Tailoring the functional Capacity of Cytotoxic T cells for future Therapies

Publikacje

A single-amino acid substitution in the adaptor LAT accelerates TCR proofreading kinetics and alters T-cell selection, maintenance and function

Autorzy: Wan-Lin Lo, Miriam Kuhlmann, Gabrielle Rizzuto, H. Atakan Ekiz, Elizabeth M. Kolawole, Monica P. Revelo, Rakieb Andargachew, Zhongmei Li, Yuan-Li Tsai, Alexander Marson, Brian D. Evavold, Dietmar Zehn & Arthur Weiss
Opublikowane w: Nature Immunology, Numer 2023 Apr;24(4):676-689, 2023, Strona(/y) 676-689, ISSN 1529-2908
Wydawca: Nature Publishing Group
DOI: 10.1038/s41590-023-01444-x

Tailoring the resolution of single-cell RNA sequencing for primary cytotoxic T cells

Autorzy: Kristiyan Kanev, Patrick Roelli, Ming Wu, Christine Wurmser, Mauro Delorenzi, Michael W. Pfaffl, Dietmar Zehn
Opublikowane w: Nature Communications, Numer 12/1, 2021, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/s41467-020-20751-7

Inflammatory signals are sufficient to elicit TOX expression in mouse and human CD8+ T cells.

Autorzy: Nicholas J. Maurice; Jacqueline Berner; Alexis K Taber; Dietmar Zehn; Martin Prlic
Opublikowane w: JCI insight, 2021, ISSN 2379-3708
Wydawca: American Society for Clinical Investigation
DOI: 10.1172/jci.insight.150744

Pyrimidine de novo synthesis inhibition selectively blocks effector but not memory T cell development

Autorzy: Stefanie Scherer, Susanne G. Oberle, Kristiyan Kanev, Ann-Katrin Gerullis, Ming Wu, Gustavo P. de Almeida, Daniel J. Puleston, Francesc Baixauli, Lilian Aly, Alessandro Greco, Tamar Nizharadze, Nils B. Becker, Madlaina v. Hoesslin, Lara V. Donhauser, Jacqueline Berner, Talyn Chu, Hayley A. McNamara, Zeynep Esencan, Patrick Roelli, Christine Wurmser, Ingo Kleiter, Maria J. G. T. Vehreschild, Christ
Opublikowane w: Nature Immunology, Numer 2023 Mar;24(3):501-515, 2023, Strona(/y) 501-515, ISSN 1529-2908
Wydawca: Nature Publishing Group
DOI: 10.1038/s41590-023-01436-x

Proliferation-competent Tcf1+ CD8 T cells in dysfunctional populations are CD4 T cell help independent

Autorzy: Kristiyan Kanev, Ming Wu, Antar Drews, Patrick Roelli, Christine Wurmser, Madlaina von Hösslin, Dietmar Zehn
Opublikowane w: Proceedings of the National Academy of Sciences, Numer 116/40, 2019, Strona(/y) 20070-20076, ISSN 0027-8424
Wydawca: National Academy of Sciences
DOI: 10.1073/pnas.1902701116

TOX reinforces the phenotype and longevity of exhausted T cells in chronic viral infection

Autorzy: Francesca Alfei, Kristiyan Kanev, Maike Hofmann, Ming Wu, Hazem E. Ghoneim, Patrick Roelli, Daniel T. Utzschneider, Madlaina von Hoesslin, Jolie G. Cullen, Yiping Fan, Vasyl Eisenberg, Dirk Wohlleber, Katja Steiger, Doron Merkler, Mauro Delorenzi, Percy A. Knolle, Cyrille J. Cohen, Robert Thimme, Benjamin Youngblood, Dietmar Zehn
Opublikowane w: Nature, Numer 571/7764, 2019, Strona(/y) 265-269, ISSN 0028-0836
Wydawca: Nature Publishing Group
DOI: 10.1038/s41586-019-1326-9

Tailoring the resolution of single-cell RNA sequencing for primary cytotoxic T cells

Autorzy: Kanev, Kristiyan; Roelli, Patrick; Wu, Ming; Wurmser, Christine; Delorenzi, Mauro; Pfaffl, Michael W.; Zehn, Dietmar
Opublikowane w: Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021), 2021, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/s41467-020-20751-7

PTPN2 Deficiency Enhances Programmed T Cell Expansion and Survival Capacity of Activated T Cells

Autorzy: Markus Flosbach, Susanne G. Oberle, Stefanie Scherer, Jana Zecha, Madlaina von Hoesslin, Florian Wiede, Vijaykumar Chennupati, Jolie G. Cullen, Markus List, Josch K. Pauling, Jan Baumbach, Bernhard Kuster, Tony Tiganis, Dietmar Zehn
Opublikowane w: Cell Reports, Numer 32/4, 2020, Strona(/y) 107957, ISSN 2211-1247
Wydawca: Cell Press
DOI: 10.1016/j.celrep.2020.107957

PTPN2 Deficiency Enhances Programmed T Cell Expansion and Survival Capacity of Activated T Cells

Autorzy: Markus Flosbach; Susanne Oberle; Stefanie Scherer; Stefanie Scherer; Jana Zecha; Madlaina von Hoesslin; Florian Wiede; Florian Wiede; Vijaykumar Chennupati; Jolie G. Cullen; Markus List; Josch Konstantin Pauling; Jan Baumbach; Bernhard Kuster; Tony Tiganis; Tony Tiganis; Dietmar Zehn; Dietmar Zehn
Opublikowane w: Cell Reports, Vol 32, Iss 4, Pp 107957- (2020), 2020, ISSN 2211-1247
Wydawca: Cell Press
DOI: 10.1016/j.celrep.2020.107957

Inflammatory signals are sufficient to elicit TOX expression in mouse and human CD8 T cells

Autorzy: Nicholas J. Maurice, Jacqueline Berner, Alexis K. Taber, Dietmar Zehn, Martin Prlic
Opublikowane w: JCI Insight, 2021, ISSN 2379-3708
Wydawca: The American Society for Clinical Investigation (ASCI)
DOI: 10.1172/jci.insight.150744

Origin and fine-tuning of effector CD8 T cell subpopulations in chronic infection

Autorzy: Kristiyan Kanev, Dietmar Zehn
Opublikowane w: Current Opinion in Virology, Numer 46, 2021, Strona(/y) 27-35, ISSN 1879-6257
Wydawca: Elsevier BV
DOI: 10.1016/j.coviro.2020.10.003

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