Novel methods in Magnetic Resonance Spectroscopy to investigate mechanisms underlying metabolic disease

Informazioni relative al progetto

MRS in diabetes

ID dell’accordo di sovvenzione: 759161

DOI

10.3030/759161

Progetto chiuso

Data della firma CE 5 Febbraio 2018

Data di avvio 1 Marzo 2018

Data di completamento 31 Luglio 2023

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale

€ 1 500 000,00

Contributo UE

€ 1 500 000,00

Coordinato da

UNIVERSITEIT MAASTRICHT
Netherlands

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Pubblicazioni

Peer reviewed articles (36)

Effects of dietary macronutrients on liver fat content in adults: a systematic review and meta-analysis of randomized controlled trials

Autori: Esther Winters-van Eekelen, Inge Verkouter, Harry P. F. Peters, Marjan Alssema, Babette G. de Roos, Vera B. Schrauwen-Hinderling, Kay H. M. Roumans, Jan W. Schoones, Peter L. Zock, Patrick Schrauwen, Frits R. Rosendaal, Olaf M. Dekkers, Renée de Mutsert
Pubblicato in: European Journal of Clinical Nutrition, 2020, ISSN 0954-3007
Editore: Nature Publishing Group
DOI: 10.1038/s41430-020-00778-1

An Empirical Approach to Derive Water T(1) from Multiparametric MR Images Using an Automated Pipeline and Comparison With Liver Stiffness

Autori: Michelotti, F. C., Kupriyanova, Y., Mori, T., Kustner, T., Heilmann, G., Bombrich, M., Moser, C. Schon, M., Kuss, O., Roden, M., Schrauwen-Hinderling, V. B.
Pubblicato in: J Magn Reson Imaging, 2023, ISSN 1522-2586
Editore: J Magn Reson Imaging
DOI: 10.1002/jmri.28906

Replacing Foods with a High-Glycemic Index and High in Saturated Fat by Alternatives with a Low Glycemic Index and Low Saturated Fat Reduces Hepatic Fat, Even in Isocaloric and Macronutrient Matched Conditions

Autori: Basset-Sagarminaga, J., Roumans, K. H. M., Havekes, B., Mensink, R. P., Peters, H. P. F., Zock, P. L., Mutsert, R., Boren, J., Lindeboom, L., Schrauwen, P., Schrauwen-Hinderling, V. B.
Pubblicato in: Nutrients, 2023, ISSN 2072-6643
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/nu15030735

Application of Magnetic Resonance Spectroscopy in metabolic research

Autori: Tineke van de Weijer, Vera B. Schrauwen-Hinderling
Pubblicato in: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Numero 1865/4, 2019, Pagina/e 741-748, ISSN 0925-4439
Editore: Elsevier BV
DOI: 10.1016/j.bbadis.2018.09.013

A randomized, double-blind crossover trial

Autori: Anna Veelen; Charlotte Andriessen; Yvo Op den Kamp; Edmundo Erazo-Tapia; Marlies de Ligt; Julian Mevenkamp; Johanna A. Jörgensen; Esther Moonen-Kornips; Gert Schaart; Russell Esterline; Bas Havekes; Jan Oscarsson; Vera B. Schrauwen-Hinderling; Esther Phielix; Patrick Schrauwen
Pubblicato in: ISSN=0026-0495;TITLE=Metabolism-Clinical and Experimental, Numero 5, 2023, ISSN 1532-8600
Editore: metabolism
DOI: 10.1016/j.metabol.2022.155396

A prolonged fast improves overnight substrate oxidation without modulating hepatic glycogen in adults with and without nonalcoholic fatty liver: A randomized crossover trial

Autori: Roumans, K. H. M., Veelen, A., Andriessen, C., Mevenkamp, J., Kornips, E., Veeraiah, P., Havekes, B., Peters, H. P. F., Lindeboom, L., Schrauwen, P., Schrauwen-Hinderling, V. B.
Pubblicato in: Obesity, 2023, ISSN 1930-739X
Editore: Obesity
DOI: 10.1002/oby.23676

Carnitine supplementation improves metabolic flexibility and skeletal muscle acetylcarnitine formation in volunteers with impaired glucose tolerance: A randomised controlled trial

Autori: Yvonne MH Bruls, Marlies de Ligt, Lucas Lindeboom, Esther Phielix, Bas Havekes, Gert Schaart, Esther Kornips, Joachim E Wildberger, Matthijs KC Hesselink, Deborah Muoio, Patrick Schrauwen, Vera B Schrauwen-Hinderling
Pubblicato in: EBioMedicine, Numero 49, 2019, Pagina/e 318-330, ISSN 2352-3964
Editore: Elsevier BV
DOI: 10.1016/j.ebiom.2019.10.017

