Carbohydrate-based fine chemicals: Development of a glycosylation platform cell factory and optimization of downstream processing for the sustainable production of glycosides.

Project Information

CARBAFIN

Grant agreement ID: 761030

DOI

10.3030/761030

Project closed

EC signature date 20 October 2017

Start date 1 January 2018

End date 30 June 2022

Funded under

• INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies – Biotechnology

Total cost

€ 6 128 058,75

EU contribution

€ 5 362 908,75

Coordinated by

ACIB GMBH
Austria

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Open Research Data Pilot (3)

First data management plan

Data management plan periodically updated

Third data management plan

Third data management plan periodically updated

Second data management plan

Second data management plan periodically updated

Other (1)

Installation of Stakeholder advisory board

Documents, reports (1)

"Report on output of online questionnaire of ""gender aspects in biotech jobs"""

Report on output of online questionnaire of gender aspects in biotech jobs

Publications

Other (5)

Second data management plan

Author(s): Christiane Luley
Published in: 2019
Publisher: European Commission

Additional file 1 of Whole cell-based catalyst for enzymatic production of the osmolyte 2-O-α-glucosylglycerol

Author(s): Schwaiger, Katharina N.; Cserjan-Puschmann, Monika; Striedner, Gerald; Nidetzky, Bernd
Published in: Microbial Cell Factories, 2021, ISSN 1475-2859
Publisher: BioMed Central Ltd.
DOI: 10.6084/m9.figshare.14385634

First data management plan

Author(s): Christiane Luley
Published in: 2018
Publisher: European Commission

Additional file 1 of Kinetic modeling of phosphorylase-catalyzed iterative β-1,4-glycosylation for degree of polymerization-controlled synthesis of soluble cello-oligosaccharides

Author(s): Klimacek, Mario; Zhong, Chao; Nidetzky, Bernd
Published in: Biotechnology for Biofuels and Bioproducts, 2021
Publisher: Springer Nature
DOI: 10.6084/m9.figshare.14767225

Installation of Stakeholder advisory board

Author(s): Christiane Luley
Published in: 2018
Publisher: European Commission

Peer reviewed articles (23)

Plasmid Design for Tunable Two‐Enzyme Co‐Expression Promotes Whole‐Cell Production of Cellobiose

Author(s): Schwaiger, Katharina N.; Voit, Alena; Dobiasová, Hana; Luley-Goedl, Christiane; Wiltschi, Birgit; Nidetzky, Bernd
Published in: Biotechnology Journal, 2020, ISSN 1860-7314
Publisher: Wiley-VCH GmbH
DOI: 10.1002/biot.202000063

β-Glucan phosphorylases in carbohydrate synthesis

Author(s): Zorica Ubiparip; Marc De Doncker; Koen Beerens; Jorick Franceus; Tom Desmet
Published in: Applied Microbiology and Biotechnology, Issue 4, 2021, ISSN 0175-7598
Publisher: Springer Verlag
DOI: 10.1007/s00253-021-11320-z

Engineering of a Thermostable Biocatalyst for the Synthesis of 2-O-Glucosylglycerol.

Author(s): Jorick Franceus; Zorica Ubiparip; Koen Beerens; Tom Desmet
Published in: ChemBioChem, Issue 2, 2021, ISSN 1439-7633
Publisher: Wiley-VCH GmbH
DOI: 10.1002/cbic.202100192

Short-Chain Cello-oligosaccharides: Intensification and Scale-up of Their Enzymatic Production and Selective Growth Promotion among Probiotic Bacteria

Author(s): Chao Zhong, Christina Ukowitz, Konrad J. Domig, Bernd Nidetzky
Published in: Journal of Agricultural and Food Chemistry, Issue 68/32, 2020, Page(s) 8557-8567, ISSN 0021-8561
Publisher: American Chemical Society
DOI: 10.1021/acs.jafc.0c02660

Whole cell-based catalyst for enzymatic production of the osmolyte 2- O -α-glucosylglycerol

Author(s): Katharina N. Schwaiger; Monika Cserjan-Puschmann; Gerald Striedner; Bernd Nidetzky
Published in: Microbial Cell Factories, Issue 7, 2021, ISSN 1475-2859
Publisher: BioMed Central
DOI: 10.1186/s12934-021-01569-4

On the donor substrate dependence of group‐transfer reactions by hydrolytic enzymes: Insight from kinetic analysis of sucrose phosphorylase‐catalyzed transglycosylation

Author(s): Mario Klimacek, Alexander Sigg, Bernd Nidetzky
Published in: Biotechnology and Bioengineering, Issue 117/10, 2020, Page(s) 2933-2943, ISSN 0006-3592
Publisher: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/bit.27471

Reducing end thiol-modified nanocellulose: Bottom-up enzymatic synthesis and use for templated assembly of silver nanoparticles into biocidal composite material

Author(s): Chao Zhong, Krisztina Zajki-Zechmeister, Bernd Nidetzky
Published in: Carbohydrate Polymers, 2021, ISSN 0144-8617
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.carbpol.2021.117772

Three-level hybrid modeling for systematic optimization of biocatalytic synthesis: α-glucosyl glycerol production by enzymatic trans-glycosylation from sucrose

Author(s): Sigg, Alexander; Klimacek, Mario; Nidetzky, Bernd
Published in: Biotechnology and Bioengineering, Issue 2, 2021, ISSN 1097-0290
Publisher: Wiley Periodicals, LLC
DOI: 10.1002/bit.27878

Engineering cascade biocatalysis in whole cells for bottom-up synthesis of cello-oligosaccharides: flux control over three enzymatic steps enables soluble production

