Interdisciplinary training network on the purinergic P2X7 receptor to control neuroinflammation and hyperexcitability in brain diseases.

Informazioni relative al progetto

PurinesDX

ID dell’accordo di sovvenzione: 766124

DOI

10.3030/766124

Progetto chiuso

Data della firma CE 17 Agosto 2017

Data di avvio 1 Settembre 2017

Data di completamento 31 Agosto 2021

Finanziato da

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Costo totale

€ 3 487 463,28

Contributo UE

€ 3 487 463,28

Coordinato da

ROYAL COLLEGE OF SURGEONS IN IRELAND
Ireland

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Documents, reports (18)

Report on gender equality in PurinesDX M48

Report on gender equality in PurinesDX

Network-wide training events M24

Workshop on “Clinical techniques and challenges in patient treatment – from Birth to Old Age” and “Good Clinical Practice” (3 days, open to scientific audience; ~ 100 participants); Workshop “Drug design – from Target genes to Medicine” (2 days, open to scientific audience; ~ 30 participants)

Network-wide training events M41

Third Annual Meeting (1 day, ESRs); Transferable skills VI “Career perspectives” (1 day, ESRs); Final network conference “International colloquium on P2X7Rs and their role in brain diseases” (2 days, open to general public, ~100 participants)

Report on communication and public engagement activities M36

Report on communication and public engagement activities

Network-wide training events M8

Introduction Programme: “Brain diseases and purinergic signalling” (2 days, open to scientific audience, ~100 participants); Transferable skills course I: “Essential Project Management” & “Innovative & Entrepreneurial Working Groups” (2 days, ESRs)

Network-wide training events M12

Workshop “Animal experimentation & behaviour assessment” (3 days, open to scientific audience, ~ 50 participants); Transferable skills course II: “Basic Research Skills & Introduction to web-based learning” (2 days, ESRs)

Launch of website, Twitter, Facebook, LinkedIn, GooglePlus

PurinesDX website and social media

Report on gender equality in PurinesDX M36

Report on gender equality in PurinesDX

Report on communication and public engagement activities M12

Report on communication and public engagement activities

Report on gender equality in PurinesDX M12

Report on gender equality in PurinesDX

Network-wide training events M36

Transferable Skills V Bootcamp “Commercialisation and industry engagement” (4 days, ESRs); Workshop “The utility of stem cell research and its potential use in the clinic” (1 day, open to scientific audience, ~50 participants)

Report on communication and public engagement activities M6

Report on communication and public engagement activities

Network-wide training events M30

Second Annual Meeting (1 day, data presentation); Workshop “Diagnostic devices: Lab bench to clinic” (2 days, open to scientific audience; ~30 participants); Research interaction day (1 day, ESRs); Transferable skills course IV “Development of medical devices” (1 day, ESRs)

Risk protocol M18

Risk protocol

Report on communication and public engagement activities M48

Report on communication and public engagement activities

Report on gender equality in PurinesDX M24

Report on gender equality in PurinesDX

Network-wide training events M18

First Annual Meeting (data presentation) (1 day, ESRs); Workshop: “In vivo imaging” (1 day, ESRs); Transferable skills course III: “Research Communication and Dissemination” (2 days, ESRs)

Report on communication and public engagement activities M24

Report on communication and public engagement activities

Other (7)

Dissemination diary and report of dissemination events M36

Dissemination diary and report of dissemination events

Dissemination diary and report of dissemination events M48

Dissemination diary and report of dissemination events

Thesis completion of ESRs

Thesis completion of ESRs hired through PurinesDX

Dissemination diary and report of dissemination events M24

Dissemination diary and report of dissemination events

Dissemination diary and report of dissemination events M12

Dissemination diary and report of dissemination events

Supervisory Board of the network

Supervisory Board members of the network

Recruitment completion and ESR contracts

Pubblicazioni

Peer reviewed articles (18)

Elevated blood purine levels as a biomarker of seizures and epilepsy

Autori: Edward Beamer, Austin Lacey, Mariana Alves, Giorgia Conte, Faming Tian, Laura Diego‐Garcia, Mohamed Khalil, Felix Rosenow, Norman Delanty, Nicholas Dale, Hany El‐Naggar, David C. Henshall, Tobias Engel
Pubblicato in: Epilepsia, Numero 62/3, 2021, Pagina/e 817-828, ISSN 0013-9580
Editore: Blackwell Publishing Inc.
DOI: 10.1111/epi.16839

Synthesis and Pharmacological Evaluation of Novel Non-nucleotide Purine Derivatives as P2X7 Antagonists for the Treatment of Neuroinflammation

