Tailoring the functional Capacity of Cytotoxic T cells for future Therapies

Publicaciones

A single-amino acid substitution in the adaptor LAT accelerates TCR proofreading kinetics and alters T-cell selection, maintenance and function

Autores: Wan-Lin Lo, Miriam Kuhlmann, Gabrielle Rizzuto, H. Atakan Ekiz, Elizabeth M. Kolawole, Monica P. Revelo, Rakieb Andargachew, Zhongmei Li, Yuan-Li Tsai, Alexander Marson, Brian D. Evavold, Dietmar Zehn & Arthur Weiss
Publicado en: Nature Immunology, Edición 2023 Apr;24(4):676-689, 2023, Página(s) 676-689, ISSN 1529-2908
Editor: Nature Publishing Group
DOI: 10.1038/s41590-023-01444-x

Tailoring the resolution of single-cell RNA sequencing for primary cytotoxic T cells

Autores: Kristiyan Kanev, Patrick Roelli, Ming Wu, Christine Wurmser, Mauro Delorenzi, Michael W. Pfaffl, Dietmar Zehn
Publicado en: Nature Communications, Edición 12/1, 2021, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-020-20751-7

Inflammatory signals are sufficient to elicit TOX expression in mouse and human CD8+ T cells.

Autores: Nicholas J. Maurice; Jacqueline Berner; Alexis K Taber; Dietmar Zehn; Martin Prlic
Publicado en: JCI insight, 2021, ISSN 2379-3708
Editor: American Society for Clinical Investigation
DOI: 10.1172/jci.insight.150744

Pyrimidine de novo synthesis inhibition selectively blocks effector but not memory T cell development

Autores: Stefanie Scherer, Susanne G. Oberle, Kristiyan Kanev, Ann-Katrin Gerullis, Ming Wu, Gustavo P. de Almeida, Daniel J. Puleston, Francesc Baixauli, Lilian Aly, Alessandro Greco, Tamar Nizharadze, Nils B. Becker, Madlaina v. Hoesslin, Lara V. Donhauser, Jacqueline Berner, Talyn Chu, Hayley A. McNamara, Zeynep Esencan, Patrick Roelli, Christine Wurmser, Ingo Kleiter, Maria J. G. T. Vehreschild, Christ
Publicado en: Nature Immunology, Edición 2023 Mar;24(3):501-515, 2023, Página(s) 501-515, ISSN 1529-2908
Editor: Nature Publishing Group
DOI: 10.1038/s41590-023-01436-x

Proliferation-competent Tcf1+ CD8 T cells in dysfunctional populations are CD4 T cell help independent

Autores: Kristiyan Kanev, Ming Wu, Antar Drews, Patrick Roelli, Christine Wurmser, Madlaina von Hösslin, Dietmar Zehn
Publicado en: Proceedings of the National Academy of Sciences, Edición 116/40, 2019, Página(s) 20070-20076, ISSN 0027-8424
Editor: National Academy of Sciences
DOI: 10.1073/pnas.1902701116

TOX reinforces the phenotype and longevity of exhausted T cells in chronic viral infection

Autores: Francesca Alfei, Kristiyan Kanev, Maike Hofmann, Ming Wu, Hazem E. Ghoneim, Patrick Roelli, Daniel T. Utzschneider, Madlaina von Hoesslin, Jolie G. Cullen, Yiping Fan, Vasyl Eisenberg, Dirk Wohlleber, Katja Steiger, Doron Merkler, Mauro Delorenzi, Percy A. Knolle, Cyrille J. Cohen, Robert Thimme, Benjamin Youngblood, Dietmar Zehn
Publicado en: Nature, Edición 571/7764, 2019, Página(s) 265-269, ISSN 0028-0836
Editor: Nature Publishing Group
DOI: 10.1038/s41586-019-1326-9

Tailoring the resolution of single-cell RNA sequencing for primary cytotoxic T cells

Autores: Kanev, Kristiyan; Roelli, Patrick; Wu, Ming; Wurmser, Christine; Delorenzi, Mauro; Pfaffl, Michael W.; Zehn, Dietmar
Publicado en: Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021), 2021, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-020-20751-7

PTPN2 Deficiency Enhances Programmed T Cell Expansion and Survival Capacity of Activated T Cells

Autores: Markus Flosbach, Susanne G. Oberle, Stefanie Scherer, Jana Zecha, Madlaina von Hoesslin, Florian Wiede, Vijaykumar Chennupati, Jolie G. Cullen, Markus List, Josch K. Pauling, Jan Baumbach, Bernhard Kuster, Tony Tiganis, Dietmar Zehn
Publicado en: Cell Reports, Edición 32/4, 2020, Página(s) 107957, ISSN 2211-1247
Editor: Cell Press
DOI: 10.1016/j.celrep.2020.107957

PTPN2 Deficiency Enhances Programmed T Cell Expansion and Survival Capacity of Activated T Cells

Autores: Markus Flosbach; Susanne Oberle; Stefanie Scherer; Stefanie Scherer; Jana Zecha; Madlaina von Hoesslin; Florian Wiede; Florian Wiede; Vijaykumar Chennupati; Jolie G. Cullen; Markus List; Josch Konstantin Pauling; Jan Baumbach; Bernhard Kuster; Tony Tiganis; Tony Tiganis; Dietmar Zehn; Dietmar Zehn
Publicado en: Cell Reports, Vol 32, Iss 4, Pp 107957- (2020), 2020, ISSN 2211-1247
Editor: Cell Press
DOI: 10.1016/j.celrep.2020.107957

Inflammatory signals are sufficient to elicit TOX expression in mouse and human CD8 T cells

Autores: Nicholas J. Maurice, Jacqueline Berner, Alexis K. Taber, Dietmar Zehn, Martin Prlic
Publicado en: JCI Insight, 2021, ISSN 2379-3708
Editor: The American Society for Clinical Investigation (ASCI)
DOI: 10.1172/jci.insight.150744

Origin and fine-tuning of effector CD8 T cell subpopulations in chronic infection

Autores: Kristiyan Kanev, Dietmar Zehn
Publicado en: Current Opinion in Virology, Edición 46, 2021, Página(s) 27-35, ISSN 1879-6257
Editor: Elsevier BV
DOI: 10.1016/j.coviro.2020.10.003

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