Novel methods in Magnetic Resonance Spectroscopy to investigate mechanisms underlying metabolic disease

Información del proyecto

MRS in diabetes

Identificador del acuerdo de subvención: 759161

DOI

10.3030/759161

Proyecto cerrado

Fecha de la firma de la CE 5 Febrero 2018

Fecha de inicio 1 Marzo 2018

Fecha de finalización 31 Julio 2023

Financiado con arreglo a

• EXCELLENT SCIENCE - European Research Council (ERC)

Coste total

€ 1 500 000,00

Aportación de la UE

€ 1 500 000,00

Coordinado por

UNIVERSITEIT MAASTRICHT
Netherlands

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Publicaciones

Peer reviewed articles (36)

Effects of dietary macronutrients on liver fat content in adults: a systematic review and meta-analysis of randomized controlled trials

Autores: Esther Winters-van Eekelen, Inge Verkouter, Harry P. F. Peters, Marjan Alssema, Babette G. de Roos, Vera B. Schrauwen-Hinderling, Kay H. M. Roumans, Jan W. Schoones, Peter L. Zock, Patrick Schrauwen, Frits R. Rosendaal, Olaf M. Dekkers, Renée de Mutsert
Publicado en: European Journal of Clinical Nutrition, 2020, ISSN 0954-3007
Editor: Nature Publishing Group
DOI: 10.1038/s41430-020-00778-1

An Empirical Approach to Derive Water T(1) from Multiparametric MR Images Using an Automated Pipeline and Comparison With Liver Stiffness

Autores: Michelotti, F. C., Kupriyanova, Y., Mori, T., Kustner, T., Heilmann, G., Bombrich, M., Moser, C. Schon, M., Kuss, O., Roden, M., Schrauwen-Hinderling, V. B.
Publicado en: J Magn Reson Imaging, 2023, ISSN 1522-2586
Editor: J Magn Reson Imaging
DOI: 10.1002/jmri.28906

Replacing Foods with a High-Glycemic Index and High in Saturated Fat by Alternatives with a Low Glycemic Index and Low Saturated Fat Reduces Hepatic Fat, Even in Isocaloric and Macronutrient Matched Conditions

Autores: Basset-Sagarminaga, J., Roumans, K. H. M., Havekes, B., Mensink, R. P., Peters, H. P. F., Zock, P. L., Mutsert, R., Boren, J., Lindeboom, L., Schrauwen, P., Schrauwen-Hinderling, V. B.
Publicado en: Nutrients, 2023, ISSN 2072-6643
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/nu15030735

Application of Magnetic Resonance Spectroscopy in metabolic research

Autores: Tineke van de Weijer, Vera B. Schrauwen-Hinderling
Publicado en: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Edición 1865/4, 2019, Página(s) 741-748, ISSN 0925-4439
Editor: Elsevier BV
DOI: 10.1016/j.bbadis.2018.09.013

A randomized, double-blind crossover trial

Autores: Anna Veelen; Charlotte Andriessen; Yvo Op den Kamp; Edmundo Erazo-Tapia; Marlies de Ligt; Julian Mevenkamp; Johanna A. Jörgensen; Esther Moonen-Kornips; Gert Schaart; Russell Esterline; Bas Havekes; Jan Oscarsson; Vera B. Schrauwen-Hinderling; Esther Phielix; Patrick Schrauwen
Publicado en: ISSN=0026-0495;TITLE=Metabolism-Clinical and Experimental, Edición 5, 2023, ISSN 1532-8600
Editor: metabolism
DOI: 10.1016/j.metabol.2022.155396

A prolonged fast improves overnight substrate oxidation without modulating hepatic glycogen in adults with and without nonalcoholic fatty liver: A randomized crossover trial

Autores: Roumans, K. H. M., Veelen, A., Andriessen, C., Mevenkamp, J., Kornips, E., Veeraiah, P., Havekes, B., Peters, H. P. F., Lindeboom, L., Schrauwen, P., Schrauwen-Hinderling, V. B.
Publicado en: Obesity, 2023, ISSN 1930-739X
Editor: Obesity
DOI: 10.1002/oby.23676

Carnitine supplementation improves metabolic flexibility and skeletal muscle acetylcarnitine formation in volunteers with impaired glucose tolerance: A randomised controlled trial

