Bio-orthogonal catalysis for cancer therapy

Informazioni relative al progetto

THERACAT

ID dell’accordo di sovvenzione: 765497

DOI 10.3030/765497

Progetto chiuso

Data della firma CE 4 Aprile 2018

Data di avvio 1 Marzo 2018

Data di completamento 31 Agosto 2022

Finanziato da

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Costo totale € 3 380 767,25

Contributo UE € 3 380 767,25

Coordinato da

FUNDACIO INSTITUT DE BIOENGINYERIA DE CATALUNYA
Spain

Risultati finali

Websites, patent fillings, videos etc. (5)

General press articles submitted to EU magazines (M48)

General press articles submitted to EU magazines M48

THERACAT conference
THERACAT video
Website completion
General press articles submitted to EU magazines (M30)

General press articles submitted to EU magazines M30

Documents, reports (5)

Training events minutes (Training event 5)

Training events minutes Training event 5

Training events minutes (Training event 1)
Training events minutes (Training event 2)
Training events minutes (Training event 4)

Training events minutes Training event 4

Training events minutes (Training event 3)

Training events minutes Training event 3

Pubblicazioni

Peer reviewed articles (12)

En Route to Stabilized Compact Conformations of Single-Chain Polymeric Nanoparticles in Complex Media

Autori: Stefan Wijker, Linlin Deng, Fabian Eisenreich, Ilja K. Voets, and Anja R. A. Palmans
Pubblicato in: Macromolecules, Numero 00249297, 2021, Pagina/e 6220-6230, ISSN 0024-9297
Editore: American Chemical Society
DOI: 10.1021/acs.macromol.2c00930

Developing Pd(II) based amphiphilic polymeric nanoparticles for pro-drug activation in complex media

Autori: Anjana Sathyan, Stephen Croke, Ana M. Perez-Lopez, Bas F.M. de Waal, Asier Unciti-Broceta, Anja R. A. Palmans
Pubblicato in: Molecular Systems Design & Engineering, Numero 20589689, 2022, ISSN 2058-9689
Editore: Royal Society of Chemistry
DOI: 10.1039/d2me00173j

Elucidating the Stability of Single-Chain Polymeric Nanoparticles in Biological Media and Living Cells

Autori: Linlin Deng, Lorenzo Albertazzi, and Anja R. A. Palmans
Pubblicato in: Biomacromolecules, Numero 15257797, 2022, Pagina/e 326-338, ISSN 1525-7797
Editore: American Chemical Society
DOI: 10.1021/acs.biomac.1c01291

Bioorthogonal Strategies for the in Vivo Synthesis or Release of Drugs

Autori: Lozhkin, B.; Ward, T. R.
Pubblicato in: Bioorganic & Medicinal Chemistry, Numero 09680896, 2021, Pagina/e 116310, ISSN 0968-0896
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.bmc.2021.116310

Tuning the Reactivity of Micellar Nanoreactors by Precise Adjustments of the Amphiphile and Substrate Hydrophobicity

Autori: Roey Amir; Shreyas Wagle; Gadi Slor; Shahar Tevet
Pubblicato in: Macromolecules, Numero 00249297, 2021, ISSN 0024-9297
Editore: American Chemical Society
DOI: 10.1021/acs.macromol.1c01755

Small Molecule Kinase Inhibitor Drugs (1995-2021): Medical Indication, Pharmacology, and Synthesis

Autori: Cecilia C Ayala-Aguilera; Teresa Valero; Álvaro Lorente-Macías; Daniel J. Baillache; Stephen Croke; Asier Unciti-Broceta
Pubblicato in: Journal of Medicinal Chemistry, Numero 00222623, 2022, Pagina/e 1047-1131, ISSN 0022-2623
Editore: American Chemical Society
DOI: 10.1021/acs.jmedchem.1c00963

A Close-to-Aromatize Approach for the Late-Stage Functionalization through Ring Closing Metathesis

Autori: Lozhkin, Boris; Ward, Thomas R
Pubblicato in: Helvetica Chimica Acta, Numero 15222675, 2021, Pagina/e e2100024, ISSN 1522-2675
Editore: John Wiley & Sons
DOI: 10.1002/hlca.202100024

Judging Enzyme-Responsive Micelles by Their Covers: Direct Comparison of Dendritic Amphiphiles with Different Hydrophilic Blocks.

Autori: Gadi Slor, Alis R. Olea, Sílvia Pujals, Ali Tigrine, Victor R. De La Rosa, Richard Hoogenboom, Lorenzo Albertazzi, Roey J. Amir
Pubblicato in: Biomacromolecules, Numero 15257797, 2021, Pagina/e 1197-1210, ISSN 1525-7797
Editore: American Chemical Society
DOI: 10.1021/acs.biomac.0c01708

Design and Evolution of Chimeric Streptavidin for Protein-Enabled Dual Gold Catalysis

Autori: Christoffel, F., Igareta, N., Pellizzoni, M. M., Tiessler-Sala, L., Lozhkin, B., Spiess, D. C., Lledos, A., Marechal, J.-D., Peterson, R. L., Ward, T. R.
Pubblicato in: Nature Catalysis, Numero 25201158, 2022, Pagina/e 643-653, ISSN 2520-1158
Editore: Nautre Research
DOI: 10.1038/s41929-021-00651-9

Transition metal catalysts for the bioorthogonal synthesis of bioactive agents.

Autori: Melissa O.N. van de L'Isle; Mari Carmen Ortega-Liebana; Asier Unciti-Broceta
Pubblicato in: Current Opinion in Chemical Biology, Numero 13675931, 2021, Pagina/e 32-42, ISSN 1367-5931
Editore: Elsevier BV
DOI: 10.1016/j.cbpa.2020.10.001

Architectural Change of the Shell-Forming Block from Linear to V-Shaped Accelerates Micellar Disassembly, but Slows the Complete Enzymatic Degradation of the Amphiphiles

Autori: Merav Segal, Lihi Ozery, Gadi Slor, Shreyas Wagle, Tamara Ehm, Roy Beck, Roey J. Amir
Pubblicato in: Biomacromolecules, Numero 15257797, 2020, Pagina/e 4076-4086, ISSN 1525-7797
Editore: American Chemical Society
DOI: 10.1021/acs.biomac.0c00882

Mapping the relationship between total and functional antibodies conjugated to nanoparticles with spectrally-resolved direct stochastic optical reconstruction microscopy (SR-dSTORM)

Autori: Emmanouil Archontakis, Laura Woythe, Bas van Hoof and Lorenzo Albertazzi
Pubblicato in: Nanoscale Advances, Numero 25160230, 2022, Pagina/e 4402-4409, ISSN 2516-0230
Editore: Royal Society of Chemistry
DOI: 10.1039/d2na00435f