Exploiting GLIOblastoma intractability to address European research TRAINing needs in translational brain tumour research, cancer systems medicine and integrative multi-omics

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Dissemination and public engagement Report 1

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Dissemination and public engagement Report 2

Dissemination and public engagement reports

Dissemination and public engagement Report 3

Dissemination and public engagement reports

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Pubblicazioni

Transcriptional CDK Inhibitors CYC065 and THZ1 Induce Apoptosis in Glioma Stem Cells Derived from Recurrent GBM

Autori: Viktorija Juric, Heiko Düssmann, Martine L. M. Lamfers, Jochen H. M. Prehn, Markus Rehm, Brona M. Murphy
Pubblicato in: Cells, Numero 10/5, 2021, Pagina/e 1182, ISSN 2073-4409
Editore: MDPI
DOI: 10.3390/cells10051182

The influence of methylation status on a stochastic model of MGMT dynamics in glioblastoma: Phenotypic selection can occur with and without a downshift in promoter methylation status

Autori: Ayoub Lasri, Marc Sturrock
Pubblicato in: Journal of Theoretical Biology, Numero 521, 2021, Pagina/e 110662, ISSN 0022-5193
Editore: Academic Press
DOI: 10.1016/j.jtbi.2021.110662

Patient-derived organoids and orthotopic xenografts of primary and recurrent gliomas represent relevant patient avatars for precision oncology

Autori: Anna Golebiewska, Ann-Christin Hau, Anaïs Oudin, Daniel Stieber, Yahaya A. Yabo, Virginie Baus, Vanessa Barthelemy, Eliane Klein, Sébastien Bougnaud, Olivier Keunen, May Wantz, Alessandro Michelucci, Virginie Neirinckx, Arnaud Muller, Tony Kaoma, Petr V. Nazarov, Francisco Azuaje, Alfonso De Falco, Ben Flies, Lorraine Richart, Suresh Poovathingal, Thais Arns, Kamil Grzyb, Andreas Mock, Christel
Pubblicato in: Acta Neuropathologica, Numero 140/6, 2020, Pagina/e 919-949, ISSN 0001-6322
Editore: Springer Verlag
DOI: 10.1007/s00401-020-02226-7

Cyclin-dependent kinase inhibitors in brain cancer: current state and future directions

Autori: Viktorija Juric, Brona Murphy
Pubblicato in: Cancer Drug Resistance, Numero 3, 2020, Pagina/e 48-62, ISSN 2578-532X
Editore: OAE Publishing Inc
DOI: 10.20517/cdr.2019.105

Linking hyperosmotic stress and apoptotic sensitivity.

Autori: Daniela Stöhr; Markus Rehm
Pubblicato in: The FEBS Journal, Numero 288/6, 2021, Pagina/e 1800-1803, ISSN 1742-464X
Editore: Blackwell Publishing Inc.
DOI: 10.1111/febs.15520

Transcriptional CDK inhibitors, CYC065 and THZ1 promote Bim-dependent apoptosis in primary and recurrent GBM through cell cycle arrest and Mcl-1 downregulation

Autori: Viktorija Juric, Lance Hudson, Joanna Fay, Cathy E. Richards, Hanne Jahns, Maïté Verreault, Franck Bielle, Ahmed Idbaih, Martine L. M. Lamfers, Ann M. Hopkins, Markus Rehm, Brona M. Murphy
Pubblicato in: Cell Death & Disease, Numero 12/8, 2021, Pagina/e 763, ISSN 2041-4889
Editore: Nature Publishing Group
DOI: 10.1038/s41419-021-04050-7

Protocol for derivation of organoids and patient-derived orthotopic xenografts from glioma patient tumors

Autori: Anaïs Oudin, Virginie Baus, Vanessa Barthelemy, Carina Fabian, Eliane Klein, Monika Dieterle, May Wantz, Ann-Christin Hau, Claire Dording, Amandine Bernard, Alessandro Michelucci, Yahaya A. Yabo, Georgia Kanli, Olivier Keunen, Rolf Bjerkvig, Simone P. Niclou, Anna Golebiewska
Pubblicato in: STAR Protocols, Numero 2/2, 2021, Pagina/e 100534, ISSN 2666-1667
Editore: Cell Press
DOI: 10.1016/j.xpro.2021.100534

