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Synthetic Circuits for Robust Orthogonal Production

Objective

The repertoire of industrially produced fine chemicals in various biological systems will rapidly expand using the tools from the emerging field of synthetic biology. However, the high-level production of non-natural products or de novo activities through synthetic circuits compromises the integrity of host organisms, which significantly impacts or even prevents the development of an industrial pipeline. Our ability to exploit the potential of synthetic biology for industrial production is constrained by our understanding of the integrated cell response when introducing a new synthetic circuit into the homeostatic network of the cell. SynCrop’s main goal is to establish a European Training Network that merges the fragmented scientific expertise in theoretical, experimental and application-driven quantitative biology to educate the next generation of researchers to construct modular and tunable synthetic circuits and foster the development of novel production platforms for food additives (e.g. vitamins, carotenoids and exopolysaccharides). Researchers with inter-disciplinary skills in both experimental and computational biology are needed to solve complex application-driven problems. SynCrop brings together ten academic partners from quantitative biology, cell engineering, microbial physiology and mathematical modelling fields and six industrial partners, including key experts in metabolic engineering and industrial biotechnology. The consortium will provide 15 early-stage researchers with cutting-edge multi-disciplinary research training, through tailored research projects, rigorous exchange of expertise among researchers and partners, and participation in specialised courses, workshops and conferences augmented by extensive training in complementary skills. SynCrop will generate a strong cohort of highly-employable scientists with unique inter-disciplinary and intersectoral skills to address complex questions and develop innovative biotechnological processes.

Coordinator

UNIVERSITAET HAMBURG
Net EU contribution
€ 498 432,96
Address
Mittelweg 177
20148 Hamburg
Germany

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Region
Hamburg Hamburg Hamburg
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00

Participants (11)

BIOSYNTIA APS
Denmark
Net EU contribution
€ 290 081,88
Address
Kogle Alle 6
2970 Horsholm

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Danmark Hovedstaden Nordsjælland
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
CHALMERS TEKNISKA HOGSKOLA AB
Sweden
Net EU contribution
€ 263 659,32
Address
-
412 96 Goteborg

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Region
Södra Sverige Västsverige Västra Götalands län
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
CHR. HANSEN A/S
Denmark
Net EU contribution
€ 290 081,88
Address
Boege Alle 10-12
2970 Hoersholm

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Region
Danmark Hovedstaden Nordsjælland
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
DSM FOOD SPECIALTIES BV
Netherlands
Net EU contribution
€ 255 374,28
Address
Alexander Fleminglaan 1
2613 AX Delft

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Region
West-Nederland Zuid-Holland Delft en Westland
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
Switzerland
Net EU contribution
€ 265 226,76
Address
Raemistrasse 101
8092 Zuerich

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Region
Schweiz/Suisse/Svizzera Zürich Zürich
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
STICHTING VU
Netherlands
Net EU contribution
€ 255 374,28
Address
De Boelelaan 1105
1081 HV Amsterdam

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Region
West-Nederland Noord-Holland Groot-Amsterdam
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
TECHNISCHE UNIVERSITAT BERLIN
Germany
Net EU contribution
€ 249 216,48
Address
Strasse Des 17 Juni 135
10623 Berlin

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Region
Berlin Berlin Berlin
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
UNIVERSITY OF ABERDEEN
United Kingdom
Net EU contribution
€ 273 287,88
Address
King's College Regent Walk
AB24 3FX Aberdeen

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Region
North Eastern Scotland Aberdeen City and Aberdeenshire
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
THE UNIVERSITY OF EDINBURGH
United Kingdom
Net EU contribution
€ 546 575,76
Address
Old College, South Bridge
EH8 9YL Edinburgh

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Region
Eastern Scotland Edinburgh
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
RIJKSUNIVERSITEIT GRONINGEN
Netherlands
Net EU contribution
€ 510 748,56
Address
Broerstraat 5
9712CP Groningen

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Region
Noord-Nederland Groningen Overig Groningen
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
UNIVERSITY OF YORK
United Kingdom
Net EU contribution
€ 273 287,88
Address
Heslington
YO10 5DD York North Yorkshire

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Region
Yorkshire and the Humber North Yorkshire York
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00

Partners (4)

Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

BIOFACTION KG
Austria
Net EU contribution
€ 0,00
Address
Kundmanngasse 39/12
1030 Wien

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Wien Wien
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

INSILICO BIOTECHNOLOGY AG
Germany
Net EU contribution
€ 0,00
Address
Meitnerstrasse 9
70563 Stuttgart

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Baden-Württemberg Stuttgart Stuttgart, Stadtkreis
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

LANTHIOPEP BV
Netherlands
Net EU contribution
€ 0,00
Address
Rozenburglaan 13b
9727 DL Groningen

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Noord-Nederland Groningen Overig Groningen
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

UNIVERSITY OF BRISTOL
United Kingdom
Net EU contribution
€ 0,00
Address
Beacon House Queens Road
BS8 1QU Bristol

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Region
South West (England) Gloucestershire, Wiltshire and Bristol/Bath area Bristol, City of
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00