Chicory as a multipurpose crop for dietary fibre and medicinal terpenes

Risultati finali

Report on environmental assessment of NPBTs of the whole value chain
Document with recommendations to Policy Makers and Business Developers
Report on societal issues facilitating or hindering chicory innovation
Final Stakeholder Assessment Report
Report describing off-target assessment tool providing checklist for selection of a minimal OTA-target

Report describing offtarget assessment tool providing checklist for selection of a minimal OTAtarget

Report on socio-economic impact assessment of NPBTs along the whole value chain

Report on socioeconomic impact assessment of NPBTs along the whole value chain

PEDR completed
Final Report on the work with the Stakeholder Advisory Group
Report with proposed guidelines for risk assessment of NPBTs including nutritional safety and evaluation of toxicity
Report on regulatory regimes concerning the use of NPBTs
An overview of inulin and terpene quantity and quality in the NPBT chicory in a typical growing period comparable to the period August to December in comparison to commercial chicory varieties
Document describing indicator mapping for relevant impact channels of NPBTs, cultivation and processed products
Technical guidance document as decision support for NPBTs approaches including patent and IPR rights
Final Scenario Report including Management Options
Interim Report on the work with the Stakeholder Advisory Group

Brochures presenting project goals
Art work. video presentations and brochures with project achievements available

Art work video presentations and brochures with project achievements available

CHIC website and social media platforms launched

Data Management Plan

Pubblicazioni

DNA-Free Genome Editing: Past, Present and Future

Autori: Janina Metje-Sprink, Jochen Menz, Dominik Modrzejewski, Thorben Sprink
Pubblicato in: Frontiers in Plant Science, Numero 9, 2019, Pagina/e 1-9, ISSN 1664-462X
Editore: Frontiers Media S. A.
DOI: 10.3389/fpls.2018.01957

Inactivation of the germacrene A synthase genes by CRISPR/Cas9 eliminates the biosynthesis of sesquiterpene lactones in Cichorium intybus L.

Autori: Katarina Cankar, Paul Bundock, Robert Sevenier, Suvi T. Häkkinen, Johanna Christina Hakkert, Jules Beekwilder, Ingrid M. Meer, Michiel Both, Dirk Bosch
Pubblicato in: Plant Biotechnology Journal, 2021, ISSN 1467-7644
Editore: Blackwell Publishing Inc.
DOI: 10.1111/pbi.13670

Indigenous Perspectives and Gene Editing in Aotearoa New Zealand

Autori: Maui Hudson, Aroha Te Pareake Mead, David Chagné, Nick Roskruge, Sandy Morrison, Phillip L. Wilcox, Andrew C. Allan
Pubblicato in: Frontiers in Bioengineering and Biotechnology, Numero 7, 2019, ISSN 2296-4185
Editore: Frontiers in Bioengineering and Biotechnology
DOI: 10.3389/fbioe.2019.00070

Lactucin Synthase Inactivation Boosts the Accumulation of Anti-inflammatory 8-Deoxylactucin and Its Derivatives in Chicory ( Cichorium intybus L.)

Autori: Katarina Cankar, Johanna Christina Hakkert, Robert Sevenier, Christina Papastolopoulou, Bert Schipper, João P Baixinho, Naiara Fernández, Melanie S Matos, Ana Teresa Serra, Claudia Nunes Santos, Khabat Vahabi, Alain Tissier, Paul Bundock, Dirk Bosch
Pubblicato in: Journal of Agricultural and Food Chemistry, 2023, ISSN 0021-8561
Editore: American Chemical Society
DOI: 10.1021/acs.jafc.2c08959

CRISPR/Cas9 targeted inactivation of the kauniolide synthase in chicory results in accumulation of costunolide and its conjugates in taproots

