Highly Integrated Nanoscale Robots for Targeted Delivery to the Central Nervous System

Project Information

HINBOTS

Grant agreement ID: 771565

DOI

10.3030/771565

Project closed

EC signature date 31 January 2018

Start date 1 September 2018

End date 31 August 2023

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 998 720,00

EU contribution

€ 1 998 720,00

Coordinated by

EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
Switzerland

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (40)

Biodegradation of Oxide Nanoparticles in Apoferritin Protein Media: A Systematic Electrochemical Approach

Author(s): Ehsan Rahimi, Donghoon Kim, Ruben Offoiach, Roger Sanchis-Gual, Xiang-Zhong Chen, Peyman Taheri, Yaiza Gonzalez-Garcia, Johannes M. C. Mol, Lorenzo Fedrizzi, Salvador Pané, Maria Lekka
Published in: Advanced Materials Interfaces, 2023, Page(s) 2300558, ISSN 2196-7350
Publisher: Wiley-VCH GmbH
DOI: 10.1002/admi.202300558

Shape-memory effect in twisted ferroic nanocomposites

Author(s): Donghoon Kim; Minsoo Kim; Steffen Reidt; Hyeon Han; Ali Baghizadeh; Peng Zeng; Hongsoo Choi; Josep Puigmartí-Luis; Morgan Trassin; Bradley J. Nelson; Xiang-Zhong Chen; Salvador Pané
Published in: Nature Communications, 14, Issue 8, 2023, Page(s) 750, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.3929/ethz-b-000598013

Mechanically interlocked 3D multi-material micromachines

Author(s): C. C. J. Alcântara, F. C. Landers, S. Kim, C. De Marco, D. Ahmed, B. J. Nelson, S. Pané
Published in: Nature Communications, Issue 11/1, 2020, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-020-19725-6

Magnetically Driven Micro and Nanorobots

Author(s): Huaijuan Zhou; Carmen C. Mayorga-Martinez; Salvador Pané; Li Zhang; Martin Pumera
Published in: Chemical Reviews 121(8), 2021, Page(s) 4999-5041, ISSN 1520-6890
Publisher: American Chemcial Society
DOI: 10.1021/acs.chemrev.0c01234

CANDYBOTS: A New Generation of 3D‐Printed Sugar‐Based Transient Small‐Scale Robots

Author(s): Simone Gervasoni, Anastasia Terzopoulou, Carlos Franco, Andrea Veciana, Norman Pedrini, Jan T. Burri, Carmela de Marco, Erdem C. Siringil, Xiang‐Zhong Chen, Bradley J. Nelson, Josep Puigmartí‐Luis, Salvador Pané
Published in: Advanced Materials, Issue 32/52, 2020, Page(s) 2005652, ISSN 0935-9648
Publisher: United Nations Industrial Developement Organization
DOI: 10.1002/adma.202005652

Magnetoelectric coupling in micropatterned BaTiO3/CoFe2O4 epitaxial thin film structures: Augmentation and site-dependency

Author(s): Donghoon Kim; Marta D. Rossell; Marco Campanini; Rolf Erni; Josep Puigmartí-Luis; Xiang-Zhong Chen; Salvador Pané
Published in: Applied Physics Letters, 119, Issue 3, 2021, Page(s) 012901, ISSN 1077-3118
Publisher: American Physics Letter
DOI: 10.1063/5.0056038

Catalytically Propelled Micro‐ and Nanoswimmers

Author(s): Bumjin Jang, Min Ye, Ayoung Hong, Xiaopu Wang, Xianghong Liu, Dohyeok Bae, Josep Puigmartí Luis, Salvador Pané
Published in: Small Science, 2023, Page(s) 2300076, ISSN 2688-4046
Publisher: Wiley-VCH GmbH
DOI: 10.1002/smsc.202300076

Magnetoelectric Effect in Hydrogen Harvesting: Magnetic Field as a Trigger of Catalytic Reactions

