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Selective Agonists For Serotonin Receptors

Deliverables

Functionally selective ligand scaffolds from virtual screening

Virtual screening for new 5HT2A ligand scaffolds with functional selectivity

Holistic signalling pathway profiles of new 5-HT2A ligands

Evaluate the receptor subtype and signalling pathwayprofiles of new inhouse lead ligands from synthesis T23 and VS T24

2nd report on dissemination activities

Report on dissemination/outreach activities

3rd report on dissemination activities

Report on dissemination/outreach activities

Functionally selective ligands from in-house synthesis

Synthesise putatively modelbased selective ligands

Model of structural mechanisms for 5-HT2A biased agonism

Build 3D molecular models for rationalisation and design of functionally selective 5HT2A ligands

1st report on dissemination activities

Report on dissemination/outreach activities

4th report on dissemination activities

Report on dissemination/outreach activities

Ligand database incl. biased agonism – public version in GPCRdb

Provide data design specifications and inhouse pilot data

SAFER web site

SAFER website implementation.

Searching for OpenAIRE data...

Publications

GPCRdb in 2021: integrating GPCR sequence, structure and function

Author(s): Albert J Kooistra, Stefan Mordalski, Gáspár Pándy-Szekeres, Mauricio Esguerra, Alibek Mamyrbekov, Christian Munk, György M Keserű, David E Gloriam
Published in: Nucleic Acids Research, 49/D1, 2020, Page(s) D335-D343, ISSN 0305-1048
Publisher: Oxford University Press
DOI: 10.1093/nar/gkaa1080

Structural insights into the lipid and ligand regulation of serotonin receptors

Author(s): Peiyu Xu, Sijie Huang, Huibing Zhang, Chunyou Mao, X. Edward Zhou, Xi Cheng, Icaro A. Simon, Dan-Dan Shen, Hsin-Yung Yen, Carol V. Robinson, Kasper Harpsøe, Bo Svensson, Jia Guo, Hualiang Jiang, David E. Gloriam, Karsten Melcher, Yi Jiang, Yan Zhang, H. Eric Xu
Published in: Nature, 592/7854, 2021, Page(s) 469-473, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-021-03376-8