issue 5, 2023, ISSN 1532-8600
Publisher: metabolism
DOI: 10.1016/j.metabol.2022.155396

A prolonged fast improves overnight substrate oxidation without modulating hepatic glycogen in adults with and without nonalcoholic fatty liver: A randomized crossover trial

Author(s): Roumans, K. H. M., Veelen, A., Andriessen, C., Mevenkamp, J., Kornips, E., Veeraiah, P., Havekes, B., Peters, H. P. F., Lindeboom, L., Schrauwen, P., Schrauwen-Hinderling, V. B.
Published in: Obesity, 2023, ISSN 1930-739X
Publisher: Obesity
DOI: 10.1002/oby.23676

Carnitine supplementation improves metabolic flexibility and skeletal muscle acetylcarnitine formation in volunteers with impaired glucose tolerance: A randomised controlled trial

Author(s): Yvonne MH Bruls, Marlies de Ligt, Lucas Lindeboom, Esther Phielix, Bas Havekes, Gert Schaart, Esther Kornips, Joachim E Wildberger, Matthijs KC Hesselink, Deborah Muoio, Patrick Schrauwen, Vera B Schrauwen-Hinderling
Published in: EBioMedicine, Issue 49, 2019, Page(s) 318-330, ISSN 2352-3964
Publisher: Elsevier BV
DOI: 10.1016/j.ebiom.2019.10.017

Resveratrol improves ex vivo mitochondrial function but does not affect insulin sensitivity or brown adipose tissue in first degree relatives of patients with type 2 diabetes

Author(s): Marlies de Ligt, Yvonne M.H. Bruls, Jan Hansen, Marie-Fleur Habets, Bas Havekes, Emmani B.M. Nascimento, Esther Moonen-Kornips, Gert Schaart, Vera B. Schrauwen-Hinderling, Wouter van Marken Lichtenbelt, Patrick Schrauwen
Published in: Molecular Metabolism, Issue 12, 2018, Page(s) 39-47, ISSN 2212-8778
Publisher: Elsevier GmbH
DOI: 10.1016/j.molmet.2018.04.004

Proton magnetic resonance spectroscopy in skeletal muscle: Experts' consensus recommendations

Author(s): Martin Krššák, Lucas Lindeboom, Vera Schrauwen‐Hinderling, Lidia S. Szczepaniak, Wim Derave, Jesper Lundbom, Douglas Befroy, Fritz Schick, Jürgen Machann, Roland Kreis, Chris Boesch
Published in: NMR in Biomedicine, 2020, ISSN 0952-3480
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/nbm.4266

Thigh muscles are more susceptible to age-related muscle loss when compared to lower leg and pelvic muscles

Author(s): Cas J. Fuchs; Remco Kuipers; Jan A. Rombouts; Kim Brouwers; Vera B. Schrauwen-Hinderling; Joachim E. Wildberger; Lex B. Verdijk; Luc J.C. van Loon
Published in: VOLUME=175;ISSN=0531-5565;TITLE=Experimental Gerontology, Issue 1, 2023, ISSN 1873-6815
Publisher: Exp Gerontol
DOI: 10.1016/j.exger.2023.112159

The tissue-specific metabolic effects of the PPARalpha agonist ciprofibrate in insulin-resistant male individuals: a double-blind, randomized, placebo-controlled crossover study

Author(s): de Wit-Verheggen, V. H. W., Vanweert, F., Raiko, J., Lienard, V., Schaart, G., Gemmink, A., Nascimento, E. B. M., Hesselink, M. K. C., Wildberger, J. E., Wierts, R., Joris, P. J., Haas, J., Montaigne, D., Staels, B., Phielix, E., Schrauwen, P., Schrauwen-Hinderling, V. B., van de Weijer, T.
Published in: Obesity, 2023, ISSN 1930-739X
Publisher: Obesity
DOI: 10.1002/oby.23874

Application of a BIlinear Rotation Decoupling (BIRD) filter in combination with J‐difference editing for indirect 13 C measurements in the human liver

Author(s): Pandichelvam Veeraiah, Kim Brouwers, Joachim E. Wildberger, Vera B. Schrauwen‐Hinderling, Lucas Lindeboom
Published in: Magnetic Resonance in Medicine, Issue 84/6, 2020, Page(s) 2911-2917, ISSN 0740-3194
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/mrm.28394

Serum sex hormone-binding globulin levels are reduced and inversely associated with intrahepatic lipid content and saturated fatty acid fraction in adult patients with glycogen storage disease type 1a

