Endothelial RNA Modifications in Vascular Homeostasis and Disease

Informations projet

MODVASC

N° de convention de subvention: 759248

DOI

10.3030/759248

Projet clôturé

Date de signature de la CE 20 Decembre 2017

Date de début 1 Juin 2018

Date de fin 31 Mars 2024

Financé au titre de

• EXCELLENT SCIENCE - European Research Council (ERC)

Coût total

€ 1 499 250,00

Contribution de l’UE

€ 1 499 250,00

Coordonné par

RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG
Germany

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Publications

Peer reviewed articles (39)

The importance of microvascular inflammation in ageing and age-related diseases: a position paper from the ESH working group on small arteries, section of microvascular inflammation

Auteurs: Mengozzi A, de Ciuceis C, Dell'oro R, Georgiopoulos G, Lazaridis A, Nosalski R, Pavlidis G, Tual-Chalot S, Agabiti-Rosei C, Anyfanti P, Camargo LL, Dąbrowska E, Quarti-Trevano F, Hellmann M, Masi S, Mavraganis G, Montezano AC, Rios FJ, Winklewski PJ, Wolf J, Costantino S, Gkaliagkousi E, Grassi G, Guzik TJ, Ikonomidis I, Narkiewicz K, Paneni F, Rizzoni D, Stamatelopoulos K, Stellos K, Taddei S, T
Publié dans: journal of hypertension, 2023, ISSN 0263-6352
Éditeur: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/hjh.0000000000003503

Beta-Secretase-1 Antisense RNA Is Associated with Vascular Ageing and Atherosclerotic Cardiovascular Disease

Auteurs: Dimitrios, Bampatsias; Ioannis, Mavroeidis; Simon, Tual-Chalot; Nikolaos I, Vlachogiannis; Francesca, Bonini; Marco, Sachse; Georgios, Mavraganis; Alexia, Mareti; Chrysoula, Kritsioti; Ageliki, Laina; Dimitrios, Delialis; Giorgia, Ciliberti; Kateryna, Sopova; Aikaterini, Gatsiou; Fabio, Martelli; Georgios, Georgiopoulos; Konstantinos, Stellos; Kimon, Stamatelopoulos
Publié dans: Thrombosis and Haemostasis, Numéro 2, 2022, ISSN 0340-6245
Éditeur: Schattauer
DOI: 10.1055/a-1914-2094

Adenosine-to-inosine Alu RNA editing controls the stability of the pro-inflammatory long noncoding RNA NEAT1 in atherosclerotic cardiovascular disease

Auteurs: Vlachogiannis NI, Sachse M, Georgiopoulos G, Zormpas E, Bampatsias D, Delialis D, Bonini F, Galyfos G, Sigala F, Stamatelopoulos K, Gatsiou A, Stellos K
Publié dans: Journal of Molecular and Cellular Cardiology, 2021, ISSN 0022-2828
Éditeur: Academic Press
DOI: 10.1016/j.yjmcc.2021.07.005

Effector T cell chemokine IP-10 predicts cardiac recovery and clinical outcomes post-myocardial infarction

Auteurs: Kateryna Sopova; Kateryna Sopova; Kateryna Sopova; Kateryna Sopova; Kateryna Sopova; Simon Tual-Chalot; Matthias Mueller-Hennessen; Matthias Mueller-Hennessen; Nikolaos I. Vlachogiannis; Georgios Georgiopoulos; Moritz Biener; Moritz Biener; Marco Sachse; Andrey Turchinovich; Maria Polycarpou-Schwarz; Luke Spray; Luke Spray; Eleni Maneta; Karim Bennaceur; Ashfaq Mohammad; Ashfaq Mohammad; Gavin Dav
Publié dans: Frontiers in Immunology, Vol 14 (2023), Numéro 4, 2023, ISSN 1664-3224
Éditeur: Frontiers Research Foundation
DOI: 10.3389/fimmu.2023.1177467

RNA epigenetics and cardiovascular diseases

Auteurs: Dorn LE, Tual-Chalot S, Stellos K, Accornero F
Publié dans: Journal of Molecular and Cellular Cardiology, 2019, ISSN 0022-2828
Éditeur: Academic Press
DOI: 10.1016/j.yjmcc.2019.03.010

Repurposing of an antiasthmatic drug may reduce NETosis and myocardial ischaemia/reperfusion injury.

