TArgeting Platelet Adhesion receptors in thrombosiS

Información del proyecto

TAPAS

Identificador del acuerdo de subvención: 766118

DOI

10.3030/766118

Proyecto cerrado

Fecha de la firma de la CE 17 Agosto 2017

Fecha de inicio 1 Enero 2018

Fecha de finalización 30 Junio 2022

Financiado con arreglo a

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Coste total

€ 3 881 891,88

Aportación de la UE

€ 3 881 891,88

Coordinado por

THE UNIVERSITY OF BIRMINGHAM
United Kingdom

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Documents, reports (1)

Progress report

Progress report of the project.

Websites, patent fillings, videos etc. (2)

Publication of e-Newsletters

D73 Publication of eNewsletters M9 21 33 42

Setup of TAPAS website (updates every 6 months)

D6.2 Setup of TAPAS website setup (M3) with updates every 6 months

Other (8)

Execution of dissemination and Outreach activities for ITN

D72 Execution of dissemination and outreach activities for ITN M17152739

Organisation of first European Summer School

D5.4: Organisation of European Summer School (M11)

Organsation of Training Workshops and Conferences

Organisation of Training Workshops and Conferences M817232939

Recruitment of 15 ESRs (with statistics of applications)

D6.3 Recruited 15 ESRs (with statistics of applications) (M9)

Dissemination and Outreach activity plan completed

D7.1 Dissemination and Outreach activity plan completed (M10)

15 PhD theses with awarded EJD degrees

D74 15 PhD theses with awarded EJD degrees M48

Organisation of second European Summer School

Organisation of second European Summer School M31

Organisation of Training Workshops and Conferences

D5.3: Organisation of Training Workshops and Conferences (M8,17,23,29,39

Publicaciones

Peer reviewed articles (29)

Multiparameter microfluidics assay of thrombus formation reveals increased sensitivity to contraction and antiplatelet agents at physiological temperature

Autores: Linda Herfs, Frauke Swieringa, Natalie Jooss, Mike Kozlowski, Floor C.J. Heubel-Moenen, René van Oerle, Patric Machiels, Yvonne Henskens, Johan W.M. Heemskerk
Publicado en: Thrombosis Research, Edición 203, 2021, Página(s) 46-56, ISSN 0049-3848
Editor: Pergamon Press
DOI: 10.1016/j.thromres.2021.04.014

Targeted Phosphoinositides Analysis Using High-Performance Ion Chromatography-Coupled Selected Reaction Monitoring Mass Spectrometry

Autores: Hilaire Yam Fung Cheung, Cristina Coman, Philipp Westhoff, Mailin Manke, Albert Sickmann, Oliver Borst, Meinrad Gawaz, Steve P. Watson, Johan W. M. Heemskerk, Robert Ahrends
Publicado en: Journal of Proteome Research, Edición 20/6, 2021, Página(s) 3114-3123, ISSN 1535-3893
Editor: American Chemical Society
DOI: 10.1021/acs.jproteome.1c00017

Effects of platelet agonists and priming on 1 the formation of platelet populations

Autores: Veninga A, Baaten C, De Simone I, Tullemans B, Kuijpers M, Heemskerk J, van der Meijden P
Publicado en: Thrombosis and Haemostasis, 2021, ISSN 0340-6245
Editor: Schattauer
DOI: 10.1055/s-0041-1735972

Rac Inhibition Causes Impaired GPVI Signalling in Human Platelets through GPVI Shedding and Reduction in PLCγ2 Phosphorylation

Autores: Neagoe, R.A.I.; Gardiner, E.E.; Stegner, D.; Nieswandt, B.; Watson, S.P.; Poulter, N.S.
Publicado en: International Journal of Molecular Sciences, Edición 23(7):3746, 2022, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms23073746

Analysis of platelets from a diet-induced obesity rat model: elucidating platelet dysfunction in obesity

Autores: María N. Barrachina, Luis A. Morán, Irene Izquierdo, Felipe F. Casanueva, María Pardo, Ángel García
Publicado en: Scientific Reports, Edición 10/1, 2020, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-020-70162-3

Platelet calcium signaling by G-protein coupled and ITAM-linked receptors regulating anoctamin-6 and procoagulant activity

Autores: Delia I. Fernández, Marijke J. E. Kuijpers, Johan W. M. Heemskerk
Publicado en: Platelets, Edición 32/7, 2021, Página(s) 863-871, ISSN 0953-7104
Editor: Taylor & Francis
DOI: 10.1080/09537104.2020.1859103