Resveratrol improves ex vivo mitochondrial function but does not affect insulin sensitivity or brown adipose tissue in first degree relatives of patients with type 2 diabetes

Autori: Marlies de Ligt, Yvonne M.H. Bruls, Jan Hansen, Marie-Fleur Habets, Bas Havekes, Emmani B.M. Nascimento, Esther Moonen-Kornips, Gert Schaart, Vera B. Schrauwen-Hinderling, Wouter van Marken Lichtenbelt, Patrick Schrauwen
Pubblicato in: Molecular Metabolism, Numero 12, 2018, Pagina/e 39-47, ISSN 2212-8778
Editore: Elsevier GmbH
DOI: 10.1016/j.molmet.2018.04.004

Proton magnetic resonance spectroscopy in skeletal muscle: Experts' consensus recommendations

Autori: Martin Krššák, Lucas Lindeboom, Vera Schrauwen‐Hinderling, Lidia S. Szczepaniak, Wim Derave, Jesper Lundbom, Douglas Befroy, Fritz Schick, Jürgen Machann, Roland Kreis, Chris Boesch
Pubblicato in: NMR in Biomedicine, 2020, ISSN 0952-3480
Editore: John Wiley & Sons Inc.
DOI: 10.1002/nbm.4266

Thigh muscles are more susceptible to age-related muscle loss when compared to lower leg and pelvic muscles

Autori: Cas J. Fuchs; Remco Kuipers; Jan A. Rombouts; Kim Brouwers; Vera B. Schrauwen-Hinderling; Joachim E. Wildberger; Lex B. Verdijk; Luc J.C. van Loon
Pubblicato in: VOLUME=175;ISSN=0531-5565;TITLE=Experimental Gerontology, Numero 1, 2023, ISSN 1873-6815
Editore: Exp Gerontol
DOI: 10.1016/j.exger.2023.112159

The tissue-specific metabolic effects of the PPARalpha agonist ciprofibrate in insulin-resistant male individuals: a double-blind, randomized, placebo-controlled crossover study

Autori: de Wit-Verheggen, V. H. W., Vanweert, F., Raiko, J., Lienard, V., Schaart, G., Gemmink, A., Nascimento, E. B. M., Hesselink, M. K. C., Wildberger, J. E., Wierts, R., Joris, P. J., Haas, J., Montaigne, D., Staels, B., Phielix, E., Schrauwen, P., Schrauwen-Hinderling, V. B., van de Weijer, T.
Pubblicato in: Obesity, 2023, ISSN 1930-739X
Editore: Obesity
DOI: 10.1002/oby.23874

Application of a BIlinear Rotation Decoupling (BIRD) filter in combination with J‐difference editing for indirect 13 C measurements in the human liver

Autori: Pandichelvam Veeraiah, Kim Brouwers, Joachim E. Wildberger, Vera B. Schrauwen‐Hinderling, Lucas Lindeboom
Pubblicato in: Magnetic Resonance in Medicine, Numero 84/6, 2020, Pagina/e 2911-2917, ISSN 0740-3194
Editore: John Wiley & Sons Inc.
DOI: 10.1002/mrm.28394

Serum sex hormone-binding globulin levels are reduced and inversely associated with intrahepatic lipid content and saturated fatty acid fraction in adult patients with glycogen storage disease type 1a

Autori: Simons, Pihg, Valkenburg, O., Telgenkamp, I., van der Waaij, K. M., de Groot, D. M., Veeraiah, P., Bons, J. A. P., Derks, T. G. J., Schalkwijk, C. G., Schrauwen-Hinderling, V. B., Stehouwer, C. D. A., Brouwers, Mcgj
Pubblicato in: J Endocrinol Invest, 2022, ISSN 1720-8386
Editore: J Endocrinol Invest
DOI: 10.1007/s40618-022-01753-2

The effect of weight loss on whole-body and tissue-specific insulin sensitivity and hepatic lipid content and composition: SWEET substudy

Autori: Pang, M. D., Bastings, Jjaj, Op den Kamp-Bruls, Y. M. H., Harrold, J. A., Kjolbaek, L., Halford, J. C. G., Adam, T. C. M., Raben, A., Schrauwen-Hinderling, V. B., Goossens, G. H., Blaak, E. E.
Pubblicato in: Obesity, 2023, ISSN 1930-739X
Editore: Obesity
DOI: 10.1002/oby.23773

