Tailoring the functional Capacity of Cytotoxic T cells for future Therapies

Informazioni relative al progetto

ToCCaTa

ID dell’accordo di sovvenzione: 772473

DOI 10.3030/772473

Progetto chiuso

Data della firma CE 22 Febbraio 2018

Data di avvio 1 Ottobre 2018

Data di completamento 30 Settembre 2023

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale € 1 999 850,00

Contributo UE € 1 999 850,00

Coordinato da

TECHNISCHE UNIVERSITAET MUENCHEN
Germany

Pubblicazioni

Peer reviewed articles (11)

A single-amino acid substitution in the adaptor LAT accelerates TCR proofreading kinetics and alters T-cell selection, maintenance and function

Autori: Wan-Lin Lo, Miriam Kuhlmann, Gabrielle Rizzuto, H. Atakan Ekiz, Elizabeth M. Kolawole, Monica P. Revelo, Rakieb Andargachew, Zhongmei Li, Yuan-Li Tsai, Alexander Marson, Brian D. Evavold, Dietmar Zehn & Arthur Weiss
Pubblicato in: Nature Immunology, Numero 2023 Apr;24(4):676-689, 2023, Pagina/e 676-689, ISSN 1529-2908
Editore: Nature Publishing Group
DOI: 10.1038/s41590-023-01444-x

Tailoring the resolution of single-cell RNA sequencing for primary cytotoxic T cells

Autori: Kristiyan Kanev, Patrick Roelli, Ming Wu, Christine Wurmser, Mauro Delorenzi, Michael W. Pfaffl, Dietmar Zehn
Pubblicato in: Nature Communications, Numero 12/1, 2021, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-020-20751-7

Inflammatory signals are sufficient to elicit TOX expression in mouse and human CD8+ T cells.

Autori: Nicholas J. Maurice; Jacqueline Berner; Alexis K Taber; Dietmar Zehn; Martin Prlic
Pubblicato in: JCI insight, 2021, ISSN 2379-3708
Editore: American Society for Clinical Investigation
DOI: 10.1172/jci.insight.150744

Pyrimidine de novo synthesis inhibition selectively blocks effector but not memory T cell development

Autori: Stefanie Scherer, Susanne G. Oberle, Kristiyan Kanev, Ann-Katrin Gerullis, Ming Wu, Gustavo P. de Almeida, Daniel J. Puleston, Francesc Baixauli, Lilian Aly, Alessandro Greco, Tamar Nizharadze, Nils B. Becker, Madlaina v. Hoesslin, Lara V. Donhauser, Jacqueline Berner, Talyn Chu, Hayley A. McNamara, Zeynep Esencan, Patrick Roelli, Christine Wurmser, Ingo Kleiter, Maria J. G. T. Vehreschild, Christ
Pubblicato in: Nature Immunology, Numero 2023 Mar;24(3):501-515, 2023, Pagina/e 501-515, ISSN 1529-2908
Editore: Nature Publishing Group
DOI: 10.1038/s41590-023-01436-x

Proliferation-competent Tcf1+ CD8 T cells in dysfunctional populations are CD4 T cell help independent

Autori: Kristiyan Kanev, Ming Wu, Antar Drews, Patrick Roelli, Christine Wurmser, Madlaina von Hösslin, Dietmar Zehn
Pubblicato in: Proceedings of the National Academy of Sciences, Numero 116/40, 2019, Pagina/e 20070-20076, ISSN 0027-8424
Editore: National Academy of Sciences
DOI: 10.1073/pnas.1902701116

TOX reinforces the phenotype and longevity of exhausted T cells in chronic viral infection

Autori: Francesca Alfei, Kristiyan Kanev, Maike Hofmann, Ming Wu, Hazem E. Ghoneim, Patrick Roelli, Daniel T. Utzschneider, Madlaina von Hoesslin, Jolie G. Cullen, Yiping Fan, Vasyl Eisenberg, Dirk Wohlleber, Katja Steiger, Doron Merkler, Mauro Delorenzi, Percy A. Knolle, Cyrille J. Cohen, Robert Thimme, Benjamin Youngblood, Dietmar Zehn
Pubblicato in: Nature, Numero 571/7764, 2019, Pagina/e 265-269, ISSN 0028-0836
Editore: Nature Publishing Group
DOI: 10.1038/s41586-019-1326-9

Tailoring the resolution of single-cell RNA sequencing for primary cytotoxic T cells

Autori: Kanev, Kristiyan; Roelli, Patrick; Wu, Ming; Wurmser, Christine; Delorenzi, Mauro; Pfaffl, Michael W.; Zehn, Dietmar
Pubblicato in: Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021), 2021, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-020-20751-7

PTPN2 Deficiency Enhances Programmed T Cell Expansion and Survival Capacity of Activated T Cells

Autori: Markus Flosbach, Susanne G. Oberle, Stefanie Scherer, Jana Zecha, Madlaina von Hoesslin, Florian Wiede, Vijaykumar Chennupati, Jolie G. Cullen, Markus List, Josch K. Pauling, Jan Baumbach, Bernhard Kuster, Tony Tiganis, Dietmar Zehn
Pubblicato in: Cell Reports, Numero 32/4, 2020, Pagina/e 107957, ISSN 2211-1247
Editore: Cell Press
DOI: 10.1016/j.celrep.2020.107957

PTPN2 Deficiency Enhances Programmed T Cell Expansion and Survival Capacity of Activated T Cells

Autori: Markus Flosbach; Susanne Oberle; Stefanie Scherer; Stefanie Scherer; Jana Zecha; Madlaina von Hoesslin; Florian Wiede; Florian Wiede; Vijaykumar Chennupati; Jolie G. Cullen; Markus List; Josch Konstantin Pauling; Jan Baumbach; Bernhard Kuster; Tony Tiganis; Tony Tiganis; Dietmar Zehn; Dietmar Zehn
Pubblicato in: Cell Reports, Vol 32, Iss 4, Pp 107957- (2020), 2020, ISSN 2211-1247
Editore: Cell Press
DOI: 10.1016/j.celrep.2020.107957

Inflammatory signals are sufficient to elicit TOX expression in mouse and human CD8 T cells

Autori: Nicholas J. Maurice, Jacqueline Berner, Alexis K. Taber, Dietmar Zehn, Martin Prlic
Pubblicato in: JCI Insight, 2021, ISSN 2379-3708
Editore: The American Society for Clinical Investigation (ASCI)
DOI: 10.1172/jci.insight.150744

Origin and fine-tuning of effector CD8 T cell subpopulations in chronic infection

Autori: Kristiyan Kanev, Dietmar Zehn
Pubblicato in: Current Opinion in Virology, Numero 46, 2021, Pagina/e 27-35, ISSN 1879-6257
Editore: Elsevier BV
DOI: 10.1016/j.coviro.2020.10.003