Endothelial RNA Modifications in Vascular Homeostasis and Disease

Informacje na temat projektu

MODVASC

Identyfikator umowy o grant: 759248

DOI

10.3030/759248

Projekt został zamknięty

Data podpisania przez KE 20 Grudnia 2017

Data rozpoczęcia 1 Czerwca 2018

Data zakończenia 31 Marca 2024

Finansowanie w ramach

• EXCELLENT SCIENCE - European Research Council (ERC)

Koszt całkowity

€ 1 499 250,00

Wkład UE

€ 1 499 250,00

Koordynowany przez

RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG
Germany

CORDIS oferuje możliwość skorzystania z odnośników do publicznie dostępnych publikacji i rezultatów projektów realizowanych w ramach programów ramowych HORYZONT.

Odnośniki do rezultatów i publikacji związanych z poszczególnymi projektami 7PR, a także odnośniki do niektórych konkretnych kategorii wyników, takich jak zbiory danych i oprogramowanie, są dynamicznie pobierane z systemu OpenAIRE .

Publikacje

Peer reviewed articles (39)

The importance of microvascular inflammation in ageing and age-related diseases: a position paper from the ESH working group on small arteries, section of microvascular inflammation

Autorzy: Mengozzi A, de Ciuceis C, Dell'oro R, Georgiopoulos G, Lazaridis A, Nosalski R, Pavlidis G, Tual-Chalot S, Agabiti-Rosei C, Anyfanti P, Camargo LL, Dąbrowska E, Quarti-Trevano F, Hellmann M, Masi S, Mavraganis G, Montezano AC, Rios FJ, Winklewski PJ, Wolf J, Costantino S, Gkaliagkousi E, Grassi G, Guzik TJ, Ikonomidis I, Narkiewicz K, Paneni F, Rizzoni D, Stamatelopoulos K, Stellos K, Taddei S, T
Opublikowane w: journal of hypertension, 2023, ISSN 0263-6352
Wydawca: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/hjh.0000000000003503

Beta-Secretase-1 Antisense RNA Is Associated with Vascular Ageing and Atherosclerotic Cardiovascular Disease

Autorzy: Dimitrios, Bampatsias; Ioannis, Mavroeidis; Simon, Tual-Chalot; Nikolaos I, Vlachogiannis; Francesca, Bonini; Marco, Sachse; Georgios, Mavraganis; Alexia, Mareti; Chrysoula, Kritsioti; Ageliki, Laina; Dimitrios, Delialis; Giorgia, Ciliberti; Kateryna, Sopova; Aikaterini, Gatsiou; Fabio, Martelli; Georgios, Georgiopoulos; Konstantinos, Stellos; Kimon, Stamatelopoulos
Opublikowane w: Thrombosis and Haemostasis, Numer 2, 2022, ISSN 0340-6245
Wydawca: Schattauer
DOI: 10.1055/a-1914-2094

Adenosine-to-inosine Alu RNA editing controls the stability of the pro-inflammatory long noncoding RNA NEAT1 in atherosclerotic cardiovascular disease

Autorzy: Vlachogiannis NI, Sachse M, Georgiopoulos G, Zormpas E, Bampatsias D, Delialis D, Bonini F, Galyfos G, Sigala F, Stamatelopoulos K, Gatsiou A, Stellos K
Opublikowane w: Journal of Molecular and Cellular Cardiology, 2021, ISSN 0022-2828
Wydawca: Academic Press
DOI: 10.1016/j.yjmcc.2021.07.005

Effector T cell chemokine IP-10 predicts cardiac recovery and clinical outcomes post-myocardial infarction

