Discovery and functional significance of post-translational N-terminal acetylation

Publicaciones

The Final Maturation State of β-actin Involves N-terminal Acetylation by NAA80, not N-terminal Arginylation by ATE1

Autores: Adrian Drazic, Evy Timmerman, Ulrike Kajan, Michaël Marie, Sylvia Varland, Francis Impens, Kris Gevaert, Thomas Arnesen
Publicado en: Journal of Molecular Biology, Edición 434/2, 2022, Página(s) 167397, ISSN 0022-2836
Editor: Academic Press
DOI: 10.1016/j.jmb.2021.167397

N-terminal acetylation shields proteins from degradation and promotes age-dependent motility and longevity

Autores: Sylvia Varland, Rui Duarte Silva, Ine Kjosås, Alexandra Faustino, Annelies Bogaert, Maximilian Billmann, Hadi Boukhatmi, Barbara Kellen, Michael Costanzo, Adrian Drazic, Camilla Osberg, Katherine Chan, Xiang Zhang, Amy Hin Yan Tong, Simonetta Andreazza, Juliette J. Lee, Lyudmila Nedyalkova, Matej Ušaj, Alexander J. Whitworth, Brenda J. Andrews, Jason Moffat, Chad L. Myers, Kris Gevaert, Charles
Publicado en: Nature Communications, 2023, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-023-42342-y

Loss of N-terminal acetyltransferase A activity induces thermally unstable ribosomal proteins and increases their turnover in Saccharomyces cerevisiae

Autores: Ulises H Guzman, Henriette Aksnes, Rasmus Ree, Nicolai Krogh, Magnus E Jakobsson, Lars J Jensen, Thomas Arnesen, Jesper V Olsen
Publicado en: Nature Communications, 2023, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-023-40224-x

Actin finally matures: uncovering machinery and impact

Autores: Thomas Arnesen, Henriette Aksnes
Publicado en: Trends in Biochemical Sciences, Edición 48/5, 2023, Página(s) 414-416, ISSN 1362-4326
Editor: Elsevier
DOI: 10.1016/j.tibs.2023.02.002

NATs at a glance

Autores: Henriette Aksnes, Nina McTiernan, Thomas Arnesen
Publicado en: Journal of Cell Science, 2023, ISSN 0021-9533
Editor: The Company of Biologists Ltd.
DOI: 10.1242/jcs.260766

Optimized bisubstrate inhibitors for the actin N-terminal acetyltransferase NAA80

Autores: Line M. Myklebust, Markus Baumann, Svein I. Støve, Håvard Foyn, Thomas Arnesen, Bengt Erik Haug
Publicado en: Frontiers in Chemistry, Edición 11, 2023, ISSN 2296-2646
Editor: Frontiers
DOI: 10.3389/fchem.2023.1202501

Co-translational, Post-translational, and Non-catalytic Roles of N-Terminal Acetyltransferases

Autores: Henriette Aksnes, Rasmus Ree, Thomas Arnesen
Publicado en: Molecular Cell, Edición 73/6, 2019, Página(s) 1097-1114, ISSN 1097-2765
Editor: Cell Press
DOI: 10.1016/j.molcel.2019.02.007

Actin polymerization and cell motility are affected by NAA80-mediated posttranslational N-terminal acetylation of actin

Autores: Henriette Aksnes, Michael Marie, Thomas Arnesen, Adrian Drazic
Publicado en: Communicative & Integrative Biology, Edición 11/4, 2018, Página(s) e1526572, ISSN 1942-0889
Editor: Landes Bioscience
DOI: 10.1080/19420889.2018.1526572

Mechanism of actin N-terminal acetylation

Autores: Grzegorz Rebowski, Malgorzata Boczkowska, Adrian Drazic, Rasmus Ree, Marianne Goris, Thomas Arnesen, Roberto Dominguez
Publicado en: Science Advances, Edición 6/15, 2020, Página(s) eaay8793, ISSN 2375-2548
Editor: AAAS
DOI: 10.1126/sciadv.aay8793

Molecular basis for N-terminal acetylation by human NatE and its modulation by HYPK

Autores: Sunbin Deng, Nina McTiernan, Xuepeng Wei, Thomas Arnesen, Ronen Marmorstein
Publicado en: Nature Communications, Edición 11/1, 2020, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-020-14584-7

N-terminal acetylation of actin by NAA80 is essential for structural integrity of the Golgi apparatus

Autores: Tobias B. Beigl, Monica Hellesvik, Jaakko Saraste, Thomas Arnesen, Henriette Aksnes
Publicado en: Experimental Cell Research, Edición 390/2, 2020, Página(s) 111961, ISSN 0014-4827
Editor: Academic Press
DOI: 10.1016/j.yexcr.2020.111961

PFN2 and NAA80 cooperate to efficiently acetylate the N-terminus of actin

Autores: Rasmus Ree, Laura Kind, Anna Kaziales, Sylvia Varland, Minglu Dai, Klaus Richter, Adrian Drazic, Thomas Arnesen
Publicado en: Journal of Biological Chemistry, Edición 295/49, 2020, Página(s) 16713-16731, ISSN 0021-9258
Editor: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1074/jbc.ra120.015468

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