Author(s): Donghoon Kim; Ipek Efe; Harun Torlakcik; Anastasia Terzopoulou; Andrea Veciana; Erdem Siringil; Fajer Mushtaq; Carlos Franco; Denis Arx; Semih Sevim; Josep Puigmartí‐Luis; Bradley Nelson; Nicola A. Spaldin; Chiara Gattinoni; Xiang‐Zhong Chen; Salvador Pané
Published in: Advanced Materials, 34 (19), Issue 10, 2022, Page(s) 2110612, ISSN 1521-4095
Publisher: Wiley-VCH
DOI: 10.1002/adma.202110612

The magnetopyroelectric effect: heat-mediated magnetoelectricity in magnetic nanoparticle-ferroelectric polymer composites

Author(s): Joaquin Llacer-Wintle; Jan Renz; Lukas Hertle; Andrea Veciana; Denis von Arx; Jiang Wu; Pere Bruna; Marija Vukomanovic; Josep Puigmartí-Luis; Bradley J. Nelson; Xiang-Zhong Chen; Salvador Pané
Published in: Materials Horizons, Issue 10 (7), 2023, Page(s) 2627-2637, ISSN 2051-6347
Publisher: The Royal Society of Chemistry
DOI: 10.1039/d2mh01361d

Advanced technologies for the fabrication of MOF thin films

Author(s): Chiara Crivello, Semih Sevim, Octavio Graniel, Carlos Franco, Salvador Pané, Josep Puigmartí-Luis, David Muñoz-Rojas
Published in: Materials Horizons, Issue 8/1, 2021, Page(s) 168-178, ISSN 2051-6347
Publisher: Royal Chemical Society
DOI: 10.1039/d0mh00898b

MoSBOTs: Magnetically Driven Biotemplated MoS2-Based Microrobots for Biomedical Applications

Author(s): de la Asuncion-Nadal, Victor; Veciana, Andrea; Ning, Shen; Terzopoulou, Anastasia; Sevim, Semih; Chen, Xiang-Zhong; Gong, De; Cai, Jun; Wendel-Garcia, Pedro; Jurado-Sanchez, Beatriz; Escarpa, Alberto; Puigmartí-Luis, Josep; Pané, Salvador
Published in: Small, 18 (33), Issue 5, 2022, Page(s) 2203821, ISSN 1613-6829
Publisher: Wiley-VCH
DOI: 10.3929/ethz-b-000560734

Inkjet-Assisted Electroformation of Magnetically Guidable Water Striders for Interfacial Microfluidic Manipulation

Author(s): Bernasconi, Roberto; Carniani, Davide; Kim, Min-Soo; Pané, Salvador; Magagnin, Luca
Published in: ACS Applied Materials & Interface 15(1), 2023, Page(s) 2396-2408, ISSN 1944-8252
Publisher: American Chemical Society
DOI: 10.1021/acsami.2c17792

A Biodegradable Magnetic Microrobot Based on Gelatin Methacrylate for Precise Delivery of Stem Cells with Mass Production Capability

Author(s): Seungmin Noh; Sungwoong Jeon; Eunhee Kim; Untaek Oh; Danbi Park; Sun Hwa Park; Sung Won Kim; Salvador Pané; Bradley J. Nelson; Jin‐young Kim; Hongsoo Choi
Published in: Small, 18 (25), Issue 4, 2022, Page(s) 2107888, ISSN 1613-6829
Publisher: Wiley-VCH
DOI: 10.1002/smll.202107888

Metal–Organic Frameworks in Motion

Author(s): Anastasia Terzopoulou, James D. Nicholas, Xiang-Zhong Chen, Bradley J. Nelson, Salvador Pané, Josep Puigmartí-Luis
Published in: Chemical Reviews, Issue 120/20, 2020, Page(s) 11175-11193, ISSN 0009-2665
Publisher: American Chemical Society
DOI: 10.1021/acs.chemrev.0c00535

Thermoset Shape Memory Polymer Variable Stiffness 4D Robotic Catheters.