Author(s): Simons, Pihg, Valkenburg, O., Telgenkamp, I., van der Waaij, K. M., de Groot, D. M., Veeraiah, P., Bons, J. A. P., Derks, T. G. J., Schalkwijk, C. G., Schrauwen-Hinderling, V. B., Stehouwer, C. D. A., Brouwers, Mcgj
Published in: J Endocrinol Invest, 2022, ISSN 1720-8386
Publisher: J Endocrinol Invest
DOI: 10.1007/s40618-022-01753-2

The effect of weight loss on whole-body and tissue-specific insulin sensitivity and hepatic lipid content and composition: SWEET substudy

Author(s): Pang, M. D., Bastings, Jjaj, Op den Kamp-Bruls, Y. M. H., Harrold, J. A., Kjolbaek, L., Halford, J. C. G., Adam, T. C. M., Raben, A., Schrauwen-Hinderling, V. B., Goossens, G. H., Blaak, E. E.
Published in: Obesity, 2023, ISSN 1930-739X
Publisher: Obesity
DOI: 10.1002/oby.23773

No evidence for brown adipose tissue activation after creatine supplementation in adult vegetarians

Author(s): Connell, N. J., Doligkeit, D., Andriessen, C., Kornips-Moonen, E., Bruls, Y. M. H., Schrauwen-Hinderling, V. B., van de Weijer, T., van Marken-Lichtenbelt, W. D., Havekes, B., Kazak, L., Spiegelman, B. M., Hoeks, J., Schrauwen, P.
Published in: Nature Metabolism, 2021, ISSN 2522-5812
Publisher: Nature Metabolism
DOI: 10.1038/s42255-020-00332-0

Relationship between de novo lipogenesis and serum sex hormone binding globulin in humans.

Author(s): Pomme I. H. G. Simons; Pomme I. H. G. Simons; Olivier Valkenburg; Ine Telgenkamp; Ine Telgenkamp; Koen M van der Waaij; Koen M van der Waaij; David M de Groot; Pandichelvam Veeraiah; Judith A P Bons; Marja-Riitta Taskinen; Jan Borén; Patrick Schrauwen; Joost H.W. Rutten; David Cassiman; Casper G. Schalkwijk; Coen D.A. Stehouwer; Coen D.A. Stehouwer; Vera B. Schrauwen-Hinderling; Leanne Hodson; Ma
Published in: VOLUME=95;ISSUE=1;STARTPAGE=101;ENDPAGE=106;ISSN=0300-0664;TITLE=Clinical Endocrinology, Issue 1, 2021, ISSN 1365-2265
Publisher: Clin Endocrinol (Oxf)
DOI: 10.1111/cen.14459

Gene expression and DNA methylation as mechanisms of disturbed metabolism in offspring after exposure to a prenatal HF diet

Author(s): Sven H. Rouschop, Tanja Karl, Angela Risch, Petronella A. van Ewijk, Vera B. Schrauwen-Hinderling, Antoon Opperhuizen, Frederik J. van Schooten, Roger W. Godschalk
Published in: Journal of Lipid Research, Issue 60/7, 2019, Page(s) 1250-1259, ISSN 0022-2275
Publisher: Lipid Research, Inc.
DOI: 10.1194/jlr.m092593

Pericardial fat and its influence on cardiac diastolic function

Author(s): Vera H. W. de Wit-Verheggen, Sibel Altintas, Romy J. M. Spee, Casper Mihl, Sander M. J. van Kuijk, Joachim E. Wildberger, Vera B. Schrauwen-Hinderling, Bas L. J. H. Kietselaer, Tineke van de Weijer
Published in: Cardiovascular Diabetology, Issue 19/1, 2020, ISSN 1475-2840
Publisher: BioMed Central
DOI: 10.1186/s12933-020-01097-2

Consumption of Alcoholic and Sugar-Sweetened Beverages is Associated with Increased Liver Fat Content in Middle-Aged Men and Women

Author(s): Esther van Eekelen, Joline W J Beulens, Anouk Geelen, Vera B Schrauwen-Hinderling, Hildo Lamb, Albert de Roos, Frits Rosendaal, Renée de Mutsert
Published in: The Journal of Nutrition, 2019, ISSN 0022-3166
Publisher: American Society for Nutritional Sciences
DOI: 10.1093/jn/nxy313

No effect of resveratrol supplementation after 6 months on insulin sensitivity in overweight adults: a randomized trial

Author(s): Marlies de Ligt, Maaike Bergman, Rodrigo Mancilla Fuentes, Hans Essers, Esther Moonen-Kornips, Bas Havekes, Vera B Schrauwen-Hinderling, Patrick Schrauwen
Published in: The American Journal of Clinical Nutrition, 2020, ISSN 0002-9165
Publisher: American Society for Clinical Nutrition, Inc.
DOI: 10.1093/ajcn/nqaa125