Author(s): Katharina N. Schwaiger, Alena Voit, Birgit Wiltschi, Bernd Nidetzky
Published in: Microbial Cell Factories, 2022, ISSN 1475-2859
Publisher: BioMed Central
DOI: 10.1186/s12934-022-01781-w

Kinetic modeling of phosphorylase-catalyzed iterative β-1,4-glycosylation for degree of polymerization-controlled synthesis of soluble cello-oligosaccharides

Author(s): Mario Klimacek; Chao Zhong; Bernd Nidetzky
Published in: Biotechnology for Biofuels, Issue 2, 2021, ISSN 2731-3654
Publisher: BMC
DOI: 10.1186/s13068-021-01982-2

Engineering of cellobiose phosphorylase for the defined synthesis of cellotriose

Author(s): Zorica Ubiparip, David Sáez Moreno, Koen Beerens, Tom Desmet
Published in: Applied Microbiology and Biotechnology, Issue 104/19, 2020, Page(s) 8327-8337, ISSN 0175-7598
Publisher: Springer Verlag
DOI: 10.1007/s00253-020-10820-8

Continuous process technology for glucoside production from sucrose using a whole cell-derived solid catalyst of sucrose phosphorylase.

Author(s): Andreas Kruschitz; Linda Peinsipp; Martin Pfeiffer; Bernd Nidetzky
Published in: Applied Microbiology and Biotechnology, Issue 7, 2021, ISSN 0175-7598
Publisher: Springer Verlag
DOI: 10.1007/s00253-021-11411-x

Product solubility control in cellooligosaccharide production by coupled cellobiose and cellodextrin phosphorylase

Author(s): Chao Zhong, Christiane Luley‐Goedl, Bernd Nidetzky
Published in: Biotechnology and Bioengineering, Issue 116(9), 2019, Page(s) 2146-2155, ISSN 0006-3592
Publisher: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/bit.27008

Sucrose Phosphorylase and Related Enzymes in Glycoside Hydrolase Family 13: Discovery, Application and Engineering

Author(s): Jorick Franceus, Tom Desmet
Published in: International Journal of Molecular Sciences, Issue 21/7, 2020, Page(s) 2526, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21072526

Three‐Enzyme Phosphorylase Cascade Immobilized on Solid Support for Biocatalytic Synthesis of Cello−oligosaccharides

Author(s): Chao Zhong, Božidar Duić, Juan M. Bolivar, Bernd Nidetzky
Published in: ChemCatChem, Issue 12/5, 2020, Page(s) 1350-1358, ISSN 1867-3880
Publisher: Wiley - VCH Verlag GmbH & CO. KGaA
DOI: 10.1002/cctc.201901964

Downstream processing technologies in the biocatalytic production of oligosaccharides

Author(s): Andreas Kruschitz, Bernd Nidetzky
Published in: Biotechnology Advances, Issue 43, 2020, Page(s) 107568, ISSN 0734-9750
Publisher: Elsevier BV
DOI: 10.1016/j.biotechadv.2020.107568

Removal of glycerol from enzymatically produced 2-α-d-glucosyl-glycerol by discontinuous diafiltration

Author(s): Andreas Kruschitz, Bernd Nidetzky
Published in: Separation and Purification Technology, Issue 241, 2020, Page(s) 116749, ISSN 1383-5866
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.seppur.2020.116749

Three‐Enzyme Phosphorylase Cascade for Integrated Production of Short‐Chain Cellodextrins

Author(s): Chao Zhong, Bernd Nidetzky
Published in: Biotechnology Journal, Issue 15/3, 2020, Page(s) 1900349, ISSN 1860-6768
Publisher: Wiley - VCH Verlag GmbH & CO. KGaA
DOI: 10.1002/biot.201900349

Reactive extraction of fructose for efficient separation of sucrose-derived glucosides produced by enzymatic glycosylation

Author(s): Kruschitz, Andreas; Nidetzky, Bernd
Published in: Green Chemistry, Issue 22(15), 2020, ISSN 1463-9270
Publisher: Royal Society of Chemistry

Internal reporting on process optimization measures: combination of economic and environmental aspects

Author(s): Rudolf Grünbichler, Barbara Petschacher, René Kollmann, Alexander Passer, Stefan Grbenic
Published in: FACTA UNIVERSITATIS, Series: Economics and Organization, 2021, ISSN 2406-050X
Publisher: University of Nis
DOI: 10.22190/fueo210622030g

Precision synthesis of reducing-end thiol-modified cellulose enabled by enzyme selection

Author(s): Chao Zhong; Bernd Nidetzky
Published in: Polymer Journal, Issue 7, 2021, ISSN 0032-3896
Publisher: Nature Publishing Group
DOI: 10.1038/s41428-021-00599-4

Phosphorylase-catalyzed bottom-up synthesis of short-chain soluble cello-oligosaccharides and property-tunable cellulosic materials

Author(s): Bernd Nidetzky, Chao Zhong
Published in: Biotechnology Advances, 2020, Page(s) 107633, ISSN 0734-9750
Publisher: Elsevier BV
DOI: 10.1016/j.biotechadv.2020.107633

Biocatalytic Production of 2-α-d-Glucosyl-glycerol for Functional Ingredient Use: Integrated Process Design and Techno-Economic Assessment

Author(s): Andreas Kruschitz; Bernd Nidetzky
Published in: ACS Sustainable Chemistry & Engineering, 2022, ISSN 2168-0485
Publisher: American Chemical Society
DOI: 10.1021/acssuschemeng.1c07210

Intellectual Property Rights

Patent (1)

COSMETIC COMPOSITION COMPRISING CELLODEXTRINS

Application/Publication number: 20 21062167
Date: 2021-05-07
Applicant(s): PFEIFER & LANGEN GMBH & CO KG