Autorzy: Kateryna Sopova; Kateryna Sopova; Kateryna Sopova; Kateryna Sopova; Kateryna Sopova; Simon Tual-Chalot; Matthias Mueller-Hennessen; Matthias Mueller-Hennessen; Nikolaos I. Vlachogiannis; Georgios Georgiopoulos; Moritz Biener; Moritz Biener; Marco Sachse; Andrey Turchinovich; Maria Polycarpou-Schwarz; Luke Spray; Luke Spray; Eleni Maneta; Karim Bennaceur; Ashfaq Mohammad; Ashfaq Mohammad; Gavin Dav
Opublikowane w: Frontiers in Immunology, Vol 14 (2023), Numer 4, 2023, ISSN 1664-3224
Wydawca: Frontiers Research Foundation
DOI: 10.3389/fimmu.2023.1177467

RNA epigenetics and cardiovascular diseases

Autorzy: Dorn LE, Tual-Chalot S, Stellos K, Accornero F
Opublikowane w: Journal of Molecular and Cellular Cardiology, 2019, ISSN 0022-2828
Wydawca: Academic Press
DOI: 10.1016/j.yjmcc.2019.03.010

Repurposing of an antiasthmatic drug may reduce NETosis and myocardial ischaemia/reperfusion injury.

Autorzy: Amponsah-Offeh M, Tual-Chalot S, Stellos K
Opublikowane w: European heart journal, 2024, ISSN 0195-668X
Wydawca: Oxford University Press
DOI: 10.1093/eurheartj/ehae201

Involvement of cardiovascular system as the critical point in coronavirus disease 2019 (COVID-19) prognosis and recovery

Autorzy: Charalampos Lazaridis, Nikolaos I. Vlachogiannis, Constantinos Bakogiannis, Ioakim Spyridopoulos, Kimon Stamatelopoulos, Ioannis Kanakakis, Vassilios Vassilikos, Konstantinos Stellos
Opublikowane w: Hellenic Journal of Cardiology, 2020, ISSN 1109-9666
Wydawca: Hellenic Cardiological Society
DOI: 10.1016/j.hjc.2020.05.004

RNA-binding proteins in vascular inflammation and atherosclerosis

Autorzy: Sachse M, Tual-Chalot S, Ciliberti G, Amponsah-Offeh M, Stamatelopoulos K, Gatsiou A, Stellos K
Opublikowane w: RNA-binding proteins in vascular inflammation and atherosclerosis, 2023, ISSN 0021-9150
Wydawca: Elsevier BV
DOI: 10.1016/j.atherosclerosis.2023.01.008

Sirtuin 5 promotes arterial thrombosis by blunting the fibrinolytic system

Autorzy: Liberale L, Akhmedov A, Vlachogiannis NI, Bonetti NR, Nageswaran V, Miranda MX, Puspitasari YM, Schwarz L, Costantino S, Paneni F, Beer JH, Ruschitzka F, Montecucco F, Lüscher TF, Stamatelopoulos K, Stellos K, Camici GG
Opublikowane w: Cardiovascular Research, 2021, ISSN 0008-6363
Wydawca: Elsevier BV
DOI: 10.1093/cvr/cvaa268

Reactive Vasodilation Predicts Mortality in Primary Systemic Light-Chain Amyloidosis

Autorzy: Kimon Stamatelopoulos, Georgios Georgiopoulos, Fani Athanasouli, Panagiota-Efstathia Nikolaou, Marita Lykka, Maria Roussou, Maria Gavriatopoulou, Aggeliki Laina, Georgia Trakada, Marietta Charakida, Dimitris Delialis, Ioannis Petropoulos, Constantinos Pamboukas, Efstathios Manios, Marina Karakitsou, Christos Papamichael, Aikaterini Gatsiou, Irene Lambrinoudaki, Evangelos Terpos, Konstantinos Stell
Opublikowane w: Circulation Research, Numer 125/8, 2019, Strona(/y) 744-758, ISSN 0009-7330
Wydawca: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circresaha.119.314862

Interleukin-17A Triggers the Release of Platelet-Derived Factors Driving Vascular Endothelial Cells toward a Pro-Angiogenic State.

