IN-Silico trials for treatment of acute Ischemic STroke

Livrables

Final public version of the population model

First version of a virtual population of stroke patients (Module I)
Final Statistical model that relates images features of clot to clot characteristics

Final statistical model that relates images features of clot to clot characteristics

Final statistical model (Module III)

Final statistical model (Module III) that relates image outcome (revascularisation, reperfusion) to clinical outcome

Periodic reporting period 3

Periodic technical reports and periodic financial and ethical reports for the ECMonth 54 is Period end report is due month 56

Outcome of in silico trials
Final report on all available models with full validation data for thrombosis and thrombolysis including the description of the increased understanding of the pathophysiological aspects of thrombosis and thrombolysis

Final report on all available models with full validation data for thrombosis and thrombolysis including the description of the increased understanding of the pathophysiological aspects of thrombosis and thrombolysisThis deliverables is not just a report but will also deliver the associated models as simulation software eg to WP6

Periodic report period 2

Periodic technical reports and periodic financial and ethical reports for the EC Report is due month 38

Validated in silico trial platform
Implementation of full 3D characterized models
Initial integration of all models
Finite element meshes of patient specific clot and vessel geometries
Second report on models for advanced versions thrombosis and thrombolysis and combined model including validation and the formal VVUQ and reports on the experiments carried out during the second 18 months of the project

Second report on models for advanced versions thrombosis and thrombolysis and combined model including validation and the formal VVUQ and reports on the experiments carried out during the second 18 months of the project. This deliverables is not just a report, but will also deliver the associated models as simulation software (e.g. to WP6).

Implementation of individual models of interaction
Quality Assurance Plan

Quality Assurance Plan to manage the quality control including a detailed risk analysis and contingency planning

In silico model for mechanical performance of thrombectomy devices
Project Handbook

Project Handbook to ensure consistent implementation of the management

Implementation of model of microvascular damage
Data Management Plan template
Validation of models with clinical data
Data base of composition-specific clot mechanical properties and a new constitutive law for clots
Modelling platform for simulation of thrombectomy performance in patient specific models
First public version of a population model to generate virtual populations
Initial report on dissemination, exploitation and sustainability plan

Initial report on dissemination, exploitation and sustainability plan with a detailed plan and schedule for all dissemination, communication, and exploitation activities. The plan will be delivered in M3, and updated to coincide with reporting period Note: All the tasks and deliverables depicted in this WP will be implemented taking into account the best practices in Data Management (WP1) and the template for Data Management Plan (D1.6)

Periodic reporting

Periodic technical reports and periodic financial and ethical reports for the EC. Report is due month 20

Implementation of VVUQ procedures and initial validation exercises on integrated models
An in silico clinical stroke trial computing environment
First report on models for thrombosis and thrombolysis and combined model describing the models and performed experiments

First report on models for thrombosis and thrombolysis and combined model describing the models and performed experiments. This deliverables is not just a report, but will also deliver the associated models as simulation software (e.g. to WP6).

Consortium Agreement

Second report on dissemination, communication and sustainability

Second dissemination, communication and sustainability report. Note: All the tasks and deliverables depicted in this WP will be implemented taking into account the best practices in Data Management (WP1) and the template for Data Management Plan (D1.6)

First report on dissemination, communication and sustainability

First dissemination, communication and sustainability report, with a review of events dissemination, communication, and exploitation results including an update of dissemination, communication, and exploitation action plan Note: All the tasks and deliverables depicted in this WP will be implemented taking into account the best practices in Data Management (WP1) and the template for Data Management Plan (D1.6)

Final dissemination, communication and sustainability report

Final dissemination communication and sustainability report with a review of the events and dissemination communication and exploitation results and reports on postproject plans for exploitations of INSIST M54Note All the tasks and deliverables depicted in this WP will be implemented taking into account the best practices in Data Management WP1 and the template for Data Management Plan D16

Publications

Early recanalization in large-vessel occlusion stroke patients transferred for endovascular treatment

Auteurs: Nerea Arrarte Terreros, Agnetha A E Bruggeman, Isabella S J Swijnenburg, Laura C C van Meenen, Adrien E Groot, Jonathan M Coutinho, Yvo B W E M Roos, Bart J Emmer, Ludo F M Beenen, Ed van Bavel, Henk A Marquering, Charles B L M Majoie
Publié dans: Journal of NeuroInterventional Surgery, 2021, Page(s) neurintsurg-2021-017441, ISSN 1759-8478
Éditeur: BMJ Publishing Group
DOI: 10.1136/neurintsurg-2021-017441

Extravasation of biodegradable microspheres in the rat brain.

