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Tailoring the functional Capacity of Cytotoxic T cells for future Therapies

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Publications

Beta cell-specific CD8+ T cells maintain stem cell memory-associated epigenetic programs during type 1 diabetes

Author(s): Hossam A. Abdelsamed, Caitlin C. Zebley, Hai Nguyen, Rachel L. Rutishauser, Yiping Fan, Hazem E. Ghoneim, Jeremy Chase Crawford, Francesca Alfei, Shanta Alli, Susan Pereira Ribeiro, Ashley H. Castellaw, Maureen A. McGargill, Hongjian Jin, Shannon K. Boi, Cate Speake, Elisavet Serti, Laurence A. Turka, Michael E. Busch, Mars Stone, Steven G. Deeks, Rafick-Pierre Sekaly, Dietmar Zehn, Eddie A. James
Published in: Nature Immunology, Issue 21/5, 2020, Page(s) 578-587, ISSN 1529-2908
DOI: 10.1038/s41590-020-0633-5

Cell-intrinsic adrenergic signaling controls the adaptive NK cell response to viral infection

Author(s): Carlos Diaz-Salazar, Regina Bou-Puerto, Adriana M. Mujal, Colleen M. Lau, Madlaina von Hoesslin, Dietmar Zehn, Joseph C. Sun
Published in: Journal of Experimental Medicine, Issue 217/4, 2020, ISSN 0022-1007
DOI: 10.1084/jem.20190549

Dynamics of the Coreceptor-LCK Interactions during T Cell Development Shape the Self-Reactivity of Peripheral CD4 and CD8 T Cells

Author(s): Veronika Horkova, Ales Drobek, Daniel Mueller, Celine Gubser, Veronika Niederlova, Lena Wyss, Carolyn G. King, Dietmar Zehn, Ondrej Stepanek
Published in: Cell Reports, Issue 30/5, 2020, Page(s) 1504-1514.e7, ISSN 2211-1247
DOI: 10.1016/j.celrep.2020.01.008

Lymphatic endothelial cells prime naïve CD8+ T cells into memory cells under steady-state conditions

Author(s): Efthymia Vokali, Shann S. Yu, Sachiko Hirosue, Marcela Rinçon-Restrepo, Fernanda V. Duraes, Stefanie Scherer, Patricia Corthésy-Henrioud, Witold W. Kilarski, Anna Mondino, Dietmar Zehn, Stéphanie Hugues, Melody A. Swartz
Published in: Nature Communications, Issue 11/1, 2020, ISSN 2041-1723
DOI: 10.1038/s41467-019-14127-9

MiR-23~27~24–mediated control of humoral immunity reveals a TOX-driven regulatory circuit in follicular helper T cell differentiation

Author(s): Cheng-Jang Wu, Sunglim Cho, Hsi-Yuan Huang, Chun-Hao Lu, Jasmin Russ, Leilani O. Cruz, Flavia Franco da Cunha, Mei-Chi Chen, Ling-Li Lin, Lindsey M. Warner, Hsin-Kai Liao, Daniel T. Utzschneider, Sara Quon, Jacqueline Berner, Niels Olsen Saraiva Camara, Dietmar Zehn, Juan Carlos Izpisua Belmonte, Li-Chen Chen, Shiang-Fu Huang, Ming-Ling Kuo, Li-Fan Lu
Published in: Science Advances, Issue 5/12, 2019, Page(s) eaaw1715, ISSN 2375-2548
DOI: 10.1126/sciadv.aaw1715

Precursor exhausted T cells: key to successful immunotherapy?

Author(s): Axel Kallies, Dietmar Zehn, Daniel T. Utzschneider
Published in: Nature Reviews Immunology, Issue 20/2, 2020, Page(s) 128-136, ISSN 1474-1733
DOI: 10.1038/s41577-019-0223-7

Defining ‘T cell exhaustion’

Author(s): Christian U. Blank, W. Nicholas Haining, Werner Held, Patrick G. Hogan, Axel Kallies, Enrico Lugli, Rachel C. Lynn, Mary Philip, Anjana Rao, Nicholas P. Restifo, Andrea Schietinger, Ton N. Schumacher, Pamela L. Schwartzberg, Arlene H. Sharpe, Daniel E. Speiser, E. John Wherry, Benjamin A. Youngblood, Dietmar Zehn
Published in: Nature Reviews Immunology, Issue 19/11, 2019, Page(s) 665-674, ISSN 1474-1733
DOI: 10.1038/s41577-019-0221-9

Proliferation-competent Tcf1+ CD8 T cells in dysfunctional populations are CD4 T cell help independent

Author(s): Kristiyan Kanev, Ming Wu, Antar Drews, Patrick Roelli, Christine Wurmser, Madlaina von Hösslin, Dietmar Zehn
Published in: Proceedings of the National Academy of Sciences, Issue 116/40, 2019, Page(s) 20070-20076, ISSN 0027-8424
DOI: 10.1073/pnas.1902701116