Auteurs: Amponsah-Offeh M, Tual-Chalot S, Stellos K
Publié dans: European heart journal, 2024, ISSN 0195-668X
Éditeur: Oxford University Press
DOI: 10.1093/eurheartj/ehae201

Involvement of cardiovascular system as the critical point in coronavirus disease 2019 (COVID-19) prognosis and recovery

Auteurs: Charalampos Lazaridis, Nikolaos I. Vlachogiannis, Constantinos Bakogiannis, Ioakim Spyridopoulos, Kimon Stamatelopoulos, Ioannis Kanakakis, Vassilios Vassilikos, Konstantinos Stellos
Publié dans: Hellenic Journal of Cardiology, 2020, ISSN 1109-9666
Éditeur: Hellenic Cardiological Society
DOI: 10.1016/j.hjc.2020.05.004

RNA-binding proteins in vascular inflammation and atherosclerosis

Auteurs: Sachse M, Tual-Chalot S, Ciliberti G, Amponsah-Offeh M, Stamatelopoulos K, Gatsiou A, Stellos K
Publié dans: RNA-binding proteins in vascular inflammation and atherosclerosis, 2023, ISSN 0021-9150
Éditeur: Elsevier BV
DOI: 10.1016/j.atherosclerosis.2023.01.008

Sirtuin 5 promotes arterial thrombosis by blunting the fibrinolytic system

Auteurs: Liberale L, Akhmedov A, Vlachogiannis NI, Bonetti NR, Nageswaran V, Miranda MX, Puspitasari YM, Schwarz L, Costantino S, Paneni F, Beer JH, Ruschitzka F, Montecucco F, Lüscher TF, Stamatelopoulos K, Stellos K, Camici GG
Publié dans: Cardiovascular Research, 2021, ISSN 0008-6363
Éditeur: Elsevier BV
DOI: 10.1093/cvr/cvaa268

Reactive Vasodilation Predicts Mortality in Primary Systemic Light-Chain Amyloidosis

Auteurs: Kimon Stamatelopoulos, Georgios Georgiopoulos, Fani Athanasouli, Panagiota-Efstathia Nikolaou, Marita Lykka, Maria Roussou, Maria Gavriatopoulou, Aggeliki Laina, Georgia Trakada, Marietta Charakida, Dimitris Delialis, Ioannis Petropoulos, Constantinos Pamboukas, Efstathios Manios, Marina Karakitsou, Christos Papamichael, Aikaterini Gatsiou, Irene Lambrinoudaki, Evangelos Terpos, Konstantinos Stell
Publié dans: Circulation Research, Numéro 125/8, 2019, Page(s) 744-758, ISSN 0009-7330
Éditeur: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circresaha.119.314862

Interleukin-17A Triggers the Release of Platelet-Derived Factors Driving Vascular Endothelial Cells toward a Pro-Angiogenic State.

Auteurs: Aikaterini Gatsiou; Aikaterini Gatsiou; Aikaterini Gatsiou; Kateryna Sopova; Kateryna Sopova; Kateryna Sopova; Alexandros D. Tselepis; Konstantinos Stellos; Konstantinos Stellos; Konstantinos Stellos
Publié dans: cells, Numéro 5, 2021, ISSN 2073-4409
Éditeur: MDPI
DOI: 10.3390/cells10081855

Adenosine-to-inosine RNA editing contributes to type I interferon responses in systemic sclerosis

Auteurs: Vlachogiannis NI, Tual-Chalot S, Zormpas E, Bonini F, Ntouros PA, Pappa M, Bournia V-K, Tektonidou MG, Souliotis VL, Mavragani CP, Stamatelopoulos K, Gatsiou A, Sfikakis PP, Stellos K
Publié dans: Journal of Autoimmunity, 2021, ISSN 0896-8411
Éditeur: Academic Press
DOI: 10.1016/j.jaut.2021.102755

Estimated pulse wave velocity improves risk stratification for all-cause mortality in patients with COVID-19

Auteurs: Stamatelopoulos K, Georgiopoulos G, Baker KF, Tiseo G, Delialis D, Lazaridis C, Barbieri G, Masi S, Vlachogiannis NI, Sopova K, Mengozzi A, Ghiadoni L, van der Loeff IS, Hanrath AT, Ajdini B, Vlachopoulos C, Dimopoulos MA, Duncan CJA, Falcone M, Stellos K; Pisa COVID-19 Research Group; Newcastle COVID-19 Research Group
Publié dans: Scientific report, 2021, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-021-99050-0

Targeting the adipose tissue: heart crosstalk in pressure overload-induced heart failure

Auteurs: Tual-Chalot S, Stellos K
Publié dans: Cardiovascular Research, 2022, ISSN 0008-6363
Éditeur: Elsevier BV
DOI: 10.1093/cvr/cvac046