Autori: Francesco Calzaferri, Paloma Narros-Fernández, Ricardo de Pascual, Antonio M.G. de Diego, Annette Nicke, Javier Egea, Antonio G. García, Cristóbal de los Ríos
Pubblicato in: Journal of Medicinal Chemistry, Numero 64/4, 2021, Pagina/e 2272-2290, ISSN 0022-2623
Editore: American Chemical Society
DOI: 10.1021/acs.jmedchem.0c02145

Polyadenylation of mRNA as a novel regulatory mechanism of gene expression in temporal lobe epilepsy

Autori: Alberto Parras, Laura de Diego-Garcia, Mariana Alves, Edward Beamer, Giorgia Conte, Eva M Jimenez-Mateos, James Morgan, Ivana Ollà, Yasmina Hernandez-Santana, Norman Delanty, Michael A Farrell, Donncha F O’Brien, Alejandro Ocampo, David C Henshall, Raúl Méndez, José J Lucas, Tobias Engel
Pubblicato in: Brain, Numero 143/7, 2020, Pagina/e 2139-2153, ISSN 0006-8950
Editore: Oxford University Press
DOI: 10.1093/brain/awaa168

The purinergic P2X7 receptor as a potential drug target to combat neuroinflammation in neurodegenerative diseases

Autori: Francesco Calzaferri, Cristina Ruiz‐Ruiz, Antonio M. G. Diego, Ricardo Pascual, Iago Méndez‐López, María F. Cano‐Abad, Victoria Maneu, Cristóbal Ríos, Luis Gandía, Antonio G. García
Pubblicato in: Medicinal Research Reviews, Numero 40/6, 2020, Pagina/e 2427-2465, ISSN 0198-6325
Editore: John Wiley & Sons Inc.
DOI: 10.1002/med.21710

Nucleotides regulate the common molecular mechanisms that underlie neurodegenerative diseases; Therapeutic implications

Autori: Álvaro Sebastián-Serrano, Laura de Diego-García, Caterina di Lauro, Carolina Bianchi, Miguel Díaz-Hernández
Pubblicato in: Brain Research Bulletin, Numero 151, 2019, Pagina/e 84-91, ISSN 0361-9230
Editore: Elsevier BV
DOI: 10.1016/j.brainresbull.2019.01.031

P2X7R antagonists in chronic stress-based depression models: a review

Autori: Iven-Alex von Muecke-Heim, Clemens Ries, Lidia Urbina, Jan M. Deussing
Pubblicato in: European Archives of Psychiatry and Clinical Neuroscience, 2021, ISSN 0940-1334
Editore: Dr. Dietrich Steinkopff Verlag
DOI: 10.1007/s00406-021-01306-3

P2X7 Receptor-Dependent Layer-Specific Changes in Neuron-Microglia Reactivity in the Prefrontal Cortex of a Phencyclidine Induced Mouse Model of Schizophrenia

Autori: Stefano Calovi, Paula Mut-Arbona, Pál Tod, András Iring, Annette Nicke, Susana Mato, E. Sylvester Vizi, Jan Tønnesen, Beata Sperlagh
Pubblicato in: Frontiers in Molecular Neuroscience, Numero 13, 2020, ISSN 1662-5099
Editore: Frontiers Research Foundation
DOI: 10.3389/fnmol.2020.566251

Deviant reporter expression and P2X4 passenger gene overexpression in the soluble EGFP BAC transgenic P2X7 reporter mouse model

Autori: Antonio Ramírez-Fernández, Lidia Urbina-Treviño, Giorgia Conte, Mariana Alves, Björn Rissiek, Anna Durner, Nicolas Scalbert, Jiong Zhang, Tim Magnus, Friedrich Koch-Nolte, Nikolaus Plesnila, Jan M. Deussing, Tobias Engel, Robin Kopp, Annette Nicke
Pubblicato in: Scientific Reports, Numero 10/1, 2020, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-020-76428-0

Acupuncture alleviates acid‐ and purine‐induced pain in rodents

Autori: Ying Zhang, Lumei Huang, Sergey A. Kozlov, Patrizia Rubini, Yong Tang, Peter Illes
Pubblicato in: British Journal of Pharmacology, Numero 177/1, 2020, Pagina/e 77-92, ISSN 0007-1188
Editore: Wiley-Blackwell
DOI: 10.1111/bph.14847

Chronic administration of P2X7 receptor antagonist JNJ-47965567 delays disease onset and progression, and improves motor performance in ALS SOD1G93A female mice

Autori: Cristina Ruiz-Ruiz, Nuria García-Magro, Pilar Negredo, Carlos Avendaño, Anindya Bhattacharya, Marc Ceusters, Antonio G. García
Pubblicato in: Disease Models & Mechanisms, Numero 13/10, 2020, ISSN 1754-8403
Editore: The Company of Biologists Ltd.
DOI: 10.1242/dmm.045732