Auteurs: van der Wijk AE, Georgakopoulou T, Steendam R, Zuidema J, Hordijk PL, Bakker ENTP, van Bavel E.
Publié dans: Drug Deliv., Numéro Dec;30(1), 2023, Page(s) 2194579, ISSN 2155-4277
Éditeur: Taylor & Francis online
DOI: 10.1080/10717544.2023.2194579

A porous circulation model of the human brain for in silico clinical trials in ischaemic stroke

Auteurs: T. I. Józsa, R. M. Padmos, N. Samuels, W. K. El-Bouri, A. G. Hoekstra, S. J. Payne
Publié dans: Interface Focus, Numéro 11/1, 2021, Page(s) 20190127, ISSN 2042-8898
Éditeur: Royal Society Publishing
DOI: 10.1098/rsfs.2019.0127

Impact of the Internal Carotid Artery Morphology on in silico Stent-Retriever Thrombectomy Outcome

Auteurs: Sara Bridio, Giulia Luraghi, Jose F. Rodriguez Matas, Gabriele Dubini, Giorgia G. Giassi, Greta Maggio, Julia N. Kawamoto, Kevin M. Moerman, Patrick McGarry, Praneeta R. Konduri, Nerea Arrarte Terreros, Henk A. Marquering, Ed van Bavel, Charles B. L. M. Majoie, Francesco Migliavacca
Publié dans: Frontiers in Medical Technology, Numéro 3, 2021, ISSN 2673-3129
Éditeur: Frontiers Media SA
DOI: 10.3389/fmedt.2021.719909

Blood clot fracture properties are dependent on red blood cell and fibrin content

Auteurs: B. Fereidoonnezhad; Anushree Dwivedi; Sarah E. Johnson; Ray McCarthy; Patrick McGarry
Publié dans: Acta Biomaterialia, Numéro 7, 2021, Page(s) 213-228, ISSN 1742-7061
Éditeur: Elsevier BV
DOI: 10.1101/2020.10.05.326165

Bifurcation occlusions and endovascular treatment outcome in acute ischemic stroke

Auteurs: Nerea Arrarte Terreros, Agnetha A E Bruggeman, Henk van Voorst, Praneeta R Konduri, Ivo G H Jansen, Manon Kappelhof, Manon L Tolhuisen, Nikki Boodt, Diederik W J Dippel, Aad van der Lugt, Wim H van Zwam, Robert J van Oostenbrugge, H. Bart van der Worp, Bart J Emmer, Frederick J A Meijer, Yvo B W E M Roos, Ed van Bavel, Henk A Marquering, Charles B L M Majoie MR CLEAN Registry investigators
Publié dans: journal of NeuroInterventional Surgery, 2022, ISSN 1759-8486
Éditeur: BMJ
DOI: 10.1136/neurintsurg-2021-018560

In silico thrombectomy trials for acute ischemic stroke.

Auteurs: Miller C, Konduri P, Bridio S, Luraghi G, Arrarte Terreros N, Boodt N, Samuels N, Rodriguez Matas JF, Migliavacca F, Lingsma H, van der Lugt A, Roos Y, Dippel D, Marquering H, Majoie C, Hoekstra A.
Publié dans: Comput Methods Programs Biomed, Numéro Jan;228, 2023, Page(s) 107244, ISSN 0169-2607
Éditeur: Elsevier BV
DOI: 10.1016/j.cmpb.2022.107244

Redistribution of TPA Fluxes in the Presence of PAI-1 Regulates Spatial Thrombolysis

Auteurs: Alexey M. Shibeko, Bastien Chopard, Alfons G. Hoekstra, Mikhail A. Panteleev
Publié dans: Biophysical Journal, Numéro 119/3, 2020, Page(s) 638-651, ISSN 0006-3495
Éditeur: Biophysical Society
DOI: 10.1016/j.bpj.2020.06.020

