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Point-of-care device based on KETs for diagnosis of food allergies

Resultado final

Health Technology Assessment v1

This is the first version of the Health Technology Assessment. It defines the criteria that a device for detecting allergies in the PoC should meet to be cost-effective against current clinical practice.

Handbook on management

The Management handbook summarises all the required knowledge for the good management of the project (in terms of administrative forms, financial aspects, quality process…).

Initial dissemination plan

The dissemination plan encompasses the publications to be developed, the target groups to aim at and the platforms to use to make known the project and its results.

Updated dissemination report

This is an updated version of the dissemination plan.

Dissemination material (Project e-newsletters and brochures).

Dissemination materials such as newsletters and brochures.

Project public website

This is a the project website to make known the project. It will also be a tool to manage the internal documents related to the project among its partners.


Molecular allergology and its impact in specific allergy diagnosis and therapy

Autores: Domingo Barber, Araceli Diaz‐Perales, Maria M. Escribese, Jörg Kleine‐Tebbe, Paolo M. Matricardi, Markus Ollert, Alexandra F. Santos, Joaquin Sastre
Publicado en: Allergy, 2021, ISSN 0105-4538
DOI: 10.1111/all.14969

The uncertainty and limit of detection in biosensors from immunoassays

Autores: Jesús de Vicente, Álvaro Lavín, Miguel Holgado, María F Laguna, Rafael Casquel, Beatriz Santamaría, Sergio Quintero, Ana L Hernández, Yolanda Ramírez
Publicado en: Measurement Science and Technology, Issue 31/4, 2020, Page(s) 044004, ISSN 0957-0233
DOI: 10.1088/1361-6501/ab49ec

Are Physicochemical Properties Shaping the Allergenic Potency of Animal Allergens?

Autores: Joana Costa, Caterina Villa, Kitty Verhoeckx, Tanja Cirkovic-Velickovic, Denise Schrama, Paola Roncada, Pedro M. Rodrigues, Cristian Piras, Laura Martín-Pedraza, Linda Monaci, Elena Molina, Gabriel Mazzucchelli, Isabel Mafra, Roberta Lupi, Daniel Lozano-Ojalvo, Colette Larré, Julia Klueber, Eva Gelencser, Cristina Bueno-Diaz, Araceli Diaz-Perales, Sara Benedé, Simona Lucia Bavaro, Annette Kuehn
Publicado en: Clinical Reviews in Allergy & Immunology, 2021, ISSN 1080-0549
DOI: 10.1007/s12016-020-08826-1

A new optical interferometric-based in vitro detection system for the specific IgE detection in serum of the main peach allergen

Autores: R.L. Espinosa, M. Garrido-Arandia, A. Romero-Sahagun, P. Herreros, L. Tramarin, M.F. Laguna, A. Díaz-Perales, M. Holgado
Publicado en: Biosensors and Bioelectronics, Issue 169, 2020, Page(s) 112641, ISSN 0956-5663
DOI: 10.1016/j.bios.2020.112641

A Comparative Study of Human Saposins

Autores: María Garrido-Arandia, Bruno Cuevas-Zuviría, Araceli Díaz-Perales, Luis Pacios
Publicado en: Molecules, Issue 23/2, 2018, Page(s) 422, ISSN 1420-3049
DOI: 10.3390/molecules23020422

Energy Landscapes of Ligand Motion Inside the Tunnel-Like Cavity of Lipid Transfer Proteins: The Case of the Pru p 3 Allergen

Autores: Bruno Cuevas-Zuviría, María Garrido-Arandia, Araceli Díaz-Perales, Luis Pacios
Publicado en: International Journal of Molecular Sciences, Issue 20/6, 2019, Page(s) 1432, ISSN 1422-0067
DOI: 10.3390/ijms20061432

Interaction of Alt a 1 with SLC22A17 in the airway mucosa

Autores: María Garrido‐Arandia, Jaime Tome‐Amat, Diego Pazos‐Castro, Vanesa Esteban, Maria M. Escribese, Guadalupe Hernández‐Ramírez, Alma Yuste‐Montalvo, Domingo Barber, Luis F. Pacios, Araceli Díaz‐Perales
Publicado en: Allergy, 2019, ISSN 0105-4538
DOI: 10.1111/all.13877

Glycosylated nanostructures in sublingual immunotherapy induce long-lasting tolerance in LTP allergy mouse model

Autores: Maria J. Rodriguez, Javier Ramos-Soriano, James R. Perkins, Ainhoa Mascaraque, Maria J. Torres, Francisca Gomez, Araceli Diaz-Perales, Javier Rojo, Cristobalina Mayorga
Publicado en: Scientific Reports, Issue 9/1, 2019, ISSN 2045-2322
DOI: 10.1038/s41598-019-40114-7

On the Determination of Uncertainty and Limit of Detection in Label-Free Biosensors