No evidence for brown adipose tissue activation after creatine supplementation in adult vegetarians

Autori: Connell, N. J., Doligkeit, D., Andriessen, C., Kornips-Moonen, E., Bruls, Y. M. H., Schrauwen-Hinderling, V. B., van de Weijer, T., van Marken-Lichtenbelt, W. D., Havekes, B., Kazak, L., Spiegelman, B. M., Hoeks, J., Schrauwen, P.
Pubblicato in: Nature Metabolism, 2021, ISSN 2522-5812
Editore: Nature Metabolism
DOI: 10.1038/s42255-020-00332-0

Relationship between de novo lipogenesis and serum sex hormone binding globulin in humans.

Autori: Pomme I. H. G. Simons; Pomme I. H. G. Simons; Olivier Valkenburg; Ine Telgenkamp; Ine Telgenkamp; Koen M van der Waaij; Koen M van der Waaij; David M de Groot; Pandichelvam Veeraiah; Judith A P Bons; Marja-Riitta Taskinen; Jan Borén; Patrick Schrauwen; Joost H.W. Rutten; David Cassiman; Casper G. Schalkwijk; Coen D.A. Stehouwer; Coen D.A. Stehouwer; Vera B. Schrauwen-Hinderling; Leanne Hodson; Ma
Pubblicato in: VOLUME=95;ISSUE=1;STARTPAGE=101;ENDPAGE=106;ISSN=0300-0664;TITLE=Clinical Endocrinology, Numero 1, 2021, ISSN 1365-2265
Editore: Clin Endocrinol (Oxf)
DOI: 10.1111/cen.14459

Gene expression and DNA methylation as mechanisms of disturbed metabolism in offspring after exposure to a prenatal HF diet

Autori: Sven H. Rouschop, Tanja Karl, Angela Risch, Petronella A. van Ewijk, Vera B. Schrauwen-Hinderling, Antoon Opperhuizen, Frederik J. van Schooten, Roger W. Godschalk
Pubblicato in: Journal of Lipid Research, Numero 60/7, 2019, Pagina/e 1250-1259, ISSN 0022-2275
Editore: Lipid Research, Inc.
DOI: 10.1194/jlr.m092593

Pericardial fat and its influence on cardiac diastolic function

Autori: Vera H. W. de Wit-Verheggen, Sibel Altintas, Romy J. M. Spee, Casper Mihl, Sander M. J. van Kuijk, Joachim E. Wildberger, Vera B. Schrauwen-Hinderling, Bas L. J. H. Kietselaer, Tineke van de Weijer
Pubblicato in: Cardiovascular Diabetology, Numero 19/1, 2020, ISSN 1475-2840
Editore: BioMed Central
DOI: 10.1186/s12933-020-01097-2

Consumption of Alcoholic and Sugar-Sweetened Beverages is Associated with Increased Liver Fat Content in Middle-Aged Men and Women

Autori: Esther van Eekelen, Joline W J Beulens, Anouk Geelen, Vera B Schrauwen-Hinderling, Hildo Lamb, Albert de Roos, Frits Rosendaal, Renée de Mutsert
Pubblicato in: The Journal of Nutrition, 2019, ISSN 0022-3166
Editore: American Society for Nutritional Sciences
DOI: 10.1093/jn/nxy313

No effect of resveratrol supplementation after 6 months on insulin sensitivity in overweight adults: a randomized trial

Autori: Marlies de Ligt, Maaike Bergman, Rodrigo Mancilla Fuentes, Hans Essers, Esther Moonen-Kornips, Bas Havekes, Vera B Schrauwen-Hinderling, Patrick Schrauwen
Pubblicato in: The American Journal of Clinical Nutrition, 2020, ISSN 0002-9165
Editore: American Society for Clinical Nutrition, Inc.
DOI: 10.1093/ajcn/nqaa125

The effect of physical activity level and exercise training on the association between plasma branched-chain amino acids and intrahepatic lipid content in participants with obesity

Autori: Vanweert, F., Boone, S. C., Brouwers, B., Mook-Kanamori, D. O., de Mutsert, R., Rosendaal, F. R., Lamb, H. J., Schrauwen-Hinderling, V. B., Schrauwen, P., Hesselink, M. K. C., Phielix, E.
Pubblicato in: Int J Obes (Lond), 2021, ISSN 1476-5497
Editore: Int J Obes (Lond)
DOI: 10.1038/s41366-021-00815-4

Postexercise changes in myocellular lipid droplet characteristics of young lean individuals are affected by circulatory nonesterified fatty acids.