Mechanical Characterization of Thrombi Retrieved With Endovascular Thrombectomy in Patients With Acute Ischemic Stroke

Auteurs: Nikki Boodt, Philip R.W. Snouckaert van Schauburg, Hajo M. Hund, Behrooz Fereidoonnezhad, J. Patrick McGarry, Ali C. Akyildiz, Adriaan C.G.M. van Es, Simon F. De Meyer, Diederik W.J. Dippel, Hester F. Lingsma, Heleen M.M. van Beusekom, Aad van der Lugt, Frank J.H. Gijsen
Publié dans: Stroke, Numéro 52/8, 2021, Page(s) 2510-2517, ISSN 0039-2499
Éditeur: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/strokeaha.120.033527

Red blood cell and platelet diffusivity and margination in the presence of cross-stream gradients in blood flows

Auteurs: Gábor Závodszky, Britt van Rooij, Ben Czaja, Victor Azizi, David de Kanter, Alfons G. Hoekstra
Publié dans: Physics of Fluids, Numéro 31/3, 2019, Page(s) 031903, ISSN 1070-6631
Éditeur: American Institute of Physics
DOI: 10.1063/1.5085881

Investigating the Mechanical Behavior of Clot Analogues Through Experimental and Computational Analysis

Auteurs: Sarah Johnson, Ray McCarthy, Michael Gilvarry, Peter E. McHugh, J. Patrick McGarry
Publié dans: Annals of Biomedical Engineering, Numéro 49/1, 2021, Page(s) 420-431, ISSN 0090-6964
Éditeur: Kluwer Academic Publishers
DOI: 10.1007/s10439-020-02570-5

Structural analysis of ischemic stroke thrombi: histological indications for therapy resistance

Auteurs: Senna Staessens, Frederik Denorme, Olivier Francois, Linda Desender, Tom Dewaele, Peter Vanacker, Hans Deckmyn, Karen Vanhoorelbeke, Tommy Andersson, Simon F. De Meyer
Publié dans: Haematologica, Numéro 105/2, 2020, Page(s) 498-507, ISSN 0390-6078
Éditeur: Ferrata Storti Foundation
DOI: 10.3324/haematol.2019.219881

Occult blood flow patterns distal to an occluded artery in acute ischemic stroke

Auteurs: Nerea Arrarte Terreros; Bettine G. van Willigen; Wera S. Niekolaas; Manon L. Tolhuisen; Josje Brouwer; Jonathan M. Coutinho; Ludo F. M. Beenen; Charles B. L. Majoie; Ed van Bavel; Henk A. Marquering
Publié dans: J Cereb Blood Flow Metab., Numéro 42, 2022, Page(s) 292-302, ISSN 0271-678X
Éditeur: Lippincott Williams & Wilkins Ltd.
DOI: 10.1177/0271678x211044941

Applicability analysis to evaluate credibility of an in silico thrombectomy procedure

Auteurs: Giulia Luraghi, Sara Bridio, Claire Miller, Alfons Hoekstra, Jose Felix Rodriguez Matas, Francesco Migliavacca
Publié dans: Journal of Biomechanics, Numéro 126, 2021, Page(s) 110631, ISSN 0021-9290
Éditeur: Elsevier BV
DOI: 10.1016/j.jbiomech.2021.110631

Modelling the leptomeningeal collateral circulation during acute ischaemic stroke

Auteurs: Raymond M. Padmos, Nerea Arrarte Terreros, Tamás I. Józsa, Gábor Závodszky, Henk A. Marquering, Charles B.L.M. Majoie, Alfons G. Hoekstra
Publié dans: Medical Engineering & Physics, Numéro 91, 2021, Page(s) 1-11, ISSN 1350-4533
Éditeur: Elsevier BV
DOI: 10.1016/j.medengphy.2021.03.003

The Ageing Brain: Investigating the Role of Age in Changes to the Human Cerebral Microvasculature With an in silico Model

Auteurs: Barnaby J. Graff; Stephen J. Payne; Wahbi K. El-Bouri; Wahbi K. El-Bouri; Wahbi K. El-Bouri
Publié dans: Frontiers in Aging Neuroscience, Numéro 8, 2021, ISSN 1663-4365
Éditeur: Frontiers Research Foundation
DOI: 10.3389/fnagi.2021.632521

