Exploiting GLIOblastoma intractability to address European research TRAINing needs in translational brain tumour research, cancer systems medicine and integrative multi-omics

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Publications

Transcriptional CDK Inhibitors CYC065 and THZ1 Induce Apoptosis in Glioma Stem Cells Derived from Recurrent GBM

Auteurs: Viktorija Juric, Heiko Düssmann, Martine L. M. Lamfers, Jochen H. M. Prehn, Markus Rehm, Brona M. Murphy
Publié dans: Cells, Numéro 10/5, 2021, Page(s) 1182, ISSN 2073-4409
Éditeur: MDPI
DOI: 10.3390/cells10051182

The influence of methylation status on a stochastic model of MGMT dynamics in glioblastoma: Phenotypic selection can occur with and without a downshift in promoter methylation status

Auteurs: Ayoub Lasri, Marc Sturrock
Publié dans: Journal of Theoretical Biology, Numéro 521, 2021, Page(s) 110662, ISSN 0022-5193
Éditeur: Academic Press
DOI: 10.1016/j.jtbi.2021.110662

Patient-derived organoids and orthotopic xenografts of primary and recurrent gliomas represent relevant patient avatars for precision oncology

Auteurs: Anna Golebiewska, Ann-Christin Hau, Anaïs Oudin, Daniel Stieber, Yahaya A. Yabo, Virginie Baus, Vanessa Barthelemy, Eliane Klein, Sébastien Bougnaud, Olivier Keunen, May Wantz, Alessandro Michelucci, Virginie Neirinckx, Arnaud Muller, Tony Kaoma, Petr V. Nazarov, Francisco Azuaje, Alfonso De Falco, Ben Flies, Lorraine Richart, Suresh Poovathingal, Thais Arns, Kamil Grzyb, Andreas Mock, Christel
Publié dans: Acta Neuropathologica, Numéro 140/6, 2020, Page(s) 919-949, ISSN 0001-6322
Éditeur: Springer Verlag
DOI: 10.1007/s00401-020-02226-7

Cyclin-dependent kinase inhibitors in brain cancer: current state and future directions

Auteurs: Viktorija Juric, Brona Murphy
Publié dans: Cancer Drug Resistance, Numéro 3, 2020, Page(s) 48-62, ISSN 2578-532X
Éditeur: OAE Publishing Inc
DOI: 10.20517/cdr.2019.105

Linking hyperosmotic stress and apoptotic sensitivity.

Auteurs: Daniela Stöhr; Markus Rehm
Publié dans: The FEBS Journal, Numéro 288/6, 2021, Page(s) 1800-1803, ISSN 1742-464X
Éditeur: Blackwell Publishing Inc.
DOI: 10.1111/febs.15520

Transcriptional CDK inhibitors, CYC065 and THZ1 promote Bim-dependent apoptosis in primary and recurrent GBM through cell cycle arrest and Mcl-1 downregulation

Auteurs: Viktorija Juric, Lance Hudson, Joanna Fay, Cathy E. Richards, Hanne Jahns, Maïté Verreault, Franck Bielle, Ahmed Idbaih, Martine L. M. Lamfers, Ann M. Hopkins, Markus Rehm, Brona M. Murphy
Publié dans: Cell Death & Disease, Numéro 12/8, 2021, Page(s) 763, ISSN 2041-4889
Éditeur: Nature Publishing Group
DOI: 10.1038/s41419-021-04050-7

Protocol for derivation of organoids and patient-derived orthotopic xenografts from glioma patient tumors

Auteurs: Anaïs Oudin, Virginie Baus, Vanessa Barthelemy, Carina Fabian, Eliane Klein, Monika Dieterle, May Wantz, Ann-Christin Hau, Claire Dording, Amandine Bernard, Alessandro Michelucci, Yahaya A. Yabo, Georgia Kanli, Olivier Keunen, Rolf Bjerkvig, Simone P. Niclou, Anna Golebiewska
Publié dans: STAR Protocols, Numéro 2/2, 2021, Page(s) 100534, ISSN 2666-1667
Éditeur: Cell Press
DOI: 10.1016/j.xpro.2021.100534

