Endothelial RNA Modifications in Vascular Homeostasis and Disease

Información del proyecto

MODVASC

Identificador del acuerdo de subvención: 759248

DOI

10.3030/759248

Proyecto cerrado

Fecha de la firma de la CE 20 Diciembre 2017

Fecha de inicio 1 Junio 2018

Fecha de finalización 31 Marzo 2024

Financiado con arreglo a

• EXCELLENT SCIENCE - European Research Council (ERC)

Coste total

€ 1 499 250,00

Aportación de la UE

€ 1 499 250,00

Coordinado por

RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG
Germany

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Publicaciones

Peer reviewed articles (39)

The importance of microvascular inflammation in ageing and age-related diseases: a position paper from the ESH working group on small arteries, section of microvascular inflammation

Autores: Mengozzi A, de Ciuceis C, Dell'oro R, Georgiopoulos G, Lazaridis A, Nosalski R, Pavlidis G, Tual-Chalot S, Agabiti-Rosei C, Anyfanti P, Camargo LL, Dąbrowska E, Quarti-Trevano F, Hellmann M, Masi S, Mavraganis G, Montezano AC, Rios FJ, Winklewski PJ, Wolf J, Costantino S, Gkaliagkousi E, Grassi G, Guzik TJ, Ikonomidis I, Narkiewicz K, Paneni F, Rizzoni D, Stamatelopoulos K, Stellos K, Taddei S, T
Publicado en: journal of hypertension, 2023, ISSN 0263-6352
Editor: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/hjh.0000000000003503

Beta-Secretase-1 Antisense RNA Is Associated with Vascular Ageing and Atherosclerotic Cardiovascular Disease

Autores: Dimitrios, Bampatsias; Ioannis, Mavroeidis; Simon, Tual-Chalot; Nikolaos I, Vlachogiannis; Francesca, Bonini; Marco, Sachse; Georgios, Mavraganis; Alexia, Mareti; Chrysoula, Kritsioti; Ageliki, Laina; Dimitrios, Delialis; Giorgia, Ciliberti; Kateryna, Sopova; Aikaterini, Gatsiou; Fabio, Martelli; Georgios, Georgiopoulos; Konstantinos, Stellos; Kimon, Stamatelopoulos
Publicado en: Thrombosis and Haemostasis, Edición 2, 2022, ISSN 0340-6245
Editor: Schattauer
DOI: 10.1055/a-1914-2094

Adenosine-to-inosine Alu RNA editing controls the stability of the pro-inflammatory long noncoding RNA NEAT1 in atherosclerotic cardiovascular disease

Autores: Vlachogiannis NI, Sachse M, Georgiopoulos G, Zormpas E, Bampatsias D, Delialis D, Bonini F, Galyfos G, Sigala F, Stamatelopoulos K, Gatsiou A, Stellos K
Publicado en: Journal of Molecular and Cellular Cardiology, 2021, ISSN 0022-2828
Editor: Academic Press
DOI: 10.1016/j.yjmcc.2021.07.005

Effector T cell chemokine IP-10 predicts cardiac recovery and clinical outcomes post-myocardial infarction

Autores: Kateryna Sopova; Kateryna Sopova; Kateryna Sopova; Kateryna Sopova; Kateryna Sopova; Simon Tual-Chalot; Matthias Mueller-Hennessen; Matthias Mueller-Hennessen; Nikolaos I. Vlachogiannis; Georgios Georgiopoulos; Moritz Biener; Moritz Biener; Marco Sachse; Andrey Turchinovich; Maria Polycarpou-Schwarz; Luke Spray; Luke Spray; Eleni Maneta; Karim Bennaceur; Ashfaq Mohammad; Ashfaq Mohammad; Gavin Dav
Publicado en: Frontiers in Immunology, Vol 14 (2023), Edición 4, 2023, ISSN 1664-3224
Editor: Frontiers Research Foundation
DOI: 10.3389/fimmu.2023.1177467

RNA epigenetics and cardiovascular diseases

Autores: Dorn LE, Tual-Chalot S, Stellos K, Accornero F
Publicado en: Journal of Molecular and Cellular Cardiology, 2019, ISSN 0022-2828
Editor: Academic Press
DOI: 10.1016/j.yjmcc.2019.03.010

Repurposing of an antiasthmatic drug may reduce NETosis and myocardial ischaemia/reperfusion injury.