The first virtual patient-specific thrombectomy procedure

Auteurs: Giulia Luraghi, Sara Bridio, Jose Felix Rodriguez Matas, Gabriele Dubini, Nikki Boodt, Frank J.H. Gijsen, Aad van der Lugt, Behrooz Fereidoonnezhad, Kevin M. Moerman, Patrick McGarry, Praneeta R. Konduri, Nerea Arrarte Terreros, Henk A. Marquering, Charles B.L.M. Majoie, Francesco Migliavacca
Publié dans: Journal of Biomechanics, Numéro 126, 2021, Page(s) 110622, ISSN 0021-9290
Éditeur: Elsevier BV
DOI: 10.1016/j.jbiomech.2021.110622

In vitro and in silico modeling of endovascular stroke treatments for acute ischemic stroke

Auteurs: Giulia Luraghi, Rachel M.E. Cahalane, Emma van de Ven, Serena C.M. Overschie, Frank J.H. Gijsen, Ali C. Akyildiz
Publié dans: Journal of Biomechanics, Numéro 127, 2021, Page(s) 110693, ISSN 0021-9290
Éditeur: Elsevier BV
DOI: 10.1016/j.jbiomech.2021.110693

A new constitutive model for permanent deformation of blood clots with application to simulation of aspiration thrombectomy

Auteurs: Behrooz Fereidoonnezhad, Patrick McGarry
Publié dans: Journal of Biomechanics, Numéro 130, 2022, ISSN 0021-9290
Éditeur: Elsevier BV
DOI: 10.1016/j.jbiomech.2021.110865

Is modeling stents still an important issue?

Auteurs: Francesco Migliavacca
Publié dans: Procedia Structural Integrity, Numéro 15, 2019, Page(s) 46-50, ISSN 2452-3216
Éditeur: Elsevier
DOI: 10.1016/j.prostr.2019.07.009

Association between thrombus composition and stroke etiology in the MR CLEAN Registry biobank

Auteurs: Hajo M. Hund, Nikki Boodt, Daniel Hansen, Willem A. Haffmans, Geert J. Lycklama à Nijeholt, Jeannette Hofmeijer, Diederik W. J. Dippel, Aad van der Lugt, Adriaan C. G. M. van Es, Heleen M. M. van Beusekom, on behalf of the MR CLEAN Registry Investigators
Publié dans: Neuroradiology, Numéro 65, 2023, Page(s) 933–943, ISSN 1476-4687
Éditeur: Springer Nature
DOI: 10.1007/s00234-023-03115-y

A new anisotropic soft tissue model for elimination of unphysical auxetic behaviour

Auteurs: B. Fereidoonnezhad, C. O’Connor, J.P. McGarry
Publié dans: Journal of Biomechanics, Numéro 111, 2020, Page(s) 110006, ISSN 0021-9290
Éditeur: Elsevier BV
DOI: 10.1016/j.jbiomech.2020.110006

A review on the association of thrombus composition with mechanical and radiological imaging characteristics in acute ischemic stroke.

Auteurs: Rachel Cahalane, Nikki Boodt, Ali Cagdas Akyildiz, Jo-anne Giezen, Manouk Mondeel, Aad van der Lugt, Henk Marquering, Frank Gijsen.
Publié dans: Journal of Biomechanics, Numéro 129, 2021, ISSN 0021-9290
Éditeur: Elsevier BV
DOI: 10.1016/j.jbiomech.2021.110816

Recovery of Hypoxic Regions in a Rat Model of Microembolism

Auteurs: Theodosia Georgakopoulou, Anne-Eva van der Wijk, Erik N.T.P. Bakker, Ed vanBavel
Publié dans: Journal of Stroke and Cerebrovascular Diseases, Numéro 30/6, 2021, Page(s) 105739, ISSN 1052-3057
Éditeur: W. B. Saunders Co., Ltd.
DOI: 10.1016/j.jstrokecerebrovasdis.2021.105739

Reliable Numerical Models of Nickel-Titanium Stents: How to Deduce the Specific Material Properties from Testing Real Devices

Auteurs: Francesca Berti; Sara Bridio; Giulia Luraghi; Sanjay Pant; Dario Allegretti; Giancarlo Pennati; Lorenza Petrini
Publié dans: Ann Biomed Eng., Numéro 00906964, 2022, Page(s) 467-481, ISSN 0090-6964
Éditeur: Kluwer Academic Publishers
DOI: 10.1007/s10439-022-02932-1

Perivascular clearance of blood proteins after blood-brain barrier disruption in a rat modelof microinfarcts.

