Risultati finali
Bar-coded TCR sequence reads of human memory T cell subsets (blood and BM) (preliminary and final)
Preliminary by M36
Preliminary and validated compartmental model and code of CD8+ T cell infiltration into tumour environmentsPreliminary by M36
Reference database of immune receptor alleles in healthy humansPreliminary and validated mechanistic models of TCR repertoire dynamics and cross-reactivity
Preliminary by M36
Preliminary and validated stochastic model of the signals regulating naive T cell maintenancePreliminary by M36
Preliminary and validated mathematical model of thymic T cell development from D1.1Preliminary by M36
Renewal rates and lifespans of human T cell subsets (blood and BM) from D1.4 (preliminary and final)Preliminary by M36
A review report per WP (draft and final)A review report per WP draft and final review M36
Preliminary and validated compartmental model of human naive and memory T cell maintenancePreliminary by M36
Estimates of diversity and uniqueness of memory T cell (blood and BM) repertoires from D2.1Estimates of diversity and uniqueness of memory T cell blood and BM repertoires from D21
Labelling data of human memory T cell subsets in blood and bone marrow (BM) (preliminary and final)Preliminary by M36
Personal career development plans (in place and reviews)Reviews at M7 M19 M31
15 trained ESRs with two secondments eachPreliminary and validated probabilistic model of T cell signal integration
Preliminary by M36
Preliminary and validated computational model and code of impact of anti-cancer treatment on T cellsPreliminary by M36
Preliminary and validated computational model and code of TCR repertoire response to tumourPreliminary by M36
Two journal articles per ESRData set of thymocyte competition (preliminary and final)
Preliminary by M36
Preliminary and validated computational model of the effect of checkpoint inhibitors on T cells in cancerPreliminary by M36
Industrial workshops (S1, S2, S3, S6, S7, T8, T9 and T10) - review M21
Network meetings (E2-E6, I2-I6, B2-B5, M2-M6, T7, S4 and S5)Network meetings (E2-E6, I2-I6, B2-B5, M2-M6, T7, S4 and S5) - review M17 and M24
Complementary skill workshop (T4, T5 and T6)Recruitment strategy in place
Conferences (E1, I1, B1, M1, T1-T3)
Review M9
Pubblicazioni
Autori:
Léa Sta
Pubblicato in:
2023
Editore:
University of Leeds
Autori:
Daniel Luque Duque
Pubblicato in:
2023
Editore:
University of Leeds
Autori:
Giulia Belluccini
Pubblicato in:
2023
Editore:
University of Leeds
Autori:
HoChan Cheon
Pubblicato in:
2023
Editore:
Maynooth University
Autori:
Giulia Belluccini, Martın Lopez-Garcia, Grant Lythe, Carmen Molina-Paris
Pubblicato in:
Scientific Reports, 2022, Pagina/e 12:11289, ISSN 2045-2322
Editore:
Nature Publishing Group
DOI:
10.1038/s41598-022-14202-0
Autori:
Stephan Wilmes; Polly-Anne Jeffrey; Jonathan Martinez-Fabregas; Maximillian Hafer; Paul K. Fyfe; Elizabeth Pohler; Silvia Gaggero; Martín López-García; Grant Lythe; Charles Taylor; T. Guerrier; David Launay; Suman Mitra; Jacob Piehler; Carmen Molina-París; Carmen Molina-París; Ignacio Moraga
Pubblicato in:
eLife, Numero 1, 2019, ISSN 2050-084X
Editore:
eLife Sciences Publications
DOI:
10.7554/elife.66014
Autori:
Mora-Bitria, L., Asquith, B
Pubblicato in:
Immunogenetics, 2023, Pagina/e 269–282, ISSN 0093-7711
Editore:
Springer Verlag
DOI:
10.1007/s00251-023-01293-w
Autori:
Flavia Feliciangeli, Hanan Dreiwi, Martín López-García, Mario Castro Ponce, Carmen Molina-París and Grant Lythe
Pubblicato in:
Journal of the Royal Society Interface, Numero 17425689, 2022, Pagina/e 20220629, ISSN 1742-5689
Editore:
The Royal Society
DOI:
10.1098/rsif.2022.0629
Autori:
HoChan Cheon, Andrey Kan, Giulio Prevedello, Simone C. Oostindie, Simon J. Dovedi, Edwin D. Hawkins, Julia M. Marchingo, Susanne Heinzel, Ken R. Duffy, Philip D. Hodgkin
Pubblicato in:
Frontiers in Bioinformatics, Numero 1, 2021, ISSN 2673-7647
Editore:
Frontiers Media SA
DOI:
10.3389/fbinf.2021.723337
Autori:
Yan Zhang, Ada W.C. Yan, Lies Boelen, Linda Hadcocks, Arafa Salam, Daniel Padrosa Gispert, Loiza Spanos, Laura Mora Bitria, Neda Nemat-Gorgani, James A. Traherne, Chrissy Roberts, Danai Koftori, Graham P. Taylor, Daniel Forton, Paul J. Norman, Steven G.E. Marsh, Robert Busch, Derek C. Macallan, and Becca Asquith
Pubblicato in:
The Journal of Clinical Investigation, Numero 2023;133(12):e169496, 2023, ISSN 0021-9738
Editore:
American Society for Clinical Investigation
DOI:
10.1172/jci169496
Autori:
Jessica Ann Gaevert, Daniel Luque Duque, Grant Lythe, Carmen Molina-París, Paul Glyndwr Thomas
Pubblicato in:
Viruses, Numero 13/9, 2021, Pagina/e 1786, ISSN 1999-4915
Editore:
Multidisciplinary Digital Publishing Institute (MDPI)
DOI:
10.3390/v13091786
Autori:
Stefanie Scherer, Susanne G Oberle, Kristiyan Kanev, Ann-Katrin Gerullis, Ming Wu, Gustavo P de Almeida, Daniel J Puleston, Francesc Baixauli, Lilian Aly, Alessandro Greco, Tamar Nizharadze, Nils B Becker, Madlaina V Hoesslin, Lara V Donhauser, Jacqueline Berner, Talyn Chu, Hayley A McNamara, Zeynep Esencan, Patrick Roelli, Christine Wurmser, Ingo Kleiter, Maria J G T Vehreschild, Christoph A Maye
Pubblicato in:
Nature Communications, Numero 24(3), 2023, Pagina/e 501-515, ISSN 1529-2908
Editore:
Nature Publishing Group
DOI:
10.1038/s41590-023-01436-x
Autori:
Weike Pei, Fuwei Shang, Xi Wang, Ann-Kathrin Fanti, Alessandro Greco, Katrin Busch, Kay Klapproth, Qin Zhang, Claudia Quedenau, Sascha Sauer, Thorsten B. Feyerabend, Thomas Höfer, Hans-Reimer Rodewald
Pubblicato in:
Cell Stem Cell, Numero 27/3, 2020, Pagina/e 383-395.e8, ISSN 1934-5909
Editore:
Cell Press
DOI:
10.1016/j.stem.2020.07.018
Autori:
María Ruiz Ortega, Natanael Spisak, Thierry Mora, Aleksandra M. Walczak
Pubblicato in:
PLOS Genetics, 2023, ISSN 1553-7390
Editore:
Public Library of Science
DOI:
10.1371/journal.pgen.1010652
Autori:
Thomas Höfer, Hans-Reimer Rodewald
Pubblicato in:
Blood, Numero 132/11, 2018, Pagina/e 1106-1113, ISSN 0006-4971
Editore:
American Society of Hematology
DOI:
10.1182/blood-2018-03-791517
Autori:
Luis de la Higuera, Martín López-García, Mario Castro, Niloufar Abourashchi, Grant Lythe, Carmen Molina-París
Pubblicato in:
Frontiers in Immunology, Numero 10, 2019, ISSN 1664-3224
Editore:
Frontiers Media SA
DOI:
10.3389/fimmu.2019.00194
Autori:
Van Thuy Truong, Paul G. Baverel, Grant D. Lythe, Paolo Vicini, James W. T. Yates, Vincent F. S. Dubois
Pubblicato in:
CPT: Pharmacometrics & Systems Pharmacology, 2021, ISSN 2163-8306
Editore:
Nature Publishing Group
DOI:
10.1002/psp4.12703
Autori:
Mina N. F. Morcos; Congxin Li; Clara M. Munz; Alessandro Greco; Nicole Dressel; Susanne Reinhardt; Katrin Sameith; Andreas Dahl; Nils B. Becker; Axel Roers; Thomas Höfer; Alexander Gerbaulet
Pubblicato in:
Nature Communications, Numero 20411723, 2022, Pagina/e 4504, ISSN 2041-1723
Editore:
Nature Publishing Group
DOI:
10.1038/s41467-022-31914-z
Autori:
Suzanne Day; Charandeep Kaur; Hannah M. Cheeseman; Emily de Groot; Leon R. McFarlane; Maniola Tanaka; Sofia Coelho; Tom Cole; Nana-Marie Lemm; Adrian Lim; Rogier W. Sanders; Becca Asquith; Robin J. Shattock; Katrina M. Pollock
Pubblicato in:
Frontiers in Immunology, 2022, Pagina/e 13:991509, ISSN 1664-3224
Editore:
Frontiers Media
DOI:
10.3389/fimmu.2022.991509
Autori:
Noor Kherreh, Siobhán Cleary, Cathal Seoighe
Pubblicato in:
Cancer Immunology, Immunotherapy, 2021, ISSN 0340-7004
Editore:
Springer Verlag
DOI:
10.1007/s00262-021-03028-w
Autori:
Barbara Bravi, Jérôme Tubiana, Simona Cocco, Rémi Monasson, Thierry Mora, Aleksandra M. Walczak
Pubblicato in:
Cell Systems, Numero 12/2, 2021, Pagina/e 195-202.e9, ISSN 2405-4712
Editore:
Cell Press
DOI:
10.1016/j.cels.2020.11.005
Autori:
Chun-Yang Lin, Joshua Wolf, David C. Brice, Yilun Sun, Macauley Locke, Sean Cherry, Ashley H. Castellaw, Marie Wehenkel, Jeremy Chase Crawford, Veronika I. Zarnitsyna, Daniel Duque, Kim J. Allison, E. Kaitlynn Allen, Scott A. Brown, Alexandra H. Mandarano, Jeremie H. Estepp, The SJTRC Study Team, Charles Taylor 5, Carmen Molina-Paris, Stacey Schultz-Cherry, Li Tang, Paul G. Thomas, Maureen A. McGa
Pubblicato in:
Cell Host and Microbe, 2021, ISSN 1931-3128
Editore:
Cell Press
DOI:
10.1016/j.chom.2021.12.005
Autori:
Milena Simovic, Michiel Bolkestein, Mahmoud Moustafa, John K L Wong, Verena Körber, Sarah Benedetto, Umar Khalid, Hannah Sophia Schreiber, Manfred Jugold, Andrey Korshunov, Daniel Hübschmann, Norman Mack, Stephan Brons, Pei-Chi Wei, Michael O Breckwoldt, Sabine Heiland, Martin Bendszus, Jürgen Debus, Thomas Höfer, Marc Zapatka, Marcel Kool, Stefan M Pfister, Amir Abdollahi, Aurélie Ernst
Pubblicato in:
Neuro-Oncology, Numero Volume 23, Numero 12, December 2021, 2021, Pagina/e 2028–2041, ISSN 1522-8517
Editore:
Duke University Press
DOI:
10.1093/neuonc/noab127
Autori:
Derek C. Macallan, Robert Busch, Becca Asquith
Pubblicato in:
Current Opinion in Systems Biology, Numero 18, 2019, Pagina/e 77-86, ISSN 2452-3100
Editore:
Elsevier Ltd
DOI:
10.1016/j.coisb.2019.10.002
Autori:
C. Pixberg, M. Zapatka, M. Hlevnjak, S. Benedetto, J.P. Suppelna, J. Heil, K. Smetanay, L. Michel, C. Fremd, V. Körber, M. Rübsam, L. Buschhorn, S. Heublein, B. Schäfgen, M. Golatta, C. Gomez, A. von Au, M. Wallwiener, S. Wolf, N. Dikow, C. Schaaf, E. Gutjahr, M. Allgäuer, A. Stenzinger, K. Pfütze, R. Kirsten, D. Hübschmann, H.-P. Sinn, D. Jäger, A. Trumpp, R. Schlenk, T. Höfer, V. Thewes,
Pubblicato in:
ESMO Open, 2022, ISSN 2059-7029
Editore:
Elsevier
DOI:
10.1016/j.esmoop.2022.100637
Autori:
Daniel F Luque Duque, Carmen Molina-Paris, Grant Lythe, Martin Lopez Garcia, Paul Glyndwr Thomas and Jessica Gaevert
Pubblicato in:
The Journal of Immunology, Numero 204 (1 Supplement), 2020, Pagina/e 94.18, ISSN 1550-6606
Editore:
The American Association of Immunologists, Inc.
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