Autores: Amponsah-Offeh M, Tual-Chalot S, Stellos K
Publicado en: European heart journal, 2024, ISSN 0195-668X
Editor: Oxford University Press
DOI: 10.1093/eurheartj/ehae201

Involvement of cardiovascular system as the critical point in coronavirus disease 2019 (COVID-19) prognosis and recovery

Autores: Charalampos Lazaridis, Nikolaos I. Vlachogiannis, Constantinos Bakogiannis, Ioakim Spyridopoulos, Kimon Stamatelopoulos, Ioannis Kanakakis, Vassilios Vassilikos, Konstantinos Stellos
Publicado en: Hellenic Journal of Cardiology, 2020, ISSN 1109-9666
Editor: Hellenic Cardiological Society
DOI: 10.1016/j.hjc.2020.05.004

RNA-binding proteins in vascular inflammation and atherosclerosis

Autores: Sachse M, Tual-Chalot S, Ciliberti G, Amponsah-Offeh M, Stamatelopoulos K, Gatsiou A, Stellos K
Publicado en: RNA-binding proteins in vascular inflammation and atherosclerosis, 2023, ISSN 0021-9150
Editor: Elsevier BV
DOI: 10.1016/j.atherosclerosis.2023.01.008

Sirtuin 5 promotes arterial thrombosis by blunting the fibrinolytic system

Autores: Liberale L, Akhmedov A, Vlachogiannis NI, Bonetti NR, Nageswaran V, Miranda MX, Puspitasari YM, Schwarz L, Costantino S, Paneni F, Beer JH, Ruschitzka F, Montecucco F, Lüscher TF, Stamatelopoulos K, Stellos K, Camici GG
Publicado en: Cardiovascular Research, 2021, ISSN 0008-6363
Editor: Elsevier BV
DOI: 10.1093/cvr/cvaa268

Reactive Vasodilation Predicts Mortality in Primary Systemic Light-Chain Amyloidosis

Autores: Kimon Stamatelopoulos, Georgios Georgiopoulos, Fani Athanasouli, Panagiota-Efstathia Nikolaou, Marita Lykka, Maria Roussou, Maria Gavriatopoulou, Aggeliki Laina, Georgia Trakada, Marietta Charakida, Dimitris Delialis, Ioannis Petropoulos, Constantinos Pamboukas, Efstathios Manios, Marina Karakitsou, Christos Papamichael, Aikaterini Gatsiou, Irene Lambrinoudaki, Evangelos Terpos, Konstantinos Stell
Publicado en: Circulation Research, Edición 125/8, 2019, Página(s) 744-758, ISSN 0009-7330
Editor: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circresaha.119.314862

Interleukin-17A Triggers the Release of Platelet-Derived Factors Driving Vascular Endothelial Cells toward a Pro-Angiogenic State.

Autores: Aikaterini Gatsiou; Aikaterini Gatsiou; Aikaterini Gatsiou; Kateryna Sopova; Kateryna Sopova; Kateryna Sopova; Alexandros D. Tselepis; Konstantinos Stellos; Konstantinos Stellos; Konstantinos Stellos
Publicado en: cells, Edición 5, 2021, ISSN 2073-4409
Editor: MDPI
DOI: 10.3390/cells10081855

Adenosine-to-inosine RNA editing contributes to type I interferon responses in systemic sclerosis

Autores: Vlachogiannis NI, Tual-Chalot S, Zormpas E, Bonini F, Ntouros PA, Pappa M, Bournia V-K, Tektonidou MG, Souliotis VL, Mavragani CP, Stamatelopoulos K, Gatsiou A, Sfikakis PP, Stellos K
Publicado en: Journal of Autoimmunity, 2021, ISSN 0896-8411
Editor: Academic Press
DOI: 10.1016/j.jaut.2021.102755

Estimated pulse wave velocity improves risk stratification for all-cause mortality in patients with COVID-19

Autores: Stamatelopoulos K, Georgiopoulos G, Baker KF, Tiseo G, Delialis D, Lazaridis C, Barbieri G, Masi S, Vlachogiannis NI, Sopova K, Mengozzi A, Ghiadoni L, van der Loeff IS, Hanrath AT, Ajdini B, Vlachopoulos C, Dimopoulos MA, Duncan CJA, Falcone M, Stellos K; Pisa COVID-19 Research Group; Newcastle COVID-19 Research Group
Publicado en: Scientific report, 2021, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-021-99050-0

Targeting the adipose tissue: heart crosstalk in pressure overload-induced heart failure

Autores: Tual-Chalot S, Stellos K
Publicado en: Cardiovascular Research, 2022, ISSN 0008-6363
Editor: Elsevier BV
DOI: 10.1093/cvr/cvac046

