Exploiting GLIOblastoma intractability to address European research TRAINing needs in translational brain tumour research, cancer systems medicine and integrative multi-omics

Resultado final

Dissemination and public engagement Report 4

Dissemination and public engagement reports

Dissemination and public engagement Report 1

Dissemination and public engagement reports

Dissemination and public engagement Report 2

Dissemination and public engagement reports

Dissemination and public engagement Report 3

Dissemination and public engagement reports

Report on GLIOTRAIN conference

GLIOTRAIN Web presence

Website, Twitter, Facebook Page construction

Publicaciones

Transcriptional CDK Inhibitors CYC065 and THZ1 Induce Apoptosis in Glioma Stem Cells Derived from Recurrent GBM

Autores: Viktorija Juric, Heiko Düssmann, Martine L. M. Lamfers, Jochen H. M. Prehn, Markus Rehm, Brona M. Murphy
Publicado en: Cells, Edición 10/5, 2021, Página(s) 1182, ISSN 2073-4409
Editor: MDPI
DOI: 10.3390/cells10051182

The influence of methylation status on a stochastic model of MGMT dynamics in glioblastoma: Phenotypic selection can occur with and without a downshift in promoter methylation status

Autores: Ayoub Lasri, Marc Sturrock
Publicado en: Journal of Theoretical Biology, Edición 521, 2021, Página(s) 110662, ISSN 0022-5193
Editor: Academic Press
DOI: 10.1016/j.jtbi.2021.110662

Patient-derived organoids and orthotopic xenografts of primary and recurrent gliomas represent relevant patient avatars for precision oncology

Autores: Anna Golebiewska, Ann-Christin Hau, Anaïs Oudin, Daniel Stieber, Yahaya A. Yabo, Virginie Baus, Vanessa Barthelemy, Eliane Klein, Sébastien Bougnaud, Olivier Keunen, May Wantz, Alessandro Michelucci, Virginie Neirinckx, Arnaud Muller, Tony Kaoma, Petr V. Nazarov, Francisco Azuaje, Alfonso De Falco, Ben Flies, Lorraine Richart, Suresh Poovathingal, Thais Arns, Kamil Grzyb, Andreas Mock, Christel
Publicado en: Acta Neuropathologica, Edición 140/6, 2020, Página(s) 919-949, ISSN 0001-6322
Editor: Springer Verlag
DOI: 10.1007/s00401-020-02226-7

Cyclin-dependent kinase inhibitors in brain cancer: current state and future directions

Autores: Viktorija Juric, Brona Murphy
Publicado en: Cancer Drug Resistance, Edición 3, 2020, Página(s) 48-62, ISSN 2578-532X
Editor: OAE Publishing Inc
DOI: 10.20517/cdr.2019.105

Linking hyperosmotic stress and apoptotic sensitivity.

Autores: Daniela Stöhr; Markus Rehm
Publicado en: The FEBS Journal, Edición 288/6, 2021, Página(s) 1800-1803, ISSN 1742-464X
Editor: Blackwell Publishing Inc.
DOI: 10.1111/febs.15520

Transcriptional CDK inhibitors, CYC065 and THZ1 promote Bim-dependent apoptosis in primary and recurrent GBM through cell cycle arrest and Mcl-1 downregulation

Autores: Viktorija Juric, Lance Hudson, Joanna Fay, Cathy E. Richards, Hanne Jahns, Maïté Verreault, Franck Bielle, Ahmed Idbaih, Martine L. M. Lamfers, Ann M. Hopkins, Markus Rehm, Brona M. Murphy
Publicado en: Cell Death & Disease, Edición 12/8, 2021, Página(s) 763, ISSN 2041-4889
Editor: Nature Publishing Group
DOI: 10.1038/s41419-021-04050-7

Protocol for derivation of organoids and patient-derived orthotopic xenografts from glioma patient tumors

