Carbohydrate-based fine chemicals: Development of a glycosylation platform cell factory and optimization of downstream processing for the sustainable production of glycosides.

Información del proyecto

CARBAFIN

Identificador del acuerdo de subvención: 761030

DOI

10.3030/761030

Proyecto cerrado

Fecha de la firma de la CE 20 Octubre 2017

Fecha de inicio 1 Enero 2018

Fecha de finalización 30 Junio 2022

Financiado con arreglo a

• INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies – Biotechnology

Coste total

€ 6 128 058,75

Aportación de la UE

€ 5 362 908,75

Coordinado por

ACIB GMBH
Austria

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Open Research Data Pilot (3)

First data management plan

Data management plan periodically updated

Third data management plan

Third data management plan periodically updated

Second data management plan

Second data management plan periodically updated

Other (1)

Installation of Stakeholder advisory board

Documents, reports (1)

"Report on output of online questionnaire of ""gender aspects in biotech jobs"""

Report on output of online questionnaire of gender aspects in biotech jobs

Publicaciones

Other (5)

Second data management plan

Autores: Christiane Luley
Publicado en: 2019
Editor: European Commission

Additional file 1 of Whole cell-based catalyst for enzymatic production of the osmolyte 2-O-α-glucosylglycerol

Autores: Schwaiger, Katharina N.; Cserjan-Puschmann, Monika; Striedner, Gerald; Nidetzky, Bernd
Publicado en: Microbial Cell Factories, 2021, ISSN 1475-2859
Editor: BioMed Central Ltd.
DOI: 10.6084/m9.figshare.14385634

First data management plan

Autores: Christiane Luley
Publicado en: 2018
Editor: European Commission

Additional file 1 of Kinetic modeling of phosphorylase-catalyzed iterative β-1,4-glycosylation for degree of polymerization-controlled synthesis of soluble cello-oligosaccharides

Autores: Klimacek, Mario; Zhong, Chao; Nidetzky, Bernd
Publicado en: Biotechnology for Biofuels and Bioproducts, 2021
Editor: Springer Nature
DOI: 10.6084/m9.figshare.14767225

Installation of Stakeholder advisory board

Autores: Christiane Luley
Publicado en: 2018
Editor: European Commission

Peer reviewed articles (23)

Plasmid Design for Tunable Two‐Enzyme Co‐Expression Promotes Whole‐Cell Production of Cellobiose

Autores: Schwaiger, Katharina N.; Voit, Alena; Dobiasová, Hana; Luley-Goedl, Christiane; Wiltschi, Birgit; Nidetzky, Bernd
Publicado en: Biotechnology Journal, 2020, ISSN 1860-7314
Editor: Wiley-VCH GmbH
DOI: 10.1002/biot.202000063

β-Glucan phosphorylases in carbohydrate synthesis

Autores: Zorica Ubiparip; Marc De Doncker; Koen Beerens; Jorick Franceus; Tom Desmet
Publicado en: Applied Microbiology and Biotechnology, Edición 4, 2021, ISSN 0175-7598
Editor: Springer Verlag
DOI: 10.1007/s00253-021-11320-z

Engineering of a Thermostable Biocatalyst for the Synthesis of 2-O-Glucosylglycerol.

Autores: Jorick Franceus; Zorica Ubiparip; Koen Beerens; Tom Desmet
Publicado en: ChemBioChem, Edición 2, 2021, ISSN 1439-7633
Editor: Wiley-VCH GmbH
DOI: 10.1002/cbic.202100192

Short-Chain Cello-oligosaccharides: Intensification and Scale-up of Their Enzymatic Production and Selective Growth Promotion among Probiotic Bacteria

Autores: Chao Zhong, Christina Ukowitz, Konrad J. Domig, Bernd Nidetzky
Publicado en: Journal of Agricultural and Food Chemistry, Edición 68/32, 2020, Página(s) 8557-8567, ISSN 0021-8561
Editor: American Chemical Society
DOI: 10.1021/acs.jafc.0c02660

