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New nanomaterials for neural stem cells drug delivery

Objective

Brain conditions such as neurodegenerative diseases, stroke and traumatic injuries are a mayor burden in modern society. Because neural stem cells (NSCs) can differentiate into new neural cells including neurons, the regulation of their proliferation, differentiation and migration represent a promising regenerative/therapeutic strategy. The hypothesis of NanoStem project is that novel nanoparticles (NPs) combined with recent identified/developed pharmaceuticals can be an efficient approach to control the biological activity of NSCs. The scientific project is organized in three work packages (WP), each focusing on specific objectives and containing well-defined deliverables. WP1 will focus on the synthesis of the nanomaterials and the uploading of the therapeutics. WP2 will take the best nanoparticles and focus more on the evaluation of the permeation and efficacy of the formulations against NSCs. WP3 will focus on in vivo studies to evaluate the formulations developed to tackle the brain and to assess their toxicity. The project will train 14 ESRs in areas including organic and polymer chemistry, cell biology, pharmacology, neuroscience, nanobiotechnology and clinical sciences. The project will also provide a substantial training program in complementary skills, targeting both professional and personal development, and translation of research and entrepreneurship. The project brings together six academic partners, one hospital and two industrial teams as full partners, complemented by four associate partners, one of which is an industrial team, distributed over a total of seven European Union member states. The consortium brings together groups with a very interdisciplinary expertise ranging from nanoparticle synthesis and characterization, computational modeling, in vitro BBB models and BBB transport, neural stem cells, animal testing and clinical expertise.

Field of science

  • /natural sciences/biological sciences/cell biology
  • /medical and health sciences/medical biotechnology/cells technologies/stem cells
  • /medical and health sciences/basic medicine/neurology/stroke
  • /social sciences/sociology/social problems/migration
  • /natural sciences/chemical sciences/polymer science
  • /social sciences/economics and business/business and management/entrepreneurship
  • /social sciences/social and economic geography/transport
  • /medical and health sciences/basic medicine/pharmacology and pharmacy
  • /natural sciences/biological sciences/neurobiology
  • /engineering and technology/nanotechnology/nano-materials
  • /natural sciences/biological sciences/neurobiology/neuroscience

Call for proposal

H2020-MSCA-ITN-2017
See other projects for this call

Funding Scheme

MSCA-ITN-ETN - European Training Networks

Coordinator

QUEEN MARY UNIVERSITY OF LONDON
Address
327 Mile End Road
E1 4NS London
United Kingdom
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 819 863,64

Participants (9)

CENTRO DE NEUROCIENCIAS E BIOLOGIACELULAR ASSOCIACAO
Portugal
EU contribution
€ 715 069,08
Address
Universidade De Coimbra Largo Marques De Pombal
3004 517 Coimbra
Activity type
Research Organisations
UNIVERSITE D'ARTOIS
France
EU contribution
€ 525 751,20
Address
Rue Du Temple 9
62000 Arras
Activity type
Higher or Secondary Education Establishments
KAROLINSKA INSTITUTET
Sweden
EU contribution
€ 263 659,32
Address
Nobels Vag 5
17177 Stockholm
Activity type
Higher or Secondary Education Establishments
CENTRO HOSPITALAR E UNIVERSITARIO DE COIMBRA E.P.E.
Portugal
EU contribution
€ 238 356,36
Address
Av De Bissaya, Praceta De Mota Pinto
3000-075 Coimbra
Activity type
Other
HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH
Germany
EU contribution
€ 249 216,48
Address
Ingolstadter Landstrasse 1
85764 Neuherberg
Activity type
Research Organisations
MYBIOTECH GMBH
Germany
EU contribution
€ 249 216,48
Address
Industriestrasse 1B
66802 Uberherrn
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
UNIVERSITAET INNSBRUCK
Austria
EU contribution
€ 255 934,08
Address
Innrain 52
6020 Innsbruck
Activity type
Higher or Secondary Education Establishments
THE UNIVERSITY OF WARWICK

Participation ended

United Kingdom
EU contribution
€ 0
Address
Kirby Corner Road - University House
CV4 8UW Coventry
Activity type
Higher or Secondary Education Establishments
THE UNIVERSITY OF BIRMINGHAM
United Kingdom
EU contribution
€ 273 287,88
Address
Edgbaston
B15 2TT Birmingham
Activity type
Higher or Secondary Education Establishments

Partners (4)

HCS Pharma
France
Address
250 Rue Salvador Allende, Batiment A
59120 Loos
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
BRAINS FOR BRAIN FOUNDATION ONLUS
Italy
Address
Via Giustiniani 3
35128 Padova
Activity type
Research Organisations
UNIVERSITAT DES SAARLANDES
Germany
Address
Campus
66123 Saarbrucken
Activity type
Higher or Secondary Education Establishments
UNIVERSIDADE DE COIMBRA
Portugal
Address
Paco Das Escolas
3001 451 Coimbra
Activity type
Higher or Secondary Education Establishments