Autori: Katarina Cankar, Johanna Christina Hakkert, Robert Sevenier, Eva Campo, Bert Schipper, Christina Papastolopoulou, Khabat Vahabi, Alain Tissier, Paul Bundock, Dirk Bosch
Pubblicato in: Frontiers in Plant Science, 2022, ISSN 1664-462X
Editore: Frontiers Media S. A.
DOI: 10.3389/fpls.2022.940003

Towards social acceptability of genome-edited plants in industrialised countries? Emerging evidence from Europe, United States, Canada, Australia, New Zealand, and Japan

Autori: Armin Spök, Thorben Sprink, Andrew C. Allan, Tomiko Yamaguchi and Christian Dayé
Pubblicato in: Frontiers in Genome Editing, 2022, ISSN 2673-3439
Editore: Frontiers
DOI: 10.3389/fgeed.2022.899331

Filter methods for MRIO tables: an evaluation

Autori: Markus Simbürger
Pubblicato in: Economic Systems Research, 2021, Pagina/e 1-20, ISSN 0953-5314
Editore: Carfax Publishing Ltd.
DOI: 10.1080/09535314.2021.1971629

Assessing the Intestinal Permeability and Anti-Inflammatory Potential of Sesquiterpene Lactones from Chicory

Autori: Melanie S. Matos, José D. Anastácio, J. William Allwood, Diogo Carregosa, Daniela Marques, Julie Sungurtas, Gordon J. McDougall, Regina Menezes, Ana A. Matias, Derek Stewart, Cláudia Nunes dos Santos
Pubblicato in: Nutrients, Numero 12/11, 2020, Pagina/e 3547, ISSN 2072-6643
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/nu12113547

Environmental and socio-economic impacts of new plant breeding technologies: A case study of root chicory for inulin productionMaria Hingsamer, Veronika Kulmer, Matthew de Roode, Michael Kernitzkyi

Autori: Maria Hingsamer, Veronika Kulmer, Matthew de Roode, Michael Kernitzkyi
Pubblicato in: Frontiers in Genome Editing., 2022, ISSN 2673-3439
Editore: Frontiers In
DOI: 10.3389/fgeed.2022.919392

Sesquiterpene Lactones: Promising Natural Compounds to Fight Inflammation

Autori: Melanie S. Matos, José D. Anastácio, Cláudia Nunes dos Santos
Pubblicato in: Pharmaceutics, Numero 13/7, 2021, Pagina/e 991, ISSN 1999-4923
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics13070991

A comparison of three different delivery methods for achieving CRISPR/Cas9 mediated genome editing in Cichorium intybus L.

Autori: Umberto Salvagnin; Katharina Unkel; Thorben Sprink; Paul Bundock; Robert Sevenier; Milica Bogdanović; Slađana Todorović; Katarina Cankar; Johanna Christina Hakkert; Elio Schijlen; Ronald Nieuwenhuis; Maria Hingsamer; Veronika Kulmer; Michael Kernitzkyi; Dirk Bosch; Stefan Martens; Mickael Malnoy
Pubblicato in: Frontiers in plant science, 2023, ISSN 1664-462X
Editore: Frontiers Media S. A.
DOI: 10.3389/fpls.2023.1111110

Genome Edited Crops Touch the Market: A View on the Global Development and Regulatory Environment

Autori: Jochen Menz, Dominik Modrzejewski, Frank Hartung, Ralf Wilhelm, Thorben Sprink
Pubblicato in: Frontiers in Plant Science, Numero 11, 2020, ISSN 1664-462X
Editore: Frontiers Media S. A.
DOI: 10.3389/fpls.2020.586027

Targeting proteases involved in the viral replication of SARS-CoV-2 by sesquiterpene lactones from chicory (Cichorium intybus L.)