Autores: Yvonne MH Bruls, Marlies de Ligt, Lucas Lindeboom, Esther Phielix, Bas Havekes, Gert Schaart, Esther Kornips, Joachim E Wildberger, Matthijs KC Hesselink, Deborah Muoio, Patrick Schrauwen, Vera B Schrauwen-Hinderling
Publicado en: EBioMedicine, Edición 49, 2019, Página(s) 318-330, ISSN 2352-3964
Editor: Elsevier BV
DOI: 10.1016/j.ebiom.2019.10.017

Resveratrol improves ex vivo mitochondrial function but does not affect insulin sensitivity or brown adipose tissue in first degree relatives of patients with type 2 diabetes

Autores: Marlies de Ligt, Yvonne M.H. Bruls, Jan Hansen, Marie-Fleur Habets, Bas Havekes, Emmani B.M. Nascimento, Esther Moonen-Kornips, Gert Schaart, Vera B. Schrauwen-Hinderling, Wouter van Marken Lichtenbelt, Patrick Schrauwen
Publicado en: Molecular Metabolism, Edición 12, 2018, Página(s) 39-47, ISSN 2212-8778
Editor: Elsevier GmbH
DOI: 10.1016/j.molmet.2018.04.004

Proton magnetic resonance spectroscopy in skeletal muscle: Experts' consensus recommendations

Autores: Martin Krššák, Lucas Lindeboom, Vera Schrauwen‐Hinderling, Lidia S. Szczepaniak, Wim Derave, Jesper Lundbom, Douglas Befroy, Fritz Schick, Jürgen Machann, Roland Kreis, Chris Boesch
Publicado en: NMR in Biomedicine, 2020, ISSN 0952-3480
Editor: John Wiley & Sons Inc.
DOI: 10.1002/nbm.4266

Thigh muscles are more susceptible to age-related muscle loss when compared to lower leg and pelvic muscles

Autores: Cas J. Fuchs; Remco Kuipers; Jan A. Rombouts; Kim Brouwers; Vera B. Schrauwen-Hinderling; Joachim E. Wildberger; Lex B. Verdijk; Luc J.C. van Loon
Publicado en: VOLUME=175;ISSN=0531-5565;TITLE=Experimental Gerontology, Edición 1, 2023, ISSN 1873-6815
Editor: Exp Gerontol
DOI: 10.1016/j.exger.2023.112159

The tissue-specific metabolic effects of the PPARalpha agonist ciprofibrate in insulin-resistant male individuals: a double-blind, randomized, placebo-controlled crossover study

Autores: de Wit-Verheggen, V. H. W., Vanweert, F., Raiko, J., Lienard, V., Schaart, G., Gemmink, A., Nascimento, E. B. M., Hesselink, M. K. C., Wildberger, J. E., Wierts, R., Joris, P. J., Haas, J., Montaigne, D., Staels, B., Phielix, E., Schrauwen, P., Schrauwen-Hinderling, V. B., van de Weijer, T.
Publicado en: Obesity, 2023, ISSN 1930-739X
Editor: Obesity
DOI: 10.1002/oby.23874

Application of a BIlinear Rotation Decoupling (BIRD) filter in combination with J‐difference editing for indirect 13 C measurements in the human liver

Autores: Pandichelvam Veeraiah, Kim Brouwers, Joachim E. Wildberger, Vera B. Schrauwen‐Hinderling, Lucas Lindeboom
Publicado en: Magnetic Resonance in Medicine, Edición 84/6, 2020, Página(s) 2911-2917, ISSN 0740-3194
Editor: John Wiley & Sons Inc.
DOI: 10.1002/mrm.28394

Serum sex hormone-binding globulin levels are reduced and inversely associated with intrahepatic lipid content and saturated fatty acid fraction in adult patients with glycogen storage disease type 1a

Autores: Simons, Pihg, Valkenburg, O., Telgenkamp, I., van der Waaij, K. M., de Groot, D. M., Veeraiah, P., Bons, J. A. P., Derks, T. G. J., Schalkwijk, C. G., Schrauwen-Hinderling, V. B., Stehouwer, C. D. A., Brouwers, Mcgj
Publicado en: J Endocrinol Invest, 2022, ISSN 1720-8386
Editor: J Endocrinol Invest
DOI: 10.1007/s40618-022-01753-2

The effect of weight loss on whole-body and tissue-specific insulin sensitivity and hepatic lipid content and composition: SWEET substudy

