Prematurity is the leading cause of death of children under 5 years of age worldwide and those who survive, show higher risk of brain injury resulting in life-long physical, neurological, or educational disability, often at great cost to families and society. Apart from the human costs, prematurity bears an economic burden which has been estimated to amount more than $26 billion annually. Hypoxic-Ischemic Encephalopathy is one of the most common forms of brain injury in preterm infants, who show an increased frequency of events potentially causing hypoperfusion and have a relatively poor autoregulatory capacity of the premature brain. To detect cerebral damage at an early stage and implement suitable treatments (e.g. oxygen therapy through mechanical ventilation), oxygen saturation and blood flow in the brain need to be measured in real-time and accurately right after the neonate’s birth. BABYLUX measures brain oxygen saturation and a relative index of blood flow in an accurate, continuous, safe and non-invasive way by means of advanced near-infrared photonic technology. At HemoPhotonics, S.L. we are committed to further develop the current BABYLUX prototype into a mature device ready to enter the neonatology market.