Author(s): Michael Mattmann; Carmela De Marco; Francesco Briatico; Stefano Tagliabue; Aron Colusso; Xiang-Zhong Chen; Jonas Lussi; Christophe Chautems; Salvador Pané; Bradley J. Nelson
Published in: Advanced Science, Vol 9, Iss 1, Pp n/a-n/a (2022), Issue 4, 2022, Page(s) 2103277, ISSN 2198-3844
Publisher: Wiley-VCH
DOI: 10.1002/advs.202103277

Piezoelectric Nanomaterials Activated by Ultrasound: The Pathway from Discovery to Future Clinical Adoption.

Author(s): A. Cafarelli; Attilio Marino; Lorenzo Vannozzi; Josep Puigmartí-Luis; Salvador Pané; Gianni Ciofani; Leonardo Ricotti
Published in: ACS Nano 15(7), 2021, Page(s) 11066-11086, ISSN 1936-086X
Publisher: American Chemical Society
DOI: 10.1021/acsnano.1c03087

Challenges and Strategies for Optimizing Corrosion and Biodegradation Stability of Biomedical Micro‐ and Nanoswimmers: A Review

Author(s): Ehsan Rahimi; Roger Sanchis‐Gual; Xiangzhong Chen; Amin Imani; Yaiza Gonzalez‐Garcia; Edouard Asselin; Arjan Mol; Lorenzo Fedrizzi; Salvador Pané; Maria Lekka
Published in: Advanced Functional Materials, Issue 33/44, 2023, Page(s) 2210345, ISSN 1616-301X
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/adfm.202210345

Biotemplating of Metal-Organic Framework Nanocrystals for Applications in Small-Scale Robotics

Author(s): Anastasia Terzopoulou; Mario Palacios‐Corella; Carlos Franco; Semih Sevim; Thomas Dysli; Fajer Mushtaq; María Romero‐Angel; Carlos Martí‐Gastaldo; De Gong; Jun Cai; Xiang‐Zhong Chen; Martin Pumera; Andrew J. deMello; Bradley J. Nelson; Salvador Pané; Josep Puigmartí‐Luis
Published in: Advanced Functional Materials 32 (13), 2022, Page(s) 2107421, ISSN 1616-3028
Publisher: Wiley-VCH
DOI: 10.1002/adfm.202107421

Multi-target cell therapy using a magnetoelectric microscale biorobot for targeted delivery and selective differentiation of SH-SY5Y cells <i>via</i> magnetically driven cell stamping

Author(s): Hyunseok Song; Dong-in Kim; Sarmad Ahmad Abbasi; Nader Latifi Gharamaleki; Eunhee Kim; Chaewon Jin; Samhwan Kim; Junsun Hwang; Jin-Young Kim; Xiang-Zhong Chen; Bradley J. Nelson; Salvador Pané; Hongsoo Choi
Published in: Material Horizon, Issue 9, 2022, Page(s) 3031-3038, ISSN 2051-6347
Publisher: Royal Society of Chemistry
DOI: 10.1039/d2mh00693f

Strain-Sensitive Flexible Magnetoelectric Ceramic Nanocomposites

Author(s): Kim, Min-Soo; Kim, Donghoon; Aktas, Buse; Choi, Hongsoo, Puigmartí-Luis, Josep; Nelson Bradley; Pané, Salvador; Chen, Xiang-Zhong
Published in: Advanced Materials Technologies 8 (6), 2023, Page(s) 2202097, ISSN 2365-709X
Publisher: Wiley
DOI: 10.1002/admt.202202097

3D Printed Template-Assisted Casting of Biocompatible Polyvinyl Alcohol-Based Soft Microswimmers with Tunable Stability

Author(s): Roger Sanchis-Gual, Hao Ye, Towa Ueno, Fabian C. Landers, Lukas Hertle, Siyu Deng, Andrea Veciana, Yanming Xia, Carlos Franco, Hongsoo Choi, Josep Puigmartí-Luis, Bradley J. Nelson, Salvador Pané
Published in: Advanced Functional Materials 2023, 2023, Page(s) 2212952, ISSN 1616-3028
Publisher: Wiley-VCH
DOI: 10.1002/adfm.202212952