Mechanisms of Vascular Inflammation and Potential Therapeutic Targets: A Position Paper From the ESH Working Group on Small Arteries

Auteurs: Rios FJ, de Ciuceis C, Georgiopoulos G, Lazaridis A, Nosalski R, Pavlidis G, Tual-Chalot S, Agabiti-Rosei C, Camargo LL, Dąbrowska E, Quarti-Trevano F, Hellmann M, Masi S, Lopreiato M, Mavraganis G, Mengozzi A, Montezano AC, Stavropoulos K, Winklewski PJ, Wolf J, Costantino S, Doumas M, Gkaliagkousi E, Grassi G, Guzik TJ, Ikonomidis I, Narkiewicz K, Paneni F, Rizzoni D, Stamatelopoulos K, Stellos
Publié dans: hypertension, 2024, ISSN 0194-911X
Éditeur: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/hypertensionaha.123.22483

A roadmap for therapeutic discovery in pulmonary hypertension associated with left heart failure. A scientific statement of the Heart Failure Association (HFA) of the ESC and the ESC Working Group on Pulmonary Circulation & Right Ventricular Function

Auteurs: Ameri P, Mercurio V, Pollesello P, Anker MS, Backs J, Bayes-Genis A, Borlaug BA, Burkhoff D, Caravita S, Chan SY, de Man F, Giannakoulas G, González A, Guazzi M, Hassoun PM, Hemnes AR, Maack C, Madden B, Melenovsky V, Müller OJ, Papp Z, Pullamsetti SS, Rainer PP, Redfield MM, Rich S, Schiattarella GG, Skaara H, Stellos K, Tedford RJ, Thum T, Vachiery JL, van der Meer P, Van Linthout S, Pruszczyk
Publié dans: European journal of heart failure, 2024, ISSN 1388-9842
Éditeur: Elsevier BV
DOI: 10.1002/ejhf.3236

The Alzheimer’s Disease Amyloid-Beta Hypothesis in Cardiovascular Aging and Disease

Auteurs: Dimitrios A. Stakos, Kimon Stamatelopoulos, Dimitrios Bampatsias, Marco Sachse, Eleftherios Zormpas, Nikolaos I. Vlachogiannis, Simon Tual-Chalot, Konstantinos Stellos
Publié dans: Journal of the American College of Cardiology, Numéro 75/8, 2020, Page(s) 952-967, ISSN 0735-1097
Éditeur: Elsevier BV
DOI: 10.1016/j.jacc.2019.12.033

Modification of the GRACE Risk Score for Risk Prediction in Patients with Acute Coronary Syndromes

Auteurs: Georgiopoulos G, Kraler S, Mueller-Hennessen M, Delialis D, Mavraganis G, Sopova K, Wenzl FA, Räber L, Biener M, Stähli BE, Maneta E, Spray L, Iglesias JF, Coelho-Lima J, Tual-Chalot S, Muller O, Mach F, Frey N, Duerschmied D, Langer HF, Katus H, Roffi M, Camici GG, Mueller C, Giannitsis E, Spyridopoulos I, Lüscher TF, Stellos K, Stamatelopoulos K.
Publié dans: JAMA cardiology, 2023, ISSN 2380-6583
Éditeur: American Medical Association
DOI: 10.1001/jamacardio.2023.2741

(Epi)transcriptomics in cardiovascular and neurological complications of COVID-19

Auteurs: Jusic A, Stellos K, Ferreira L, Baker AH, Devaux Y
Publié dans: Journal of molecular and cellular cardiology plus, 2022, ISSN 2772-9761
Éditeur: Elsevier
DOI: 10.1016/j.jmccpl.2022.100013

Dawn of Epitranscriptomic Medicine

Auteurs: Aikaterini Gatsiou, Konstantinos Stellos
Publié dans: Circulation: Genomic and Precision Medicine, Numéro 11/9, 2018, ISSN 2574-8300
Éditeur: American Heart Association
DOI: 10.1161/circgen.118.001927

Circulating Progenitor Cells Predict Clinical Outcomes in Patients With Coronary Artery Disease and Renal Insufficiency

Auteurs: Vlachogiannis NI, Stellos K
Publié dans: JACC: Basic to Translational Science, 2020, ISSN 2452-302X
Éditeur: Elsevier Inc
DOI: 10.1016/j.jacbts.2020.07.002

Clinical frailty, and not features of acute infection, is associated with late mortality in COVID‐19: a retrospective cohort study

