Tailoring the functional Capacity of Cytotoxic T cells for future Therapies

Project Information

ToCCaTa

Grant agreement ID: 772473

DOI 10.3030/772473

Project closed

EC signature date 22 February 2018

Start date 1 October 2018

End date 30 September 2023

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 1 999 850,00

EU contribution € 1 999 850,00

Coordinated by

TECHNISCHE UNIVERSITAET MUENCHEN
Germany

Publications

Peer reviewed articles (11)

A single-amino acid substitution in the adaptor LAT accelerates TCR proofreading kinetics and alters T-cell selection, maintenance and function

Author(s): Wan-Lin Lo, Miriam Kuhlmann, Gabrielle Rizzuto, H. Atakan Ekiz, Elizabeth M. Kolawole, Monica P. Revelo, Rakieb Andargachew, Zhongmei Li, Yuan-Li Tsai, Alexander Marson, Brian D. Evavold, Dietmar Zehn & Arthur Weiss
Published in: Nature Immunology, Issue 2023 Apr;24(4):676-689, 2023, Page(s) 676-689, ISSN 1529-2908
Publisher: Nature Publishing Group
DOI: 10.1038/s41590-023-01444-x

Tailoring the resolution of single-cell RNA sequencing for primary cytotoxic T cells

Author(s): Kristiyan Kanev, Patrick Roelli, Ming Wu, Christine Wurmser, Mauro Delorenzi, Michael W. Pfaffl, Dietmar Zehn
Published in: Nature Communications, Issue 12/1, 2021, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-020-20751-7

Inflammatory signals are sufficient to elicit TOX expression in mouse and human CD8+ T cells.

Author(s): Nicholas J. Maurice; Jacqueline Berner; Alexis K Taber; Dietmar Zehn; Martin Prlic
Published in: JCI insight, 2021, ISSN 2379-3708
Publisher: American Society for Clinical Investigation
DOI: 10.1172/jci.insight.150744

Pyrimidine de novo synthesis inhibition selectively blocks effector but not memory T cell development

Author(s): Stefanie Scherer, Susanne G. Oberle, Kristiyan Kanev, Ann-Katrin Gerullis, Ming Wu, Gustavo P. de Almeida, Daniel J. Puleston, Francesc Baixauli, Lilian Aly, Alessandro Greco, Tamar Nizharadze, Nils B. Becker, Madlaina v. Hoesslin, Lara V. Donhauser, Jacqueline Berner, Talyn Chu, Hayley A. McNamara, Zeynep Esencan, Patrick Roelli, Christine Wurmser, Ingo Kleiter, Maria J. G. T. Vehreschild, Christ
Published in: Nature Immunology, Issue 2023 Mar;24(3):501-515, 2023, Page(s) 501-515, ISSN 1529-2908
Publisher: Nature Publishing Group
DOI: 10.1038/s41590-023-01436-x

Proliferation-competent Tcf1+ CD8 T cells in dysfunctional populations are CD4 T cell help independent

Author(s): Kristiyan Kanev, Ming Wu, Antar Drews, Patrick Roelli, Christine Wurmser, Madlaina von Hösslin, Dietmar Zehn
Published in: Proceedings of the National Academy of Sciences, Issue 116/40, 2019, Page(s) 20070-20076, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.1902701116

TOX reinforces the phenotype and longevity of exhausted T cells in chronic viral infection

Author(s): Francesca Alfei, Kristiyan Kanev, Maike Hofmann, Ming Wu, Hazem E. Ghoneim, Patrick Roelli, Daniel T. Utzschneider, Madlaina von Hoesslin, Jolie G. Cullen, Yiping Fan, Vasyl Eisenberg, Dirk Wohlleber, Katja Steiger, Doron Merkler, Mauro Delorenzi, Percy A. Knolle, Cyrille J. Cohen, Robert Thimme, Benjamin Youngblood, Dietmar Zehn
Published in: Nature, Issue 571/7764, 2019, Page(s) 265-269, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-019-1326-9

Tailoring the resolution of single-cell RNA sequencing for primary cytotoxic T cells

Author(s): Kanev, Kristiyan; Roelli, Patrick; Wu, Ming; Wurmser, Christine; Delorenzi, Mauro; Pfaffl, Michael W.; Zehn, Dietmar
Published in: Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021), 2021, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-020-20751-7

PTPN2 Deficiency Enhances Programmed T Cell Expansion and Survival Capacity of Activated T Cells

Author(s): Markus Flosbach, Susanne G. Oberle, Stefanie Scherer, Jana Zecha, Madlaina von Hoesslin, Florian Wiede, Vijaykumar Chennupati, Jolie G. Cullen, Markus List, Josch K. Pauling, Jan Baumbach, Bernhard Kuster, Tony Tiganis, Dietmar Zehn
Published in: Cell Reports, Issue 32/4, 2020, Page(s) 107957, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2020.107957

PTPN2 Deficiency Enhances Programmed T Cell Expansion and Survival Capacity of Activated T Cells

Author(s): Markus Flosbach; Susanne Oberle; Stefanie Scherer; Stefanie Scherer; Jana Zecha; Madlaina von Hoesslin; Florian Wiede; Florian Wiede; Vijaykumar Chennupati; Jolie G. Cullen; Markus List; Josch Konstantin Pauling; Jan Baumbach; Bernhard Kuster; Tony Tiganis; Tony Tiganis; Dietmar Zehn; Dietmar Zehn
Published in: Cell Reports, Vol 32, Iss 4, Pp 107957- (2020), 2020, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2020.107957

Inflammatory signals are sufficient to elicit TOX expression in mouse and human CD8 T cells

Author(s): Nicholas J. Maurice, Jacqueline Berner, Alexis K. Taber, Dietmar Zehn, Martin Prlic
Published in: JCI Insight, 2021, ISSN 2379-3708
Publisher: The American Society for Clinical Investigation (ASCI)
DOI: 10.1172/jci.insight.150744

Origin and fine-tuning of effector CD8 T cell subpopulations in chronic infection

Author(s): Kristiyan Kanev, Dietmar Zehn
Published in: Current Opinion in Virology, Issue 46, 2021, Page(s) 27-35, ISSN 1879-6257
Publisher: Elsevier BV
DOI: 10.1016/j.coviro.2020.10.003