The ubiquitin system in RAS-driven disease

Project Information

UB-RASDisease

Grant agreement ID: 772649

DOI 10.3030/772649

Project closed

EC signature date 19 March 2018

Start date 1 April 2018

End date 31 March 2023

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 1 999 796,00

EU contribution € 1 999 796,00

Coordinated by

VIB VZW
Belgium

Publications

Peer reviewed articles (7)

Cracking the Monoubiquitin Code of Genetic Diseases

Author(s): Raj Nayan Sewduth, Maria Francesca Baietti, Anna A. Sablina
Published in: International Journal of Molecular Sciences, Issue 21/9, 2020, Page(s) 3036, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21093036

The Noonan Syndrome Gene Lztr1 Controls Cardiovascular Function by Regulating Vesicular Trafficking

Author(s): Raj Nayan Sewduth, Silvia Pandolfi, Mikhail Steklov, Aidana Sheryazdanova, Peihua Zhao, Nathan Criem, Maria F. Baietti, Benoit Lechat, Rozeen Quarck, Francis Impens, Anna A. Sablina
Published in: Circulation Research, Issue 126/10, 2020, Page(s) 1379-1393, ISSN 0009-7330
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circresaha.119.315730

Loss-of-Function Mutations in TRAF7 and KLF4 Cooperatively Activate RAS-Like GTPase Signaling and Promote Meningioma Development.

Author(s): Paul Najm; Peihua Zhao; Mikhail Steklov; Raj Nayan Sewduth; Maria Francesca Baietti; Silvia Pandolfi; Nathan Criem; Benoit Lechat; Teresa Mendes Maia; Delphi Van Haver; Nikky Corthout; Sven Eyckerman; Francis Impens; Anna Sablina
Published in: Cancer Research, 2021, ISSN 0008-5472
Publisher: American Association for Cancer Research
DOI: 10.1158/0008-5472.can-20-3669

Targeted STAT1 therapy for LZTR1-driven peripheral nerve sheath tumor

Author(s): Tonci Ivanisevic, Mikhail Steklov, Benoit Lechat, Christopher Cawthorne, Willy Gsell, Greetje Vande Velde, Christophe Deroose, Koen Van Laere, Uwe Himmelreich, Raj N Sewduth, Anna A Sablina
Published in: Cancer Communications, 2023, ISSN 2523-3548
Publisher: Wiley Online Library
DOI: 10.1002/cac2.12490

Mutations in LZTR1 drive human disease by dysregulating RAS ubiquitination

Author(s): M. Steklov, S. Pandolfi, M. F. Baietti, A. Batiuk, P. Carai, P. Najm, M. Zhang, H. Jang, F. Renzi, Y. Cai, L. Abbasi Asbagh, T. Pastor, M. De Troyer, M. Simicek, E. Radaelli, H. Brems, E. Legius, J. Tavernier, K. Gevaert, F. Impens, L. Messiaen, R. Nussinov, S. Heymans, S. Eyckerman, A. A. Sablina
Published in: Science, Issue 362/6419, 2018, Page(s) 1177-1182, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.aap7607

Spatial mechano-signaling regulation of GTPases through non-degradative ubiquitination

Author(s): RN Sewduth, P Carai, T Ivanisevic, M Zhang, H Jang, B Lechat, D Van Haver, F Impens, R Nussinov, EA Jones, AA Sablina
Published in: Advanced Science, 2023, ISSN 2198-3844
Publisher: Wiley Online Library
DOI: 10.1002/advs.202303367

The regulation of the protein interaction network by monoubiquitination

Author(s): Wout Magits; Anna A. Sablina
Published in: Current Opinion in Structural Biology, 2022, ISSN 0959-440X
Publisher: Elsevier BV
DOI: 10.1016/j.sbi.2022.102333