Auteurs: Nikolaos I. Vlachogiannis; Kenneth F. Baker; Georgios Georgiopoulos; Charalampos Lazaridis; Ina Schim van der Loeff; Aidan T. Hanrath; Kateryna Sopova; Simon Tual‐Chalot; Aikaterini Gatsiou; Ioakim Spyridopoulos; Kimon Stamatelopoulos; Christopher J.A. Duncan; Konstantinos Stellos
Publié dans: Journal of Cachexia, Sarcopenia and Muscle, Vol 13, Iss 3, Pp 1502-1513 (2022), Numéro 1, 2022, ISSN 2190-5991
Éditeur: Springer Verlag
DOI: 10.1002/jcsm.12966

Noncoding RNAs in age-related cardiovascular diseases

Auteurs: Jusic A, Thomas PB, Wettinger SB, Dogan S, Farrugia R, Gaetano C, Tuna BG, Pinet F, Robinson EL, Tual-Chalot S, Stellos K, Devaux Y
Publié dans: Ageing Research Reviews, 2022, ISSN 1568-1637
Éditeur: Elsevier BV
DOI: 10.1016/j.arr.2022.101610

Additive contribution of microRNA-34a/b/c to human arterial ageing and atherosclerosis

Auteurs: Gatsiou A, Georgiopoulos G, Vlachogiannis NI, Pfisterer L, Fischer A, Sachse M, Laina A, Bonini F, Delialis D, Tual-Chalot S, Zormpas E, Achangwa R, Jiang L, Kontogiannis C, Patras R, Hermeking H, Zeiher AM, Stamatelopoulos K, Dimmeler S, Stellos K
Publié dans: Atherosclerosis, 2021, ISSN 0021-9150
Éditeur: Elsevier BV
DOI: 10.1016/j.atherosclerosis.2021.05.005

Drug repurposing to prevent pressure overload-induced cardiac hypertrophy and heart failure

Auteurs: Tual-Chalot S, Stellos K
Publié dans: European heart journal, 2021, ISSN 0195-668X
Éditeur: Oxford University Press
DOI: 10.1093/eurheartj/ehab427

Therapeutic potential of adenosine kinase inhibition in vascular disease

Auteurs: Tual-Chalot S, Stellos K
Publié dans: Cardiovascular research, 2021, ISSN 0008-6363
Éditeur: Elsevier BV
DOI: 10.1093/cvr/cvaa122

MicroRNA-based therapy of postmyocardial infarction heart failure

Auteurs: Tual-Chalot S, Stellos K
Publié dans: Hellenic Journal of Cardiology, 2021, ISSN 1109-9666
Éditeur: Hellenic Cardiological Society
DOI: 10.1016/j.hjc.2021.03.006

Increased adenosine-to-inosine RNA editing in rheumatoid arthritis

Auteurs: Nikolaos I. Vlachogiannis, Aikaterini Gatsiou, Domenico Alessandro Silvestris, Kimon Stamatelopoulos, Maria G. Tektonidou, Angela Gallo, Petros P. Sfikakis, Konstantinos Stellos
Publié dans: Journal of Autoimmunity, Numéro 106, 2020, Page(s) 102329, ISSN 0896-8411
Éditeur: Academic Press
DOI: 10.1016/j.jaut.2019.102329

Cathepsin S Levels and Survival Among Patients With Non-ST-Segment Elevation Acute Coronary Syndromes

Auteurs: Kimon Stamatelopoulos; Matthias Mueller-Hennessen; Georgios Georgiopoulos; Pedro Lopez-Ayala; Marco Sachse; Nikolaos I. Vlachogiannis; Kateryna Sopova; Dimitrios Delialis; Francesca Bonini; Raphael Patras; Giorgia Ciliberti; Mehrshad Vafaie; Moritz Biener; Jasper Boeddinghaus; Thomas Nestelberger; Luca Koechlin; Simon Tual-Chalot; Ioannis Kanakakis; Aikaterini Gatsiou; Hugo Katus; Ioakim Spyridopo
Publié dans: Journal of the American College of Cardiology, Numéro 1, 2022, ISSN 0735-1097
Éditeur: Elsevier BV
DOI: 10.1016/j.jacc.2022.05.055

RNA Therapeutics in Cardiovascular Precision Medicine

Auteurs: Ageliki Laina, Aikaterini Gatsiou, Georgios Georgiopoulos, Kimon Stamatelopoulos, Konstantinos Stellos
Publié dans: Frontiers in Physiology, Numéro 9, 2018, ISSN 1664-042X
Éditeur: Frontiers Research Foundation
DOI: 10.3389/fphys.2018.00953