Autorzy: Aikaterini Gatsiou; Aikaterini Gatsiou; Aikaterini Gatsiou; Kateryna Sopova; Kateryna Sopova; Kateryna Sopova; Alexandros D. Tselepis; Konstantinos Stellos; Konstantinos Stellos; Konstantinos Stellos
Opublikowane w: cells, Numer 5, 2021, ISSN 2073-4409
Wydawca: MDPI
DOI: 10.3390/cells10081855

Adenosine-to-inosine RNA editing contributes to type I interferon responses in systemic sclerosis

Autorzy: Vlachogiannis NI, Tual-Chalot S, Zormpas E, Bonini F, Ntouros PA, Pappa M, Bournia V-K, Tektonidou MG, Souliotis VL, Mavragani CP, Stamatelopoulos K, Gatsiou A, Sfikakis PP, Stellos K
Opublikowane w: Journal of Autoimmunity, 2021, ISSN 0896-8411
Wydawca: Academic Press
DOI: 10.1016/j.jaut.2021.102755

Estimated pulse wave velocity improves risk stratification for all-cause mortality in patients with COVID-19

Autorzy: Stamatelopoulos K, Georgiopoulos G, Baker KF, Tiseo G, Delialis D, Lazaridis C, Barbieri G, Masi S, Vlachogiannis NI, Sopova K, Mengozzi A, Ghiadoni L, van der Loeff IS, Hanrath AT, Ajdini B, Vlachopoulos C, Dimopoulos MA, Duncan CJA, Falcone M, Stellos K; Pisa COVID-19 Research Group; Newcastle COVID-19 Research Group
Opublikowane w: Scientific report, 2021, ISSN 2045-2322
Wydawca: Nature Publishing Group
DOI: 10.1038/s41598-021-99050-0

Targeting the adipose tissue: heart crosstalk in pressure overload-induced heart failure

Autorzy: Tual-Chalot S, Stellos K
Opublikowane w: Cardiovascular Research, 2022, ISSN 0008-6363
Wydawca: Elsevier BV
DOI: 10.1093/cvr/cvac046

Mechanisms of Vascular Inflammation and Potential Therapeutic Targets: A Position Paper From the ESH Working Group on Small Arteries

Autorzy: Rios FJ, de Ciuceis C, Georgiopoulos G, Lazaridis A, Nosalski R, Pavlidis G, Tual-Chalot S, Agabiti-Rosei C, Camargo LL, Dąbrowska E, Quarti-Trevano F, Hellmann M, Masi S, Lopreiato M, Mavraganis G, Mengozzi A, Montezano AC, Stavropoulos K, Winklewski PJ, Wolf J, Costantino S, Doumas M, Gkaliagkousi E, Grassi G, Guzik TJ, Ikonomidis I, Narkiewicz K, Paneni F, Rizzoni D, Stamatelopoulos K, Stellos
Opublikowane w: hypertension, 2024, ISSN 0194-911X
Wydawca: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/hypertensionaha.123.22483

A roadmap for therapeutic discovery in pulmonary hypertension associated with left heart failure. A scientific statement of the Heart Failure Association (HFA) of the ESC and the ESC Working Group on Pulmonary Circulation & Right Ventricular Function

Autorzy: Ameri P, Mercurio V, Pollesello P, Anker MS, Backs J, Bayes-Genis A, Borlaug BA, Burkhoff D, Caravita S, Chan SY, de Man F, Giannakoulas G, González A, Guazzi M, Hassoun PM, Hemnes AR, Maack C, Madden B, Melenovsky V, Müller OJ, Papp Z, Pullamsetti SS, Rainer PP, Redfield MM, Rich S, Schiattarella GG, Skaara H, Stellos K, Tedford RJ, Thum T, Vachiery JL, van der Meer P, Van Linthout S, Pruszczyk
Opublikowane w: European journal of heart failure, 2024, ISSN 1388-9842
Wydawca: Elsevier BV
DOI: 10.1002/ejhf.3236

The Alzheimer’s Disease Amyloid-Beta Hypothesis in Cardiovascular Aging and Disease

