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New nanomaterials for neural stem cells drug delivery

Objective

Brain conditions such as neurodegenerative diseases, stroke and traumatic injuries are a mayor burden in modern society. Because neural stem cells (NSCs) can differentiate into new neural cells including neurons, the regulation of their proliferation, differentiation and migration represent a promising regenerative/therapeutic strategy. The hypothesis of NanoStem project is that novel nanoparticles (NPs) combined with recent identified/developed pharmaceuticals can be an efficient approach to control the biological activity of NSCs. The scientific project is organized in three work packages (WP), each focusing on specific objectives and containing well-defined deliverables. WP1 will focus on the synthesis of the nanomaterials and the uploading of the therapeutics. WP2 will take the best nanoparticles and focus more on the evaluation of the permeation and efficacy of the formulations against NSCs. WP3 will focus on in vivo studies to evaluate the formulations developed to tackle the brain and to assess their toxicity. The project will train 14 ESRs in areas including organic and polymer chemistry, cell biology, pharmacology, neuroscience, nanobiotechnology and clinical sciences. The project will also provide a substantial training program in complementary skills, targeting both professional and personal development, and translation of research and entrepreneurship. The project brings together six academic partners, one hospital and two industrial teams as full partners, complemented by four associate partners, one of which is an industrial team, distributed over a total of seven European Union member states. The consortium brings together groups with a very interdisciplinary expertise ranging from nanoparticle synthesis and characterization, computational modeling, in vitro BBB models and BBB transport, neural stem cells, animal testing and clinical expertise.

Coordinator

QUEEN MARY UNIVERSITY OF LONDON
Net EU contribution
€ 819 863,64
Address
327 Mile End Road
E1 4NS London
United Kingdom

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Region
London Inner London — East Tower Hamlets
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00

Participants (9)

CENTRO DE NEUROCIENCIAS E BIOLOGIACELULAR ASSOCIACAO
Portugal
Net EU contribution
€ 715 069,08
Address
Universidade De Coimbra Largo Marques De Pombal
3004 517 Coimbra

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Region
Continente Centro (PT) Região de Coimbra
Activity type
Research Organisations
Non-EU contribution
€ 0,00
UNIVERSITE D'ARTOIS
France
Net EU contribution
€ 525 751,20
Address
Rue Du Temple 9
62000 Arras

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Region
Hauts-de-France Nord-Pas de Calais Pas-de-Calais
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
KAROLINSKA INSTITUTET
Sweden
Net EU contribution
€ 263 659,32
Address
Nobels Vag 5
17177 Stockholm

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Region
Östra Sverige Stockholm Stockholms län
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
CENTRO HOSPITALAR E UNIVERSITARIO DE COIMBRA EPE
Portugal
Net EU contribution
€ 238 356,36
Address
Av De Bissaya, Praceta De Mota Pinto
3000-075 Coimbra

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Region
Continente Centro (PT) Região de Coimbra
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Non-EU contribution
€ 0,00
HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH
Germany
Net EU contribution
€ 249 216,48
Address
Ingolstadter Landstrasse 1
85764 Neuherberg

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Region
Bayern Oberbayern München, Landkreis
Activity type
Research Organisations
Non-EU contribution
€ 0,00
MYBIOTECH GMBH
Germany
Net EU contribution
€ 249 216,48
Address
Industriestrasse 1b
66802 Uberherrn

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Saarland Saarland Saarlouis
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
UNIVERSITAET INNSBRUCK
Austria
Net EU contribution
€ 255 934,08
Address
Innrain 52
6020 Innsbruck

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Region
Westösterreich Tirol Innsbruck
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
THE UNIVERSITY OF WARWICK

Participation ended

United Kingdom
Net EU contribution
€ 0,00
Address
Kirby Corner Road - University House
CV4 8UW Coventry

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Region
West Midlands (England) West Midlands Coventry
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
THE UNIVERSITY OF BIRMINGHAM
United Kingdom
Net EU contribution
€ 273 287,88
Address
Edgbaston
B15 2TT Birmingham

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Region
West Midlands (England) West Midlands Birmingham
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00

Partners (4)

Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

HCS Pharma
France
Net EU contribution
€ 0,00
Address
250 Rue Salvador Allende, Batiment A
59120 Loos

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Region
Hauts-de-France Nord-Pas de Calais Nord
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

BRAINS FOR BRAIN FOUNDATION ONLUS
Italy
Net EU contribution
€ 0,00
Address
Via Giustiniani 3
35128 Padova

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Region
Nord-Est Veneto Padova
Activity type
Research Organisations
Non-EU contribution
€ 0,00
Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

UNIVERSITAT DES SAARLANDES
Germany
Net EU contribution
€ 0,00
Address
Campus
66123 Saarbrucken

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Region
Saarland Saarland Regionalverband Saarbrücken
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

UNIVERSIDADE DE COIMBRA
Portugal
Net EU contribution
€ 0,00
Address
Paco Das Escolas
3004-531 Coimbra

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Region
Continente Centro (PT) Região de Coimbra
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00