Whole cell-based catalyst for enzymatic production of the osmolyte 2- O -α-glucosylglycerol

Autores: Katharina N. Schwaiger; Monika Cserjan-Puschmann; Gerald Striedner; Bernd Nidetzky
Publicado en: Microbial Cell Factories, Edición 7, 2021, ISSN 1475-2859
Editor: BioMed Central
DOI: 10.1186/s12934-021-01569-4

On the donor substrate dependence of group‐transfer reactions by hydrolytic enzymes: Insight from kinetic analysis of sucrose phosphorylase‐catalyzed transglycosylation

Autores: Mario Klimacek, Alexander Sigg, Bernd Nidetzky
Publicado en: Biotechnology and Bioengineering, Edición 117/10, 2020, Página(s) 2933-2943, ISSN 0006-3592
Editor: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/bit.27471

Reducing end thiol-modified nanocellulose: Bottom-up enzymatic synthesis and use for templated assembly of silver nanoparticles into biocidal composite material

Autores: Chao Zhong, Krisztina Zajki-Zechmeister, Bernd Nidetzky
Publicado en: Carbohydrate Polymers, 2021, ISSN 0144-8617
Editor: Pergamon Press Ltd.
DOI: 10.1016/j.carbpol.2021.117772

Three-level hybrid modeling for systematic optimization of biocatalytic synthesis: α-glucosyl glycerol production by enzymatic trans-glycosylation from sucrose

Autores: Sigg, Alexander; Klimacek, Mario; Nidetzky, Bernd
Publicado en: Biotechnology and Bioengineering, Edición 2, 2021, ISSN 1097-0290
Editor: Wiley Periodicals, LLC
DOI: 10.1002/bit.27878

Engineering cascade biocatalysis in whole cells for bottom-up synthesis of cello-oligosaccharides: flux control over three enzymatic steps enables soluble production

Autores: Katharina N. Schwaiger, Alena Voit, Birgit Wiltschi, Bernd Nidetzky
Publicado en: Microbial Cell Factories, 2022, ISSN 1475-2859
Editor: BioMed Central
DOI: 10.1186/s12934-022-01781-w

Kinetic modeling of phosphorylase-catalyzed iterative β-1,4-glycosylation for degree of polymerization-controlled synthesis of soluble cello-oligosaccharides

Autores: Mario Klimacek; Chao Zhong; Bernd Nidetzky
Publicado en: Biotechnology for Biofuels, Edición 2, 2021, ISSN 2731-3654
Editor: BMC
DOI: 10.1186/s13068-021-01982-2

Engineering of cellobiose phosphorylase for the defined synthesis of cellotriose

Autores: Zorica Ubiparip, David Sáez Moreno, Koen Beerens, Tom Desmet
Publicado en: Applied Microbiology and Biotechnology, Edición 104/19, 2020, Página(s) 8327-8337, ISSN 0175-7598
Editor: Springer Verlag
DOI: 10.1007/s00253-020-10820-8

Continuous process technology for glucoside production from sucrose using a whole cell-derived solid catalyst of sucrose phosphorylase.

Autores: Andreas Kruschitz; Linda Peinsipp; Martin Pfeiffer; Bernd Nidetzky
Publicado en: Applied Microbiology and Biotechnology, Edición 7, 2021, ISSN 0175-7598
Editor: Springer Verlag
DOI: 10.1007/s00253-021-11411-x

Product solubility control in cellooligosaccharide production by coupled cellobiose and cellodextrin phosphorylase

Autores: Chao Zhong, Christiane Luley‐Goedl, Bernd Nidetzky
Publicado en: Biotechnology and Bioengineering, Edición 116(9), 2019, Página(s) 2146-2155, ISSN 0006-3592
Editor: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/bit.27008

Sucrose Phosphorylase and Related Enzymes in Glycoside Hydrolase Family 13: Discovery, Application and Engineering