Targeting platelet inhibition receptors for novel therapies: PECAM-1 and G6b-B

Autores: Soriano Jerez, E.M., J.M. Gibbins, and C.E. Hughes
Publicado en: Platelets, 2021, ISSN 0953-7104
Editor: Taylor & Francis
DOI: 10.1080/09537104.2021.1882668

Phosphoproteomic Analysis of Platelets in Severe Obesity Uncovers Platelet Reactivity and Signaling Pathways Alterations

Autores: María N. Barrachina, Lidia Hermida-Nogueira, Luis A. Moran, Vanessa Casas, Sarah M. Hicks, Aurelio M. Sueiro, Ying Di, Robert K. Andrews, Steve P. Watson, Elizabeth E. Gardiner, Joaquin Abian, Montserrat Carrascal, María Pardo, Ángel García
Publicado en: Arteriosclerosis, Thrombosis, and Vascular Biology, 2020, ISSN 1079-5642
Editor: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/atvbaha.120.314485

Structure-function relationship of the platelet glycoprotein VI (GPVI) receptor: does it matter if it is a dimer or monomer?

Autores: Joanne C. Clark, Foteini-Nafsika Damaskinaki, Yam Fung Hilaire Cheung, Alexandre Slater, Steve P. Watson
Publicado en: Platelets, 2021, Página(s) 1-8, ISSN 0953-7104
Editor: Taylor & Francis
DOI: 10.1080/09537104.2021.1887469

Platelet-primed interactions of coagulation and anticoagulation pathways in flow-dependent thrombus formation

Autores: Sanne L. N. Brouns, Johanna P. van Geffen, Elena Campello, Frauke Swieringa, Luca Spiezia, René van Oerle, Isabella Provenzale, Remco Verdoold, Richard W. Farndale, Kenneth J. Clemetson, Henri M. H. Spronk, Paola E. J. van der Meijden, Rachel Cavill, Marijke J. E. Kuijpers, Elisabetta Castoldi, Paolo Simioni, Johan W. M. Heemskerk
Publicado en: Scientific Reports, Edición 10/1, 2020, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-020-68438-9

The PI3Kδ Inhibitor Idelalisib Diminishes Platelet Function and Shows Antithrombotic Potential

Autores: María N. Barrachina, Irene Izquierdo, Lidia Hermida-Nogueira, Luis A. Morán, Amparo Pérez, Ana B. Arroyo, Nuria García-Barberá, Rocío González-Conejero, Sara Troitiño, Johannes A. Eble, José Rivera, Constantino Martínez, María I. Loza, Eduardo Domínguez, Ángel García
Publicado en: International Journal of Molecular Sciences, Edición 22/7, 2021, Página(s) 3304, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22073304

Overcoming challenges in developing small molecule inhibitors for GPVI and CLEC-2

Autores: Foteini-Nafsika Damaskinaki, Luis A. Moran, Angel Garcia, Barrie Kellam, Steve P. Watson
Publicado en: Platelets, 2021, Página(s) 1-9, ISSN 0953-7104
Editor: Taylor & Francis
DOI: 10.1080/09537104.2020.1863939

Role of Platelet Glycoprotein VI and Tyrosine Kinase Syk in Thrombus Formation on Collagen-Like Surfaces

Autores: Natalie J. Jooss, Ilaria De Simone, Isabella Provenzale, Delia I. Fernández, Sanne L.N. Brouns, Richard W. Farndale, Yvonne M.C. Henskens, Marijke J.E. Kuijpers, Hugo ten Cate, Paola E.J. van der Meijden, Rachel Cavill, Johan W.M. Heemskerk
Publicado en: International Journal of Molecular Sciences, Edición 20/11, 2019, Página(s) 2788, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms20112788

Interspecies differences in protein expression do not impact the spatiotemporal regulation of GPVI mediated activation

Autores: Joanne L. Dunster, Amanda J. Unsworth, Alexander P. Bye, Elizabeth J Haining, Marcin A. Sowa, Ying Di, Tanya Sage, Chiara Pallini, Jeremy A. Pike, Alexander.T. Hardy, Bernhard Nieswandt, Ángel García, Steve P. Watson, Natalie S. Poulter, Jonathan M. Gibbins, Alice Y. Pollitt
Publicado en: Journal of Thrombosis and Haemostasis, 2019, ISSN 1538-7933
Editor: Blackwell Publishing Inc.
DOI: 10.1111/jth.14673

