Project description
Saliva-based diagnosis of heart failure at the point-of-care
Heart failure is a global health challenge with increasing prevalence and poor prognosis, while diagnosis and therapy monitoring lack personalised and reliable tools. To address these challenges, the EU-funded KardiaTool project aims to develop a portable device that can diagnose heart failure and monitor therapy at the point of care using saliva samples. The device will incorporate different heart failure biomarkers from saliva offering a cost-effective alternative to blood-based screening. The convenience of operation and potential for continuous monitoring offered by the KardiaTool solution are expected to improve clinical practice and care of patients with heart failure.
Objective
The aim of the KardiaTool project is to translate a laboratory proven concept of a saliva biosensor to the clinical practice for addressing the priority needs in personalized HF diagnostics and therapy monitoring at the point of care. The KardiaTool platform includes: (i) An easy to use portable POC device (KardiaPOC) with a disposable Lab-on-a-Chip (LOC), for the non-invasive, rapid and accurate qualitative and quantitative assessment of HF biomarkers, from saliva samples. KardiaPOC device will integrate a variety of sensors, actuators, Microelectromechanical systems (MEMS), micro-electronics, bio-chemicals and functionalized magnetic nanoparticles (MNPs), onto a disposable, low cost LOC. (ii) A decision support software (KardiaSoft) based on predictive modelling techniques, that analyzes the POC data and other patient’s data, directly added by the healthcare professionals, and delivers information related to HF diagnosis and therapy monitoring. The innovation lays in the incorporation of four novel saliva biomarkers that have been proven in a laboratory setting and bring a new promising concept for addressing the priority needs of the clinical arena. KardiaPOC will provide the capability of simultaneously extracting key information from the saliva biomarkers: (i) NT-proBNP, (ii) TNF-a, (iii) Interleukin- 10, (iv) Cortisol. It is expected that identifying a comparable source to blood, for biomarker information, such as saliva, that is cost effective, less invasive, more convenient and acceptable for both patients and healthcare professionals would be beneficial for the healthcare community. The challenge of KardiaTool is: (i) to translate a laboratory proven concept of a saliva biosensor into an MNBS platform, for HF diagnostics and therapy monitoring, at the point of care, following GLP (ii) to validate the MNBS platform through pre-clinical and clinical testing following GCP and (iii) to industrialize the outcomes following GMP towards progress to marketization
Fields of science
- engineering and technologyelectrical engineering, electronic engineering, information engineeringelectronic engineeringsensorsbiosensors
- social sciencessociologydemographymortality
- engineering and technologyother engineering and technologiesmicrotechnologylab on a chip
- medical and health sciencesclinical medicinecardiologycardiovascular diseases
- natural scienceschemical sciencesanalytical chemistrymass spectrometry
Programme(s)
Funding Scheme
RIA - Research and Innovation actionCoordinator
69622 Villeurbanne Cedex
France
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Participants (16)
70013 Irakleio
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28006 Madrid
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56126 Pisa
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80686 Munchen
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69100 VILLEURBANNE
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
7521 PV Enschede
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
3001 Leuven
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45110 Ioannina
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94800 Villejuif
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
00185 Roma
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Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.
56126 Pisa
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19803 WILMINGTON
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
GU2 7XH Guildford
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4 Dublin
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Participation ended
69342 Lyon
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Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.
Participation ended
69622 Villeurbanne Cedex
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