The effect of physical activity level and exercise training on the association between plasma branched-chain amino acids and intrahepatic lipid content in participants with obesity

Author(s): Vanweert, F., Boone, S. C., Brouwers, B., Mook-Kanamori, D. O., de Mutsert, R., Rosendaal, F. R., Lamb, H. J., Schrauwen-Hinderling, V. B., Schrauwen, P., Hesselink, M. K. C., Phielix, E.
Published in: Int J Obes (Lond), 2021, ISSN 1476-5497
Publisher: Int J Obes (Lond)
DOI: 10.1038/s41366-021-00815-4

Postexercise changes in myocellular lipid droplet characteristics of young lean individuals are affected by circulatory nonesterified fatty acids.

Author(s): Sabine Daemen; Nynke van Polanen; Lena Bilet; Esther Phielix; Esther Moonen-Kornips; Vera B. Schrauwen-Hinderling; Patrick Schrauwen; Matthijs K. C. Hesselink
Published in: urn:issn:0193-1849, Issue 1, 2021, ISSN 1522-1555
Publisher: Am J Physiol Endocrinol Metab
DOI: 10.1152/ajpendo.00654.2020

Hepatic saturated fatty acid fraction is associated with de novo lipogenesis and hepatic insulin resistance

Author(s): Kay H. M. Roumans, Lucas Lindeboom, Pandichelvam Veeraiah, Carlijn M. E. Remie, Esther Phielix, Bas Havekes, Yvonne M. H. Bruls, Martijn C. G. J. Brouwers, Marcus Ståhlman, Marjan Alssema, Harry P. F. Peters, Renée de Mutsert, Bart Staels, Marja-Riitta Taskinen, Jan Borén, Patrick Schrauwen, Vera B. Schrauwen-Hinderling
Published in: Nature Communications, Issue 11/1, 2020, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-020-15684-0

L-carnitine infusion does not alleviate lipid-induced insulin resistance and metabolic inflexibility

Author(s): Yvonne M. H. Bruls, Yvo J. M. op den Kamp, Esther Phielix, Lucas Lindeboom, Bas Havekes, Gert Schaart, Esther Moonen-Kornips, Joachim E. Wildberger, Matthijs K. C. Hesselink, Patrick Schrauwen, Vera B. Schrauwen-Hinderling
Published in: PLOS ONE, Issue 15/9, 2020, Page(s) e0239506, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0239506

A randomized placebo-controlled clinical trial for pharmacological activation of BCAA catabolism in patients with type 2 diabetes

Author(s): Vanweert, F., Neinast, M., Tapia, E. E., van de Weijer, T., Hoeks, J., Schrauwen-Hinderling, V. B., Blair, M. C., Bornstein, M. R., Hesselink, M. K. C., Schrauwen, P., Arany, Z., Phielix, E.
Published in: Nature Communications, 2022, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-022-31249-9

Substrate utilization and metabolic profile in response to overfeeding with a high-fat diet in South Asian and white men: a sedentary lifestyle study

Author(s): Siti N Wulan, Vera B Schrauwen-Hinderling, Klaas R Westerterp, Guy Plasqui
Published in: International Journal of Obesity, 2019, ISSN 0307-0565
Publisher: Nature Publishing Group
DOI: 10.1038/s41366-019-0368-2

Sitting less elicits metabolic responses similar to exercise and enhances insulin sensitivity in postmenopausal women.

Author(s): Carlijn M. E. Remie; Georges E. Janssens; L. Bilet; Michel van Weeghel; Bernard M. F. M. Duvivier; Vera H. W. de Wit; Niels J. Connell; Johanna A. Jörgensen; Bauke V. Schomakers; Vera B. Schrauwen-Hinderling; Joris Hoeks; Matthijs K. C. Hesselink; Esther Phielix; Riekelt H. Houtkooper; Patrick Schrauwen
Published in: Diabetologia, 64(12), 2817 - 2828. Springer, Cham, Issue 2, 2021, ISSN 1432-0428
Publisher: Diabetologia
DOI: 10.1007/s00125-021-05558-5

Characterization of BAT activity in rats using invasive and non-invasive techniques

Author(s): Andreas Paulus, Petronella A. van Ewijk, Emmani B. M. Nascimento, Marijke De Saint-Hubert, Geert Hendrikx, Andrea Vogg, Ivo Pooters, Melanie Schnijderberg, Joris Vanderlocht, Gerard Bos, Boudewijn Brans, Vera B. Schrauwen-Hinderling, Felix M. Mottaghy, Matthias Bauwens
Published in: PLOS ONE, Issue 14/5, 2019, Page(s) e0215852, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0215852

