Interdisciplinary training network on the purinergic P2X7 receptor to control neuroinflammation and hyperexcitability in brain diseases.

Información del proyecto

PurinesDX

Identificador del acuerdo de subvención: 766124

DOI

10.3030/766124

Proyecto cerrado

Fecha de la firma de la CE 17 Agosto 2017

Fecha de inicio 1 Septiembre 2017

Fecha de finalización 31 Agosto 2021

Financiado con arreglo a

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Coste total

€ 3 487 463,28

Aportación de la UE

€ 3 487 463,28

Coordinado por

ROYAL COLLEGE OF SURGEONS IN IRELAND
Ireland

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Documents, reports (18)

Report on gender equality in PurinesDX M48

Report on gender equality in PurinesDX

Network-wide training events M24

Workshop on “Clinical techniques and challenges in patient treatment – from Birth to Old Age” and “Good Clinical Practice” (3 days, open to scientific audience; ~ 100 participants); Workshop “Drug design – from Target genes to Medicine” (2 days, open to scientific audience; ~ 30 participants)

Network-wide training events M41

Third Annual Meeting (1 day, ESRs); Transferable skills VI “Career perspectives” (1 day, ESRs); Final network conference “International colloquium on P2X7Rs and their role in brain diseases” (2 days, open to general public, ~100 participants)

Report on communication and public engagement activities M36

Report on communication and public engagement activities

Network-wide training events M8

Introduction Programme: “Brain diseases and purinergic signalling” (2 days, open to scientific audience, ~100 participants); Transferable skills course I: “Essential Project Management” & “Innovative & Entrepreneurial Working Groups” (2 days, ESRs)

Network-wide training events M12

Workshop “Animal experimentation & behaviour assessment” (3 days, open to scientific audience, ~ 50 participants); Transferable skills course II: “Basic Research Skills & Introduction to web-based learning” (2 days, ESRs)

Launch of website, Twitter, Facebook, LinkedIn, GooglePlus

PurinesDX website and social media

Report on gender equality in PurinesDX M36

Report on gender equality in PurinesDX

Report on communication and public engagement activities M12

Report on communication and public engagement activities

Report on gender equality in PurinesDX M12

Report on gender equality in PurinesDX

Network-wide training events M36

Transferable Skills V Bootcamp “Commercialisation and industry engagement” (4 days, ESRs); Workshop “The utility of stem cell research and its potential use in the clinic” (1 day, open to scientific audience, ~50 participants)

Report on communication and public engagement activities M6

Report on communication and public engagement activities

Network-wide training events M30

Second Annual Meeting (1 day, data presentation); Workshop “Diagnostic devices: Lab bench to clinic” (2 days, open to scientific audience; ~30 participants); Research interaction day (1 day, ESRs); Transferable skills course IV “Development of medical devices” (1 day, ESRs)

Risk protocol M18

Risk protocol

Report on communication and public engagement activities M48

Report on communication and public engagement activities

Report on gender equality in PurinesDX M24

Report on gender equality in PurinesDX

Network-wide training events M18

First Annual Meeting (data presentation) (1 day, ESRs); Workshop: “In vivo imaging” (1 day, ESRs); Transferable skills course III: “Research Communication and Dissemination” (2 days, ESRs)

Report on communication and public engagement activities M24

Report on communication and public engagement activities

Other (7)

Dissemination diary and report of dissemination events M36

Dissemination diary and report of dissemination events

Dissemination diary and report of dissemination events M48

Dissemination diary and report of dissemination events

Thesis completion of ESRs

Thesis completion of ESRs hired through PurinesDX

Dissemination diary and report of dissemination events M24

Dissemination diary and report of dissemination events

Dissemination diary and report of dissemination events M12

Dissemination diary and report of dissemination events

Supervisory Board of the network

Supervisory Board members of the network

Recruitment completion and ESR contracts

Publicaciones

Peer reviewed articles (18)

Elevated blood purine levels as a biomarker of seizures and epilepsy

Autores: Edward Beamer, Austin Lacey, Mariana Alves, Giorgia Conte, Faming Tian, Laura Diego‐Garcia, Mohamed Khalil, Felix Rosenow, Norman Delanty, Nicholas Dale, Hany El‐Naggar, David C. Henshall, Tobias Engel
Publicado en: Epilepsia, Edición 62/3, 2021, Página(s) 817-828, ISSN 0013-9580
Editor: Blackwell Publishing Inc.
DOI: 10.1111/epi.16839

Synthesis and Pharmacological Evaluation of Novel Non-nucleotide Purine Derivatives as P2X7 Antagonists for the Treatment of Neuroinflammation

