Discovery and functional significance of post-translational N-terminal acetylation

Informazioni relative al progetto

NterAct

ID dell’accordo di sovvenzione: 772039

DOI 10.3030/772039

Progetto chiuso

Data della firma CE 13 Aprile 2018

Data di avvio 1 Giugno 2018

Data di completamento 31 Maggio 2023

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale € 1 999 273,00

Contributo UE € 1 999 273,00

Coordinato da

UNIVERSITETET I BERGEN
Norway

Pubblicazioni

Peer reviewed articles (12)

The Final Maturation State of β-actin Involves N-terminal Acetylation by NAA80, not N-terminal Arginylation by ATE1

Autori: Adrian Drazic, Evy Timmerman, Ulrike Kajan, Michaël Marie, Sylvia Varland, Francis Impens, Kris Gevaert, Thomas Arnesen
Pubblicato in: Journal of Molecular Biology, Numero 434/2, 2022, Pagina/e 167397, ISSN 0022-2836
Editore: Academic Press
DOI: 10.1016/j.jmb.2021.167397

N-terminal acetylation shields proteins from degradation and promotes age-dependent motility and longevity

Autori: Sylvia Varland, Rui Duarte Silva, Ine Kjosås, Alexandra Faustino, Annelies Bogaert, Maximilian Billmann, Hadi Boukhatmi, Barbara Kellen, Michael Costanzo, Adrian Drazic, Camilla Osberg, Katherine Chan, Xiang Zhang, Amy Hin Yan Tong, Simonetta Andreazza, Juliette J. Lee, Lyudmila Nedyalkova, Matej Ušaj, Alexander J. Whitworth, Brenda J. Andrews, Jason Moffat, Chad L. Myers, Kris Gevaert, Charles
Pubblicato in: Nature Communications, 2023, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-023-42342-y

Loss of N-terminal acetyltransferase A activity induces thermally unstable ribosomal proteins and increases their turnover in Saccharomyces cerevisiae

Autori: Ulises H Guzman, Henriette Aksnes, Rasmus Ree, Nicolai Krogh, Magnus E Jakobsson, Lars J Jensen, Thomas Arnesen, Jesper V Olsen
Pubblicato in: Nature Communications, 2023, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-023-40224-x

Actin finally matures: uncovering machinery and impact

Autori: Thomas Arnesen, Henriette Aksnes
Pubblicato in: Trends in Biochemical Sciences, Numero 48/5, 2023, Pagina/e 414-416, ISSN 1362-4326
Editore: Elsevier
DOI: 10.1016/j.tibs.2023.02.002

NATs at a glance

Autori: Henriette Aksnes, Nina McTiernan, Thomas Arnesen
Pubblicato in: Journal of Cell Science, 2023, ISSN 0021-9533
Editore: The Company of Biologists Ltd.
DOI: 10.1242/jcs.260766

Optimized bisubstrate inhibitors for the actin N-terminal acetyltransferase NAA80

Autori: Line M. Myklebust, Markus Baumann, Svein I. Støve, Håvard Foyn, Thomas Arnesen, Bengt Erik Haug
Pubblicato in: Frontiers in Chemistry, Numero 11, 2023, ISSN 2296-2646
Editore: Frontiers
DOI: 10.3389/fchem.2023.1202501

Co-translational, Post-translational, and Non-catalytic Roles of N-Terminal Acetyltransferases

Autori: Henriette Aksnes, Rasmus Ree, Thomas Arnesen
Pubblicato in: Molecular Cell, Numero 73/6, 2019, Pagina/e 1097-1114, ISSN 1097-2765
Editore: Cell Press
DOI: 10.1016/j.molcel.2019.02.007

Actin polymerization and cell motility are affected by NAA80-mediated posttranslational N-terminal acetylation of actin

Autori: Henriette Aksnes, Michael Marie, Thomas Arnesen, Adrian Drazic
Pubblicato in: Communicative & Integrative Biology, Numero 11/4, 2018, Pagina/e e1526572, ISSN 1942-0889
Editore: Landes Bioscience
DOI: 10.1080/19420889.2018.1526572

Mechanism of actin N-terminal acetylation

Autori: Grzegorz Rebowski, Malgorzata Boczkowska, Adrian Drazic, Rasmus Ree, Marianne Goris, Thomas Arnesen, Roberto Dominguez
Pubblicato in: Science Advances, Numero 6/15, 2020, Pagina/e eaay8793, ISSN 2375-2548
Editore: AAAS
DOI: 10.1126/sciadv.aay8793

Molecular basis for N-terminal acetylation by human NatE and its modulation by HYPK

Autori: Sunbin Deng, Nina McTiernan, Xuepeng Wei, Thomas Arnesen, Ronen Marmorstein
Pubblicato in: Nature Communications, Numero 11/1, 2020, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-020-14584-7

N-terminal acetylation of actin by NAA80 is essential for structural integrity of the Golgi apparatus

Autori: Tobias B. Beigl, Monica Hellesvik, Jaakko Saraste, Thomas Arnesen, Henriette Aksnes
Pubblicato in: Experimental Cell Research, Numero 390/2, 2020, Pagina/e 111961, ISSN 0014-4827
Editore: Academic Press
DOI: 10.1016/j.yexcr.2020.111961

PFN2 and NAA80 cooperate to efficiently acetylate the N-terminus of actin

Autori: Rasmus Ree, Laura Kind, Anna Kaziales, Sylvia Varland, Minglu Dai, Klaus Richter, Adrian Drazic, Thomas Arnesen
Pubblicato in: Journal of Biological Chemistry, Numero 295/49, 2020, Pagina/e 16713-16731, ISSN 0021-9258
Editore: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1074/jbc.ra120.015468