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Selective Agonists For Serotonin Receptors

Objective

SAFER will train 5 ESRs, PhD students, to obtain ample scientific, business and transferrable skills, arming them with the expertise to translate knowledge into products and services with importance for European industry and society. All ESRs will first train together at one university to develop complementary skills and basic research data; and subsequently move to two SMEs for applied and commercial research.

The ultimate scientific goal for the SAFER program is to gain molecular understanding and improve selectivity in treatments
of CNS-related disorders. This will be done through an interdisciplinary and intersectoral approach, building on a strong complementarity between partners, with a particular focus on the serotonin 5-HT2A receptor – the primary target for many pharmaceuticals and hallucinogens. SAFER will generate and cross-interpret pharmacology and crystallographic data, and construct computational mechanistic models and databases that can explain and guide its experiments. Thus, SAFER will gain new insights into molecular mechanisms that are fundamental to understand the biological and therapeutic effects, and to develop safer drugs.
SAFER ESRs will be highly competitive on the job market and much in demand. In particular, crystallography and biased signalling pharmacology of G protein-coupled receptors (e.g. 5-HT2A) are new and highly active research fields, today mastered by only a very few research groups worldwide. The timing and location of SAFER are particularly opportune, taking advantage of the new synchrotron MAX IV in Lund, Sweden, which is world leading for the study of challenging crystals. SAFER will seek to exploit innovation opportunities from novel molecular mechanisms, ligands, and crystal structures. The results will be integrated into a public community resource, GPCRdb, giving a unique potential to achieve community impact and long-term sustainability.

Field of science

  • /social sciences/economics and business/business and management/commerce
  • /natural sciences/computer and information sciences/databases
  • /natural sciences/earth and related environmental sciences/geology/mineralogy/crystallography
  • /social sciences/economics and business
  • /engineering and technology/materials engineering/crystals
  • /social sciences/economics and business/business and management/employment
  • /social sciences/other social sciences/social sciences interdisciplinary/sustainable development
  • /social sciences/sociology/governance/public services
  • /medical and health sciences/basic medicine/pharmacology and pharmacy

Call for proposal

H2020-MSCA-ITN-2017
See other projects for this call

Funding Scheme

MSCA-ITN-EID - European Industrial Doctorates

Coordinator

KOBENHAVNS UNIVERSITET
Address
Norregade 10
1165 Kobenhavn
Denmark
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 290 081,88

Participants (2)

SAROMICS BIOSTRUCTURES AB
Sweden
EU contribution
€ 512 670,90
Address
Medicon Village
223 81 Lund
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
ENAMINE LIMITED LIABILITY COMPANY,RESEARCH AND PRODUCTION ENTERPRISE
Ukraine
EU contribution
€ 483 878,16
Address
78 Chervonotkatska Str.
02094 Kyiv
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)