Autores: Pang, M. D., Bastings, Jjaj, Op den Kamp-Bruls, Y. M. H., Harrold, J. A., Kjolbaek, L., Halford, J. C. G., Adam, T. C. M., Raben, A., Schrauwen-Hinderling, V. B., Goossens, G. H., Blaak, E. E.
Publicado en: Obesity, 2023, ISSN 1930-739X
Editor: Obesity
DOI: 10.1002/oby.23773

No evidence for brown adipose tissue activation after creatine supplementation in adult vegetarians

Autores: Connell, N. J., Doligkeit, D., Andriessen, C., Kornips-Moonen, E., Bruls, Y. M. H., Schrauwen-Hinderling, V. B., van de Weijer, T., van Marken-Lichtenbelt, W. D., Havekes, B., Kazak, L., Spiegelman, B. M., Hoeks, J., Schrauwen, P.
Publicado en: Nature Metabolism, 2021, ISSN 2522-5812
Editor: Nature Metabolism
DOI: 10.1038/s42255-020-00332-0

Relationship between de novo lipogenesis and serum sex hormone binding globulin in humans.

Autores: Pomme I. H. G. Simons; Pomme I. H. G. Simons; Olivier Valkenburg; Ine Telgenkamp; Ine Telgenkamp; Koen M van der Waaij; Koen M van der Waaij; David M de Groot; Pandichelvam Veeraiah; Judith A P Bons; Marja-Riitta Taskinen; Jan Borén; Patrick Schrauwen; Joost H.W. Rutten; David Cassiman; Casper G. Schalkwijk; Coen D.A. Stehouwer; Coen D.A. Stehouwer; Vera B. Schrauwen-Hinderling; Leanne Hodson; Ma
Publicado en: VOLUME=95;ISSUE=1;STARTPAGE=101;ENDPAGE=106;ISSN=0300-0664;TITLE=Clinical Endocrinology, Edición 1, 2021, ISSN 1365-2265
Editor: Clin Endocrinol (Oxf)
DOI: 10.1111/cen.14459

Gene expression and DNA methylation as mechanisms of disturbed metabolism in offspring after exposure to a prenatal HF diet

Autores: Sven H. Rouschop, Tanja Karl, Angela Risch, Petronella A. van Ewijk, Vera B. Schrauwen-Hinderling, Antoon Opperhuizen, Frederik J. van Schooten, Roger W. Godschalk
Publicado en: Journal of Lipid Research, Edición 60/7, 2019, Página(s) 1250-1259, ISSN 0022-2275
Editor: Lipid Research, Inc.
DOI: 10.1194/jlr.m092593

Pericardial fat and its influence on cardiac diastolic function

Autores: Vera H. W. de Wit-Verheggen, Sibel Altintas, Romy J. M. Spee, Casper Mihl, Sander M. J. van Kuijk, Joachim E. Wildberger, Vera B. Schrauwen-Hinderling, Bas L. J. H. Kietselaer, Tineke van de Weijer
Publicado en: Cardiovascular Diabetology, Edición 19/1, 2020, ISSN 1475-2840
Editor: BioMed Central
DOI: 10.1186/s12933-020-01097-2

Consumption of Alcoholic and Sugar-Sweetened Beverages is Associated with Increased Liver Fat Content in Middle-Aged Men and Women

Autores: Esther van Eekelen, Joline W J Beulens, Anouk Geelen, Vera B Schrauwen-Hinderling, Hildo Lamb, Albert de Roos, Frits Rosendaal, Renée de Mutsert
Publicado en: The Journal of Nutrition, 2019, ISSN 0022-3166
Editor: American Society for Nutritional Sciences
DOI: 10.1093/jn/nxy313

No effect of resveratrol supplementation after 6 months on insulin sensitivity in overweight adults: a randomized trial

Autores: Marlies de Ligt, Maaike Bergman, Rodrigo Mancilla Fuentes, Hans Essers, Esther Moonen-Kornips, Bas Havekes, Vera B Schrauwen-Hinderling, Patrick Schrauwen
Publicado en: The American Journal of Clinical Nutrition, 2020, ISSN 0002-9165
Editor: American Society for Clinical Nutrition, Inc.
DOI: 10.1093/ajcn/nqaa125

The effect of physical activity level and exercise training on the association between plasma branched-chain amino acids and intrahepatic lipid content in participants with obesity

Autores: Vanweert, F., Boone, S. C., Brouwers, B., Mook-Kanamori, D. O., de Mutsert, R., Rosendaal, F. R., Lamb, H. J., Schrauwen-Hinderling, V. B., Schrauwen, P., Hesselink, M. K. C., Phielix, E.
Publicado en: Int J Obes (Lond), 2021, ISSN 1476-5497
Editor: Int J Obes (Lond)
DOI: 10.1038/s41366-021-00815-4

Postexercise changes in myocellular lipid droplet characteristics of young lean individuals are affected by circulatory nonesterified fatty acids.