Chrono-pharmacology-based antiplatelet therapy for acute myocardial infarction

Auteurs: Tual-Chalot S, Stellos K
Publié dans: European Heart Journal, 2022, ISSN 0195-668X
Éditeur: Oxford University Press
DOI: 10.1093/eurheartj/ehac120

Activation of telomerase by TA-65 enhances immunity and reduces inflammation post myocardial infarction Randomized Pilot Trial

Auteurs: Bawamia B, Spray L, Wangsaputra VK, Bennaceur K, Vahabi S, Stellos K, Kharatikoopaei E, Ogundimu E, Gale CP, Keavney B, Maier R, Hancock H, Richardson GD, Austin D, Spyridopoulos I
Publié dans: GeroScience, 2023, ISSN 2509-2723
Éditeur: Springer
DOI: 10.1007/s11357-023-00794-6

Clinical value of amyloid-beta1-40 as a marker of thromboinflammation in Antiphospholipid Syndrome

Auteurs: Tektonidou MG, Kravvariti E, Vlachogiannis NI, Georgiopoulos G, Mantzou A, Sfikakis PP, Stellos K, Stamatelopoulos K
Publié dans: Rheumatology, 2020, ISSN 1462-0324
Éditeur: Oxford University Press
DOI: 10.1093/rheumatology/keaa548

First-in-human gene editing for lipid lowering: the initial results

Auteurs: Tual-Chalot S, Stellos K
Publié dans: Cardiovascular Research, 2024, ISSN 0008-6363
Éditeur: Elsevier BV
DOI: 10.1093/cvr/cvae037

RNA modifications in cardiovascular health and disease

Auteurs: Gatsiou A, Stellos K
Publié dans: Natur e Review Cardiology, 2023, ISSN 1759-5002
Éditeur: Nature Publishing Group
DOI: 10.1038/s41569-022-00804-8

Circulating Amyloid Beta 1-40 Is Associated with Increased Rate of Progression of Atherosclerosis in Menopause: A Prospective Cohort Study.

Auteurs: Irene Lambrinoudaki; Dimitrios Delialis; Georgios Georgiopoulos; Georgios Georgiopoulos; Simon Tual-Chalot; Nikolaos I. Vlachogiannis; Raphael Patras; Evmorfia Aivalioti; Eleni Armeni; Areti Augoulea; Nikolaos Tsoltos; Anastasia Soureti; Konstantinos Stellos; Konstantinos Stellos; Kimon Stamatelopoulos; Kimon Stamatelopoulos
Publié dans: Thrombosis and Haemostasis, 2021, ISSN 0340-6245
Éditeur: Schattauer
DOI: 10.1055/s-0040-1721144

Prognostic value of admission high-sensitivity troponin in patients with ST-elevation myocardial infarction

Auteurs: Coelho-Lima J, Georgiopoulos G, Ahmed J, Adil Syeda, Gaskin D, Bakogiannis C, Sopova k, Ahmed F, Ahmed H, Spray L, Richardson G, Bagnall A, Stellos K, Stamatelopoulos K, Spyridopoulos I
Publié dans: Heart BMJ, 2021, ISSN 1355-6037
Éditeur: BMJ Publishing Group
DOI: 10.1136/heartjnl-2021-319225

The RNA editor ADAR2 promotes immune cell trafficking by enhancing endothelial responses to interleukin-6 during sterile inflammation

Auteurs: Gatsiou A, Tual-Chalot S, Napoli M, Ortega-Gomez A, Regen T, Badolia R, Cesarini V, Garcia-Gonzalez C, Chevre R, Ciliberti G, Silvestre-Roig C, Martini M, Hoffmann J, Hamouche R, Visker JR, Diakos N, Wietelmann A, Silvestris DA, Georgiopoulos G, Moshfegh A, Schneider A, Chen W, Guenther S, Backs J, Kwak S, Selzman CH, Stamatelopoulos K, Rose-John S, Trautwein C, Spyridopoulos I, Braun T, Waisman A
Publié dans: Immunity, 2023, ISSN 1074-7613
Éditeur: Cell Press
DOI: 10.1016/j.immuni.2023.03.021

Endothelial dysfunction and immunothrombosis in sepsis

Auteurs: Eleni Maneta; Evmorfia Aivalioti; Simon Tual-Chalot; Besa Emini Veseli; Aikaterini Gatsiou; Kimon Stamatelopoulos; Kimon Stamatelopoulos; Konstantinos Stellos; Konstantinos Stellos; Konstantinos Stellos; Konstantinos Stellos
Publié dans: Frontiers in Immunology, 2023, ISSN 1664-3224
Éditeur: Frontiers
DOI: 10.3389/fimmu.2023.1144229