Autori: María Ángeles Ávila-Gálvez , Carlos Rafael-Pita, Naiara Fernández, João Baixinho, José D. Anastácio, Katarina Cankar, Dirk Bosch, and Cláudia Nunes dos Santos
Pubblicato in: Food & Function, 2022, ISSN 1756-4646
Editore: Elsevier BV
DOI: 10.1039/d2fo00933a

SCOPE enables type III CRISPR-Cas diagnostics using flexible targeting and stringent CARF ribonuclease activation

Autori: Jurre A. Steens, Yifan Zhu, David W. Taylor, Jack P. K. Bravo, Stijn H. P. Prinsen, Cor D. Schoen, Bart J. F. Keijser, Michel Ossendrijver, L. Marije Hofstra, Stan J. J. Brouns, Akeo Shinkai, John van der Oost & Raymond H. J. Staals
Pubblicato in: Nature, 2021, ISSN 1476-4687
Editore: Nature
DOI: 10.1038/s41467-021-25337-5

Chicory Extracts and Sesquiterpene Lactones Show Potent Activity against Bacterial and Fungal Pathogens

Autori: Suvi T. Häkkinen, Marina Soković, Liisa Nohynek, Ana Ćirić, Marija Ivanov, Dejan Stojković, Irina Tsitko, Melanie Matos, João P. Baixinho, Viktoriya Ivasiv, Naiara Fernández, Claudia Nunes dos Santos, Kirsi-Marja Oksman-Caldentey
Pubblicato in: Pharmaceuticals, Numero 14/9, 2021, Pagina/e 941, ISSN 1424-8247
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ph14090941

Supercritical CO2 Extraction as a Tool to Isolate Anti-Inflammatory Sesquiterpene Lactones from Cichorium intybus L. Roots

Autori: João P. Baixinho, José D. Anastácio, Viktoriya Ivasiv, Katarina Cankar, Dirk Bosch, Regina Menezes, Matthew de Roode, Cláudia Nunes dos Santos, Ana A. Matias, Naiara Fernández
Pubblicato in: Molecules, Numero 26/9, 2021, Pagina/e 2583, ISSN 1420-3049
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules26092583

Metabolic engineering in chicory by CRISPR/CAS9 editing

Autori: Milica Bogdanović, Slađana Todorović, Katarina Ćuković, Milan
Pubblicato in: 2020
Editore: "XI International Agriculture Symposium ""AGROSYM 2020"""

Evaluation of antimicrobial properties of chicory extracts”, The third congress of biologists of Serbia, p. 257. Zlatibor, 21-25.09.2022.

Autori: Ćirić, A., Ivanov, M., Stojković, D., Glamočlija, J., Kostić, M., Petrović, J., Soković, M.
Pubblicato in: 2022
Editore: The third congress of biologists of Serbia

Development of 4 conceptually different NPBTs in C. intybus

Autori: Salvagnin, U.; Malnoy, M.; Martens, S.; Hakkert, H.; Van der Meer, I.; Sevenier, R.; Bundock, P.; de Both, M. (2020). Development of 4 conceptually different NPBTs in C. intybus. In: The 7th International Horticulture Research Conference, Online, July 1st-30th, 2020. url: http://www.hortres-conference.org/poster2.php?id=348 handle:
Pubblicato in: 2020
Editore: Hortress Conference

Supercritical fluid extraction of Chicory reveals its antimicrobial, antibiofilm and wound healing potentials. 4th International Conference on Plant Biology (23rd SPPS Meeting), 6-8 October 2022, Belgrade, p. 96.

Autori: Stojković, D., Ivanov, M., Ćirić, A., Petrović, J., Kostić, M., Glamočlija, J., Soković, M.
Pubblicato in: 2022
Editore: 4th International Conference on Plant Biology

Social Acceptability of Cisgenic Plants: Public Perception, Consumer Preferences, and Legal Regulation

Autori: Dayé, Christian, Armin Spök, Andrew C. Allan, Tomiko Yamaguchi, and Thorben Sprink
Pubblicato in: 2023
Editore: Springer Link
DOI: 10.1007/978-3-031-10721-4_3

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