Whole Blood Based Multiparameter Assessment of Thrombus Formation in Standard Microfluidic Devices to Proxy In Vivo Haemostasis and Thrombosis

Autores: Isabella Provenzale, Sanne L. N. Brouns, Paola E. J. van der Meijden, Frauke Swieringa, Johan W. M. Heemskerk
Publicado en: Micromachines, Edición 10/11, 2019, Página(s) 787, ISSN 2072-666X
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/mi10110787

A Comprehensive Tyrosine Phosphoproteomic Analysis Reveals Novel Components of the Platelet CLEC-2 Signaling Cascade

Autores: Irene Izquierdo, María N. Barrachina, Lidia Hermida-Nogueira, Vanessa Casas, Luis A. Morán, Serena Lacerenza, Roberto Pinto-Llorente, Johannes A. Eble, Vivian de los Ríos, Eduardo Domínguez, María I. Loza, José Ignacio Casal, Montserrat Carrascal, Joaquín Abián, Angel García
Publicado en: Thrombosis and Haemostasis, Edición 120/02, 2020, Página(s) 262-276, ISSN 0340-6245
Editor: Schattauer
DOI: 10.1055/s-0039-3400295

Localised endothelial‐based control of platelet aggregation and coagulation under flow: a proof‐of‐principle vessel‐on‐a‐chip study

Autores: Sanne L.N. Brouns, Isabella Provenzale, Johanna P. van Geffen, Paola E. van der Meijden, Johan W.M. Heemskerk
Publicado en: Journal of Thrombosis and Haemostasis, 2019, ISSN 1538-7933
Editor: Blackwell Publishing Inc.
DOI: 10.1111/jth.14719

Thrombo-Inflammation in Cardiovascular Disease: An Expert Consensus Document from the Third Maastricht Consensus Conference on Thrombosis

Autores: Elisa d’Alessandro, Christian Becker, Wolfgang Bergmeier, Christoph Bode, Joshua H. Bourne, Helena Brown, Harry R. Buller, Arina J. ten Cate-Hoek, Vincent ten Cate, Yvonne J. M. van Cauteren, Yam F. H. Cheung, Audrey Cleuren, Danielle Coenen, Harry J. G. M. Crijns, Ilaria de Simone, Sophie C. Dolleman, Christine Espinola Klein, Delia I. Fernandez, Lianne Granneman, Arnoud van t Hof, Peter Henke,
Publicado en: Thrombosis and Haemostasis, Edición 120/04, 2020, Página(s) 538-564, ISSN 0340-6245
Editor: Schattauer
DOI: 10.1055/s-0040-1708035

Temporal Roles of Platelet and Coagulation Pathways in Collagen- and Tissue Factor-Induced Thrombus Formation

Autores: Navarro S, Stegner D, Nieswandt B, Heemskerk JWM, Kuijpers MJE
Publicado en: International Journal of Molecular Sciences, 2022, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms23010358

Katacine is a new ligand of CLEC-2 that acts as a platelet agonist

Autores: Morán LA, Di Y, Sowa MA, Hermida-Nogueira L, Barrachina MN, Martin E, Mize TH, Clark JC, Eble JA, Moreira D, Pollitt AY, Loza MI, Domínguez E, Watson SP, Garcia A
Publicado en: Thrombosis and Haemostasis, 2022, ISSN 0340-6245
Editor: Schattauer
DOI: 10.1055/a-1772-1069

Evidence that GPVI is Expressed as a Mixture of Monomers and Dimers, and that the D2 Domain is not Essential for GPVI Activation

Autores: Joanne C. Clark, Raluca A. I. Neagoe, Malou Zuidscherwoude, Deirdre M. Kavanagh, Alexandre Slater, Eleyna M. Martin, Mark Soave, David Stegner, Bernhard Nieswandt, Natalie S. Poulter, Johan Hummert, Dirk-Peter Herten, Michael G. Tomlinson, Stephen J. Hill, Steve P. Watson
Publicado en: Thrombosis and Haemostasis, 2021, ISSN 0340-6245
Editor: Schattauer
DOI: 10.1055/a-1401-5014

Tyrosine Kinase Inhibitor Sunitinib Delays Platelet-Induced Coagulation: Additive Effects of Aspirin

