A European training network for the discovery of neurotrophins small molecule mimetics as candidate therapeutic agents for neurodegeneration and neuroinflammation

Livrables

Detailed report of the training events implemented during the EuroNeurotrophin training weeks This deliverable will be updated at M23 and M34

International Conference and Neurotrophin Cluster Day

Programme abstracts participants networking activities ESRs poster and oral presentations

Project website and presence in online media

Creation and maintenance of a website dedicated to the EuroNeurotrophin project. Regular updating and an annual newsletter will be carried out on the website.Presence in facebook, hashtagTwitter, LinkedIn and ResearchGate.

Publications

Coarse-Grained Molecular Dynamics Simulations of the p75 Neurotrophin Receptor Transmembrane Domain

Auteurs: Alexandros Tsengenes; Rebecca C. Wade
Publié dans: Biophysical Journal, 2021, Page(s) vol. 120, issue 3, p. 302a
Éditeur: Cell Press
DOI: 10.1016/j.bpj.2020.11.1927

Understanding the Transmembrane Dimerization Interface of TrkA and TrkB Receptors

Auteurs: Athanasiou, C., & Wade, R. C.
Publié dans: Biophysical Journal, 2021, Page(s) 120(3), 303a
Éditeur: Cell Press
DOI: 10.1016/j.bpj.2020.11.1930

Synthesis of dehydroepiandrosterone (DHEA) derivatives substituted by three membered -17-spiro substituents

Auteurs: Alessia Latorrata
Publié dans: 2022
Éditeur: National and Kapodistrian University of Athens

In silico screening and Hit to Lead development of small molecules neurotrophin receptors ligands

Auteurs: Mirjana ANTONIJEVIC
Publié dans: 2021
Éditeur: UNIVERSITE CAEN NORMANDIE

Development and Biological Characterization of a Novel Selective TrkA Agonist with Neuroprotective Properties against Amyloid Toxicity

Auteurs: Rogdakis, T.; Charou, D., Latorrata, A., Papadimitriou, E., Tsengenes, A., Athanasiou, C., Papadopoulou, M., Chalikiopoulou, C., Katsila, T., Ramos, I., Prousis, K.C., Wade, R.C., Sidiropoulou, K., Calogeropoulou, T., Gravanis, A., Charalampopoulos, I.
Publié dans: Biomedicines, Numéro 22279059, 2022, Page(s) Volume 10, p 614, ISSN 2227-9059
Éditeur: MDPI
DOI: 10.3390/biomedicines10030614

ENT-A010, a Novel Steroid Derivative, Displays Neuroprotective Functions and Modulates Microglial Responses

Auteurs: Yilmaz C, Rogdakis T, Latorrata A, Thanou E, Karadima E, Papadimitriou E, Siapi E, Li KW, Katsila T, Calogeropoulou T, Charalampopoulos I, Alexaki VI
Publié dans: Biomolecules; Volume 12; Numéro 3; Pages: 424, Numéro Monthly, 2022, Page(s) 1-22, ISSN 2218-273X
Éditeur: MDPI
DOI: 10.3390/biom12030424

DHEA Inhibits Leukocyte Recruitment through Regulation of the Integrin Antagonist DEL-1

Auteurs: Athanasios Ziogas, Tomoki Maekawa, Johannes R. Wiessner, Thi Trang Le, David Sprott, Maria Troullinaki, Ales Neuwirth, Vasiliki Anastasopoulou, Sylvia Grossklaus, Kyoung-Jin Chung, Markus Sperandio, Triantafyllos Chavakis, George Hajishengallis, Vasileia Ismini Alexaki
Publié dans: The Journal of Immunology, Numéro 204/5, 2020, Page(s) 1214-1224, ISSN 0022-1767
Éditeur: American Association of Immunologists
DOI: 10.4049/jimmunol.1900746

Neurosteroids as regulators of neuroinflammation

Auteurs: Canelif Yilmaz, Kanelina Karali, Georgia Fodelianaki, Achille Gravanis, Triantafyllos Chavakis, Ioannis Charalampopoulos, Vasileia Ismini Alexaki
Publié dans: Frontiers in Neuroendocrinology, Numéro 55, 2019, Page(s) 100788, ISSN 0091-3022
Éditeur: Academic Press
DOI: 10.1016/j.yfrne.2019.100788

C9orf72 expansion within astrocytes reduces metabolic flexibility in amyotrophic lateral sclerosis.

Auteurs: Allen, S.P.; Hall, B.; Woof, R.; Francis, L.; Gatto, N.; Shaw, A.C.; Myszczynska, M.; Hemingway, J.; Coldicott, I.; Willcock, A.; Job, L.; Hughes, R.M.; Boschian, C.; Bayatti, N.; Heath, P.R.; Bandmann, O.; Mortiboys, H.; Ferraiuolo, L.; Shaw, P.J.
Publié dans: Brain, Numéro Monthly, 2019, Page(s) Volume 142, Numéro 12, Pages 3771–3790, ISSN 0006-8950
Éditeur: Oxford University Press
DOI: 10.1093/brain/awz302

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