Attenuation of chronic antiviral T-cell responses through constitutive COX2-dependent prostanoid synthesis by lymph node fibroblasts

Author(s): Karin Schaeuble, Hélène Cannelle, Stéphanie Favre, Hsin-Ying Huang, Susanne G. Oberle, Daniel E. Speiser, Dietmar Zehn, Sanjiv A. Luther
Published in: PLOS Biology, Issue 17/7, 2019, Page(s) e3000072, ISSN 1545-7885
DOI: 10.1371/journal.pbio.3000072

TOX reinforces the phenotype and longevity of exhausted T cells in chronic viral infection

Author(s): Francesca Alfei, Kristiyan Kanev, Maike Hofmann, Ming Wu, Hazem E. Ghoneim, Patrick Roelli, Daniel T. Utzschneider, Madlaina von Hoesslin, Jolie G. Cullen, Yiping Fan, Vasyl Eisenberg, Dirk Wohlleber, Katja Steiger, Doron Merkler, Mauro Delorenzi, Percy A. Knolle, Cyrille J. Cohen, Robert Thimme, Benjamin Youngblood, Dietmar Zehn
Published in: Nature, Issue 571/7764, 2019, Page(s) 265-269, ISSN 0028-0836
DOI: 10.1038/s41586-019-1326-9

Polyamines and eIF5A Hypusination Modulate Mitochondrial Respiration and Macrophage Activation

Author(s): Daniel J. Puleston, Michael D. Buck, Ramon I. Klein Geltink, Ryan L. Kyle, George Caputa, David O’Sullivan, Alanna M. Cameron, Angela Castoldi, Yaarub Musa, Agnieszka M. Kabat, Ying Zhang, Lea J. Flachsmann, Cameron S. Field, Annette E. Patterson, Stefanie Scherer, Francesca Alfei, Francesc Baixauli, S. Kyle Austin, Beth Kelly, Mai Matsushita, Jonathan D. Curtis, Katarzyna M. Grzes, Matteo Villa
Published in: Cell Metabolism, Issue 30/2, 2019, Page(s) 352-363.e8, ISSN 1550-4131
DOI: 10.1016/j.cmet.2019.05.003

Acetate Promotes T Cell Effector Function during Glucose Restriction

Author(s): Jing Qiu, Matteo Villa, David E. Sanin, Michael D. Buck, David O’Sullivan, Reagan Ching, Mai Matsushita, Katarzyna M. Grzes, Frances Winkler, Chih-Hao Chang, Jonathan D. Curtis, Ryan L. Kyle, Nikki Van Teijlingen Bakker, Mauro Corrado, Fabian Haessler, Francesca Alfei, Joy Edwards-Hicks, Leonard B. Maggi, Dietmar Zehn, Takeshi Egawa, Bertram Bengsch, Ramon I. Klein Geltink, Thomas Jenuwein, Edwa
Published in: Cell Reports, Issue 27/7, 2019, Page(s) 2063-2074.e5, ISSN 2211-1247
DOI: 10.1016/j.celrep.2019.04.022

MicroRNA-155 Expression Is Enhanced by T-cell Receptor Stimulation Strength and Correlates with Improved Tumor Control in Melanoma

Author(s): Amaia Martinez-Usatorre, Lorenzo F. Sempere, Santiago J. Carmona, Laura Carretero-Iglesia, Gwennaëlle Monnot, Daniel E. Speiser, Nathalie Rufer, Alena Donda, Dietmar Zehn, Camilla Jandus, Pedro Romero
Published in: Cancer Immunology Research, Issue 7/6, 2019, Page(s) 1013-1024, ISSN 2326-6066
DOI: 10.1158/2326-6066.cir-18-0504

Leveraging TCR Affinity in Adoptive Immunotherapy against Shared Tumor/Self-Antigens

Author(s): Aaron M. Miller, Milad Bahmanof, Dietmar Zehn, Ezra E.W. Cohen, Stephen P. Schoenberger
Published in: Cancer Immunology Research, Issue 7/1, 2019, Page(s) 40-49, ISSN 2326-6066
DOI: 10.1158/2326-6066.cir-18-0371

Perforin inhibition protects from lethal endothelial damage during fulminant viral hepatitis

Author(s): M. Welz, S. Eickhoff, Z. Abdullah, J. Trebicka, K. H. Gartlan, J. A. Spicer, A. J. Demetris, H. Akhlaghi, M. Anton, K. Manske, D. Zehn, B. Nieswandt, C. Kurts, J. A. Trapani, P. Knolle, D. Wohlleber, W. Kastenmüller
Published in: Nature Communications, Issue 9/1, 2018, ISSN 2041-1723
DOI: 10.1038/s41467-018-07213-x