Autores: Francesco Calzaferri, Paloma Narros-Fernández, Ricardo de Pascual, Antonio M.G. de Diego, Annette Nicke, Javier Egea, Antonio G. García, Cristóbal de los Ríos
Publicado en: Journal of Medicinal Chemistry, Edición 64/4, 2021, Página(s) 2272-2290, ISSN 0022-2623
Editor: American Chemical Society
DOI: 10.1021/acs.jmedchem.0c02145

Polyadenylation of mRNA as a novel regulatory mechanism of gene expression in temporal lobe epilepsy

Autores: Alberto Parras, Laura de Diego-Garcia, Mariana Alves, Edward Beamer, Giorgia Conte, Eva M Jimenez-Mateos, James Morgan, Ivana Ollà, Yasmina Hernandez-Santana, Norman Delanty, Michael A Farrell, Donncha F O’Brien, Alejandro Ocampo, David C Henshall, Raúl Méndez, José J Lucas, Tobias Engel
Publicado en: Brain, Edición 143/7, 2020, Página(s) 2139-2153, ISSN 0006-8950
Editor: Oxford University Press
DOI: 10.1093/brain/awaa168

The purinergic P2X7 receptor as a potential drug target to combat neuroinflammation in neurodegenerative diseases

Autores: Francesco Calzaferri, Cristina Ruiz‐Ruiz, Antonio M. G. Diego, Ricardo Pascual, Iago Méndez‐López, María F. Cano‐Abad, Victoria Maneu, Cristóbal Ríos, Luis Gandía, Antonio G. García
Publicado en: Medicinal Research Reviews, Edición 40/6, 2020, Página(s) 2427-2465, ISSN 0198-6325
Editor: John Wiley & Sons Inc.
DOI: 10.1002/med.21710

Nucleotides regulate the common molecular mechanisms that underlie neurodegenerative diseases; Therapeutic implications

Autores: Álvaro Sebastián-Serrano, Laura de Diego-García, Caterina di Lauro, Carolina Bianchi, Miguel Díaz-Hernández
Publicado en: Brain Research Bulletin, Edición 151, 2019, Página(s) 84-91, ISSN 0361-9230
Editor: Elsevier BV
DOI: 10.1016/j.brainresbull.2019.01.031

P2X7R antagonists in chronic stress-based depression models: a review

Autores: Iven-Alex von Muecke-Heim, Clemens Ries, Lidia Urbina, Jan M. Deussing
Publicado en: European Archives of Psychiatry and Clinical Neuroscience, 2021, ISSN 0940-1334
Editor: Dr. Dietrich Steinkopff Verlag
DOI: 10.1007/s00406-021-01306-3

P2X7 Receptor-Dependent Layer-Specific Changes in Neuron-Microglia Reactivity in the Prefrontal Cortex of a Phencyclidine Induced Mouse Model of Schizophrenia

Autores: Stefano Calovi, Paula Mut-Arbona, Pál Tod, András Iring, Annette Nicke, Susana Mato, E. Sylvester Vizi, Jan Tønnesen, Beata Sperlagh
Publicado en: Frontiers in Molecular Neuroscience, Edición 13, 2020, ISSN 1662-5099
Editor: Frontiers Research Foundation
DOI: 10.3389/fnmol.2020.566251

Deviant reporter expression and P2X4 passenger gene overexpression in the soluble EGFP BAC transgenic P2X7 reporter mouse model

Autores: Antonio Ramírez-Fernández, Lidia Urbina-Treviño, Giorgia Conte, Mariana Alves, Björn Rissiek, Anna Durner, Nicolas Scalbert, Jiong Zhang, Tim Magnus, Friedrich Koch-Nolte, Nikolaus Plesnila, Jan M. Deussing, Tobias Engel, Robin Kopp, Annette Nicke
Publicado en: Scientific Reports, Edición 10/1, 2020, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-020-76428-0

Acupuncture alleviates acid‐ and purine‐induced pain in rodents

Autores: Ying Zhang, Lumei Huang, Sergey A. Kozlov, Patrizia Rubini, Yong Tang, Peter Illes
Publicado en: British Journal of Pharmacology, Edición 177/1, 2020, Página(s) 77-92, ISSN 0007-1188
Editor: Wiley-Blackwell
DOI: 10.1111/bph.14847

Chronic administration of P2X7 receptor antagonist JNJ-47965567 delays disease onset and progression, and improves motor performance in ALS SOD1G93A female mice

Autores: Cristina Ruiz-Ruiz, Nuria García-Magro, Pilar Negredo, Carlos Avendaño, Anindya Bhattacharya, Marc Ceusters, Antonio G. García
Publicado en: Disease Models & Mechanisms, Edición 13/10, 2020, ISSN 1754-8403
Editor: The Company of Biologists Ltd.
DOI: 10.1242/dmm.045732