Autori: Sabine Daemen; Nynke van Polanen; Lena Bilet; Esther Phielix; Esther Moonen-Kornips; Vera B. Schrauwen-Hinderling; Patrick Schrauwen; Matthijs K. C. Hesselink
Pubblicato in: urn:issn:0193-1849, Numero 1, 2021, ISSN 1522-1555
Editore: Am J Physiol Endocrinol Metab
DOI: 10.1152/ajpendo.00654.2020

Hepatic saturated fatty acid fraction is associated with de novo lipogenesis and hepatic insulin resistance

Autori: Kay H. M. Roumans, Lucas Lindeboom, Pandichelvam Veeraiah, Carlijn M. E. Remie, Esther Phielix, Bas Havekes, Yvonne M. H. Bruls, Martijn C. G. J. Brouwers, Marcus Ståhlman, Marjan Alssema, Harry P. F. Peters, Renée de Mutsert, Bart Staels, Marja-Riitta Taskinen, Jan Borén, Patrick Schrauwen, Vera B. Schrauwen-Hinderling
Pubblicato in: Nature Communications, Numero 11/1, 2020, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-020-15684-0

L-carnitine infusion does not alleviate lipid-induced insulin resistance and metabolic inflexibility

Autori: Yvonne M. H. Bruls, Yvo J. M. op den Kamp, Esther Phielix, Lucas Lindeboom, Bas Havekes, Gert Schaart, Esther Moonen-Kornips, Joachim E. Wildberger, Matthijs K. C. Hesselink, Patrick Schrauwen, Vera B. Schrauwen-Hinderling
Pubblicato in: PLOS ONE, Numero 15/9, 2020, Pagina/e e0239506, ISSN 1932-6203
Editore: Public Library of Science
DOI: 10.1371/journal.pone.0239506

A randomized placebo-controlled clinical trial for pharmacological activation of BCAA catabolism in patients with type 2 diabetes

Autori: Vanweert, F., Neinast, M., Tapia, E. E., van de Weijer, T., Hoeks, J., Schrauwen-Hinderling, V. B., Blair, M. C., Bornstein, M. R., Hesselink, M. K. C., Schrauwen, P., Arany, Z., Phielix, E.
Pubblicato in: Nature Communications, 2022, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-022-31249-9

Substrate utilization and metabolic profile in response to overfeeding with a high-fat diet in South Asian and white men: a sedentary lifestyle study

Autori: Siti N Wulan, Vera B Schrauwen-Hinderling, Klaas R Westerterp, Guy Plasqui
Pubblicato in: International Journal of Obesity, 2019, ISSN 0307-0565
Editore: Nature Publishing Group
DOI: 10.1038/s41366-019-0368-2

Sitting less elicits metabolic responses similar to exercise and enhances insulin sensitivity in postmenopausal women.

Autori: Carlijn M. E. Remie; Georges E. Janssens; L. Bilet; Michel van Weeghel; Bernard M. F. M. Duvivier; Vera H. W. de Wit; Niels J. Connell; Johanna A. Jörgensen; Bauke V. Schomakers; Vera B. Schrauwen-Hinderling; Joris Hoeks; Matthijs K. C. Hesselink; Esther Phielix; Riekelt H. Houtkooper; Patrick Schrauwen
Pubblicato in: Diabetologia, 64(12), 2817 - 2828. Springer, Cham, Numero 2, 2021, ISSN 1432-0428
Editore: Diabetologia
DOI: 10.1007/s00125-021-05558-5

Characterization of BAT activity in rats using invasive and non-invasive techniques

Autori: Andreas Paulus, Petronella A. van Ewijk, Emmani B. M. Nascimento, Marijke De Saint-Hubert, Geert Hendrikx, Andrea Vogg, Ivo Pooters, Melanie Schnijderberg, Joris Vanderlocht, Gerard Bos, Boudewijn Brans, Vera B. Schrauwen-Hinderling, Felix M. Mottaghy, Matthias Bauwens
Pubblicato in: PLOS ONE, Numero 14/5, 2019, Pagina/e e0215852, ISSN 1932-6203
Editore: Public Library of Science
DOI: 10.1371/journal.pone.0215852