Auteurs: Georgakopoulou T, van der Wijk AE, van Bavel E, Bakker ENTP.
Publié dans: Microvasc Res., Numéro Mar 7;148, 2023, Page(s) 104515, ISSN 1751-6161
Éditeur: Elsevier BV
DOI: 10.1016/j.mvr.2023.104515

Stroke Etiology and Thrombus Computed Tomography Characteristics in Patients With Acute Ischemic Stroke

Auteurs: Nikki Boodt, Kars C.J. Compagne, Bruna G. Dutra, Noor Samuels, Manon L. Tolhuisen, Heitor C.B.R. Alves, Manon Kappelhof, Geert J. Lycklama à Nijeholt, Henk. A. Marquering, Charles B.L.M. Majoie, Hester F. Lingsma, Diederik W.J. Dippel, Aad van der Lugt, Yvo Roos, Robert van Oostenbrugge, Wim van Zwam, Jelis Boiten, Jan Albert Vos, Ivo Jansen, Maxim Mulder, Robert-Jan Goldhoorn, Wouter Schonewille
Publié dans: Stroke, Numéro 51/6, 2020, Page(s) 1727-1735, ISSN 0039-2499
Éditeur: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/strokeaha.119.027749

Blood Pressure in the First 6 Hours Following Endovascular Treatment for Ischemic Stroke Is Associated With Outcome

Auteurs: Samuels N, van de Graaf RA, van den Berg CAL, Uniken Venema SM, Bala K, van Doormaal PJ, van der Steen W, Witvoet E, Boiten J, den Hertog H, Schonewille WJ, Hofmeijer J, Schreuder F, Schreuder TAHCML, van der Worp HB, Roos YBWEM, Majoie CBLM, Burke JF, van Es ACGM, van der Lugt A, Roozenbeek B, Lingsma HF, Dippel DWJ; MR CLEAN Registry Investigators.
Publié dans: Stroke., Numéro 20479980, 2021, Page(s) 3514-3522, ISSN 2047-9980
Éditeur: Wiley-Blackwell
DOI: 10.1161/strokeaha.120.033657

Perivascular Clearance of Blood Proteins after Blood-Brain Barrier Disruption in a Rat Model of Micro-Infarcts

Auteurs: Theodosia Georgakopoulou; Anne-Eva van der Wijk; Ed van Bavel; Erik N.T.P. Bakker
Publié dans: Microvascular research, Numéro Volume 148, July 2023, 2023, Page(s) 104515, ISSN 1751-6161
Éditeur: Elsevier BV
DOI: 10.2139/ssrn.4292893

Automated final lesion segmentation in posterior circulation acute ischemic stroke using deep learning

Auteurs: Riaan Zoetmulder; Praneeta R Konduri; Iris V Obdeijn; Efstratios Gavves; Ivana Išgum; Charles B. L. M. Majoie; Diederik W.J. Dippel; Yvo B.W.E.M. Roos; Mayank Goyal; Mayank Goyal; Peter Mitchell; Bruce C.V. Campbell; Demetrius K. Lopes; Gernot Reimann; Tudor G Jovin; Jeffrey L. Saver; Keith W. Muir; Phil White; Serge Bracard; Bailiang Chen; Scott Brown; Wouter J. Schonewille; Erik J.R.J. van der
Publié dans: Diagnostics, Numéro Sep 4;11(9), 2021, Page(s) 1621, ISSN 2075-4418
Éditeur: MDPI
DOI: 10.3390/diagnostics11091621

Modelling collateral flow and thrombus permeability during acute ischaemic stroke

Auteurs: Raymond M. Padmos; Nerea Arrarte Terreros; Tamás I. Józsa; Gábor Závodszky; Henk A. Marquering; Charles B. L. M. Majoie; Stephen J. Payne; Alfons G. Hoekstra
Publié dans: Journal of the Royal Society, Interface, Numéro vol. 19 , no. 195, 2022, Page(s) 20220649, ISSN 1742-5662
Éditeur: The royal society publishing
DOI: 10.1098/rsif.2022.0649