Helical Klinotactic Locomotion of Two‐Link Nanoswimmers with Dual‐Function Drug‐Loaded Soft Polysaccharide Hinges

Author(s): Jiaen Wu, Bumjin Jang, Yuval Harduf, Zvi Chapnik, Ömer Bartu Avci, Xiangzhong Chen, Josep Puigmartí‐Luis, Olgac Ergeneman, Bradley J. Nelson, Yizhar Or, Salvador Pané
Published in: Advanced Science, Issue 8/8, 2021, Page(s) 2004458, ISSN 2198-3844
Publisher: Wiley
DOI: 10.1002/advs.202004458

Shape Memory Alloy (SMA) Actuators: The Role of Material, Form, and Scaling Effects

Author(s): Min‐Soo Kim; Jae‐Kyung Heo; Hugo Rodrigue; Hyun‐Taek Lee; Salvador Pané; Min‐Woo Han; Sung‐Hoon Ahn
Published in: Advanced Materials, Issue 35 (33), 2023, Page(s) 2208517, ISSN 0935-9648
Publisher: United Nations Industrial Developement Organization
DOI: 10.1002/adma.202208517

High‐Resolution SPECT Imaging of Stimuli‐Responsive Soft Microrobots

Author(s): Veronica Iacovacci, Alain Blanc, Henwei Huang, Leonardo Ricotti, Roger Schibli, Arianna Menciassi, Martin Behe, Salvador Pané, Bradley J. Nelson
Published in: Small, Issue 15/34, 2019, Page(s) 1900709, ISSN 1613-6810
Publisher: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/smll.201900709

Strain gradient mediated magnetoelectricity in Fe-Ga/P(VDF-TrFE) multiferroic bilayers integrated on silicon

Author(s): Aliona Nicolenco, Andrés Gómez, Xiang-Zhong Chen, Enric Menéndez, Jordina Fornell, Salvador Pané, Eva Pellicer, Jordi Sort
Published in: Applied Materials Today, Issue 19, 2020, Page(s) 100579, ISSN 2352-9407
Publisher: Elsevier
DOI: 10.1016/j.apmt.2020.100579

MOFBOTS: Metal–Organic‐Framework‐Based Biomedical Microrobots

Author(s): Xiaopu Wang, Xiang‐Zhong Chen, Carlos C. J. Alcântara, Semih Sevim, Marcus Hoop, Anastasia Terzopoulou, Carmela de Marco, Chengzhi Hu, Andrew J. de Mello, Paolo Falcaro, Shuhei Furukawa, Bradley J. Nelson, Josep Puigmartí‐Luis, Salvador Pané
Published in: Advanced Materials, Issue 31/27, 2019, Page(s) 1901592, ISSN 0935-9648
Publisher: United Nations Industrial Developement Organization
DOI: 10.1002/adma.201901592

Tissue response to neural implants: the use of model systems towards new design solutions of implantable microelectrodes

Author(s): Gulino, Maurizio; Kim, Donghoon; Pané, Salvador; Santos, Sofia Duque; Pêgo, Ana Paula
Published in: Frontiers in Neuroscience, Vol 13 (2019), Issue 13, 2019, Page(s) 689, ISSN 1662-453X
Publisher: Frontiers Media
DOI: 10.3929/ethz-b-000354228

In‐Flow MOF Lithography

Author(s): Semih Sevim, Carlos Franco, Hongjun Liu, Hervé Roussel, Laetitia Rapenne, Juan Rubio‐Zuazo, Xiang‐Zhong Chen, Salvador Pané, David Muñoz‐Rojas, Andrew J. deMello, Josep Puigmartí‐Luis
Published in: Advanced Materials Technologies, Issue 4/6, 2019, Page(s) 1800666, ISSN 2365-709X
Publisher: Wiley
DOI: 10.1002/admt.201800666

