Deliverables
Virtual screening for new 5HT2A ligand scaffolds with functional selectivity
Holistic signalling pathway profiles of new 5-HT2A ligandsEvaluate the receptor subtype and signalling pathwayprofiles of new inhouse lead ligands from synthesis T23 and VS T24
2nd report on dissemination activitiesReport on dissemination/outreach activities
3rd report on dissemination activitiesReport on dissemination/outreach activities
Functionally selective ligands from in-house synthesisSynthesise putatively modelbased selective ligands
Model of structural mechanisms for 5-HT2A biased agonismBuild 3D molecular models for rationalisation and design of functionally selective 5HT2A ligands
1st report on dissemination activitiesReport on dissemination/outreach activities
4th report on dissemination activitiesReport on dissemination/outreach activities
Provide data design specifications and inhouse pilot data
SAFER web siteSAFER website implementation.
Publications
Author(s):
Albert J Kooistra, Stefan Mordalski, Gáspár Pándy-Szekeres, Mauricio Esguerra, Alibek Mamyrbekov, Christian Munk, György M Keserű, David E Gloriam
Published in:
Nucleic Acids Research, Issue 49/D1, 2020, Page(s) D335-D343, ISSN 0305-1048
Publisher:
Oxford University Press
DOI:
10.1093/nar/gkaa1080
Author(s):
Peiyu Xu, Sijie Huang, Huibing Zhang, Chunyou Mao, X. Edward Zhou, Xi Cheng, Icaro A. Simon, Dan-Dan Shen, Hsin-Yung Yen, Carol V. Robinson, Kasper Harpsøe, Bo Svensson, Jia Guo, Hualiang Jiang, David E. Gloriam, Karsten Melcher, Yi Jiang, Yan Zhang, H. Eric Xu
Published in:
Nature, Issue 592/7854, 2021, Page(s) 469-473, ISSN 0028-0836
Publisher:
Nature Publishing Group
DOI:
10.1038/s41586-021-03376-8
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