Master regulators associated with poor prognosis in glioblastoma multiforme

Auteurs: M P Kalya, T Beisbarth, A Kel
Publié dans: Biomeditsinskaya khimiya, Numéro 67/3, 2021, Page(s) 201-212, ISSN 2310-6972
Éditeur: Institute of Biomedical Chemistry
DOI: 10.18097/pbmc20216703201

New hints towards a precision medicine strategy for IDH wild-type glioblastoma

Auteurs: K. White, K. Connor, J. Clerkin, B.M. Murphy, M. Salvucci, A.C. O'Farrell, M. Rehm, D. O'Brien, J.H.M. Prehn, S.P. Niclou, M.L.M. Lamfers, M. Verreault, A. Idbaih, R. Verhaak, A. Golebiewska, A.T. Byrne
Publié dans: Annals of Oncology, Numéro 31/12, 2020, Page(s) 1679-1692, ISSN 0923-7534
Éditeur: Oxford University Press
DOI: 10.1016/j.annonc.2020.08.2336

Phenotypic selection through cell death: stochastic modelling of O-6-methylguanine-DNA methyltransferase dynamics

Auteurs: Ayoub Lasri, Viktorija Juric, Maité Verreault, Franck Bielle, Ahmed Idbaih, Alexander Kel, Brona Murphy, Marc Sturrock
Publié dans: Royal Society Open Science, Numéro 7/7, 2020, Page(s) 191243, ISSN 2054-5703
Éditeur: Royal Society Publishing
DOI: 10.1098/rsos.191243

IGFBP2 Is a Potential Master Regulator Driving the Dysregulated Gene Network Responsible for Short Survival in Glioblastoma Multiforme

Auteurs: Manasa Kalya, Alexander Kel, Darius Wlochowitz, Edgar Wingender, Tim Beißbarth
Publié dans: Frontiers in Genetics, Numéro 12, 2021, ISSN 1664-8021
Éditeur: Frontiers Media
DOI: 10.3389/fgene.2021.670240

Sensitization of glioblastoma cells to TRAIL-induced apoptosis by IAP- and Bcl-2 antagonism

Auteurs: Frank A. Lincoln, Dirke Imig, Chiara Boccellato, Viktorija Juric, Janis Noonan, Roland E. Kontermann, Frank Allgöwer, Brona M. Murphy, Markus Rehm
Publié dans: Cell Death & Disease, Numéro 9/11, 2018, Page(s) 1112, ISSN 2041-4889
Éditeur: Nature Publishing Group
DOI: 10.1038/s41419-018-1160-2

Bax retrotranslocation potentiates Bcl-xL’s antiapoptotic activity and is essential for switch-like transitions between MOMP competency and resistance

Auteurs: Annika Hantusch; Kushal K. Das; Ana J. García-Sáez; Thomas Brunner; Markus Rehm
Publié dans: Cell Death & Disease, Numéro 9 (4), 2018, Page(s) 430, ISSN 2041-4889
Éditeur: Nature Publishing Group
DOI: 10.1038/s41419-018-0464-6

RGD-decorated cholesterol stabilized polyplexes for targeted siRNA delivery to glioblastoma cells

Auteurs: Bo Lou, Kate Connor, Kieron Sweeney, Ian S. Miller, Alice O’Farrell, Eduardo Ruiz-Hernandez, David M. Murray, Garry P. Duffy, Alan Wolfe, Enrico Mastrobattista, Annette T. Byrne, Wim E. Hennink
Publié dans: Drug Delivery and Translational Research, Numéro 9/3, 2019, Page(s) 679-693, ISSN 2190-393X
Éditeur: Springer Pub. Co.,
DOI: 10.1007/s13346-019-00637-y

Durability of cell line xenograft resection models to interrogate tumor micro-environment targeting agents

Auteurs: Ian S. Miller, Liam P. Shiels, Emer Conroy, Kate Connor, Patrick Dicker, William M. Gallagher, Norma O’ Donovan, Robert S. Kerbel, John Crown, Annette T. Byrne
Publié dans: Scientific Reports, Numéro 9/1, 2019, Page(s) 9204, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-019-45444-0

