Livrables
Bar-coded TCR sequence reads of human memory T cell subsets (blood and BM) (preliminary and final)
Preliminary by M36
Preliminary and validated compartmental model and code of CD8+ T cell infiltration into tumour environmentsPreliminary by M36
Reference database of immune receptor alleles in healthy humansPreliminary and validated mechanistic models of TCR repertoire dynamics and cross-reactivity
Preliminary by M36
Preliminary and validated stochastic model of the signals regulating naive T cell maintenancePreliminary by M36
Preliminary and validated mathematical model of thymic T cell development from D1.1Preliminary by M36
Renewal rates and lifespans of human T cell subsets (blood and BM) from D1.4 (preliminary and final)Preliminary by M36
A review report per WP (draft and final)A review report per WP draft and final review M36
Preliminary and validated compartmental model of human naive and memory T cell maintenancePreliminary by M36
Estimates of diversity and uniqueness of memory T cell (blood and BM) repertoires from D2.1Estimates of diversity and uniqueness of memory T cell blood and BM repertoires from D21
Labelling data of human memory T cell subsets in blood and bone marrow (BM) (preliminary and final)Preliminary by M36
Personal career development plans (in place and reviews)Reviews at M7 M19 M31
15 trained ESRs with two secondments eachPreliminary and validated probabilistic model of T cell signal integration
Preliminary by M36
Preliminary and validated computational model and code of impact of anti-cancer treatment on T cellsPreliminary by M36
Preliminary and validated computational model and code of TCR repertoire response to tumourPreliminary by M36
Two journal articles per ESRData set of thymocyte competition (preliminary and final)
Preliminary by M36
Preliminary and validated computational model of the effect of checkpoint inhibitors on T cells in cancerPreliminary by M36
Industrial workshops (S1, S2, S3, S6, S7, T8, T9 and T10) - review M21
Network meetings (E2-E6, I2-I6, B2-B5, M2-M6, T7, S4 and S5)Network meetings (E2-E6, I2-I6, B2-B5, M2-M6, T7, S4 and S5) - review M17 and M24
Complementary skill workshop (T4, T5 and T6)Recruitment strategy in place
Conferences (E1, I1, B1, M1, T1-T3)
Review M9
Publications
Auteurs:
Léa Sta
Publié dans:
2023
Éditeur:
University of Leeds
Auteurs:
Daniel Luque Duque
Publié dans:
2023
Éditeur:
University of Leeds
Auteurs:
Giulia Belluccini
Publié dans:
2023
Éditeur:
University of Leeds
Auteurs:
HoChan Cheon
Publié dans:
2023
Éditeur:
Maynooth University
Auteurs:
Giulia Belluccini, Martın Lopez-Garcia, Grant Lythe, Carmen Molina-Paris
Publié dans:
Scientific Reports, 2022, Page(s) 12:11289, ISSN 2045-2322
Éditeur:
Nature Publishing Group
DOI:
10.1038/s41598-022-14202-0
Auteurs:
Stephan Wilmes; Polly-Anne Jeffrey; Jonathan Martinez-Fabregas; Maximillian Hafer; Paul K. Fyfe; Elizabeth Pohler; Silvia Gaggero; Martín López-García; Grant Lythe; Charles Taylor; T. Guerrier; David Launay; Suman Mitra; Jacob Piehler; Carmen Molina-París; Carmen Molina-París; Ignacio Moraga
Publié dans:
eLife, Numéro 1, 2019, ISSN 2050-084X
Éditeur:
eLife Sciences Publications
DOI:
10.7554/elife.66014
Auteurs:
Mora-Bitria, L., Asquith, B
Publié dans:
Immunogenetics, 2023, Page(s) 269–282, ISSN 0093-7711
Éditeur:
Springer Verlag
DOI:
10.1007/s00251-023-01293-w
Auteurs:
Flavia Feliciangeli, Hanan Dreiwi, Martín López-García, Mario Castro Ponce, Carmen Molina-París and Grant Lythe
Publié dans:
Journal of the Royal Society Interface, Numéro 17425689, 2022, Page(s) 20220629, ISSN 1742-5689
Éditeur:
The Royal Society
DOI:
10.1098/rsif.2022.0629
Auteurs:
HoChan Cheon, Andrey Kan, Giulio Prevedello, Simone C. Oostindie, Simon J. Dovedi, Edwin D. Hawkins, Julia M. Marchingo, Susanne Heinzel, Ken R. Duffy, Philip D. Hodgkin
Publié dans:
Frontiers in Bioinformatics, Numéro 1, 2021, ISSN 2673-7647
Éditeur:
Frontiers Media SA
DOI:
10.3389/fbinf.2021.723337
Auteurs:
Yan Zhang, Ada W.C. Yan, Lies Boelen, Linda Hadcocks, Arafa Salam, Daniel Padrosa Gispert, Loiza Spanos, Laura Mora Bitria, Neda Nemat-Gorgani, James A. Traherne, Chrissy Roberts, Danai Koftori, Graham P. Taylor, Daniel Forton, Paul J. Norman, Steven G.E. Marsh, Robert Busch, Derek C. Macallan, and Becca Asquith
Publié dans:
The Journal of Clinical Investigation, Numéro 2023;133(12):e169496, 2023, ISSN 0021-9738
Éditeur:
American Society for Clinical Investigation
DOI:
10.1172/jci169496
Auteurs:
Jessica Ann Gaevert, Daniel Luque Duque, Grant Lythe, Carmen Molina-París, Paul Glyndwr Thomas
Publié dans:
Viruses, Numéro 13/9, 2021, Page(s) 1786, ISSN 1999-4915
Éditeur:
Multidisciplinary Digital Publishing Institute (MDPI)
DOI:
10.3390/v13091786
Auteurs:
Stefanie Scherer, Susanne G Oberle, Kristiyan Kanev, Ann-Katrin Gerullis, Ming Wu, Gustavo P de Almeida, Daniel J Puleston, Francesc Baixauli, Lilian Aly, Alessandro Greco, Tamar Nizharadze, Nils B Becker, Madlaina V Hoesslin, Lara V Donhauser, Jacqueline Berner, Talyn Chu, Hayley A McNamara, Zeynep Esencan, Patrick Roelli, Christine Wurmser, Ingo Kleiter, Maria J G T Vehreschild, Christoph A Maye
Publié dans:
Nature Communications, Numéro 24(3), 2023, Page(s) 501-515, ISSN 1529-2908
Éditeur:
Nature Publishing Group
DOI:
10.1038/s41590-023-01436-x
Auteurs:
Weike Pei, Fuwei Shang, Xi Wang, Ann-Kathrin Fanti, Alessandro Greco, Katrin Busch, Kay Klapproth, Qin Zhang, Claudia Quedenau, Sascha Sauer, Thorsten B. Feyerabend, Thomas Höfer, Hans-Reimer Rodewald
Publié dans:
Cell Stem Cell, Numéro 27/3, 2020, Page(s) 383-395.e8, ISSN 1934-5909
Éditeur:
Cell Press
DOI:
10.1016/j.stem.2020.07.018
Auteurs:
María Ruiz Ortega, Natanael Spisak, Thierry Mora, Aleksandra M. Walczak
Publié dans:
PLOS Genetics, 2023, ISSN 1553-7390
Éditeur:
Public Library of Science
DOI:
10.1371/journal.pgen.1010652
Auteurs:
Thomas Höfer, Hans-Reimer Rodewald
Publié dans:
Blood, Numéro 132/11, 2018, Page(s) 1106-1113, ISSN 0006-4971
Éditeur:
American Society of Hematology
DOI:
10.1182/blood-2018-03-791517
Auteurs:
Luis de la Higuera, Martín López-García, Mario Castro, Niloufar Abourashchi, Grant Lythe, Carmen Molina-París
Publié dans:
Frontiers in Immunology, Numéro 10, 2019, ISSN 1664-3224
Éditeur:
Frontiers Media SA
DOI:
10.3389/fimmu.2019.00194
Auteurs:
Van Thuy Truong, Paul G. Baverel, Grant D. Lythe, Paolo Vicini, James W. T. Yates, Vincent F. S. Dubois
Publié dans:
CPT: Pharmacometrics & Systems Pharmacology, 2021, ISSN 2163-8306
Éditeur:
Nature Publishing Group
DOI:
10.1002/psp4.12703
Auteurs:
Mina N. F. Morcos; Congxin Li; Clara M. Munz; Alessandro Greco; Nicole Dressel; Susanne Reinhardt; Katrin Sameith; Andreas Dahl; Nils B. Becker; Axel Roers; Thomas Höfer; Alexander Gerbaulet
Publié dans:
Nature Communications, Numéro 20411723, 2022, Page(s) 4504, ISSN 2041-1723
Éditeur:
Nature Publishing Group
DOI:
10.1038/s41467-022-31914-z
Auteurs:
Suzanne Day; Charandeep Kaur; Hannah M. Cheeseman; Emily de Groot; Leon R. McFarlane; Maniola Tanaka; Sofia Coelho; Tom Cole; Nana-Marie Lemm; Adrian Lim; Rogier W. Sanders; Becca Asquith; Robin J. Shattock; Katrina M. Pollock
Publié dans:
Frontiers in Immunology, 2022, Page(s) 13:991509, ISSN 1664-3224
Éditeur:
Frontiers Media
DOI:
10.3389/fimmu.2022.991509
Auteurs:
Noor Kherreh, Siobhán Cleary, Cathal Seoighe
Publié dans:
Cancer Immunology, Immunotherapy, 2021, ISSN 0340-7004
Éditeur:
Springer Verlag
DOI:
10.1007/s00262-021-03028-w
Auteurs:
Barbara Bravi, Jérôme Tubiana, Simona Cocco, Rémi Monasson, Thierry Mora, Aleksandra M. Walczak
Publié dans:
Cell Systems, Numéro 12/2, 2021, Page(s) 195-202.e9, ISSN 2405-4712
Éditeur:
Cell Press
DOI:
10.1016/j.cels.2020.11.005
Auteurs:
Chun-Yang Lin, Joshua Wolf, David C. Brice, Yilun Sun, Macauley Locke, Sean Cherry, Ashley H. Castellaw, Marie Wehenkel, Jeremy Chase Crawford, Veronika I. Zarnitsyna, Daniel Duque, Kim J. Allison, E. Kaitlynn Allen, Scott A. Brown, Alexandra H. Mandarano, Jeremie H. Estepp, The SJTRC Study Team, Charles Taylor 5, Carmen Molina-Paris, Stacey Schultz-Cherry, Li Tang, Paul G. Thomas, Maureen A. McGa
Publié dans:
Cell Host and Microbe, 2021, ISSN 1931-3128
Éditeur:
Cell Press
DOI:
10.1016/j.chom.2021.12.005
Auteurs:
Milena Simovic, Michiel Bolkestein, Mahmoud Moustafa, John K L Wong, Verena Körber, Sarah Benedetto, Umar Khalid, Hannah Sophia Schreiber, Manfred Jugold, Andrey Korshunov, Daniel Hübschmann, Norman Mack, Stephan Brons, Pei-Chi Wei, Michael O Breckwoldt, Sabine Heiland, Martin Bendszus, Jürgen Debus, Thomas Höfer, Marc Zapatka, Marcel Kool, Stefan M Pfister, Amir Abdollahi, Aurélie Ernst
Publié dans:
Neuro-Oncology, Numéro Volume 23, Numéro 12, December 2021, 2021, Page(s) 2028–2041, ISSN 1522-8517
Éditeur:
Duke University Press
DOI:
10.1093/neuonc/noab127
Auteurs:
Derek C. Macallan, Robert Busch, Becca Asquith
Publié dans:
Current Opinion in Systems Biology, Numéro 18, 2019, Page(s) 77-86, ISSN 2452-3100
Éditeur:
Elsevier Ltd
DOI:
10.1016/j.coisb.2019.10.002
Auteurs:
C. Pixberg, M. Zapatka, M. Hlevnjak, S. Benedetto, J.P. Suppelna, J. Heil, K. Smetanay, L. Michel, C. Fremd, V. Körber, M. Rübsam, L. Buschhorn, S. Heublein, B. Schäfgen, M. Golatta, C. Gomez, A. von Au, M. Wallwiener, S. Wolf, N. Dikow, C. Schaaf, E. Gutjahr, M. Allgäuer, A. Stenzinger, K. Pfütze, R. Kirsten, D. Hübschmann, H.-P. Sinn, D. Jäger, A. Trumpp, R. Schlenk, T. Höfer, V. Thewes,
Publié dans:
ESMO Open, 2022, ISSN 2059-7029
Éditeur:
Elsevier
DOI:
10.1016/j.esmoop.2022.100637
Auteurs:
Daniel F Luque Duque, Carmen Molina-Paris, Grant Lythe, Martin Lopez Garcia, Paul Glyndwr Thomas and Jessica Gaevert
Publié dans:
The Journal of Immunology, Numéro 204 (1 Supplement), 2020, Page(s) 94.18, ISSN 1550-6606
Éditeur:
The American Association of Immunologists, Inc.
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