Imaging Technologies for Biomedical Micro‐ and Nanoswimmers

Author(s): Salvador Pané, Josep Puigmartí‐Luis, Christos Bergeles, Xiang‐Zhong Chen, Eva Pellicer, Jordi Sort, Vanda Počepcová, Antoine Ferreira, Bradley J. Nelson
Published in: Advanced Materials Technologies, Issue 4/4, 2019, Page(s) 1800575, ISSN 2365-709X
Publisher: Wiley
DOI: 10.1002/admt.201800575

3D‐Printed Soft Magnetoelectric Microswimmers for Delivery and Differentiation of Neuron‐Like Cells

Author(s): Mei Dong, Xiaopu Wang, Xiang‐Zhong Chen, Fajer Mushtaq, Siyu Deng, Caihong Zhu, Harun Torlakcik, Anastasia Terzopoulou, Xiao‐Hua Qin, Xuanzhong Xiao, Josep Puigmartí‐Luis, Hongsoo Choi, Ana Paula Pêgo, Qun‐Dong Shen, Bradley J. Nelson, Salvador Pané
Published in: Advanced Functional Materials, Issue 30/17, 2020, Page(s) 1910323, ISSN 1616-301X
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/adfm.201910323

Biomimetic Synthesis of Sub-20 nm Covalent Organic Frameworks in Water

Author(s): Carlos Franco, David Rodríguez-San-Miguel, Alessandro Sorrenti, Semih Sevim, Ramon Pons, Ana E. Platero-Prats, Marko Pavlovic, Istvan Szilágyi, M. Luisa Ruiz Gonzalez, José M. González-Calbet, Davide Bochicchio, Luca Pesce, Giovanni M. Pavan, Inhar Imaz, Mary Cano-Sarabia, Daniel Maspoch, Salvador Pané, Andrew J. de Mello, Felix Zamora, Josep Puigmartí-Luis
Published in: Journal of the American Chemical Society, Issue 142/7, 2020, Page(s) 3540-3547, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.9b12389

Magnetic PiezoBOTs: a microrobotic approach for targeted amyloid protein dissociation

Author(s): Shen Ning, Roger Sanchis-Gual, Carlos Franco, Pedro D. Wendel-Garcia, Hao Ye, Andrea Veciana, Qiao Tang, Semih Sevim, Lukas Hertle, Joaquin Llacer-Wintle, Xiao-Hua Qin, Caihong Zhu, Jun Cai, Xiangzhong Chen, Bradley J. Nelson, Josep Puigmartí-Luis and Salvador Pané
Published in: Nanoscale, Issue 15, 2023, Page(s) 14800, ISSN 2040-3364
Publisher: Royal Society of Chemistry
DOI: 10.1039/d3nr02418k

Conductive properties of triphenylene MOFs and COFs

Author(s): Contreras-Pereda, Noemi; Pané, Salvador; Puigmartí-Luis, Josep; Ruiz-Molina, Daniel
Published in: Coordination Chemistry Reviews, Issue 460, 2022, Page(s) 214459, ISSN 0010-8545
Publisher: Elsevier BV
DOI: 10.1016/j.ccr.2022.214459

Enhanced Piezocatalytic Performance of BaTiO$_3$ Nanosheets with Highly Exposed {001} Facets

Author(s): Tang, Qiao; Wu, Jiang; Kim, Donghoon; Franco, Carlos; Terzopoulou, Anastasia; Veciana, Andrea; Puigmartí-Luis, Josep; Chen, Xiang-Zhong; Nelson, Bradley J.; Pané, Salvador
Published in: Advanced Functional Materials, 32 (35), Issue 2, 2022, Page(s) 2202180, ISSN 1616-301X
Publisher: John Wiley & Sons Ltd.
DOI: 10.3929/ethz-b-000555906

Biodegradable Metal–Organic Framework‐Based Microrobots (MOFBOTs)

Author(s): Anastasia Terzopoulou, Xiaopu Wang, Xiang‐Zhong Chen, Mario Palacios‐Corella, Carlos Pujante, Javier Herrero‐Martín, Xiao‐Hua Qin, Jordi Sort, Andrew J. deMello, Bradley J. Nelson, Josep Puigmartí‐Luis, Salvador Pané
Published in: Advanced Healthcare Materials, Issue 9/20, 2020, Page(s) 2001031, ISSN 2192-2640
Publisher: John Wiley and Sons Ltd
DOI: 10.1002/adhm.202001031