Autores: Delia I. Fernández, Alicia Veninga, Bibian M. E. Tullemans, Constance C. F. M. J. Baaten, Linsey J. F. Peters, Maureen J. B. Aarts, Johannes A. Eble, Elena Campello, Luca Spiezia, Paolo Simioni, Emiel P. C. van der Vorst, Paola E. J. van der Meijden, Johan W. M. Heemskerk, Marijke J. E. Kuijpers
Publicado en: Thrombosis and Haemostasis, 2021, ISSN 0340-6245
Editor: Schattauer
DOI: 10.1055/s-0041-1730312

A large-scale histological investigation gives insight into the structure of ischemic stroke thrombi

Autores: Natalie J. Jooss, Natalie S. Poulter
Publicado en: Platelets, 2021, Página(s) 1-4, ISSN 0953-7104
Editor: Taylor & Francis
DOI: 10.1080/09537104.2020.1869713

Clonal hematopoietic mutations linked to platelet traits and the risk of thrombosis or bleeding

Autores: Alicia Veninga, Ilaria De Simone, Johan W.M. Heemskerk, Hugo ten Cate, Paola E.J. van der Meijden
Publicado en: Haematologica, Edición 105/8, 2020, Página(s) 2020-2031, ISSN 0390-6078
Editor: Ferrata Storti Foundation
DOI: 10.3324/haematol.2019.235994

Assessment of a complete and classified platelet proteome from genome-wide transcripts of human platelets and megakaryocytes covering platelet functions

Autores: Jingnan Huang, Frauke Swieringa, Fiorella A. Solari, Isabella Provenzale, Luigi Grassi, Ilaria De Simone, Constance C. F. M. J. Baaten, Rachel Cavill, Albert Sickmann, Mattia Frontini, Johan W. M. Heemskerk
Publicado en: Scientific Reports, Edición 11/1, 2021, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-021-91661-x

Nonredundant Roles of Platelet Glycoprotein VI and Integrin αIIbβ3 in Fibrin-Mediated Microthrombus Formation

Autores: Gina Perrella, Jingnan Huang, Isabella Provenzale, Frauke Swieringa, Floor C.J.I. Heubel-Moenen, Richard W. Farndale, Mark Roest, Paola E.J. van der Meijden, Mark Thomas, Robert A.S. Ariëns, Martine Jandrot-Perrus, Steve P. Watson, Johan W.M. Heemskerk
Publicado en: Arteriosclerosis, Thrombosis, and Vascular Biology, Edición 41/2, 2021, ISSN 1079-5642
Editor: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/atvbaha.120.314641

Ultra-high-throughput Ca2+ assay in platelets to distinguish ITAM-linked and G-protein-coupled receptor activation

Autores: Fernández, D. I., Provenzale, I., Cheung, H. Y. F., van Groningen, J., Tullemans, B. M. E., Veninga, A., Dunster, J. L., Honarnejad, S., van den Hurk, H., Kuijpers, M. J. E., & Heemskerk, J. W. M.
Publicado en: iScience, 2021, ISSN 2589-0042
Editor: Elsevier
DOI: 10.1016/j.isci.2021.103718

Structural characterization of a novel GPVI-nanobody complex reveals a biologically active domain-swapped GPVI dimer

Autores: Alexandre Slater, Ying Di, Joanne C. Clark, Natalie J. Jooss, Eleyna M. Martin, Fawaz Alenazy, Mark R. Thomas, Robert A. S. Ariëns, Andrew B. Herr, Natalie S. Poulter, Jonas Emsley, Steve P. Watson
Publicado en: Blood, Edición 137/24, 2021, Página(s) 3443-3453, ISSN 0006-4971
Editor: American Society of Hematology
DOI: 10.1182/blood.2020009440

Multiparameter Evaluation of the Platelet-Inhibitory Effects of Tyrosine Kinase Inhibitors Used for Cancer Treatment

Autores: Tullemans BME, Veninga A, Fernandez DI, Aarts MJB, Eble JA, van der Meijden PEJ, Heemskerk JWM, Kuijpers MJE
Publicado en: International Journal of Molecular Sciences, 2021, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms222011199

Other (1)

Antibody-mediated depletion of human CLEC-2 in a novel humanised mouse model

Autores: Helena C Brown, Sarah Beck, Stefano Navarro, Ying Di, Eva M Soriano Jerez, Jana Kaczmarzyk, Steven G. Thomas, Valbona Mirakaj, Steve P Watson, Bernhard Nieswandt, David Stegner
Publicado en: bioRxiv, 2021
Editor: Cold Spring Harbor Laboratory
DOI: 10.1101/2021.10.03.462933