Targeting the RhoGEF βPIX/COOL-1 in Glioblastoma: Proof of Concept Studies

Auteurs: Kate Connor, David W. Murray, Monika A. Jarzabek, Nhan L. Tran, Kieron White, Patrick Dicker, Kieron J. Sweeney, Philip J. O’Halloran, Brian MacCarthy, Liam P. Shiels, Francesca Lodi, Diether Lambrechts, Jann N. Sarkaria, Raymond M. Schiffelers, Marc Symons, Annette T. Byrne
Publié dans: Cancers, Numéro 12/12, 2020, Page(s) 3531, ISSN 2072-6694
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers12123531

Implementing Patient-Derived Xenografts to Assess the Effectiveness of Cyclin-Dependent Kinase Inhibitors in Glioblastoma

Auteurs: Janis J. Noonan, Monika Jarzabek, Frank A. Lincoln, Brenton L. Cavanagh, Arhona R. Pariag, Viktorija Juric, Leonie S. Young, Keith L. Ligon, Hanne Jahns, Daniella Zheleva, Jochen H. M. Prehn, Markus Rehm, Annette T. Byrne, Brona M. Murphy
Publié dans: Cancers, Numéro 11/12, 2019, Page(s) 2005, ISSN 2072-6694
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers11122005

Marizomib sensitizes primary glioma cells to apoptosis induced by a latest-generation TRAIL receptor agonist

Auteurs: Chiara Boccellato, Emily Kolbe, Nathalie Peters, Viktorija Juric, Gavin Fullstone, Maïté Verreault, Ahmed Idbaih, Martine L. M. Lamfers, Brona M. Murphy, Markus Rehm
Publié dans: Cell Death & Disease, Numéro 12/7, 2021, ISSN 2041-4889
Éditeur: Nature Publishing Group
DOI: 10.1038/s41419-021-03927-x

Generation, characterization, and drug sensitivities of 12 patient-derived IDH1-mutant glioma cell cultures

Auteurs: Cassandra Verheul, Ioannis Ntafoulis, Trisha V Kers, Youri Hoogstrate, Pier G Mastroberardino, Sander Barnhoorn, César Payán-Gómez, Romain Tching Chi Yen, Eduard A Struys, Stijn L W Koolen, Clemens M F Dirven, Sieger Leenstra, Pim J French, Martine L M Lamfers
Publié dans: Neuro-Oncology Advances, Numéro 3/1, 2021, ISSN 2632-2498
Éditeur: Oxford Academic
DOI: 10.1093/noajnl/vdab103

System-based approaches as prognostic tools for glioblastoma

Auteurs: Manuela Salvucci, Zaitun Zakaria, Steven Carberry, Amanda Tivnan, Volker Seifert, Donat Kögel, Brona M. Murphy, Jochen H. M. Prehn
Publié dans: BMC Cancer, Numéro 19/1, 2019, Page(s) 1092, ISSN 1471-2407
Éditeur: BioMed Central
DOI: 10.1186/s12885-019-6280-2

Single-cell profiling of myeloid cells in glioblastoma across species and disease stage reveals macrophage competition and specialization

Auteurs: Ana Rita Pombo Antunes, Isabelle Scheyltjens, Francesca Lodi, Julie Messiaen, Asier Antoranz, Johnny Duerinck, Daliya Kancheva, Liesbet Martens, Karen De Vlaminck, Hannah Van Hove, Signe Schmidt Kjølner Hansen, Francesca Maria Bosisio, Koen Van der Borght, Steven De Vleeschouwer, Raf Sciot, Luc Bouwens, Michiel Verfaillie, Niels Vandamme, Roosmarijn E. Vandenbroucke, Olivier De Wever, Yvan Saeys,
Publié dans: Nature Neuroscience, Numéro 24/4, 2021, Page(s) 595-610, ISSN 1097-6256
Éditeur: Nature Publishing Group
DOI: 10.1038/s41593-020-00789-y

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