A European training network for the discovery of neurotrophins small molecule mimetics as candidate therapeutic agents for neurodegeneration and neuroinflammation

Información del proyecto

EuroNeurotrophin

Identificador del acuerdo de subvención: 765704

DOI

10.3030/765704

Proyecto cerrado

Fecha de la firma de la CE 17 Agosto 2017

Fecha de inicio 1 Enero 2018

Fecha de finalización 31 Marzo 2022

Financiado con arreglo a

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Coste total

€ 3 544 314,08

Aportación de la UE

€ 3 544 314,08

Coordinado por

ETHNIKO IDRYMA EREVNON
Greece

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Documents, reports (1)

Three annual training weeks

Detailed report of the training events implemented during the EuroNeurotrophin training weeks This deliverable will be updated at M23 and M34

Other (1)

International Conference and Neurotrophin Cluster Day

Programme abstracts participants networking activities ESRs poster and oral presentations

Websites, patent fillings, videos etc. (1)

Project website and presence in online media

Creation and maintenance of a website dedicated to the EuroNeurotrophin project. Regular updating and an annual newsletter will be carried out on the website.Presence in facebook, hashtagTwitter, LinkedIn and ResearchGate.

Publicaciones

Conference proceedings (2)

Coarse-Grained Molecular Dynamics Simulations of the p75 Neurotrophin Receptor Transmembrane Domain

Autores: Alexandros Tsengenes; Rebecca C. Wade
Publicado en: Biophysical Journal, 2021, Página(s) vol. 120, issue 3, p. 302a
Editor: Cell Press
DOI: 10.1016/j.bpj.2020.11.1927

Understanding the Transmembrane Dimerization Interface of TrkA and TrkB Receptors

Autores: Athanasiou, C., & Wade, R. C.
Publicado en: Biophysical Journal, 2021, Página(s) 120(3), 303a
Editor: Cell Press
DOI: 10.1016/j.bpj.2020.11.1930

Thesis and dissertations (2)

Synthesis of dehydroepiandrosterone (DHEA) derivatives substituted by three membered -17-spiro substituents

Autores: Alessia Latorrata
Publicado en: 2022
Editor: National and Kapodistrian University of Athens

In silico screening and Hit to Lead development of small molecules neurotrophin receptors ligands

Autores: Mirjana ANTONIJEVIC
Publicado en: 2021
Editor: UNIVERSITE CAEN NORMANDIE

Peer reviewed articles (5)

Development and Biological Characterization of a Novel Selective TrkA Agonist with Neuroprotective Properties against Amyloid Toxicity

Autores: Rogdakis, T.; Charou, D., Latorrata, A., Papadimitriou, E., Tsengenes, A., Athanasiou, C., Papadopoulou, M., Chalikiopoulou, C., Katsila, T., Ramos, I., Prousis, K.C., Wade, R.C., Sidiropoulou, K., Calogeropoulou, T., Gravanis, A., Charalampopoulos, I.
Publicado en: Biomedicines, Edición 22279059, 2022, Página(s) Volume 10, p 614, ISSN 2227-9059
Editor: MDPI
DOI: 10.3390/biomedicines10030614

ENT-A010, a Novel Steroid Derivative, Displays Neuroprotective Functions and Modulates Microglial Responses

Autores: Yilmaz C, Rogdakis T, Latorrata A, Thanou E, Karadima E, Papadimitriou E, Siapi E, Li KW, Katsila T, Calogeropoulou T, Charalampopoulos I, Alexaki VI
Publicado en: Biomolecules; Volume 12; Edición 3; Pages: 424, Edición Monthly, 2022, Página(s) 1-22, ISSN 2218-273X
Editor: MDPI
DOI: 10.3390/biom12030424

DHEA Inhibits Leukocyte Recruitment through Regulation of the Integrin Antagonist DEL-1

Autores: Athanasios Ziogas, Tomoki Maekawa, Johannes R. Wiessner, Thi Trang Le, David Sprott, Maria Troullinaki, Ales Neuwirth, Vasiliki Anastasopoulou, Sylvia Grossklaus, Kyoung-Jin Chung, Markus Sperandio, Triantafyllos Chavakis, George Hajishengallis, Vasileia Ismini Alexaki
Publicado en: The Journal of Immunology, Edición 204/5, 2020, Página(s) 1214-1224, ISSN 0022-1767
Editor: American Association of Immunologists
DOI: 10.4049/jimmunol.1900746

Neurosteroids as regulators of neuroinflammation

Autores: Canelif Yilmaz, Kanelina Karali, Georgia Fodelianaki, Achille Gravanis, Triantafyllos Chavakis, Ioannis Charalampopoulos, Vasileia Ismini Alexaki
Publicado en: Frontiers in Neuroendocrinology, Edición 55, 2019, Página(s) 100788, ISSN 0091-3022
Editor: Academic Press
DOI: 10.1016/j.yfrne.2019.100788

C9orf72 expansion within astrocytes reduces metabolic flexibility in amyotrophic lateral sclerosis.

Autores: Allen, S.P.; Hall, B.; Woof, R.; Francis, L.; Gatto, N.; Shaw, A.C.; Myszczynska, M.; Hemingway, J.; Coldicott, I.; Willcock, A.; Job, L.; Hughes, R.M.; Boschian, C.; Bayatti, N.; Heath, P.R.; Bandmann, O.; Mortiboys, H.; Ferraiuolo, L.; Shaw, P.J.
Publicado en: Brain, Edición Monthly, 2019, Página(s) Volume 142, Edición 12, Pages 3771–3790, ISSN 0006-8950
Editor: Oxford University Press
DOI: 10.1093/brain/awz302