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Discovery and functional significance of post-translational N-terminal acetylation


The Final Maturation State of β-actin Involves N-terminal Acetylation by NAA80, not N-terminal Arginylation by ATE1

Author(s): Adrian Drazic, Evy Timmerman, Ulrike Kajan, Michaël Marie, Sylvia Varland, Francis Impens, Kris Gevaert, Thomas Arnesen
Published in: Journal of Molecular Biology, Issue 434/2, 2022, Page(s) 167397, ISSN 0022-2836
Publisher: Academic Press
DOI: 10.1016/j.jmb.2021.167397

Loss of N-terminal acetyltransferase A activity induces thermally unstable ribosomal proteins and increases their turnover in Saccharomyces cerevisiae

Author(s): Ulises H Guzman, Henriette Aksnes, Rasmus Ree, Nicolai Krogh, Magnus E Jakobsson, Lars J Jensen, Thomas Arnesen, Jesper V Olsen
Published in: Nature Communications, 2023, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-023-40224-x

Actin finally matures: uncovering machinery and impact

Author(s): Thomas Arnesen, Henriette Aksnes
Published in: Trends in Biochemical Sciences, Issue 48/5, 2023, Page(s) 414-416, ISSN 1362-4326
Publisher: Elsevier
DOI: 10.1016/j.tibs.2023.02.002

Optimized bisubstrate inhibitors for the actin N-terminal acetyltransferase NAA80

Author(s): Line M. Myklebust, Markus Baumann, Svein I. Støve, Håvard Foyn, Thomas Arnesen, Bengt Erik Haug
Published in: Frontiers in Chemistry, Issue 11, 2023, ISSN 2296-2646
Publisher: Frontiers
DOI: 10.3389/fchem.2023.1202501

Co-translational, Post-translational, and Non-catalytic Roles of N-Terminal Acetyltransferases

Author(s): Henriette Aksnes, Rasmus Ree, Thomas Arnesen
Published in: Molecular Cell, Issue 73/6, 2019, Page(s) 1097-1114, ISSN 1097-2765
Publisher: Cell Press
DOI: 10.1016/j.molcel.2019.02.007

Actin polymerization and cell motility are affected by NAA80-mediated posttranslational N-terminal acetylation of actin

Author(s): Henriette Aksnes, Michael Marie, Thomas Arnesen, Adrian Drazic
Published in: Communicative & Integrative Biology, Issue 11/4, 2018, Page(s) e1526572, ISSN 1942-0889
Publisher: Landes Bioscience
DOI: 10.1080/19420889.2018.1526572

Mechanism of actin N-terminal acetylation

Author(s): Grzegorz Rebowski, Malgorzata Boczkowska, Adrian Drazic, Rasmus Ree, Marianne Goris, Thomas Arnesen, Roberto Dominguez
Published in: Science Advances, Issue 6/15, 2020, Page(s) eaay8793, ISSN 2375-2548
Publisher: AAAS
DOI: 10.1126/sciadv.aay8793

Molecular basis for N-terminal acetylation by human NatE and its modulation by HYPK

Author(s): Sunbin Deng, Nina McTiernan, Xuepeng Wei, Thomas Arnesen, Ronen Marmorstein
Published in: Nature Communications, Issue 11/1, 2020, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-020-14584-7

N-terminal acetylation of actin by NAA80 is essential for structural integrity of the Golgi apparatus

Author(s): Tobias B. Beigl, Monica Hellesvik, Jaakko Saraste, Thomas Arnesen, Henriette Aksnes
Published in: Experimental Cell Research, Issue 390/2, 2020, Page(s) 111961, ISSN 0014-4827
Publisher: Academic Press
DOI: 10.1016/j.yexcr.2020.111961

PFN2 and NAA80 cooperate to efficiently acetylate the N-terminus of actin

Author(s): Rasmus Ree, Laura Kind, Anna Kaziales, Sylvia Varland, Minglu Dai, Klaus Richter, Adrian Drazic, Thomas Arnesen
Published in: Journal of Biological Chemistry, Issue 295/49, 2020, Page(s) 16713-16731, ISSN 0021-9258
Publisher: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1074/jbc.ra120.015468

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