Autores: Jorick Franceus, Tom Desmet
Publicado en: International Journal of Molecular Sciences, Edición 21/7, 2020, Página(s) 2526, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21072526

Three‐Enzyme Phosphorylase Cascade Immobilized on Solid Support for Biocatalytic Synthesis of Cello−oligosaccharides

Autores: Chao Zhong, Božidar Duić, Juan M. Bolivar, Bernd Nidetzky
Publicado en: ChemCatChem, Edición 12/5, 2020, Página(s) 1350-1358, ISSN 1867-3880
Editor: Wiley - VCH Verlag GmbH & CO. KGaA
DOI: 10.1002/cctc.201901964

Downstream processing technologies in the biocatalytic production of oligosaccharides

Autores: Andreas Kruschitz, Bernd Nidetzky
Publicado en: Biotechnology Advances, Edición 43, 2020, Página(s) 107568, ISSN 0734-9750
Editor: Elsevier BV
DOI: 10.1016/j.biotechadv.2020.107568

Removal of glycerol from enzymatically produced 2-α-d-glucosyl-glycerol by discontinuous diafiltration

Autores: Andreas Kruschitz, Bernd Nidetzky
Publicado en: Separation and Purification Technology, Edición 241, 2020, Página(s) 116749, ISSN 1383-5866
Editor: Pergamon Press Ltd.
DOI: 10.1016/j.seppur.2020.116749

Three‐Enzyme Phosphorylase Cascade for Integrated Production of Short‐Chain Cellodextrins

Autores: Chao Zhong, Bernd Nidetzky
Publicado en: Biotechnology Journal, Edición 15/3, 2020, Página(s) 1900349, ISSN 1860-6768
Editor: Wiley - VCH Verlag GmbH & CO. KGaA
DOI: 10.1002/biot.201900349

Reactive extraction of fructose for efficient separation of sucrose-derived glucosides produced by enzymatic glycosylation

Autores: Kruschitz, Andreas; Nidetzky, Bernd
Publicado en: Green Chemistry, Edición 22(15), 2020, ISSN 1463-9270
Editor: Royal Society of Chemistry

Internal reporting on process optimization measures: combination of economic and environmental aspects

Autores: Rudolf Grünbichler, Barbara Petschacher, René Kollmann, Alexander Passer, Stefan Grbenic
Publicado en: FACTA UNIVERSITATIS, Series: Economics and Organization, 2021, ISSN 2406-050X
Editor: University of Nis
DOI: 10.22190/fueo210622030g

Precision synthesis of reducing-end thiol-modified cellulose enabled by enzyme selection

Autores: Chao Zhong; Bernd Nidetzky
Publicado en: Polymer Journal, Edición 7, 2021, ISSN 0032-3896
Editor: Nature Publishing Group
DOI: 10.1038/s41428-021-00599-4

Phosphorylase-catalyzed bottom-up synthesis of short-chain soluble cello-oligosaccharides and property-tunable cellulosic materials

Autores: Bernd Nidetzky, Chao Zhong
Publicado en: Biotechnology Advances, 2020, Página(s) 107633, ISSN 0734-9750
Editor: Elsevier BV
DOI: 10.1016/j.biotechadv.2020.107633

Biocatalytic Production of 2-α-d-Glucosyl-glycerol for Functional Ingredient Use: Integrated Process Design and Techno-Economic Assessment

Autores: Andreas Kruschitz; Bernd Nidetzky
Publicado en: ACS Sustainable Chemistry & Engineering, 2022, ISSN 2168-0485
Editor: American Chemical Society
DOI: 10.1021/acssuschemeng.1c07210

Derechos de propiedad intelectual

Patent (1)

COSMETIC COMPOSITION COMPRISING CELLODEXTRINS

Número de solicitud/publicación: 20 21062167
Fecha: 2021-05-07
Solicitante(s): PFEIFER & LANGEN GMBH & CO KG