Autorzy: Dimitrios A. Stakos, Kimon Stamatelopoulos, Dimitrios Bampatsias, Marco Sachse, Eleftherios Zormpas, Nikolaos I. Vlachogiannis, Simon Tual-Chalot, Konstantinos Stellos
Opublikowane w: Journal of the American College of Cardiology, Numer 75/8, 2020, Strona(/y) 952-967, ISSN 0735-1097
Wydawca: Elsevier BV
DOI: 10.1016/j.jacc.2019.12.033

Modification of the GRACE Risk Score for Risk Prediction in Patients with Acute Coronary Syndromes

Autorzy: Georgiopoulos G, Kraler S, Mueller-Hennessen M, Delialis D, Mavraganis G, Sopova K, Wenzl FA, Räber L, Biener M, Stähli BE, Maneta E, Spray L, Iglesias JF, Coelho-Lima J, Tual-Chalot S, Muller O, Mach F, Frey N, Duerschmied D, Langer HF, Katus H, Roffi M, Camici GG, Mueller C, Giannitsis E, Spyridopoulos I, Lüscher TF, Stellos K, Stamatelopoulos K.
Opublikowane w: JAMA cardiology, 2023, ISSN 2380-6583
Wydawca: American Medical Association
DOI: 10.1001/jamacardio.2023.2741

(Epi)transcriptomics in cardiovascular and neurological complications of COVID-19

Autorzy: Jusic A, Stellos K, Ferreira L, Baker AH, Devaux Y
Opublikowane w: Journal of molecular and cellular cardiology plus, 2022, ISSN 2772-9761
Wydawca: Elsevier
DOI: 10.1016/j.jmccpl.2022.100013

Dawn of Epitranscriptomic Medicine

Autorzy: Aikaterini Gatsiou, Konstantinos Stellos
Opublikowane w: Circulation: Genomic and Precision Medicine, Numer 11/9, 2018, ISSN 2574-8300
Wydawca: American Heart Association
DOI: 10.1161/circgen.118.001927

Circulating Progenitor Cells Predict Clinical Outcomes in Patients With Coronary Artery Disease and Renal Insufficiency

Autorzy: Vlachogiannis NI, Stellos K
Opublikowane w: JACC: Basic to Translational Science, 2020, ISSN 2452-302X
Wydawca: Elsevier Inc
DOI: 10.1016/j.jacbts.2020.07.002

Clinical frailty, and not features of acute infection, is associated with late mortality in COVID‐19: a retrospective cohort study

Autorzy: Nikolaos I. Vlachogiannis; Kenneth F. Baker; Georgios Georgiopoulos; Charalampos Lazaridis; Ina Schim van der Loeff; Aidan T. Hanrath; Kateryna Sopova; Simon Tual‐Chalot; Aikaterini Gatsiou; Ioakim Spyridopoulos; Kimon Stamatelopoulos; Christopher J.A. Duncan; Konstantinos Stellos
Opublikowane w: Journal of Cachexia, Sarcopenia and Muscle, Vol 13, Iss 3, Pp 1502-1513 (2022), Numer 1, 2022, ISSN 2190-5991
Wydawca: Springer Verlag
DOI: 10.1002/jcsm.12966

Noncoding RNAs in age-related cardiovascular diseases

Autorzy: Jusic A, Thomas PB, Wettinger SB, Dogan S, Farrugia R, Gaetano C, Tuna BG, Pinet F, Robinson EL, Tual-Chalot S, Stellos K, Devaux Y
Opublikowane w: Ageing Research Reviews, 2022, ISSN 1568-1637
Wydawca: Elsevier BV
DOI: 10.1016/j.arr.2022.101610

Additive contribution of microRNA-34a/b/c to human arterial ageing and atherosclerosis