Master regulators associated with poor prognosis in glioblastoma multiforme

Autori: M P Kalya, T Beisbarth, A Kel
Pubblicato in: Biomeditsinskaya khimiya, Numero 67/3, 2021, Pagina/e 201-212, ISSN 2310-6972
Editore: Institute of Biomedical Chemistry
DOI: 10.18097/pbmc20216703201

New hints towards a precision medicine strategy for IDH wild-type glioblastoma

Autori: K. White, K. Connor, J. Clerkin, B.M. Murphy, M. Salvucci, A.C. O'Farrell, M. Rehm, D. O'Brien, J.H.M. Prehn, S.P. Niclou, M.L.M. Lamfers, M. Verreault, A. Idbaih, R. Verhaak, A. Golebiewska, A.T. Byrne
Pubblicato in: Annals of Oncology, Numero 31/12, 2020, Pagina/e 1679-1692, ISSN 0923-7534
Editore: Oxford University Press
DOI: 10.1016/j.annonc.2020.08.2336

Phenotypic selection through cell death: stochastic modelling of O-6-methylguanine-DNA methyltransferase dynamics

Autori: Ayoub Lasri, Viktorija Juric, Maité Verreault, Franck Bielle, Ahmed Idbaih, Alexander Kel, Brona Murphy, Marc Sturrock
Pubblicato in: Royal Society Open Science, Numero 7/7, 2020, Pagina/e 191243, ISSN 2054-5703
Editore: Royal Society Publishing
DOI: 10.1098/rsos.191243

IGFBP2 Is a Potential Master Regulator Driving the Dysregulated Gene Network Responsible for Short Survival in Glioblastoma Multiforme

Autori: Manasa Kalya, Alexander Kel, Darius Wlochowitz, Edgar Wingender, Tim Beißbarth
Pubblicato in: Frontiers in Genetics, Numero 12, 2021, ISSN 1664-8021
Editore: Frontiers Media
DOI: 10.3389/fgene.2021.670240

Sensitization of glioblastoma cells to TRAIL-induced apoptosis by IAP- and Bcl-2 antagonism

Autori: Frank A. Lincoln, Dirke Imig, Chiara Boccellato, Viktorija Juric, Janis Noonan, Roland E. Kontermann, Frank Allgöwer, Brona M. Murphy, Markus Rehm
Pubblicato in: Cell Death & Disease, Numero 9/11, 2018, Pagina/e 1112, ISSN 2041-4889
Editore: Nature Publishing Group
DOI: 10.1038/s41419-018-1160-2

Bax retrotranslocation potentiates Bcl-xL’s antiapoptotic activity and is essential for switch-like transitions between MOMP competency and resistance

Autori: Annika Hantusch; Kushal K. Das; Ana J. García-Sáez; Thomas Brunner; Markus Rehm
Pubblicato in: Cell Death & Disease, Numero 9 (4), 2018, Pagina/e 430, ISSN 2041-4889
Editore: Nature Publishing Group
DOI: 10.1038/s41419-018-0464-6

RGD-decorated cholesterol stabilized polyplexes for targeted siRNA delivery to glioblastoma cells

Autori: Bo Lou, Kate Connor, Kieron Sweeney, Ian S. Miller, Alice O’Farrell, Eduardo Ruiz-Hernandez, David M. Murray, Garry P. Duffy, Alan Wolfe, Enrico Mastrobattista, Annette T. Byrne, Wim E. Hennink
Pubblicato in: Drug Delivery and Translational Research, Numero 9/3, 2019, Pagina/e 679-693, ISSN 2190-393X
Editore: Springer Pub. Co.,
DOI: 10.1007/s13346-019-00637-y

Durability of cell line xenograft resection models to interrogate tumor micro-environment targeting agents

