Discovery and functional significance of post-translational N-terminal acetylation

Project Information

NterAct

Grant agreement ID: 772039

DOI 10.3030/772039

Project closed

EC signature date 13 April 2018

Start date 1 June 2018

End date 31 May 2023

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 1 999 273,00

EU contribution € 1 999 273,00

Coordinated by

UNIVERSITETET I BERGEN
Norway

Publications

Peer reviewed articles (12)

The Final Maturation State of β-actin Involves N-terminal Acetylation by NAA80, not N-terminal Arginylation by ATE1

Author(s): Adrian Drazic, Evy Timmerman, Ulrike Kajan, Michaël Marie, Sylvia Varland, Francis Impens, Kris Gevaert, Thomas Arnesen
Published in: Journal of Molecular Biology, Issue 434/2, 2022, Page(s) 167397, ISSN 0022-2836
Publisher: Academic Press
DOI: 10.1016/j.jmb.2021.167397

N-terminal acetylation shields proteins from degradation and promotes age-dependent motility and longevity

Author(s): Sylvia Varland, Rui Duarte Silva, Ine Kjosås, Alexandra Faustino, Annelies Bogaert, Maximilian Billmann, Hadi Boukhatmi, Barbara Kellen, Michael Costanzo, Adrian Drazic, Camilla Osberg, Katherine Chan, Xiang Zhang, Amy Hin Yan Tong, Simonetta Andreazza, Juliette J. Lee, Lyudmila Nedyalkova, Matej Ušaj, Alexander J. Whitworth, Brenda J. Andrews, Jason Moffat, Chad L. Myers, Kris Gevaert, Charles
Published in: Nature Communications, 2023, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-023-42342-y

Loss of N-terminal acetyltransferase A activity induces thermally unstable ribosomal proteins and increases their turnover in Saccharomyces cerevisiae

Author(s): Ulises H Guzman, Henriette Aksnes, Rasmus Ree, Nicolai Krogh, Magnus E Jakobsson, Lars J Jensen, Thomas Arnesen, Jesper V Olsen
Published in: Nature Communications, 2023, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-023-40224-x

Actin finally matures: uncovering machinery and impact

Author(s): Thomas Arnesen, Henriette Aksnes
Published in: Trends in Biochemical Sciences, Issue 48/5, 2023, Page(s) 414-416, ISSN 1362-4326
Publisher: Elsevier
DOI: 10.1016/j.tibs.2023.02.002

NATs at a glance

Author(s): Henriette Aksnes, Nina McTiernan, Thomas Arnesen
Published in: Journal of Cell Science, 2023, ISSN 0021-9533
Publisher: The Company of Biologists Ltd.
DOI: 10.1242/jcs.260766

Optimized bisubstrate inhibitors for the actin N-terminal acetyltransferase NAA80

Author(s): Line M. Myklebust, Markus Baumann, Svein I. Støve, Håvard Foyn, Thomas Arnesen, Bengt Erik Haug
Published in: Frontiers in Chemistry, Issue 11, 2023, ISSN 2296-2646
Publisher: Frontiers
DOI: 10.3389/fchem.2023.1202501

Co-translational, Post-translational, and Non-catalytic Roles of N-Terminal Acetyltransferases

Author(s): Henriette Aksnes, Rasmus Ree, Thomas Arnesen
Published in: Molecular Cell, Issue 73/6, 2019, Page(s) 1097-1114, ISSN 1097-2765
Publisher: Cell Press
DOI: 10.1016/j.molcel.2019.02.007

Actin polymerization and cell motility are affected by NAA80-mediated posttranslational N-terminal acetylation of actin

Author(s): Henriette Aksnes, Michael Marie, Thomas Arnesen, Adrian Drazic
Published in: Communicative & Integrative Biology, Issue 11/4, 2018, Page(s) e1526572, ISSN 1942-0889
Publisher: Landes Bioscience
DOI: 10.1080/19420889.2018.1526572

Mechanism of actin N-terminal acetylation

Author(s): Grzegorz Rebowski, Malgorzata Boczkowska, Adrian Drazic, Rasmus Ree, Marianne Goris, Thomas Arnesen, Roberto Dominguez
Published in: Science Advances, Issue 6/15, 2020, Page(s) eaay8793, ISSN 2375-2548
Publisher: AAAS
DOI: 10.1126/sciadv.aay8793

Molecular basis for N-terminal acetylation by human NatE and its modulation by HYPK

Author(s): Sunbin Deng, Nina McTiernan, Xuepeng Wei, Thomas Arnesen, Ronen Marmorstein
Published in: Nature Communications, Issue 11/1, 2020, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-020-14584-7

N-terminal acetylation of actin by NAA80 is essential for structural integrity of the Golgi apparatus

Author(s): Tobias B. Beigl, Monica Hellesvik, Jaakko Saraste, Thomas Arnesen, Henriette Aksnes
Published in: Experimental Cell Research, Issue 390/2, 2020, Page(s) 111961, ISSN 0014-4827
Publisher: Academic Press
DOI: 10.1016/j.yexcr.2020.111961

PFN2 and NAA80 cooperate to efficiently acetylate the N-terminus of actin

Author(s): Rasmus Ree, Laura Kind, Anna Kaziales, Sylvia Varland, Minglu Dai, Klaus Richter, Adrian Drazic, Thomas Arnesen
Published in: Journal of Biological Chemistry, Issue 295/49, 2020, Page(s) 16713-16731, ISSN 0021-9258
Publisher: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1074/jbc.ra120.015468