Autores: Álvaro Lavín, Jesús Vicente, Miguel Holgado, María Laguna, Rafael Casquel, Beatriz Santamaría, María Maigler, Ana Hernández, Yolanda Ramírez
Publicado en: Sensors, Issue 18/7, 2018, Page(s) 2038, ISSN 1424-8220
DOI: 10.3390/s18072038

A Proof-of-Concept of Label-Free Biosensing System for Food Allergy Diagnostics in Biophotonic Sensing Cells: Performance Comparison with ImmunoCAP

Autores: Rocio Espinosa, María Laguna, Fátima Fernández, Beatriz Santamaria, Francisco Sanza, Maria Maigler, Juan Álvarez-Millán, Víctor Canalejas-Tejero, Miguel Holgado
Publicado en: Sensors, Issue 18/8, 2018, Page(s) 2686, ISSN 1424-8220
DOI: 10.3390/s18082686

A New Device Based on Interferometric Optical Detection Method for Label-Free Screening of C-Reactive Protein

Autores: Maria V. Maigler, Miguel Holgado, Maria Fe Laguna, Francisco J. Sanza, Beatriz Santamaria, Alvaro Lavin, Rocio L. Espinosa
Publicado en: IEEE Transactions on Instrumentation and Measurement, 2018, Page(s) 1-7, ISSN 0018-9456
DOI: 10.1109/tim.2018.2876073

Performance of basophil activation test and specific IgG4 as diagnostic tools in nonspecific lipid transfer protein allergy: Antwerp‐Barcelona comparison

Autores: Ine I. Decuyper, Mariona Pascal, Athina L. Van Gasse, Christel Mertens, Araceli Díaz‐Perales, Giovanna Araujo, Maria Torradeflot, Josefina Rius, Sara Balsells, Rosa M. Muñoz‐Cano, Joan Bartra, Lynne Li, Vito Sabato, Margo M. Hagendorens, Chris H. Bridts, Luc S. De Clerck, Didier G. Ebo, Margaretha A. Faber
Publicado en: Allergy, Issue 75/3, 2020, Page(s) 616-624, ISSN 0105-4538
DOI: 10.1111/all.14040

A Point-of-Care Based on Label-Free Interferometric Optical Detection Method to Evaluate Interferon Gamma (IFN-γ): A Correlation with the ELISA Technique

Autores: María Fe Laguna Heras, Yolanda Ramirez, Celia Fernández Martín, Rocío L. Espinosa, Alvaro Lavín, Miguel Holgado
Publicado en: Sensors, Issue 20/17, 2020, Page(s) 4776, ISSN 1424-8220
DOI: 10.3390/s20174776

The diagnosis and management of allergic reactions in patients sensitized to non‐specific lipid transfer proteins

Autores: Isabel J. Skypala, Joan Bartra, Didier G. Ebo, Margaretha Antje Faber, Montserrat Fernández‐Rivas, Francisca Gomez, Olga Luengo, Stephen J. Till, Riccardo Asero, Domingo Barber, Lorenzo Cecchi, Araceli Diaz Perales, Karin Hoffmann‐Sommergruber, Elide Anna Pastorello, Ines Swoboda, Anastasios. P. Konstantinopoulos, Ronald Ree, Enrico Scala
Publicado en: Allergy, 2021, ISSN 0105-4538
DOI: 10.1111/all.14797

Are Physicochemical Properties Shaping the Allergenic Potency of Plant Allergens?

Autores: Joana Costa, Simona Lucia Bavaro, Sara Benedé, Araceli Diaz-Perales, Cristina Bueno-Diaz, Eva Gelencser, Julia Klueber, Colette Larré, Daniel Lozano-Ojalvo, Roberta Lupi, Isabel Mafra, Gabriel Mazzucchelli, Elena Molina, Linda Monaci, Laura Martín-Pedraza, Cristian Piras, Pedro M. Rodrigues, Paola Roncada, Denise Schrama, Tanja Cirkovic-Velickovic, Kitty Verhoeckx, Caterina Villa, Annette Kuehn
Publicado en: Clinical Reviews in Allergy & Immunology, 2021, ISSN 1080-0549
DOI: 10.1007/s12016-020-08810-9

The key to the allergenicity of lipid transfer protein (LTP) ligands: A structural characterization

Autores: Zulema Gonzalez-Klein, Bruno Cuevas-Zuviria, Andrea Wangorsch, Guadalupe Hernandez-Ramirez, Diego Pazos-Castro, Carmen Oeo-Santos, Alejandro Romero-Sahagun, Luis F. Pacios, Jaime Tome-Amat, Stephan Scheurer, Araceli Diaz-Perales, María Garrido-Arandia
Publicado en: Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, Issue 1866/7, 2021, Page(s) 158928, ISSN 1388-1981
DOI: 10.1016/j.bbalip.2021.158928

Optical Vapor Sensors Based on Periodic Resonant Nanopillar Structures

Autores: Sergio Quintero, Rafael Casquel, Maria Fe Laguna, Miguel Holgado
Publicado en: ACS Omega, Issue 5/40, 2020, Page(s) 25913-25918, ISSN 2470-1343
DOI: 10.1021/acsomega.0c03279