Mechanisms of Vascular Inflammation and Potential Therapeutic Targets: A Position Paper From the ESH Working Group on Small Arteries

Autores: Rios FJ, de Ciuceis C, Georgiopoulos G, Lazaridis A, Nosalski R, Pavlidis G, Tual-Chalot S, Agabiti-Rosei C, Camargo LL, Dąbrowska E, Quarti-Trevano F, Hellmann M, Masi S, Lopreiato M, Mavraganis G, Mengozzi A, Montezano AC, Stavropoulos K, Winklewski PJ, Wolf J, Costantino S, Doumas M, Gkaliagkousi E, Grassi G, Guzik TJ, Ikonomidis I, Narkiewicz K, Paneni F, Rizzoni D, Stamatelopoulos K, Stellos
Publicado en: hypertension, 2024, ISSN 0194-911X
Editor: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/hypertensionaha.123.22483

A roadmap for therapeutic discovery in pulmonary hypertension associated with left heart failure. A scientific statement of the Heart Failure Association (HFA) of the ESC and the ESC Working Group on Pulmonary Circulation & Right Ventricular Function

Autores: Ameri P, Mercurio V, Pollesello P, Anker MS, Backs J, Bayes-Genis A, Borlaug BA, Burkhoff D, Caravita S, Chan SY, de Man F, Giannakoulas G, González A, Guazzi M, Hassoun PM, Hemnes AR, Maack C, Madden B, Melenovsky V, Müller OJ, Papp Z, Pullamsetti SS, Rainer PP, Redfield MM, Rich S, Schiattarella GG, Skaara H, Stellos K, Tedford RJ, Thum T, Vachiery JL, van der Meer P, Van Linthout S, Pruszczyk
Publicado en: European journal of heart failure, 2024, ISSN 1388-9842
Editor: Elsevier BV
DOI: 10.1002/ejhf.3236

The Alzheimer’s Disease Amyloid-Beta Hypothesis in Cardiovascular Aging and Disease

Autores: Dimitrios A. Stakos, Kimon Stamatelopoulos, Dimitrios Bampatsias, Marco Sachse, Eleftherios Zormpas, Nikolaos I. Vlachogiannis, Simon Tual-Chalot, Konstantinos Stellos
Publicado en: Journal of the American College of Cardiology, Edición 75/8, 2020, Página(s) 952-967, ISSN 0735-1097
Editor: Elsevier BV
DOI: 10.1016/j.jacc.2019.12.033

Modification of the GRACE Risk Score for Risk Prediction in Patients with Acute Coronary Syndromes

Autores: Georgiopoulos G, Kraler S, Mueller-Hennessen M, Delialis D, Mavraganis G, Sopova K, Wenzl FA, Räber L, Biener M, Stähli BE, Maneta E, Spray L, Iglesias JF, Coelho-Lima J, Tual-Chalot S, Muller O, Mach F, Frey N, Duerschmied D, Langer HF, Katus H, Roffi M, Camici GG, Mueller C, Giannitsis E, Spyridopoulos I, Lüscher TF, Stellos K, Stamatelopoulos K.
Publicado en: JAMA cardiology, 2023, ISSN 2380-6583
Editor: American Medical Association
DOI: 10.1001/jamacardio.2023.2741

(Epi)transcriptomics in cardiovascular and neurological complications of COVID-19

Autores: Jusic A, Stellos K, Ferreira L, Baker AH, Devaux Y
Publicado en: Journal of molecular and cellular cardiology plus, 2022, ISSN 2772-9761
Editor: Elsevier
DOI: 10.1016/j.jmccpl.2022.100013

Dawn of Epitranscriptomic Medicine

Autores: Aikaterini Gatsiou, Konstantinos Stellos
Publicado en: Circulation: Genomic and Precision Medicine, Edición 11/9, 2018, ISSN 2574-8300
Editor: American Heart Association
DOI: 10.1161/circgen.118.001927

Circulating Progenitor Cells Predict Clinical Outcomes in Patients With Coronary Artery Disease and Renal Insufficiency

Autores: Vlachogiannis NI, Stellos K
Publicado en: JACC: Basic to Translational Science, 2020, ISSN 2452-302X
Editor: Elsevier Inc
DOI: 10.1016/j.jacbts.2020.07.002

Clinical frailty, and not features of acute infection, is associated with late mortality in COVID‐19: a retrospective cohort study

