Discovery and functional significance of post-translational N-terminal acetylation

Publications

The Final Maturation State of β-actin Involves N-terminal Acetylation by NAA80, not N-terminal Arginylation by ATE1

Auteurs: Adrian Drazic, Evy Timmerman, Ulrike Kajan, Michaël Marie, Sylvia Varland, Francis Impens, Kris Gevaert, Thomas Arnesen
Publié dans: Journal of Molecular Biology, Numéro 434/2, 2022, Page(s) 167397, ISSN 0022-2836
Éditeur: Academic Press
DOI: 10.1016/j.jmb.2021.167397

N-terminal acetylation shields proteins from degradation and promotes age-dependent motility and longevity

Auteurs: Sylvia Varland, Rui Duarte Silva, Ine Kjosås, Alexandra Faustino, Annelies Bogaert, Maximilian Billmann, Hadi Boukhatmi, Barbara Kellen, Michael Costanzo, Adrian Drazic, Camilla Osberg, Katherine Chan, Xiang Zhang, Amy Hin Yan Tong, Simonetta Andreazza, Juliette J. Lee, Lyudmila Nedyalkova, Matej Ušaj, Alexander J. Whitworth, Brenda J. Andrews, Jason Moffat, Chad L. Myers, Kris Gevaert, Charles
Publié dans: Nature Communications, 2023, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-023-42342-y

Loss of N-terminal acetyltransferase A activity induces thermally unstable ribosomal proteins and increases their turnover in Saccharomyces cerevisiae

Auteurs: Ulises H Guzman, Henriette Aksnes, Rasmus Ree, Nicolai Krogh, Magnus E Jakobsson, Lars J Jensen, Thomas Arnesen, Jesper V Olsen
Publié dans: Nature Communications, 2023, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-023-40224-x

Actin finally matures: uncovering machinery and impact

Auteurs: Thomas Arnesen, Henriette Aksnes
Publié dans: Trends in Biochemical Sciences, Numéro 48/5, 2023, Page(s) 414-416, ISSN 1362-4326
Éditeur: Elsevier
DOI: 10.1016/j.tibs.2023.02.002

NATs at a glance

Auteurs: Henriette Aksnes, Nina McTiernan, Thomas Arnesen
Publié dans: Journal of Cell Science, 2023, ISSN 0021-9533
Éditeur: The Company of Biologists Ltd.
DOI: 10.1242/jcs.260766

Optimized bisubstrate inhibitors for the actin N-terminal acetyltransferase NAA80

Auteurs: Line M. Myklebust, Markus Baumann, Svein I. Støve, Håvard Foyn, Thomas Arnesen, Bengt Erik Haug
Publié dans: Frontiers in Chemistry, Numéro 11, 2023, ISSN 2296-2646
Éditeur: Frontiers
DOI: 10.3389/fchem.2023.1202501

Co-translational, Post-translational, and Non-catalytic Roles of N-Terminal Acetyltransferases

Auteurs: Henriette Aksnes, Rasmus Ree, Thomas Arnesen
Publié dans: Molecular Cell, Numéro 73/6, 2019, Page(s) 1097-1114, ISSN 1097-2765
Éditeur: Cell Press
DOI: 10.1016/j.molcel.2019.02.007

Actin polymerization and cell motility are affected by NAA80-mediated posttranslational N-terminal acetylation of actin

Auteurs: Henriette Aksnes, Michael Marie, Thomas Arnesen, Adrian Drazic
Publié dans: Communicative & Integrative Biology, Numéro 11/4, 2018, Page(s) e1526572, ISSN 1942-0889
Éditeur: Landes Bioscience
DOI: 10.1080/19420889.2018.1526572

Mechanism of actin N-terminal acetylation

Auteurs: Grzegorz Rebowski, Malgorzata Boczkowska, Adrian Drazic, Rasmus Ree, Marianne Goris, Thomas Arnesen, Roberto Dominguez
Publié dans: Science Advances, Numéro 6/15, 2020, Page(s) eaay8793, ISSN 2375-2548
Éditeur: AAAS
DOI: 10.1126/sciadv.aay8793

Molecular basis for N-terminal acetylation by human NatE and its modulation by HYPK

Auteurs: Sunbin Deng, Nina McTiernan, Xuepeng Wei, Thomas Arnesen, Ronen Marmorstein
Publié dans: Nature Communications, Numéro 11/1, 2020, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-020-14584-7

N-terminal acetylation of actin by NAA80 is essential for structural integrity of the Golgi apparatus

Auteurs: Tobias B. Beigl, Monica Hellesvik, Jaakko Saraste, Thomas Arnesen, Henriette Aksnes
Publié dans: Experimental Cell Research, Numéro 390/2, 2020, Page(s) 111961, ISSN 0014-4827
Éditeur: Academic Press
DOI: 10.1016/j.yexcr.2020.111961

PFN2 and NAA80 cooperate to efficiently acetylate the N-terminus of actin

Auteurs: Rasmus Ree, Laura Kind, Anna Kaziales, Sylvia Varland, Minglu Dai, Klaus Richter, Adrian Drazic, Thomas Arnesen
Publié dans: Journal of Biological Chemistry, Numéro 295/49, 2020, Page(s) 16713-16731, ISSN 0021-9258
Éditeur: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1074/jbc.ra120.015468

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