Liver fat storage pathways: methodologies and dietary effects

Autori: Roumans, K. H. M., Basset Sagarminaga, J., Peters, H. P. F., Schrauwen, P., Schrauwen-Hinderling, V. B.
Pubblicato in: Curr Opin Lipidol, 2021, ISSN 1473-6535
Editore: Curr Opin Lipidol
DOI: 10.1097/mol.0000000000000720

Timing of physical activity in relation to liver fat content and insulin resistance

Autori: van der Velde, Jhpm. Boone, S. C., Winters-van Eekelen, E., Hesselink, M. K. C., Schrauwen-Hinderling, V. B., Schrauwen, P., Lamb, H. J., Rosendaal, F. R., de Mutsert, R.
Pubblicato in: Diabetologia, 2023, ISSN 1432-0428
Editore: Diabetologia
DOI: 10.1007/s00125-022-05813-3

Nicotinamide riboside supplementation alters body composition and skeletal muscle acetylcarnitine concentrations in healthy obese humans

Autori: Carlijn M E Remie, Kay H M Roumans, Michiel P B Moonen, Niels J Connell, Bas Havekes, Julian Mevenkamp, Lucas Lindeboom, Vera H W de Wit, Tineke van de Weijer, Suzanne A B M Aarts, Esther Lutgens, Bauke V Schomakers, Hyung L Elfrink, Rubén Zapata-Pérez, Riekelt H Houtkooper, Johan Auwerx, Joris Hoeks, Vera B Schrauwen-Hinderling, Esther Phielix, Patrick Schrauwen
Pubblicato in: The American Journal of Clinical Nutrition, Numero 112/2, 2020, Pagina/e 413-426, ISSN 0002-9165
Editore: American Society for Clinical Nutrition, Inc.
DOI: 10.1093/ajcn/nqaa072

Invasive and noninvasive markers of human skeletal muscle mitochondrial function

Autori: Mancilla, R., Pava-Mejia, D., van Polanen, N., de Wit, V., Bergman, M., Grevendonk, L., Jorgensen, J., Kornips, E., Hoeks, J., Hesselink, M. K. C., Schrauwen-Hinderling, V. B.
Pubblicato in: Physiol Rep, 2023, ISSN 2051-817X
Editore: Physiol Rep
DOI: 10.14814/phy2.15734

Additional file 1 of Pericardial fat and its influence on cardiac diastolic function

Autori: Wit-Verheggen, Vera H. W. De; Altintas, Sibel; Spee, Romy J. M.; Mihl, Casper; Kuijk, Sander M. J. Van; Wildberger, Joachim E.; Schrauwen-Hinderling, Vera B.; Kietselaer, Bas L. J. H.; Weijer, Tineke Van De
Pubblicato in: Cardiovasc Diobetol, Numero 1, 2020, ISSN 1475-2840
Editore: BioMed Central
DOI: 10.6084/m9.figshare.12819333

One-leg inactivity induces a reduction in mitochondrial oxidative capacity, intramyocellular lipid accumulation and reduced insulin signalling upon lipid infusion: a human study with unilateral limb suspension

Autori: Lena Bilet, Esther Phielix, Tineke van de Weijer, Anne Gemmink, Madeleen Bosma, Esther Moonen-Kornips, Johanna A. Jorgensen, Gert Schaart, Dongyan Zhang, Kenneth Meijer, Maria Hopman, Matthijs K. C. Hesselink, D. Margriet Ouwens, Gerald I. Shulman, Vera B. Schrauwen-Hinderling, Patrick Schrauwen
Pubblicato in: Diabetologia, Numero 63/6, 2020, Pagina/e 1211-1222, ISSN 0012-186X
Editore: Springer Verlag
DOI: 10.1007/s00125-020-05128-1

Ectopic lipid deposition in muscle and liver, quantified by proton magnetic resonance spectroscopy

Autori: Buitinga, M., Veeraiah, P., Haans, F., Schrauwen-Hinderling, V. B.
Pubblicato in: Obesity, 2023, ISSN 1930-739X
Editore: Obesity
DOI: 10.1002/oby.23865

Skeletal muscle mitochondrial inertia is associated with carnitine acetyltransferase activity and physical function in humans

Autori: Mancilla, R. F., Lindeboom, L., Grevendonk, L., Hoeks, J., Koves, T. R., Muoio, D. M., Schrauwen, P., Schrauwen-Hinderling, V., Hesselink, M. K.
Pubblicato in: JCI Insight, 2023, ISSN 2379-3708
Editore: JCI Insight
DOI: 10.1172/jci.insight.163855