Thrombolysis: Observations and numerical models

Auteurs: Remy Petkantchin; Raymond Padmos; Karim Zouaoui Boudjeltia; Franck Raynaud; Bastien Chopard
Publié dans: Journal of Biomechanics, 132:110902. Elsevier, Numéro 9, 2022, ISSN 0021-9290
Éditeur: Elsevier BV
DOI: 10.1016/j.jbiomech.2021.110902

Combined stent-retriever and aspiration intra-arterial thrombectomy performance for fragmentable blood clots: A proof-of-concept computational study

Auteurs: Giulia Luraghi, Sara Bridio, Vittorio Lissoni, Gabriele Dubini, Anushree Dwivedi, Ray McCarthy, Behrooz Fereidoonnezhad, Patrick McGarry, Frank J.H. Gijsen, Jose Felix Rodriguez Matas, Francesco Migliavacca
Publié dans: Journal of the Mechanical Behavior of Biomedical Materials, Numéro Volume 135, 2022, Page(s) 105462, ISSN 1751-6161
Éditeur: Elsevier BV
DOI: 10.1016/j.jmbbm.2022.105462

Studying Stroke Thrombus Composition After Thrombectomy: What Can We Learn?

Auteurs: Senna Staessens, Olivier François, Waleed Brinjikji, Karen M. Doyle, Peter Vanacker, Tommy Andersson and Simon F. De Meyer
Publié dans: Stroke, Numéro 20479980, 2021, Page(s) 3718–3727, ISSN 2047-9980
Éditeur: Wiley-Blackwell
DOI: 10.1161/strokeaha.121.034289

From perviousness to permeability, modelling and measuring intra-thrombus flow in acute ischemic stroke

Auteurs: Nerea Arrarte Terreros, Manon L. Tolhuisen, Edwin Bennink, Hugo W.A.M. de Jong, Ludo F.M. Beenen, Charles B.L.M. Majoie, Ed van Bavel, Henk A. Marquering
Publié dans: Journal of Biomechanics, Numéro 111, 2020, Page(s) 110001, ISSN 0021-9290
Éditeur: Elsevier BV
DOI: 10.1016/j.jbiomech.2020.110001

Quantification of hypoxic regions distant from occlusions in cerebral penetrating arteriole trees

Auteurs: Yidan Xue; Theodosia Georgakopoulou; Anne-Eva van der Wijk; Tamás I. Józsa; Ed van Bavel; Stephen J. Payne
Publié dans: PLoS Computational Biology, Numéro 18, 2022, ISSN 1553-734X
Éditeur: Public Library of Science
DOI: 10.1101/2022.05.06.490869

Measuring the effect of thrombosis, thrombus maturation and thrombolysis on clot mechanical properties in an in-vitro model.

Auteurs: Anushree Dwivedi; Aoife Glynn; Sarah Johnson; Sarah Johnson; Sharon Duffy; Sharon Duffy; Behrooz Fereidoonnezhad; Patrick McGarry; Michael Gilvarry; Ray McCarthy
Publié dans: Journal of Biomechanics, Numéro 129, 2021, ISSN 0021-9290
Éditeur: Elsevier BV
DOI: 10.1016/j.jbiomech.2021.110731

A new compressible hyperelastic model for the multi-axial deformation of blood clot occlusions in vessels

Auteurs: Behrooz Fereidoonnezhad, Kevin M. Moerman, Sarah Johnson, Ray McCarthy, Patrick J. McGarry
Publié dans: Biomechanics and Modeling in Mechanobiology, 2021, ISSN 1617-7959
Éditeur: Springer Verlag
DOI: 10.1007/s10237-021-01446-4

Extravasation of Microspheres in a Rat Model of Silent Brain Infarcts

Auteurs: Anne-Eva van der Wijk, Nadia Lachkar, Judith de Vos, Anita E. Grootemaat, Nicole N. van der Wel, Peter L. Hordijk, Erik N.T.P. Bakker, Ed vanBavel
Publié dans: Stroke, Numéro 50/6, 2019, Page(s) 1590-1594, ISSN 0039-2499
Éditeur: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/strokeaha.119.024975

