A European training network for the discovery of neurotrophins small molecule mimetics as candidate therapeutic agents for neurodegeneration and neuroinflammation

Informazioni relative al progetto

EuroNeurotrophin

ID dell’accordo di sovvenzione: 765704

DOI

10.3030/765704

Progetto chiuso

Data della firma CE 17 Agosto 2017

Data di avvio 1 Gennaio 2018

Data di completamento 31 Marzo 2022

Finanziato da

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Costo totale

€ 3 544 314,08

Contributo UE

€ 3 544 314,08

Coordinato da

ETHNIKO IDRYMA EREVNON
Greece

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Documents, reports (1)

Three annual training weeks

Detailed report of the training events implemented during the EuroNeurotrophin training weeks This deliverable will be updated at M23 and M34

Other (1)

International Conference and Neurotrophin Cluster Day

Programme abstracts participants networking activities ESRs poster and oral presentations

Websites, patent fillings, videos etc. (1)

Project website and presence in online media

Creation and maintenance of a website dedicated to the EuroNeurotrophin project. Regular updating and an annual newsletter will be carried out on the website.Presence in facebook, hashtagTwitter, LinkedIn and ResearchGate.

Pubblicazioni

Conference proceedings (2)

Coarse-Grained Molecular Dynamics Simulations of the p75 Neurotrophin Receptor Transmembrane Domain

Autori: Alexandros Tsengenes; Rebecca C. Wade
Pubblicato in: Biophysical Journal, 2021, Pagina/e vol. 120, issue 3, p. 302a
Editore: Cell Press
DOI: 10.1016/j.bpj.2020.11.1927

Understanding the Transmembrane Dimerization Interface of TrkA and TrkB Receptors

Autori: Athanasiou, C., & Wade, R. C.
Pubblicato in: Biophysical Journal, 2021, Pagina/e 120(3), 303a
Editore: Cell Press
DOI: 10.1016/j.bpj.2020.11.1930

Thesis and dissertations (2)

Synthesis of dehydroepiandrosterone (DHEA) derivatives substituted by three membered -17-spiro substituents

Autori: Alessia Latorrata
Pubblicato in: 2022
Editore: National and Kapodistrian University of Athens

In silico screening and Hit to Lead development of small molecules neurotrophin receptors ligands

Autori: Mirjana ANTONIJEVIC
Pubblicato in: 2021
Editore: UNIVERSITE CAEN NORMANDIE

Peer reviewed articles (5)

Development and Biological Characterization of a Novel Selective TrkA Agonist with Neuroprotective Properties against Amyloid Toxicity

Autori: Rogdakis, T.; Charou, D., Latorrata, A., Papadimitriou, E., Tsengenes, A., Athanasiou, C., Papadopoulou, M., Chalikiopoulou, C., Katsila, T., Ramos, I., Prousis, K.C., Wade, R.C., Sidiropoulou, K., Calogeropoulou, T., Gravanis, A., Charalampopoulos, I.
Pubblicato in: Biomedicines, Numero 22279059, 2022, Pagina/e Volume 10, p 614, ISSN 2227-9059
Editore: MDPI
DOI: 10.3390/biomedicines10030614

ENT-A010, a Novel Steroid Derivative, Displays Neuroprotective Functions and Modulates Microglial Responses

Autori: Yilmaz C, Rogdakis T, Latorrata A, Thanou E, Karadima E, Papadimitriou E, Siapi E, Li KW, Katsila T, Calogeropoulou T, Charalampopoulos I, Alexaki VI
Pubblicato in: Biomolecules; Volume 12; Numero 3; Pages: 424, Numero Monthly, 2022, Pagina/e 1-22, ISSN 2218-273X
Editore: MDPI
DOI: 10.3390/biom12030424

DHEA Inhibits Leukocyte Recruitment through Regulation of the Integrin Antagonist DEL-1

Autori: Athanasios Ziogas, Tomoki Maekawa, Johannes R. Wiessner, Thi Trang Le, David Sprott, Maria Troullinaki, Ales Neuwirth, Vasiliki Anastasopoulou, Sylvia Grossklaus, Kyoung-Jin Chung, Markus Sperandio, Triantafyllos Chavakis, George Hajishengallis, Vasileia Ismini Alexaki
Pubblicato in: The Journal of Immunology, Numero 204/5, 2020, Pagina/e 1214-1224, ISSN 0022-1767
Editore: American Association of Immunologists
DOI: 10.4049/jimmunol.1900746

Neurosteroids as regulators of neuroinflammation

Autori: Canelif Yilmaz, Kanelina Karali, Georgia Fodelianaki, Achille Gravanis, Triantafyllos Chavakis, Ioannis Charalampopoulos, Vasileia Ismini Alexaki
Pubblicato in: Frontiers in Neuroendocrinology, Numero 55, 2019, Pagina/e 100788, ISSN 0091-3022
Editore: Academic Press
DOI: 10.1016/j.yfrne.2019.100788

C9orf72 expansion within astrocytes reduces metabolic flexibility in amyotrophic lateral sclerosis.

Autori: Allen, S.P.; Hall, B.; Woof, R.; Francis, L.; Gatto, N.; Shaw, A.C.; Myszczynska, M.; Hemingway, J.; Coldicott, I.; Willcock, A.; Job, L.; Hughes, R.M.; Boschian, C.; Bayatti, N.; Heath, P.R.; Bandmann, O.; Mortiboys, H.; Ferraiuolo, L.; Shaw, P.J.
Pubblicato in: Brain, Numero Monthly, 2019, Pagina/e Volume 142, Numero 12, Pages 3771–3790, ISSN 0006-8950
Editore: Oxford University Press
DOI: 10.1093/brain/awz302