Autores: Anaïs Oudin, Virginie Baus, Vanessa Barthelemy, Carina Fabian, Eliane Klein, Monika Dieterle, May Wantz, Ann-Christin Hau, Claire Dording, Amandine Bernard, Alessandro Michelucci, Yahaya A. Yabo, Georgia Kanli, Olivier Keunen, Rolf Bjerkvig, Simone P. Niclou, Anna Golebiewska
Publicado en: STAR Protocols, Edición 2/2, 2021, Página(s) 100534, ISSN 2666-1667
Editor: Cell Press
DOI: 10.1016/j.xpro.2021.100534

Master regulators associated with poor prognosis in glioblastoma multiforme

Autores: M P Kalya, T Beisbarth, A Kel
Publicado en: Biomeditsinskaya khimiya, Edición 67/3, 2021, Página(s) 201-212, ISSN 2310-6972
Editor: Institute of Biomedical Chemistry
DOI: 10.18097/pbmc20216703201

New hints towards a precision medicine strategy for IDH wild-type glioblastoma

Autores: K. White, K. Connor, J. Clerkin, B.M. Murphy, M. Salvucci, A.C. O'Farrell, M. Rehm, D. O'Brien, J.H.M. Prehn, S.P. Niclou, M.L.M. Lamfers, M. Verreault, A. Idbaih, R. Verhaak, A. Golebiewska, A.T. Byrne
Publicado en: Annals of Oncology, Edición 31/12, 2020, Página(s) 1679-1692, ISSN 0923-7534
Editor: Oxford University Press
DOI: 10.1016/j.annonc.2020.08.2336

Phenotypic selection through cell death: stochastic modelling of O-6-methylguanine-DNA methyltransferase dynamics

Autores: Ayoub Lasri, Viktorija Juric, Maité Verreault, Franck Bielle, Ahmed Idbaih, Alexander Kel, Brona Murphy, Marc Sturrock
Publicado en: Royal Society Open Science, Edición 7/7, 2020, Página(s) 191243, ISSN 2054-5703
Editor: Royal Society Publishing
DOI: 10.1098/rsos.191243

IGFBP2 Is a Potential Master Regulator Driving the Dysregulated Gene Network Responsible for Short Survival in Glioblastoma Multiforme

Autores: Manasa Kalya, Alexander Kel, Darius Wlochowitz, Edgar Wingender, Tim Beißbarth
Publicado en: Frontiers in Genetics, Edición 12, 2021, ISSN 1664-8021
Editor: Frontiers Media
DOI: 10.3389/fgene.2021.670240

Sensitization of glioblastoma cells to TRAIL-induced apoptosis by IAP- and Bcl-2 antagonism

Autores: Frank A. Lincoln, Dirke Imig, Chiara Boccellato, Viktorija Juric, Janis Noonan, Roland E. Kontermann, Frank Allgöwer, Brona M. Murphy, Markus Rehm
Publicado en: Cell Death & Disease, Edición 9/11, 2018, Página(s) 1112, ISSN 2041-4889
Editor: Nature Publishing Group
DOI: 10.1038/s41419-018-1160-2

Bax retrotranslocation potentiates Bcl-xL’s antiapoptotic activity and is essential for switch-like transitions between MOMP competency and resistance

Autores: Annika Hantusch; Kushal K. Das; Ana J. García-Sáez; Thomas Brunner; Markus Rehm
Publicado en: Cell Death & Disease, Edición 9 (4), 2018, Página(s) 430, ISSN 2041-4889
Editor: Nature Publishing Group
DOI: 10.1038/s41419-018-0464-6

RGD-decorated cholesterol stabilized polyplexes for targeted siRNA delivery to glioblastoma cells

Autores: Bo Lou, Kate Connor, Kieron Sweeney, Ian S. Miller, Alice O’Farrell, Eduardo Ruiz-Hernandez, David M. Murray, Garry P. Duffy, Alan Wolfe, Enrico Mastrobattista, Annette T. Byrne, Wim E. Hennink
Publicado en: Drug Delivery and Translational Research, Edición 9/3, 2019, Página(s) 679-693, ISSN 2190-393X
Editor: Springer Pub. Co.,
DOI: 10.1007/s13346-019-00637-y

Durability of cell line xenograft resection models to interrogate tumor micro-environment targeting agents

