Obiettivo When bionic devices such as cochlear implants, bionic eyes and brain-machine interfaces are implanted into the body they induce an inflammatory response that is difficult to control. Metals used historically for these types of devices are both stiff and inorganic, which makes them recognisable as foreign to the soft and organic human nervous system. Consequently, these implants are tolerated by the body rather than integrated and the device is walled off in a scar tissue capsule. As a result high powered and unsafe currents are required to activate tissues and produce a therapeutic response. I have brought together concepts from tissue engineering for regenerative medicine and bionic device technologies to pioneer living bioelectronics – creating a functional neural cell component as part of the device to avert scar formation. My laboratory has established a range of novel conductive polymeric biomaterials which can be used to coat existing devices or fabricate new devices from conductive polymers, hydrogels, proteins and cells.Living Bionics is based on a world-wide unique combination of technologies and proposes to combine electronic devices with cell laden polymers to generate devices that can bridge the implant interface and improve tissue integration. Pioneering and ground breaking research within Living Bionics includes:• An engineered hydrogel that can support differentiation of stem cells into neural cell networks on devices• 3D patterning of living polymer electrode arrays that contain cells• Understanding of the combined effects of environmental, biological and electrical cues to guide cell fate and create connections to nerve tissues• In vivo proof of principle in the murine modelLiving Bionics will be a ground breaking step towards safer neural cell stimulation, which is more compatible with tissue survival and regeneration. This research will create a paradigm shift in biomedical electrode design with tremendous impact on healthcare worldwide. Campo scientifico scienze naturaliscienze biologicheneurobiologiascienze mediche e della salutebiotecnologia medicaingegneria dei tessutiscienze naturaliscienze chimichescienze dei polimeriscienze mediche e della salutebiotecnologia medicatecnologie cellularicellule staminaliscienze mediche e della salutebiotecnologia medicaimpianti Parole chiave Neuroprogenitor cells Conductive polymers Medical electrodes Programma(i) H2020-EU.1.1. - EXCELLENT SCIENCE - European Research Council (ERC) Main Programme Argomento(i) ERC-2017-COG - ERC Consolidator Grant Invito a presentare proposte ERC-2017-COG Vedi altri progetti per questo bando Meccanismo di finanziamento ERC-COG - Consolidator Grant Coordinatore IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE Contribution nette de l'UE € 1 996 745,00 Indirizzo South kensington campus exhibition road SW7 2AZ London Regno Unito Mostra sulla mappa Regione London Inner London — West Westminster Tipo di attività Higher or Secondary Education Establishments Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Partecipazione a programmi di R&I dell'UE Opens in new window Rete di collaborazione HORIZON Opens in new window Altri finanziamenti € 0,00 Beneficiari (1) Classifica in ordine alfabetico Classifica per Contributo netto dell'UE Espandi tutto Riduci tutto IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE Regno Unito Contribution nette de l'UE € 1 996 745,00 Indirizzo South kensington campus exhibition road SW7 2AZ London Mostra sulla mappa Regione London Inner London — West Westminster Tipo di attività Higher or Secondary Education Establishments Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Partecipazione a programmi di R&I dell'UE Opens in new window Rete di collaborazione HORIZON Opens in new window Altri finanziamenti € 0,00
