Agent-Based Modelling of Gene Networks to model clonal selection in the tumour microenvironment and predict therapeutic resistance

Project Information

MicroC

Grant agreement ID: 772970

DOI 10.3030/772970

EC signature date 7 March 2018

Start date 1 June 2018

End date 30 November 2024

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 1 996 325,00

EU contribution € 1 996 325,00

Coordinated by

UNIVERSITA COMMERCIALE LUIGI BOCCONI
Italy

Publications

Peer reviewed articles (4)

Guidelines for using sigQC for systematic evaluation of gene signatures

Author(s): Andrew Dhawan, Alessandro Barberis, Wei-Chen Cheng, Enric Domingo, Catharine West, Tim Maughan, Jacob G. Scott, Adrian L. Harris, Francesca M. Buffa
Published in: Nature Protocols, Issue 14/5, 2019, Page(s) 1377-1400, ISSN 1754-2189
Publisher: Nature Publishing Group
DOI: 10.1038/s41596-019-0136-8

Modeling genotypes in their microenvironment to predict single- and multi-cellular behavior

Author(s): Dimitrios Voukantsis, Kenneth Kahn, Martin Hadley, Rowan Wilson, Francesca M Buffa
Published in: GigaScience, Issue 8/3, 2019, ISSN 2047-217X
Publisher: Oxford University Press
DOI: 10.1093/gigascience/giz010

Pan-cancer characterisation of microRNA across cancer hallmarks reveals microRNA-mediated downregulation of tumour suppressors

Author(s): Andrew Dhawan, Jacob G. Scott, Adrian L. Harris, Francesca M. Buffa
Published in: Nature Communications, Issue 9/1, 2018, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-018-07657-1

Heritable genetic variants in key cancer genes link cancer risk with anthropometric traits

Author(s): Matteo Di Giovannantonio, Benjamin HL Harris, Ping Zhang, Isaac Kitchen-Smith, Lingyun Xiong, Natasha Sahgal, Giovanni Stracquadanio, Marsha Wallace, Sarah Blagden, Simon Lord, David Harris, Adrian H.L. Harris, Francesca M. Buffa, Gareth L. Bond
Published in: Journal of Medical Genetics, 2020, Page(s) jmedgenet-2019-106799, ISSN 0022-2593
Publisher: British Medical Association
DOI: 10.1136/jmedgenet-2019-106799