Liver fat storage pathways: methodologies and dietary effects

Author(s): Roumans, K. H. M., Basset Sagarminaga, J., Peters, H. P. F., Schrauwen, P., Schrauwen-Hinderling, V. B.
Published in: Curr Opin Lipidol, 2021, ISSN 1473-6535
Publisher: Curr Opin Lipidol
DOI: 10.1097/mol.0000000000000720

Timing of physical activity in relation to liver fat content and insulin resistance

Author(s): van der Velde, Jhpm. Boone, S. C., Winters-van Eekelen, E., Hesselink, M. K. C., Schrauwen-Hinderling, V. B., Schrauwen, P., Lamb, H. J., Rosendaal, F. R., de Mutsert, R.
Published in: Diabetologia, 2023, ISSN 1432-0428
Publisher: Diabetologia
DOI: 10.1007/s00125-022-05813-3

Nicotinamide riboside supplementation alters body composition and skeletal muscle acetylcarnitine concentrations in healthy obese humans

Author(s): Carlijn M E Remie, Kay H M Roumans, Michiel P B Moonen, Niels J Connell, Bas Havekes, Julian Mevenkamp, Lucas Lindeboom, Vera H W de Wit, Tineke van de Weijer, Suzanne A B M Aarts, Esther Lutgens, Bauke V Schomakers, Hyung L Elfrink, Rubén Zapata-Pérez, Riekelt H Houtkooper, Johan Auwerx, Joris Hoeks, Vera B Schrauwen-Hinderling, Esther Phielix, Patrick Schrauwen
Published in: The American Journal of Clinical Nutrition, Issue 112/2, 2020, Page(s) 413-426, ISSN 0002-9165
Publisher: American Society for Clinical Nutrition, Inc.
DOI: 10.1093/ajcn/nqaa072

Invasive and noninvasive markers of human skeletal muscle mitochondrial function

Author(s): Mancilla, R., Pava-Mejia, D., van Polanen, N., de Wit, V., Bergman, M., Grevendonk, L., Jorgensen, J., Kornips, E., Hoeks, J., Hesselink, M. K. C., Schrauwen-Hinderling, V. B.
Published in: Physiol Rep, 2023, ISSN 2051-817X
Publisher: Physiol Rep
DOI: 10.14814/phy2.15734

Additional file 1 of Pericardial fat and its influence on cardiac diastolic function

Author(s): Wit-Verheggen, Vera H. W. De; Altintas, Sibel; Spee, Romy J. M.; Mihl, Casper; Kuijk, Sander M. J. Van; Wildberger, Joachim E.; Schrauwen-Hinderling, Vera B.; Kietselaer, Bas L. J. H.; Weijer, Tineke Van De
Published in: Cardiovasc Diobetol, Issue 1, 2020, ISSN 1475-2840
Publisher: BioMed Central
DOI: 10.6084/m9.figshare.12819333

One-leg inactivity induces a reduction in mitochondrial oxidative capacity, intramyocellular lipid accumulation and reduced insulin signalling upon lipid infusion: a human study with unilateral limb suspension

Author(s): Lena Bilet, Esther Phielix, Tineke van de Weijer, Anne Gemmink, Madeleen Bosma, Esther Moonen-Kornips, Johanna A. Jorgensen, Gert Schaart, Dongyan Zhang, Kenneth Meijer, Maria Hopman, Matthijs K. C. Hesselink, D. Margriet Ouwens, Gerald I. Shulman, Vera B. Schrauwen-Hinderling, Patrick Schrauwen
Published in: Diabetologia, Issue 63/6, 2020, Page(s) 1211-1222, ISSN 0012-186X
Publisher: Springer Verlag
DOI: 10.1007/s00125-020-05128-1

Ectopic lipid deposition in muscle and liver, quantified by proton magnetic resonance spectroscopy

Author(s): Buitinga, M., Veeraiah, P., Haans, F., Schrauwen-Hinderling, V. B.
Published in: Obesity, 2023, ISSN 1930-739X
Publisher: Obesity
DOI: 10.1002/oby.23865

Skeletal muscle mitochondrial inertia is associated with carnitine acetyltransferase activity and physical function in humans

Author(s): Mancilla, R. F., Lindeboom, L., Grevendonk, L., Hoeks, J., Koves, T. R., Muoio, D. M., Schrauwen, P., Schrauwen-Hinderling, V., Hesselink, M. K.
Published in: JCI Insight, 2023, ISSN 2379-3708
Publisher: JCI Insight
DOI: 10.1172/jci.insight.163855

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