Bi-directional genetic modulation of GSK-3β exacerbates hippocampal neuropathology in experimental status epilepticus

Autores: Tobias Engel, Raquel Gómez-Sintes, Mariana Alves, Eva M. Jimenez-Mateos, Marta Fernández-Nogales, Amaya Sanz-Rodriguez, James Morgan, Edward Beamer, Alberto Rodríguez-Matellán, Mark Dunleavy, Takanori Sano, Jesus Avila, Miguel Medina, Felix Hernandez, José J. Lucas, David C. Henshall
Publicado en: Cell Death & Disease, Edición 9/10, 2018, ISSN 2041-4889
Editor: Nature Publishing Group
DOI: 10.1038/s41419-018-0963-5

Amyloid Peptide Induced Neuroinflammation Increases the P2X7 Receptor Expression in Microglial Cells, Impacting on Its Functionality

Autores: Carlos Martínez-Frailes, Caterina Di Lauro, Carolina Bianchi, Laura de Diego-García, Álvaro Sebastián-Serrano, Lisardo Boscá, Miguel Díaz-Hernández
Publicado en: Frontiers in Cellular Neuroscience, Edición 13, 2019, ISSN 1662-5102
Editor: Frontiers Research Foundation
DOI: 10.3389/fncel.2019.00143

The ASIC3/P2X3 cognate receptor is a pain-relevant and ligand-gated cationic channel

Autores: Gabriele Stephan, Lumei Huang, Yong Tang, Sandra Vilotti, Elsa Fabbretti, Ye Yu, Wolfgang Nörenberg, Heike Franke, Flóra Gölöncsér, Beáta Sperlágh, Anke Dopychai, Ralf Hausmann, Günther Schmalzing, Patrizia Rubini, Peter Illes
Publicado en: Nature Communications, Edición 9/1, 2018, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-018-03728-5

MicroRNA-22 Controls Aberrant Neurogenesis and Changes in Neuronal Morphology After Status Epilepticus

Autores: Edward H. Beamer, Jeronimo Jurado-Arjona, Eva M. Jimenez-Mateos, James Morgan, Cristina R. Reschke, Aidan Kenny, Gioacchino de Leo, Luis A. Olivos-Oré, Marina Arribas-Blázquez, Stephen F. Madden, Jesús Merchán-Rubira, Norman Delanty, Michael A. Farrell, Donncha F. O’Brien, Jesus Avila, Miguel Diaz-Hernandez, M. Teresa Miras-Portugal, Antonio R. Artalejo, Felix Hernandez, David C. Henshall, T
Publicado en: Frontiers in Molecular Neuroscience, Edición 11, 2018, ISSN 1662-5099
Editor: Frontiers Research Foundation
DOI: 10.3389/fnmol.2018.00442

The Role of P2X7 Receptor in Alzheimer’s Disease

Autores: Linda Francistiová, Carolina Bianchi, Caterina Di Lauro, Álvaro Sebastián-Serrano, Laura de Diego-García, Julianna Kobolák, András Dinnyés, Miguel Díaz-Hernández
Publicado en: Frontiers in Molecular Neuroscience, Edición 13, 2020, ISSN 1662-5099
Editor: Frontiers Research Foundation
DOI: 10.3389/fnmol.2020.00094

P2X7 Interactions and Signaling – Making Head or Tail of It

Autores: Robin Kopp, Anna Krautloher, Antonio Ramírez-Fernández, Annette Nicke
Publicado en: Frontiers in Molecular Neuroscience, Edición 12, 2019, ISSN 1662-5099
Editor: Frontiers Research Foundation
DOI: 10.3389/fnmol.2019.00183

P2X7 Receptor-Dependent microRNA Expression Profile in the Brain Following Status Epilepticus in Mice

Autores: Giorgia Conte, Ngoc T. Nguyen, Mariana Alves, Laura de Diego-Garcia, Aidan Kenny, Annette Nicke, David C. Henshall, Eva M. Jimenez-Mateos, Tobias Engel
Publicado en: Frontiers in Molecular Neuroscience, Edición 13, 2020, ISSN 1662-5099
Editor: Frontiers Research Foundation
DOI: 10.3389/fnmol.2020.00127

P2X7 Receptor Antagonism as a Potential Therapy in Amyotrophic Lateral Sclerosis

Autores: Cristina Ruiz-Ruiz, Francesco Calzaferri, Antonio G. García
Publicado en: Frontiers in Molecular Neuroscience, Edición 13, 2020, ISSN 1662-5099
Editor: Frontiers Research Foundation
DOI: 10.3389/fnmol.2020.00093