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Design and photo-optimization of Photosensitizer for Human Health and Food security applications or “how light can save lives”

Objective

The development of active compounds that can efficiently fight microbial infections and cancer are of utmost importance for food security and human health, two main challenges for Europe. Tetrapyrrolic photosensitizers (PS) are good candidates to meet these expectations. These photo-excitable molecules induce cell death via the formation of oxygen reactive species (ROS) and present very low toxicity in the absence of light. They are already used in photodynamic therapy (PDT) for cancer or skin disease treatments or in photo-antimicrobial chemo-therapy (PACT). Unfortunately, the research and training are still largely fragmented in this field in Europe. Some scientific barriers have to be overcome to increase their efficacy, e.g. improvement of the excitation pathways, ROS production, specific cell targeting, Gram (-) bactericidal effect and prevention and/or eradication of biofilms. That is why the EJD Polythea project aims developing an integrated and multidisciplinary approach of PDT through the implementation of 10 PhD research projects. The Polythea consortium proposes to develop (i) new tetrapyrrolic PS for various types of PDT including anti-cancer, anti-bacterial, anti-inflammatory and immune-activating application, improving their photophysical and biological properties; and (ii) innovative bio-inspired drug carriers or supports.
In parallel, a joint doctorate structure gathering 5 countries will be created and a multidisciplinary and inter-sectorial training programme will be implemented through network events and secondments to non-academic partners. It will provide a common background on PDT to the ESRs and make them more valuable employees, effective at problem solving. Practical applications should come out of this project such as first aid bandages, new skin/anti-tumour treatments, self-sterilizing surfaces for food industry or prosthetic devices.

Field of science

  • /medical and health sciences/clinical medicine/oncology/cancer
  • /engineering and technology/other engineering and technologies/food and beverages/food safety

Call for proposal

H2020-MSCA-ITN-2017
See other projects for this call

Funding Scheme

MSCA-ITN-EJD - European Joint Doctorates

Coordinator

UNIVERSITE DE LIMOGES
Address
François Mitterrand 33
87032 Limoges
France
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 525 751,20

Participants (6)

THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN
Ireland
EU contribution
€ 797 023,80
Address
College Green
2 Dublin
Activity type
Higher or Secondary Education Establishments
POLITECHNIKA WROCLAWSKA
Poland
EU contribution
€ 224 137,44
Address
Wybrzeze Wyspianskiego 27
50-370 Wroclaw
Activity type
Higher or Secondary Education Establishments
UNIVERSITEIT VAN AMSTERDAM
Netherlands
EU contribution
€ 255 374,28
Address
Spui 21
1012WX Amsterdam
Activity type
Higher or Secondary Education Establishments
UNIVERSIDADE DE COIMBRA
Portugal
EU contribution
€ 238 356,36
Address
Paco Das Escolas
3001 451 Coimbra
Activity type
Higher or Secondary Education Establishments
UNIVERSITE DE NEUCHATEL
Switzerland
EU contribution
€ 265 226,76
Address
Faubourg De L'hopital 41
2000 Neuchatel
Activity type
Higher or Secondary Education Establishments
BIOEMISSION TECHNOLOGY SOLUTIONS IKE
Greece
EU contribution
€ 242 386,92
Address
Alexandras Avenue 116
114 72 Athina
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)