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Targeting neuroinflammation to combat pathological pain in neurodegenerative diseases and chronic pain syndromes

Objective

Damage to the central (CNS) and peripheral (PNS) nervous systems causes altered perception of pain (pathological pain) which is a common feature of diseases that have high prevalence in the European Union. Both increases and decreases in the ability to perceive pain impair both performance at work and quality of life. Pathological pain in neurodegenerative diseases, musculoskeletal diseases and peripheral neuropathies is associated with neuroinflammation, the inflammatory process whereby non-neuronal (inflammatory and glia) cells interact with neurones by releasing molecules that modulate pain signalling. TOBeATPAIN suggest that neuroinflammation represents an underlying mechanism of pathological pain states encompassing those with a PNS or CNS origin. The focus of this ITN will be on the mechanisms by which non-neuronal cells impact on neuronal activity in order to identify innovative non-neuronal targets for the treatment of pathological pain in peripheral macrophages or CNS microglia/astrocytes. TOBeATPAIN delivers high-level scientific and innovation-oriented complementary training, forging career pathways to increase inter-sectorial and transnational employability of young entrepreneurially-minded scientists in the academic and industrial sectors. It combines the expertise of 5 leading academic institutions, 2 pharmaceutical companies and 1 SME as Beneficiaries, together with 2 SMEs and 1 non-profit research charity as Partner Organisations, from 4 European countries. Fully aligned with the ‘Knowledge Triangle’ (business, research, higher education) platform, eleven ESRs will gain valuable knowledge and multidisciplinary skills through interdisciplinary research projects that integrate state-of-the-art technologies, supervision by and secondments to industrial Network organisations, Network-wide and local training activities, and specialized transferable skills focused in the acquisition of the ‘3-Knowledges’ (K-creation, K-exploitation, K-communication).

Call for proposal

H2020-MSCA-ITN-2017
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Coordinator

KING'S COLLEGE LONDON
Address
Strand
WC2R 2LS London
United Kingdom
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 728 767,68

Participants (7)

KAROLINSKA INSTITUTET
Sweden
EU contribution
€ 527 318,64
Address
Nobels Vag 5
17177 Stockholm
Activity type
Higher or Secondary Education Establishments
MEDIZINISCHE UNIVERSITAT INNSBRUCK
Austria
EU contribution
€ 255 934,08
Address
Christoph Probst Platz 1
6020 Innsbruck
Activity type
Higher or Secondary Education Establishments
UNIVERSITATSKLINIKUM JENA
Germany
EU contribution
€ 498 432,96
Address
Kastanienstr.1
07747 Jena
Activity type
Higher or Secondary Education Establishments
UNIVERSITAETSKLINIKUM WUERZBURG - KLINIKUM DER BAYERISCHEN JULIUS-MAXIMILIANS-UNIVERSITAT
Germany
EU contribution
€ 249 216,48
Address
Josef-schneider-strasse 2
97080 Wurzburg
Activity type
Higher or Secondary Education Establishments
KANCERA AB
Sweden
EU contribution
€ 263 659,32
Address
Banvaktsvagen 22 Karolinska Institutet Science Park
171 48 Solna
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
BIONORICA RESEARCH GMBH
Austria
EU contribution
€ 255 934,08
Address
Mitterweg 24
6020 Innsbruck
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
ELI LILLY AND COMPANY LTD

Participation ended

United Kingdom
EU contribution
€ 91 095,96
Address
Lilly House Basingview
RG21 4FA Basingstoke
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)