Bi-directional genetic modulation of GSK-3β exacerbates hippocampal neuropathology in experimental status epilepticus

Autori: Tobias Engel, Raquel Gómez-Sintes, Mariana Alves, Eva M. Jimenez-Mateos, Marta Fernández-Nogales, Amaya Sanz-Rodriguez, James Morgan, Edward Beamer, Alberto Rodríguez-Matellán, Mark Dunleavy, Takanori Sano, Jesus Avila, Miguel Medina, Felix Hernandez, José J. Lucas, David C. Henshall
Pubblicato in: Cell Death & Disease, Numero 9/10, 2018, ISSN 2041-4889
Editore: Nature Publishing Group
DOI: 10.1038/s41419-018-0963-5

Amyloid Peptide Induced Neuroinflammation Increases the P2X7 Receptor Expression in Microglial Cells, Impacting on Its Functionality

Autori: Carlos Martínez-Frailes, Caterina Di Lauro, Carolina Bianchi, Laura de Diego-García, Álvaro Sebastián-Serrano, Lisardo Boscá, Miguel Díaz-Hernández
Pubblicato in: Frontiers in Cellular Neuroscience, Numero 13, 2019, ISSN 1662-5102
Editore: Frontiers Research Foundation
DOI: 10.3389/fncel.2019.00143

The ASIC3/P2X3 cognate receptor is a pain-relevant and ligand-gated cationic channel

Autori: Gabriele Stephan, Lumei Huang, Yong Tang, Sandra Vilotti, Elsa Fabbretti, Ye Yu, Wolfgang Nörenberg, Heike Franke, Flóra Gölöncsér, Beáta Sperlágh, Anke Dopychai, Ralf Hausmann, Günther Schmalzing, Patrizia Rubini, Peter Illes
Pubblicato in: Nature Communications, Numero 9/1, 2018, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-018-03728-5

MicroRNA-22 Controls Aberrant Neurogenesis and Changes in Neuronal Morphology After Status Epilepticus

Autori: Edward H. Beamer, Jeronimo Jurado-Arjona, Eva M. Jimenez-Mateos, James Morgan, Cristina R. Reschke, Aidan Kenny, Gioacchino de Leo, Luis A. Olivos-Oré, Marina Arribas-Blázquez, Stephen F. Madden, Jesús Merchán-Rubira, Norman Delanty, Michael A. Farrell, Donncha F. O’Brien, Jesus Avila, Miguel Diaz-Hernandez, M. Teresa Miras-Portugal, Antonio R. Artalejo, Felix Hernandez, David C. Henshall, T
Pubblicato in: Frontiers in Molecular Neuroscience, Numero 11, 2018, ISSN 1662-5099
Editore: Frontiers Research Foundation
DOI: 10.3389/fnmol.2018.00442

The Role of P2X7 Receptor in Alzheimer’s Disease

Autori: Linda Francistiová, Carolina Bianchi, Caterina Di Lauro, Álvaro Sebastián-Serrano, Laura de Diego-García, Julianna Kobolák, András Dinnyés, Miguel Díaz-Hernández
Pubblicato in: Frontiers in Molecular Neuroscience, Numero 13, 2020, ISSN 1662-5099
Editore: Frontiers Research Foundation
DOI: 10.3389/fnmol.2020.00094

P2X7 Interactions and Signaling – Making Head or Tail of It

Autori: Robin Kopp, Anna Krautloher, Antonio Ramírez-Fernández, Annette Nicke
Pubblicato in: Frontiers in Molecular Neuroscience, Numero 12, 2019, ISSN 1662-5099
Editore: Frontiers Research Foundation
DOI: 10.3389/fnmol.2019.00183

P2X7 Receptor-Dependent microRNA Expression Profile in the Brain Following Status Epilepticus in Mice

Autori: Giorgia Conte, Ngoc T. Nguyen, Mariana Alves, Laura de Diego-Garcia, Aidan Kenny, Annette Nicke, David C. Henshall, Eva M. Jimenez-Mateos, Tobias Engel
Pubblicato in: Frontiers in Molecular Neuroscience, Numero 13, 2020, ISSN 1662-5099
Editore: Frontiers Research Foundation
DOI: 10.3389/fnmol.2020.00127

P2X7 Receptor Antagonism as a Potential Therapy in Amyotrophic Lateral Sclerosis

Autori: Cristina Ruiz-Ruiz, Francesco Calzaferri, Antonio G. García
Pubblicato in: Frontiers in Molecular Neuroscience, Numero 13, 2020, ISSN 1662-5099
Editore: Frontiers Research Foundation
DOI: 10.3389/fnmol.2020.00093