A European training network for the discovery of neurotrophins small molecule mimetics as candidate therapeutic agents for neurodegeneration and neuroinflammation

Project Information

EuroNeurotrophin

Grant agreement ID: 765704

DOI

10.3030/765704

Project closed

EC signature date 17 August 2017

Start date 1 January 2018

End date 31 March 2022

Funded under

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Total cost

€ 3 544 314,08

EU contribution

€ 3 544 314,08

Coordinated by

ETHNIKO IDRYMA EREVNON
Greece

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Documents, reports (1)

Three annual training weeks

Detailed report of the training events implemented during the EuroNeurotrophin training weeks This deliverable will be updated at M23 and M34

Other (1)

International Conference and Neurotrophin Cluster Day

Programme abstracts participants networking activities ESRs poster and oral presentations

Websites, patent fillings, videos etc. (1)

Project website and presence in online media

Creation and maintenance of a website dedicated to the EuroNeurotrophin project. Regular updating and an annual newsletter will be carried out on the website.Presence in facebook, hashtagTwitter, LinkedIn and ResearchGate.

Publications

Conference proceedings (2)

Coarse-Grained Molecular Dynamics Simulations of the p75 Neurotrophin Receptor Transmembrane Domain

Author(s): Alexandros Tsengenes; Rebecca C. Wade
Published in: Biophysical Journal, 2021, Page(s) vol. 120, issue 3, p. 302a
Publisher: Cell Press
DOI: 10.1016/j.bpj.2020.11.1927

Understanding the Transmembrane Dimerization Interface of TrkA and TrkB Receptors

Author(s): Athanasiou, C., & Wade, R. C.
Published in: Biophysical Journal, 2021, Page(s) 120(3), 303a
Publisher: Cell Press
DOI: 10.1016/j.bpj.2020.11.1930

Thesis and dissertations (2)

Synthesis of dehydroepiandrosterone (DHEA) derivatives substituted by three membered -17-spiro substituents

Author(s): Alessia Latorrata
Published in: 2022
Publisher: National and Kapodistrian University of Athens

In silico screening and Hit to Lead development of small molecules neurotrophin receptors ligands

Author(s): Mirjana ANTONIJEVIC
Published in: 2021
Publisher: UNIVERSITE CAEN NORMANDIE

Peer reviewed articles (5)

Development and Biological Characterization of a Novel Selective TrkA Agonist with Neuroprotective Properties against Amyloid Toxicity

Author(s): Rogdakis, T.; Charou, D., Latorrata, A., Papadimitriou, E., Tsengenes, A., Athanasiou, C., Papadopoulou, M., Chalikiopoulou, C., Katsila, T., Ramos, I., Prousis, K.C., Wade, R.C., Sidiropoulou, K., Calogeropoulou, T., Gravanis, A., Charalampopoulos, I.
Published in: Biomedicines, Issue 22279059, 2022, Page(s) Volume 10, p 614, ISSN 2227-9059
Publisher: MDPI
DOI: 10.3390/biomedicines10030614

ENT-A010, a Novel Steroid Derivative, Displays Neuroprotective Functions and Modulates Microglial Responses

Author(s): Yilmaz C, Rogdakis T, Latorrata A, Thanou E, Karadima E, Papadimitriou E, Siapi E, Li KW, Katsila T, Calogeropoulou T, Charalampopoulos I, Alexaki VI
Published in: Biomolecules; Volume 12; Issue 3; Pages: 424, Issue Monthly, 2022, Page(s) 1-22, ISSN 2218-273X
Publisher: MDPI
DOI: 10.3390/biom12030424

DHEA Inhibits Leukocyte Recruitment through Regulation of the Integrin Antagonist DEL-1

Author(s): Athanasios Ziogas, Tomoki Maekawa, Johannes R. Wiessner, Thi Trang Le, David Sprott, Maria Troullinaki, Ales Neuwirth, Vasiliki Anastasopoulou, Sylvia Grossklaus, Kyoung-Jin Chung, Markus Sperandio, Triantafyllos Chavakis, George Hajishengallis, Vasileia Ismini Alexaki
Published in: The Journal of Immunology, Issue 204/5, 2020, Page(s) 1214-1224, ISSN 0022-1767
Publisher: American Association of Immunologists
DOI: 10.4049/jimmunol.1900746

Neurosteroids as regulators of neuroinflammation

Author(s): Canelif Yilmaz, Kanelina Karali, Georgia Fodelianaki, Achille Gravanis, Triantafyllos Chavakis, Ioannis Charalampopoulos, Vasileia Ismini Alexaki
Published in: Frontiers in Neuroendocrinology, Issue 55, 2019, Page(s) 100788, ISSN 0091-3022
Publisher: Academic Press
DOI: 10.1016/j.yfrne.2019.100788

C9orf72 expansion within astrocytes reduces metabolic flexibility in amyotrophic lateral sclerosis.

Author(s): Allen, S.P.; Hall, B.; Woof, R.; Francis, L.; Gatto, N.; Shaw, A.C.; Myszczynska, M.; Hemingway, J.; Coldicott, I.; Willcock, A.; Job, L.; Hughes, R.M.; Boschian, C.; Bayatti, N.; Heath, P.R.; Bandmann, O.; Mortiboys, H.; Ferraiuolo, L.; Shaw, P.J.
Published in: Brain, Issue Monthly, 2019, Page(s) Volume 142, Issue 12, Pages 3771–3790, ISSN 0006-8950
Publisher: Oxford University Press
DOI: 10.1093/brain/awz302