Autores: Nikolaos I. Vlachogiannis; Kenneth F. Baker; Georgios Georgiopoulos; Charalampos Lazaridis; Ina Schim van der Loeff; Aidan T. Hanrath; Kateryna Sopova; Simon Tual‐Chalot; Aikaterini Gatsiou; Ioakim Spyridopoulos; Kimon Stamatelopoulos; Christopher J.A. Duncan; Konstantinos Stellos
Publicado en: Journal of Cachexia, Sarcopenia and Muscle, Vol 13, Iss 3, Pp 1502-1513 (2022), Edición 1, 2022, ISSN 2190-5991
Editor: Springer Verlag
DOI: 10.1002/jcsm.12966

Noncoding RNAs in age-related cardiovascular diseases

Autores: Jusic A, Thomas PB, Wettinger SB, Dogan S, Farrugia R, Gaetano C, Tuna BG, Pinet F, Robinson EL, Tual-Chalot S, Stellos K, Devaux Y
Publicado en: Ageing Research Reviews, 2022, ISSN 1568-1637
Editor: Elsevier BV
DOI: 10.1016/j.arr.2022.101610

Additive contribution of microRNA-34a/b/c to human arterial ageing and atherosclerosis

Autores: Gatsiou A, Georgiopoulos G, Vlachogiannis NI, Pfisterer L, Fischer A, Sachse M, Laina A, Bonini F, Delialis D, Tual-Chalot S, Zormpas E, Achangwa R, Jiang L, Kontogiannis C, Patras R, Hermeking H, Zeiher AM, Stamatelopoulos K, Dimmeler S, Stellos K
Publicado en: Atherosclerosis, 2021, ISSN 0021-9150
Editor: Elsevier BV
DOI: 10.1016/j.atherosclerosis.2021.05.005

Drug repurposing to prevent pressure overload-induced cardiac hypertrophy and heart failure

Autores: Tual-Chalot S, Stellos K
Publicado en: European heart journal, 2021, ISSN 0195-668X
Editor: Oxford University Press
DOI: 10.1093/eurheartj/ehab427

Therapeutic potential of adenosine kinase inhibition in vascular disease

Autores: Tual-Chalot S, Stellos K
Publicado en: Cardiovascular research, 2021, ISSN 0008-6363
Editor: Elsevier BV
DOI: 10.1093/cvr/cvaa122

MicroRNA-based therapy of postmyocardial infarction heart failure

Autores: Tual-Chalot S, Stellos K
Publicado en: Hellenic Journal of Cardiology, 2021, ISSN 1109-9666
Editor: Hellenic Cardiological Society
DOI: 10.1016/j.hjc.2021.03.006

Increased adenosine-to-inosine RNA editing in rheumatoid arthritis

Autores: Nikolaos I. Vlachogiannis, Aikaterini Gatsiou, Domenico Alessandro Silvestris, Kimon Stamatelopoulos, Maria G. Tektonidou, Angela Gallo, Petros P. Sfikakis, Konstantinos Stellos
Publicado en: Journal of Autoimmunity, Edición 106, 2020, Página(s) 102329, ISSN 0896-8411
Editor: Academic Press
DOI: 10.1016/j.jaut.2019.102329

Cathepsin S Levels and Survival Among Patients With Non-ST-Segment Elevation Acute Coronary Syndromes

Autores: Kimon Stamatelopoulos; Matthias Mueller-Hennessen; Georgios Georgiopoulos; Pedro Lopez-Ayala; Marco Sachse; Nikolaos I. Vlachogiannis; Kateryna Sopova; Dimitrios Delialis; Francesca Bonini; Raphael Patras; Giorgia Ciliberti; Mehrshad Vafaie; Moritz Biener; Jasper Boeddinghaus; Thomas Nestelberger; Luca Koechlin; Simon Tual-Chalot; Ioannis Kanakakis; Aikaterini Gatsiou; Hugo Katus; Ioakim Spyridopo
Publicado en: Journal of the American College of Cardiology, Edición 1, 2022, ISSN 0735-1097
Editor: Elsevier BV
DOI: 10.1016/j.jacc.2022.05.055

RNA Therapeutics in Cardiovascular Precision Medicine

Autores: Ageliki Laina, Aikaterini Gatsiou, Georgios Georgiopoulos, Kimon Stamatelopoulos, Konstantinos Stellos
Publicado en: Frontiers in Physiology, Edición 9, 2018, ISSN 1664-042X
Editor: Frontiers Research Foundation
DOI: 10.3389/fphys.2018.00953