3D Motion Manipulation for Micro‐ and Nanomachines: Progress and Future Directions

Author(s): Hai Huang, Shihao Yang, Yulong Ying, Xiangzhong Chen, Josep Puigmartí-Luis, Li Zhang and Salvador Pané
Published in: Advanced Materials, 2023, Page(s) 2305925, ISSN 0935-9648
Publisher: United Nations Industrial Developement Organization
DOI: 10.1002/adma.202305925

Biodegradable Small-Scale Swimmers for Biomedical Applications.

Author(s): Joaquin Llacer-Wintle; Antón Rivas-Dapena; Xiang-Zhong Chen; Eva Pellicer; Bradley J. Nelson; Josep Puigmartí-Luis; Salvador Pané
Published in: Advanced Materials 33(42), 2021, Page(s) 2102049, ISSN 1521-4095
Publisher: Wiley-CH
DOI: 10.1002/adma.202102049

Magnetically Guided Catheters, Micro- and Nanorobots for Spinal Cord Stimulation

Author(s): Torlakcik, Harun; Sarica, Can; Bayer, Patrick; Yamamoto, Kazuaki; Iori-Morin, Christian; Hodaie, Mojgan; Kalia, Suneil K.; Neimat, Joseph S.; Hernesniemi, Juha; Bhatia, Anuj; Nelson, Bradley J.; Pané, Salvador; Lozano, Andres M.; Zemmar, Ajmal
Published in: Forntiers in Neurorobotics, Issue 15, 2021, ISSN 1662-5218
Publisher: Frontiers Research Foundation
DOI: 10.3389/fnbot.2021.749024

Tuning oxygen vacancies in Bi4Ti3O12 nanosheets to boost piezo-photocatalytic activity

Author(s): Qiao Tang; Jiang Wu; Xiang-Zhong Chen; Roger Sanchis-Gual; Andrea Veciana; Carlos Franco; Donghoon Kim; Ivan Surin; Javier Pérez-Ramírez; Michele Mattera; Anastasia Terzopoulou; Ni Qin; Marija Vukomanovic; Bradley J. Nelson; Josep Puigmartí-Luis; Salvador Pané
Published in: Nano Energy, 108, Issue 2, 2023, Page(s) 108202, ISSN 2211-2855
Publisher: Elsevier BV
DOI: 10.1016/j.nanoen.2023.108202

In flow-based technologies: A new paradigm for the synthesis and processing of covalent-organic frameworks

Author(s): Martinez-Bulit, Pablo; Sorrenti, Alessandro; Rodriguez San Miguel, David; Mattera, Michele; Belce, Yonca; Xia, Yanming; Ma, Shenglin, Huang, Mu-Hua, Pané, Salvador; Pugimartí-Luis, Josep
Published in: Chemical Engineering Journal 435(3), 2022, Page(s) 135117, ISSN 1385-8947
Publisher: Elsevier BV
DOI: 10.1016/j.cej.2022.135117

Book chapters (1)

Powering and Fabrication of Small-Scale Robotics Systems

Author(s): Salvador Pané; Pedro D. Wendel-García; Yonca Belce; Xiang-Zhong Chen; Josep Puigmartí-Luis
Published in: Current Robotics Reports, 2 (4), Issue 10, 2021, Page(s) 427-440
Publisher: Springer
DOI: 10.1007/s43154-021-00066-1

Conference proceedings (1)

Shape memory polymer variable stiffness magnetic catheters with hybrid stiffness control

Author(s): Mattmann, Michael; Boehler, Quentin; Chen, Xiang-Zhong; Pané, Salvador; Nelson, Bradley
Published in: 2022 IEEE/RSJ International Conference on Intelligent Robots and Systems (IROS), Issue 8, 2022, Page(s) 9589-9595, ISBN 978-1-6654-7927-1
Publisher: IEEE
DOI: 10.1109/iros47612.2022.9981935