Autori: Ian S. Miller, Liam P. Shiels, Emer Conroy, Kate Connor, Patrick Dicker, William M. Gallagher, Norma O’ Donovan, Robert S. Kerbel, John Crown, Annette T. Byrne
Pubblicato in: Scientific Reports, Numero 9/1, 2019, Pagina/e 9204, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-019-45444-0

Targeting the RhoGEF βPIX/COOL-1 in Glioblastoma: Proof of Concept Studies

Autori: Kate Connor, David W. Murray, Monika A. Jarzabek, Nhan L. Tran, Kieron White, Patrick Dicker, Kieron J. Sweeney, Philip J. O’Halloran, Brian MacCarthy, Liam P. Shiels, Francesca Lodi, Diether Lambrechts, Jann N. Sarkaria, Raymond M. Schiffelers, Marc Symons, Annette T. Byrne
Pubblicato in: Cancers, Numero 12/12, 2020, Pagina/e 3531, ISSN 2072-6694
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers12123531

Implementing Patient-Derived Xenografts to Assess the Effectiveness of Cyclin-Dependent Kinase Inhibitors in Glioblastoma

Autori: Janis J. Noonan, Monika Jarzabek, Frank A. Lincoln, Brenton L. Cavanagh, Arhona R. Pariag, Viktorija Juric, Leonie S. Young, Keith L. Ligon, Hanne Jahns, Daniella Zheleva, Jochen H. M. Prehn, Markus Rehm, Annette T. Byrne, Brona M. Murphy
Pubblicato in: Cancers, Numero 11/12, 2019, Pagina/e 2005, ISSN 2072-6694
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers11122005

Marizomib sensitizes primary glioma cells to apoptosis induced by a latest-generation TRAIL receptor agonist

Autori: Chiara Boccellato, Emily Kolbe, Nathalie Peters, Viktorija Juric, Gavin Fullstone, Maïté Verreault, Ahmed Idbaih, Martine L. M. Lamfers, Brona M. Murphy, Markus Rehm
Pubblicato in: Cell Death & Disease, Numero 12/7, 2021, ISSN 2041-4889
Editore: Nature Publishing Group
DOI: 10.1038/s41419-021-03927-x

Generation, characterization, and drug sensitivities of 12 patient-derived IDH1-mutant glioma cell cultures

Autori: Cassandra Verheul, Ioannis Ntafoulis, Trisha V Kers, Youri Hoogstrate, Pier G Mastroberardino, Sander Barnhoorn, César Payán-Gómez, Romain Tching Chi Yen, Eduard A Struys, Stijn L W Koolen, Clemens M F Dirven, Sieger Leenstra, Pim J French, Martine L M Lamfers
Pubblicato in: Neuro-Oncology Advances, Numero 3/1, 2021, ISSN 2632-2498
Editore: Oxford Academic
DOI: 10.1093/noajnl/vdab103

System-based approaches as prognostic tools for glioblastoma

Autori: Manuela Salvucci, Zaitun Zakaria, Steven Carberry, Amanda Tivnan, Volker Seifert, Donat Kögel, Brona M. Murphy, Jochen H. M. Prehn
Pubblicato in: BMC Cancer, Numero 19/1, 2019, Pagina/e 1092, ISSN 1471-2407
Editore: BioMed Central
DOI: 10.1186/s12885-019-6280-2

Single-cell profiling of myeloid cells in glioblastoma across species and disease stage reveals macrophage competition and specialization

Autori: Ana Rita Pombo Antunes, Isabelle Scheyltjens, Francesca Lodi, Julie Messiaen, Asier Antoranz, Johnny Duerinck, Daliya Kancheva, Liesbet Martens, Karen De Vlaminck, Hannah Van Hove, Signe Schmidt Kjølner Hansen, Francesca Maria Bosisio, Koen Van der Borght, Steven De Vleeschouwer, Raf Sciot, Luc Bouwens, Michiel Verfaillie, Niels Vandamme, Roosmarijn E. Vandenbroucke, Olivier De Wever, Yvan Saeys,
Pubblicato in: Nature Neuroscience, Numero 24/4, 2021, Pagina/e 595-610, ISSN 1097-6256
Editore: Nature Publishing Group
DOI: 10.1038/s41593-020-00789-y

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