Autores: Ian S. Miller, Liam P. Shiels, Emer Conroy, Kate Connor, Patrick Dicker, William M. Gallagher, Norma O’ Donovan, Robert S. Kerbel, John Crown, Annette T. Byrne
Publicado en: Scientific Reports, Edición 9/1, 2019, Página(s) 9204, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-019-45444-0

Targeting the RhoGEF βPIX/COOL-1 in Glioblastoma: Proof of Concept Studies

Autores: Kate Connor, David W. Murray, Monika A. Jarzabek, Nhan L. Tran, Kieron White, Patrick Dicker, Kieron J. Sweeney, Philip J. O’Halloran, Brian MacCarthy, Liam P. Shiels, Francesca Lodi, Diether Lambrechts, Jann N. Sarkaria, Raymond M. Schiffelers, Marc Symons, Annette T. Byrne
Publicado en: Cancers, Edición 12/12, 2020, Página(s) 3531, ISSN 2072-6694
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers12123531

Implementing Patient-Derived Xenografts to Assess the Effectiveness of Cyclin-Dependent Kinase Inhibitors in Glioblastoma

Autores: Janis J. Noonan, Monika Jarzabek, Frank A. Lincoln, Brenton L. Cavanagh, Arhona R. Pariag, Viktorija Juric, Leonie S. Young, Keith L. Ligon, Hanne Jahns, Daniella Zheleva, Jochen H. M. Prehn, Markus Rehm, Annette T. Byrne, Brona M. Murphy
Publicado en: Cancers, Edición 11/12, 2019, Página(s) 2005, ISSN 2072-6694
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers11122005

Marizomib sensitizes primary glioma cells to apoptosis induced by a latest-generation TRAIL receptor agonist

Autores: Chiara Boccellato, Emily Kolbe, Nathalie Peters, Viktorija Juric, Gavin Fullstone, Maïté Verreault, Ahmed Idbaih, Martine L. M. Lamfers, Brona M. Murphy, Markus Rehm
Publicado en: Cell Death & Disease, Edición 12/7, 2021, ISSN 2041-4889
Editor: Nature Publishing Group
DOI: 10.1038/s41419-021-03927-x

Generation, characterization, and drug sensitivities of 12 patient-derived IDH1-mutant glioma cell cultures

Autores: Cassandra Verheul, Ioannis Ntafoulis, Trisha V Kers, Youri Hoogstrate, Pier G Mastroberardino, Sander Barnhoorn, César Payán-Gómez, Romain Tching Chi Yen, Eduard A Struys, Stijn L W Koolen, Clemens M F Dirven, Sieger Leenstra, Pim J French, Martine L M Lamfers
Publicado en: Neuro-Oncology Advances, Edición 3/1, 2021, ISSN 2632-2498
Editor: Oxford Academic
DOI: 10.1093/noajnl/vdab103

System-based approaches as prognostic tools for glioblastoma

Autores: Manuela Salvucci, Zaitun Zakaria, Steven Carberry, Amanda Tivnan, Volker Seifert, Donat Kögel, Brona M. Murphy, Jochen H. M. Prehn
Publicado en: BMC Cancer, Edición 19/1, 2019, Página(s) 1092, ISSN 1471-2407
Editor: BioMed Central
DOI: 10.1186/s12885-019-6280-2

Single-cell profiling of myeloid cells in glioblastoma across species and disease stage reveals macrophage competition and specialization

Autores: Ana Rita Pombo Antunes, Isabelle Scheyltjens, Francesca Lodi, Julie Messiaen, Asier Antoranz, Johnny Duerinck, Daliya Kancheva, Liesbet Martens, Karen De Vlaminck, Hannah Van Hove, Signe Schmidt Kjølner Hansen, Francesca Maria Bosisio, Koen Van der Borght, Steven De Vleeschouwer, Raf Sciot, Luc Bouwens, Michiel Verfaillie, Niels Vandamme, Roosmarijn E. Vandenbroucke, Olivier De Wever, Yvan Saeys,
Publicado en: Nature Neuroscience, Edición 24/4, 2021, Página(s) 595-610, ISSN 1097-6256
Editor: Nature Publishing Group
DOI: 10.1038/s41593-020-00789-y

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