Autores: Sabine Daemen; Nynke van Polanen; Lena Bilet; Esther Phielix; Esther Moonen-Kornips; Vera B. Schrauwen-Hinderling; Patrick Schrauwen; Matthijs K. C. Hesselink
Publicado en: urn:issn:0193-1849, Edición 1, 2021, ISSN 1522-1555
Editor: Am J Physiol Endocrinol Metab
DOI: 10.1152/ajpendo.00654.2020

Hepatic saturated fatty acid fraction is associated with de novo lipogenesis and hepatic insulin resistance

Autores: Kay H. M. Roumans, Lucas Lindeboom, Pandichelvam Veeraiah, Carlijn M. E. Remie, Esther Phielix, Bas Havekes, Yvonne M. H. Bruls, Martijn C. G. J. Brouwers, Marcus Ståhlman, Marjan Alssema, Harry P. F. Peters, Renée de Mutsert, Bart Staels, Marja-Riitta Taskinen, Jan Borén, Patrick Schrauwen, Vera B. Schrauwen-Hinderling
Publicado en: Nature Communications, Edición 11/1, 2020, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-020-15684-0

L-carnitine infusion does not alleviate lipid-induced insulin resistance and metabolic inflexibility

Autores: Yvonne M. H. Bruls, Yvo J. M. op den Kamp, Esther Phielix, Lucas Lindeboom, Bas Havekes, Gert Schaart, Esther Moonen-Kornips, Joachim E. Wildberger, Matthijs K. C. Hesselink, Patrick Schrauwen, Vera B. Schrauwen-Hinderling
Publicado en: PLOS ONE, Edición 15/9, 2020, Página(s) e0239506, ISSN 1932-6203
Editor: Public Library of Science
DOI: 10.1371/journal.pone.0239506

A randomized placebo-controlled clinical trial for pharmacological activation of BCAA catabolism in patients with type 2 diabetes

Autores: Vanweert, F., Neinast, M., Tapia, E. E., van de Weijer, T., Hoeks, J., Schrauwen-Hinderling, V. B., Blair, M. C., Bornstein, M. R., Hesselink, M. K. C., Schrauwen, P., Arany, Z., Phielix, E.
Publicado en: Nature Communications, 2022, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-022-31249-9

Substrate utilization and metabolic profile in response to overfeeding with a high-fat diet in South Asian and white men: a sedentary lifestyle study

Autores: Siti N Wulan, Vera B Schrauwen-Hinderling, Klaas R Westerterp, Guy Plasqui
Publicado en: International Journal of Obesity, 2019, ISSN 0307-0565
Editor: Nature Publishing Group
DOI: 10.1038/s41366-019-0368-2

Sitting less elicits metabolic responses similar to exercise and enhances insulin sensitivity in postmenopausal women.

Autores: Carlijn M. E. Remie; Georges E. Janssens; L. Bilet; Michel van Weeghel; Bernard M. F. M. Duvivier; Vera H. W. de Wit; Niels J. Connell; Johanna A. Jörgensen; Bauke V. Schomakers; Vera B. Schrauwen-Hinderling; Joris Hoeks; Matthijs K. C. Hesselink; Esther Phielix; Riekelt H. Houtkooper; Patrick Schrauwen
Publicado en: Diabetologia, 64(12), 2817 - 2828. Springer, Cham, Edición 2, 2021, ISSN 1432-0428
Editor: Diabetologia
DOI: 10.1007/s00125-021-05558-5

Characterization of BAT activity in rats using invasive and non-invasive techniques

Autores: Andreas Paulus, Petronella A. van Ewijk, Emmani B. M. Nascimento, Marijke De Saint-Hubert, Geert Hendrikx, Andrea Vogg, Ivo Pooters, Melanie Schnijderberg, Joris Vanderlocht, Gerard Bos, Boudewijn Brans, Vera B. Schrauwen-Hinderling, Felix M. Mottaghy, Matthias Bauwens
Publicado en: PLOS ONE, Edición 14/5, 2019, Página(s) e0215852, ISSN 1932-6203
Editor: Public Library of Science
DOI: 10.1371/journal.pone.0215852