Autorzy: Gatsiou A, Georgiopoulos G, Vlachogiannis NI, Pfisterer L, Fischer A, Sachse M, Laina A, Bonini F, Delialis D, Tual-Chalot S, Zormpas E, Achangwa R, Jiang L, Kontogiannis C, Patras R, Hermeking H, Zeiher AM, Stamatelopoulos K, Dimmeler S, Stellos K
Opublikowane w: Atherosclerosis, 2021, ISSN 0021-9150
Wydawca: Elsevier BV
DOI: 10.1016/j.atherosclerosis.2021.05.005

Drug repurposing to prevent pressure overload-induced cardiac hypertrophy and heart failure

Autorzy: Tual-Chalot S, Stellos K
Opublikowane w: European heart journal, 2021, ISSN 0195-668X
Wydawca: Oxford University Press
DOI: 10.1093/eurheartj/ehab427

Therapeutic potential of adenosine kinase inhibition in vascular disease

Autorzy: Tual-Chalot S, Stellos K
Opublikowane w: Cardiovascular research, 2021, ISSN 0008-6363
Wydawca: Elsevier BV
DOI: 10.1093/cvr/cvaa122

MicroRNA-based therapy of postmyocardial infarction heart failure

Autorzy: Tual-Chalot S, Stellos K
Opublikowane w: Hellenic Journal of Cardiology, 2021, ISSN 1109-9666
Wydawca: Hellenic Cardiological Society
DOI: 10.1016/j.hjc.2021.03.006

Increased adenosine-to-inosine RNA editing in rheumatoid arthritis

Autorzy: Nikolaos I. Vlachogiannis, Aikaterini Gatsiou, Domenico Alessandro Silvestris, Kimon Stamatelopoulos, Maria G. Tektonidou, Angela Gallo, Petros P. Sfikakis, Konstantinos Stellos
Opublikowane w: Journal of Autoimmunity, Numer 106, 2020, Strona(/y) 102329, ISSN 0896-8411
Wydawca: Academic Press
DOI: 10.1016/j.jaut.2019.102329

Cathepsin S Levels and Survival Among Patients With Non-ST-Segment Elevation Acute Coronary Syndromes

Autorzy: Kimon Stamatelopoulos; Matthias Mueller-Hennessen; Georgios Georgiopoulos; Pedro Lopez-Ayala; Marco Sachse; Nikolaos I. Vlachogiannis; Kateryna Sopova; Dimitrios Delialis; Francesca Bonini; Raphael Patras; Giorgia Ciliberti; Mehrshad Vafaie; Moritz Biener; Jasper Boeddinghaus; Thomas Nestelberger; Luca Koechlin; Simon Tual-Chalot; Ioannis Kanakakis; Aikaterini Gatsiou; Hugo Katus; Ioakim Spyridopo
Opublikowane w: Journal of the American College of Cardiology, Numer 1, 2022, ISSN 0735-1097
Wydawca: Elsevier BV
DOI: 10.1016/j.jacc.2022.05.055

RNA Therapeutics in Cardiovascular Precision Medicine

Autorzy: Ageliki Laina, Aikaterini Gatsiou, Georgios Georgiopoulos, Kimon Stamatelopoulos, Konstantinos Stellos
Opublikowane w: Frontiers in Physiology, Numer 9, 2018, ISSN 1664-042X
Wydawca: Frontiers Research Foundation
DOI: 10.3389/fphys.2018.00953

Chrono-pharmacology-based antiplatelet therapy for acute myocardial infarction

Autorzy: Tual-Chalot S, Stellos K
Opublikowane w: European Heart Journal, 2022, ISSN 0195-668X
Wydawca: Oxford University Press
DOI: 10.1093/eurheartj/ehac120

Activation of telomerase by TA-65 enhances immunity and reduces inflammation post myocardial infarction Randomized Pilot Trial

Autorzy: Bawamia B, Spray L, Wangsaputra VK, Bennaceur K, Vahabi S, Stellos K, Kharatikoopaei E, Ogundimu E, Gale CP, Keavney B, Maier R, Hancock H, Richardson GD, Austin D, Spyridopoulos I
Opublikowane w: GeroScience, 2023, ISSN 2509-2723
Wydawca: Springer
DOI: 10.1007/s11357-023-00794-6

