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Agent-Based Modelling of Gene Networks to model clonal selection in the tumour microenvironment and predict therapeutic resistance


E2F1 proteolysis via SCF ‐cyclin F underlies synthetic lethality between cyclin F loss and Chk1 inhibition

Author(s): Kamila Burdova, Hongbin Yang, Roberta Faedda, Samuel Hume, Jagat Chauhan, Daniel Ebner, Benedikt M Kessler, Iolanda Vendrell, David H Drewry, Carrow I Wells, Stephanie B Hatch, Grigory L Dianov, Francesca M Buffa, Vincenzo D'Angiolella
Published in: The EMBO Journal, Issue 38/20, 2019, ISSN 0261-4189
Publisher: Nature Publishing Group
DOI: 10.15252/embj.2018101443

Transcriptomic analysis of human primary breast cancer identifies fatty acid oxidation as a target for metformin

Author(s): Simon R. Lord, Jennifer M. Collins, Wei-Chen Cheng, Syed Haider, Simon Wigfield, Edoardo Gaude, Barbara A. Fielding, Katherine E. Pinnick, Ulrike Harjes, Ashvina Segaran, Pooja Jha, Gerald Hoefler, Michael N. Pollak, Alastair M. Thompson, Pankaj G. Roy, Ruth. English, Rosie F. Adams, Christian Frezza, Francesca M. Buffa, Fredrik Karpe, Adrian L. Harris
Published in: British Journal of Cancer, Issue 122/2, 2020, Page(s) 258-265, ISSN 0007-0920
Publisher: Nature Publishing Group
DOI: 10.1038/s41416-019-0665-5

Guidelines for using sigQC for systematic evaluation of gene signatures

Author(s): Andrew Dhawan, Alessandro Barberis, Wei-Chen Cheng, Enric Domingo, Catharine West, Tim Maughan, Jacob G. Scott, Adrian L. Harris, Francesca M. Buffa
Published in: Nature Protocols, Issue 14/5, 2019, Page(s) 1377-1400, ISSN 1754-2189
Publisher: Nature Publishing Group
DOI: 10.1038/s41596-019-0136-8

Modeling genotypes in their microenvironment to predict single- and multi-cellular behavior

Author(s): Dimitrios Voukantsis, Kenneth Kahn, Martin Hadley, Rowan Wilson, Francesca M Buffa
Published in: GigaScience, Issue 8/3, 2019, ISSN 2047-217X
Publisher: Oxford University Press
DOI: 10.1093/gigascience/giz010

Pan-cancer characterisation of microRNA across cancer hallmarks reveals microRNA-mediated downregulation of tumour suppressors

Author(s): Andrew Dhawan, Jacob G. Scott, Adrian L. Harris, Francesca M. Buffa
Published in: Nature Communications, Issue 9/1, 2018, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-018-07657-1

Integrated Pharmacodynamic Analysis Identifies Two Metabolic Adaption Pathways to Metformin in Breast Cancer

Author(s): Simon R. Lord, Wei-Chen Cheng, Dan Liu, Edoardo Gaude, Syed Haider, Tom Metcalf, Neel Patel, Eugene J. Teoh, Fergus Gleeson, Kevin Bradley, Simon Wigfield, Christos Zois, Daniel R. McGowan, Mei-Lin Ah-See, Alastair M. Thompson, Anand Sharma, Luc Bidaut, Michael Pollak, Pankaj G. Roy, Fredrik Karpe, Tim James, Ruth English, Rosie F. Adams, Leticia Campo, Lisa Ayers, Cameron Snell, Ioannis Roxanis,
Published in: Cell Metabolism, Issue 28/5, 2018, Page(s) 679-688.e4, ISSN 1550-4131
Publisher: Cell Press
DOI: 10.1016/j.cmet.2018.08.021

Heritable genetic variants in key cancer genes link cancer risk with anthropometric traits

Author(s): Matteo Di Giovannantonio, Benjamin HL Harris, Ping Zhang, Isaac Kitchen-Smith, Lingyun Xiong, Natasha Sahgal, Giovanni Stracquadanio, Marsha Wallace, Sarah Blagden, Simon Lord, David Harris, Adrian H.L. Harris, Francesca M. Buffa, Gareth L. Bond
Published in: Journal of Medical Genetics, 2020, Page(s) jmedgenet-2019-106799, ISSN 0022-2593
Publisher: British Medical Association
DOI: 10.1136/jmedgenet-2019-106799

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