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Synthetic Circuits for Robust Orthogonal Production

Objective

The repertoire of industrially produced fine chemicals in various biological systems will rapidly expand using the tools from the emerging field of synthetic biology. However, the high-level production of non-natural products or de novo activities through synthetic circuits compromises the integrity of host organisms, which significantly impacts or even prevents the development of an industrial pipeline. Our ability to exploit the potential of synthetic biology for industrial production is constrained by our understanding of the integrated cell response when introducing a new synthetic circuit into the homeostatic network of the cell. SynCrop’s main goal is to establish a European Training Network that merges the fragmented scientific expertise in theoretical, experimental and application-driven quantitative biology to educate the next generation of researchers to construct modular and tunable synthetic circuits and foster the development of novel production platforms for food additives (e.g. vitamins, carotenoids and exopolysaccharides). Researchers with inter-disciplinary skills in both experimental and computational biology are needed to solve complex application-driven problems. SynCrop brings together ten academic partners from quantitative biology, cell engineering, microbial physiology and mathematical modelling fields and six industrial partners, including key experts in metabolic engineering and industrial biotechnology. The consortium will provide 15 early-stage researchers with cutting-edge multi-disciplinary research training, through tailored research projects, rigorous exchange of expertise among researchers and partners, and participation in specialised courses, workshops and conferences augmented by extensive training in complementary skills. SynCrop will generate a strong cohort of highly-employable scientists with unique inter-disciplinary and intersectoral skills to address complex questions and develop innovative biotechnological processes.

Field of science

  • /natural sciences/biological sciences/synthetic biology
  • /engineering and technology/industrial biotechnology
  • /engineering and technology/industrial biotechnology/metabolic engineering
  • /medical and health sciences/basic medicine/physiology

Call for proposal

H2020-MSCA-ITN-2017
See other projects for this call

Funding Scheme

MSCA-ITN-ETN - European Training Networks

Coordinator

UNIVERSITAET HAMBURG
Address
Mittelweg 177
20148 Hamburg
Germany
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 498 432,96

Participants (11)

BIOSYNTIA APS
Denmark
EU contribution
€ 290 081,88
Address
Kogle Alle 6
2970 Horsholm
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
CHALMERS TEKNISKA HOEGSKOLA AB
Sweden
EU contribution
€ 263 659,32
Address
-
41296 Goeteborg
Activity type
Higher or Secondary Education Establishments
CHR. HANSEN A/S
Denmark
EU contribution
€ 290 081,88
Address
Boege Alle 10-12
2970 Hoersholm
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
DSM FOOD SPECIALTIES BV
Netherlands
EU contribution
€ 255 374,28
Address
Alexander Fleminglaan 1
2613 AX Delft
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
Switzerland
EU contribution
€ 265 226,76
Address
Raemistrasse 101
8092 Zuerich
Activity type
Higher or Secondary Education Establishments
STICHTING VU
Netherlands
EU contribution
€ 255 374,28
Address
De Boelelaan 1105
1081 HV Amsterdam
Activity type
Higher or Secondary Education Establishments
TECHNISCHE UNIVERSITAT BERLIN
Germany
EU contribution
€ 249 216,48
Address
Strasse Des 17 Juni 135
10623 Berlin
Activity type
Higher or Secondary Education Establishments
THE UNIVERSITY COURT OF THE UNIVERSITY OF ABERDEEN
United Kingdom
EU contribution
€ 273 287,88
Address
King's College Regent Walk
AB24 3FX Aberdeen
Activity type
Higher or Secondary Education Establishments
THE UNIVERSITY OF EDINBURGH
United Kingdom
EU contribution
€ 546 575,76
Address
Old College, South Bridge
EH8 9YL Edinburgh
Activity type
Higher or Secondary Education Establishments
RIJKSUNIVERSITEIT GRONINGEN
Netherlands
EU contribution
€ 510 748,56
Address
Broerstraat 5
9712CP Groningen
Activity type
Higher or Secondary Education Establishments
UNIVERSITY OF YORK
United Kingdom
EU contribution
€ 273 287,88
Address
Heslington
YO10 5DD York North Yorkshire
Activity type
Higher or Secondary Education Establishments

Partners (4)

BIOFACTION KG
Austria
Address
Kundmanngasse 39/12
1030 Wien
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
INSILICO BIOTECHNOLOGY AG
Germany
Address
Meitnerstrasse 9
70563 Stuttgart
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
LANTHIOPEP BV
Netherlands
Address
Rozenburglaan 13B
9727 DL Groningen
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
UNIVERSITY OF BRISTOL
United Kingdom
Address
Beacon House Queens Road
BS8 1QU Bristol
Activity type
Higher or Secondary Education Establishments