Objective
Brain conditions such as neurodegenerative diseases, stroke and traumatic injuries are a mayor burden in modern society. Because neural stem cells (NSCs) can differentiate into new neural cells including neurons, the regulation of their proliferation, differentiation and migration represent a promising regenerative/therapeutic strategy. The hypothesis of NanoStem project is that novel nanoparticles (NPs) combined with recent identified/developed pharmaceuticals can be an efficient approach to control the biological activity of NSCs. The scientific project is organized in three work packages (WP), each focusing on specific objectives and containing well-defined deliverables. WP1 will focus on the synthesis of the nanomaterials and the uploading of the therapeutics. WP2 will take the best nanoparticles and focus more on the evaluation of the permeation and efficacy of the formulations against NSCs. WP3 will focus on in vivo studies to evaluate the formulations developed to tackle the brain and to assess their toxicity. The project will train 14 ESRs in areas including organic and polymer chemistry, cell biology, pharmacology, neuroscience, nanobiotechnology and clinical sciences. The project will also provide a substantial training program in complementary skills, targeting both professional and personal development, and translation of research and entrepreneurship. The project brings together six academic partners, one hospital and two industrial teams as full partners, complemented by four associate partners, one of which is an industrial team, distributed over a total of seven European Union member states. The consortium brings together groups with a very interdisciplinary expertise ranging from nanoparticle synthesis and characterization, computational modeling, in vitro BBB models and BBB transport, neural stem cells, animal testing and clinical expertise.
Fields of science
- medical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugs
- natural scienceschemical sciencespolymer sciences
- medical and health sciencesmedical biotechnologycells technologiesstem cells
- medical and health sciencesbasic medicineneurologystroke
- engineering and technologynanotechnologynano-materials
Programme(s)
Coordinator
E1 4NS London
United Kingdom
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Participants (9)
3004 517 Coimbra
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62000 Arras
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17177 Stockholm
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3000-075 Coimbra
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85764 Neuherberg
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66802 Uberherrn
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
6020 Innsbruck
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Participation ended
CV4 8UW COVENTRY
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B15 2TT Birmingham
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Partners (4)
Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
59120 Loos
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
35128 Padova
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
66123 Saarbrucken
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
3004-531 Coimbra
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