Chrono-pharmacology-based antiplatelet therapy for acute myocardial infarction

Autores: Tual-Chalot S, Stellos K
Publicado en: European Heart Journal, 2022, ISSN 0195-668X
Editor: Oxford University Press
DOI: 10.1093/eurheartj/ehac120

Activation of telomerase by TA-65 enhances immunity and reduces inflammation post myocardial infarction Randomized Pilot Trial

Autores: Bawamia B, Spray L, Wangsaputra VK, Bennaceur K, Vahabi S, Stellos K, Kharatikoopaei E, Ogundimu E, Gale CP, Keavney B, Maier R, Hancock H, Richardson GD, Austin D, Spyridopoulos I
Publicado en: GeroScience, 2023, ISSN 2509-2723
Editor: Springer
DOI: 10.1007/s11357-023-00794-6

Clinical value of amyloid-beta1-40 as a marker of thromboinflammation in Antiphospholipid Syndrome

Autores: Tektonidou MG, Kravvariti E, Vlachogiannis NI, Georgiopoulos G, Mantzou A, Sfikakis PP, Stellos K, Stamatelopoulos K
Publicado en: Rheumatology, 2020, ISSN 1462-0324
Editor: Oxford University Press
DOI: 10.1093/rheumatology/keaa548

First-in-human gene editing for lipid lowering: the initial results

Autores: Tual-Chalot S, Stellos K
Publicado en: Cardiovascular Research, 2024, ISSN 0008-6363
Editor: Elsevier BV
DOI: 10.1093/cvr/cvae037

RNA modifications in cardiovascular health and disease

Autores: Gatsiou A, Stellos K
Publicado en: Natur e Review Cardiology, 2023, ISSN 1759-5002
Editor: Nature Publishing Group
DOI: 10.1038/s41569-022-00804-8

Circulating Amyloid Beta 1-40 Is Associated with Increased Rate of Progression of Atherosclerosis in Menopause: A Prospective Cohort Study.

Autores: Irene Lambrinoudaki; Dimitrios Delialis; Georgios Georgiopoulos; Georgios Georgiopoulos; Simon Tual-Chalot; Nikolaos I. Vlachogiannis; Raphael Patras; Evmorfia Aivalioti; Eleni Armeni; Areti Augoulea; Nikolaos Tsoltos; Anastasia Soureti; Konstantinos Stellos; Konstantinos Stellos; Kimon Stamatelopoulos; Kimon Stamatelopoulos
Publicado en: Thrombosis and Haemostasis, 2021, ISSN 0340-6245
Editor: Schattauer
DOI: 10.1055/s-0040-1721144

Prognostic value of admission high-sensitivity troponin in patients with ST-elevation myocardial infarction

Autores: Coelho-Lima J, Georgiopoulos G, Ahmed J, Adil Syeda, Gaskin D, Bakogiannis C, Sopova k, Ahmed F, Ahmed H, Spray L, Richardson G, Bagnall A, Stellos K, Stamatelopoulos K, Spyridopoulos I
Publicado en: Heart BMJ, 2021, ISSN 1355-6037
Editor: BMJ Publishing Group
DOI: 10.1136/heartjnl-2021-319225

The RNA editor ADAR2 promotes immune cell trafficking by enhancing endothelial responses to interleukin-6 during sterile inflammation

Autores: Gatsiou A, Tual-Chalot S, Napoli M, Ortega-Gomez A, Regen T, Badolia R, Cesarini V, Garcia-Gonzalez C, Chevre R, Ciliberti G, Silvestre-Roig C, Martini M, Hoffmann J, Hamouche R, Visker JR, Diakos N, Wietelmann A, Silvestris DA, Georgiopoulos G, Moshfegh A, Schneider A, Chen W, Guenther S, Backs J, Kwak S, Selzman CH, Stamatelopoulos K, Rose-John S, Trautwein C, Spyridopoulos I, Braun T, Waisman A
Publicado en: Immunity, 2023, ISSN 1074-7613
Editor: Cell Press
DOI: 10.1016/j.immuni.2023.03.021

Endothelial dysfunction and immunothrombosis in sepsis

Autores: Eleni Maneta; Evmorfia Aivalioti; Simon Tual-Chalot; Besa Emini Veseli; Aikaterini Gatsiou; Kimon Stamatelopoulos; Kimon Stamatelopoulos; Konstantinos Stellos; Konstantinos Stellos; Konstantinos Stellos; Konstantinos Stellos
Publicado en: Frontiers in Immunology, 2023, ISSN 1664-3224
Editor: Frontiers
DOI: 10.3389/fimmu.2023.1144229