Liver fat storage pathways: methodologies and dietary effects

Autores: Roumans, K. H. M., Basset Sagarminaga, J., Peters, H. P. F., Schrauwen, P., Schrauwen-Hinderling, V. B.
Publicado en: Curr Opin Lipidol, 2021, ISSN 1473-6535
Editor: Curr Opin Lipidol
DOI: 10.1097/mol.0000000000000720

Timing of physical activity in relation to liver fat content and insulin resistance

Autores: van der Velde, Jhpm. Boone, S. C., Winters-van Eekelen, E., Hesselink, M. K. C., Schrauwen-Hinderling, V. B., Schrauwen, P., Lamb, H. J., Rosendaal, F. R., de Mutsert, R.
Publicado en: Diabetologia, 2023, ISSN 1432-0428
Editor: Diabetologia
DOI: 10.1007/s00125-022-05813-3

Nicotinamide riboside supplementation alters body composition and skeletal muscle acetylcarnitine concentrations in healthy obese humans

Autores: Carlijn M E Remie, Kay H M Roumans, Michiel P B Moonen, Niels J Connell, Bas Havekes, Julian Mevenkamp, Lucas Lindeboom, Vera H W de Wit, Tineke van de Weijer, Suzanne A B M Aarts, Esther Lutgens, Bauke V Schomakers, Hyung L Elfrink, Rubén Zapata-Pérez, Riekelt H Houtkooper, Johan Auwerx, Joris Hoeks, Vera B Schrauwen-Hinderling, Esther Phielix, Patrick Schrauwen
Publicado en: The American Journal of Clinical Nutrition, Edición 112/2, 2020, Página(s) 413-426, ISSN 0002-9165
Editor: American Society for Clinical Nutrition, Inc.
DOI: 10.1093/ajcn/nqaa072

Invasive and noninvasive markers of human skeletal muscle mitochondrial function

Autores: Mancilla, R., Pava-Mejia, D., van Polanen, N., de Wit, V., Bergman, M., Grevendonk, L., Jorgensen, J., Kornips, E., Hoeks, J., Hesselink, M. K. C., Schrauwen-Hinderling, V. B.
Publicado en: Physiol Rep, 2023, ISSN 2051-817X
Editor: Physiol Rep
DOI: 10.14814/phy2.15734

Additional file 1 of Pericardial fat and its influence on cardiac diastolic function

Autores: Wit-Verheggen, Vera H. W. De; Altintas, Sibel; Spee, Romy J. M.; Mihl, Casper; Kuijk, Sander M. J. Van; Wildberger, Joachim E.; Schrauwen-Hinderling, Vera B.; Kietselaer, Bas L. J. H.; Weijer, Tineke Van De
Publicado en: Cardiovasc Diobetol, Edición 1, 2020, ISSN 1475-2840
Editor: BioMed Central
DOI: 10.6084/m9.figshare.12819333

One-leg inactivity induces a reduction in mitochondrial oxidative capacity, intramyocellular lipid accumulation and reduced insulin signalling upon lipid infusion: a human study with unilateral limb suspension

Autores: Lena Bilet, Esther Phielix, Tineke van de Weijer, Anne Gemmink, Madeleen Bosma, Esther Moonen-Kornips, Johanna A. Jorgensen, Gert Schaart, Dongyan Zhang, Kenneth Meijer, Maria Hopman, Matthijs K. C. Hesselink, D. Margriet Ouwens, Gerald I. Shulman, Vera B. Schrauwen-Hinderling, Patrick Schrauwen
Publicado en: Diabetologia, Edición 63/6, 2020, Página(s) 1211-1222, ISSN 0012-186X
Editor: Springer Verlag
DOI: 10.1007/s00125-020-05128-1

Ectopic lipid deposition in muscle and liver, quantified by proton magnetic resonance spectroscopy

Autores: Buitinga, M., Veeraiah, P., Haans, F., Schrauwen-Hinderling, V. B.
Publicado en: Obesity, 2023, ISSN 1930-739X
Editor: Obesity
DOI: 10.1002/oby.23865

Skeletal muscle mitochondrial inertia is associated with carnitine acetyltransferase activity and physical function in humans

Autores: Mancilla, R. F., Lindeboom, L., Grevendonk, L., Hoeks, J., Koves, T. R., Muoio, D. M., Schrauwen, P., Schrauwen-Hinderling, V., Hesselink, M. K.
Publicado en: JCI Insight, 2023, ISSN 2379-3708
Editor: JCI Insight
DOI: 10.1172/jci.insight.163855