Clinical value of amyloid-beta1-40 as a marker of thromboinflammation in Antiphospholipid Syndrome

Autorzy: Tektonidou MG, Kravvariti E, Vlachogiannis NI, Georgiopoulos G, Mantzou A, Sfikakis PP, Stellos K, Stamatelopoulos K
Opublikowane w: Rheumatology, 2020, ISSN 1462-0324
Wydawca: Oxford University Press
DOI: 10.1093/rheumatology/keaa548

First-in-human gene editing for lipid lowering: the initial results

Autorzy: Tual-Chalot S, Stellos K
Opublikowane w: Cardiovascular Research, 2024, ISSN 0008-6363
Wydawca: Elsevier BV
DOI: 10.1093/cvr/cvae037

RNA modifications in cardiovascular health and disease

Autorzy: Gatsiou A, Stellos K
Opublikowane w: Natur e Review Cardiology, 2023, ISSN 1759-5002
Wydawca: Nature Publishing Group
DOI: 10.1038/s41569-022-00804-8

Circulating Amyloid Beta 1-40 Is Associated with Increased Rate of Progression of Atherosclerosis in Menopause: A Prospective Cohort Study.

Autorzy: Irene Lambrinoudaki; Dimitrios Delialis; Georgios Georgiopoulos; Georgios Georgiopoulos; Simon Tual-Chalot; Nikolaos I. Vlachogiannis; Raphael Patras; Evmorfia Aivalioti; Eleni Armeni; Areti Augoulea; Nikolaos Tsoltos; Anastasia Soureti; Konstantinos Stellos; Konstantinos Stellos; Kimon Stamatelopoulos; Kimon Stamatelopoulos
Opublikowane w: Thrombosis and Haemostasis, 2021, ISSN 0340-6245
Wydawca: Schattauer
DOI: 10.1055/s-0040-1721144

Prognostic value of admission high-sensitivity troponin in patients with ST-elevation myocardial infarction

Autorzy: Coelho-Lima J, Georgiopoulos G, Ahmed J, Adil Syeda, Gaskin D, Bakogiannis C, Sopova k, Ahmed F, Ahmed H, Spray L, Richardson G, Bagnall A, Stellos K, Stamatelopoulos K, Spyridopoulos I
Opublikowane w: Heart BMJ, 2021, ISSN 1355-6037
Wydawca: BMJ Publishing Group
DOI: 10.1136/heartjnl-2021-319225

The RNA editor ADAR2 promotes immune cell trafficking by enhancing endothelial responses to interleukin-6 during sterile inflammation

Autorzy: Gatsiou A, Tual-Chalot S, Napoli M, Ortega-Gomez A, Regen T, Badolia R, Cesarini V, Garcia-Gonzalez C, Chevre R, Ciliberti G, Silvestre-Roig C, Martini M, Hoffmann J, Hamouche R, Visker JR, Diakos N, Wietelmann A, Silvestris DA, Georgiopoulos G, Moshfegh A, Schneider A, Chen W, Guenther S, Backs J, Kwak S, Selzman CH, Stamatelopoulos K, Rose-John S, Trautwein C, Spyridopoulos I, Braun T, Waisman A
Opublikowane w: Immunity, 2023, ISSN 1074-7613
Wydawca: Cell Press
DOI: 10.1016/j.immuni.2023.03.021

Endothelial dysfunction and immunothrombosis in sepsis

Autorzy: Eleni Maneta; Evmorfia Aivalioti; Simon Tual-Chalot; Besa Emini Veseli; Aikaterini Gatsiou; Kimon Stamatelopoulos; Kimon Stamatelopoulos; Konstantinos Stellos; Konstantinos Stellos; Konstantinos Stellos; Konstantinos Stellos
Opublikowane w: Frontiers in Immunology, 2023, ISSN 1664-3224
Wydawca: Frontiers
DOI: 10.3389/fimmu.2023.1144229