Quantitative 3D analysis of tissue damage in a rat model of microembolization

Auteurs: Georgakopoulou T, van der Wijk AE, Bakker ENTP, vanBavel E; INSIST investigators.
Publié dans: J Biomech., Numéro 128, 2021, Page(s) 110723, ISSN 0021-9290
Éditeur: Elsevier BV
DOI: 10.1016/j.jbiomech.2021.110723

On the Sensitivity Analysis of Porous Finite Element Models for Cerebral Perfusion Estimation

Auteurs: T. I. Józsa, R. M. Padmos, W. K. El-Bouri, A. G. Hoekstra, S. J. Payne
Publié dans: Annals of Biomedical Engineering, 2021, ISSN 0090-6964
Éditeur: Kluwer Academic Publishers
DOI: 10.1007/s10439-021-02808-w

Modelling the impact of clot fragmentation on the microcirculation after thrombectomy

Auteurs: Wahbi K. El-Bouri, Andrew MacGowan, Tamás I. Józsa, Matthew J. Gounis, Stephen J. Payne
Publié dans: PLOS Computational Biology, Numéro 17/3, 2021, Page(s) e1008515, ISSN 1553-7358
Éditeur: PLOS
DOI: 10.1371/journal.pcbi.1008515

In-Silico Trials for Treatment of Acute Ischemic Stroke

Auteurs: Praneeta R. Konduri, Henk A. Marquering, Ed E. van Bavel, Alfons Hoekstra, Charles B. L. M. Majoie
Publié dans: Frontiers in Neurology, Numéro 11, 2020, ISSN 1664-2295
Éditeur: Frontiers Research Foundation
DOI: 10.3389/fneur.2020.558125

Novel hyperelastic models for large volumetric deformations

Auteurs: Kevin M. Moerman, Behrooz Fereidoonnezhad, J. Patrick McGarry
Publié dans: International Journal of Solids and Structures, Numéro 193-194, 2020, Page(s) 474-491, ISSN 0020-7683
Éditeur: Pergamon Press Ltd.
DOI: 10.1016/j.ijsolstr.2020.01.019

Histological stroke clot analysis after thrombectomy: Technical aspects and recommendations

Auteurs: S Staessens, S Fitzgerald, T Andersson, F Clarençon, F Denorme, MJ Gounis, W Hacke, DS Liebeskind, I Szikora, ACGM van Es, W Brinjikji, KM Doyle, SF De Meyer
Publié dans: International Journal of Stroke, Numéro 15/5, 2020, Page(s) 467-476, ISSN 1747-4930
Éditeur: Blackwell
DOI: 10.1177/1747493019884527

Detailed histological analysis of a thrombectomy-resistant ischemic stroke thrombus: a case report

Auteurs: Senna Staessens, Olivier François, Linda Desender, Peter Vanacker, Tom Dewaele, Raf Sciot, Karen Vanhoorelbeke, Tommy Andersson, Simon F. De Meyer
Publié dans: Thrombosis Journal, Numéro 19/1, 2021, ISSN 1477-9560
Éditeur: BioMed Central
DOI: 10.1186/s12959-021-00262-1

Thrombus heterogeneity in ischemic stroke

Auteurs: Senna Staessens, Simon F. De Meyer
Publié dans: Platelets, 2020, Page(s) 1-9, ISSN 0953-7104
Éditeur: Taylor & Francis
DOI: 10.1080/09537104.2020.1748586

Quantitative thrombus characteristics on thin-slice computed tomography improve prediction of thrombus histopathology: results of the MR CLEAN Registry.

Auteurs: Hund H, Boodt N, Arrarte Terreros N, Taha A, Marquering HA, van Es ACGM, Bokkers RPH, Lycklama À Nijeholt GJ, Majoie CBLM, Dippel DWJ, Lingsma HF, van Beusekom HMM, van der Lugt A;MR CLEAN Registry Investigators.
Publié dans: European Radiology, 2022, ISSN 0938-7994
Éditeur: Springer Verlag
DOI: 10.1007/s00330-022-08762-y

The Role of Edema in Subacute Lesion Progression After Treatment of Acute Ischemic Stroke

Auteurs: Konduri, Praneeta; van Kranendonk, Katinka; Boers, Anna; Treurniet, Kilian; Berkhemer, Olvert; Yoo, Albert J.; van Zwam, Wim; Oostenbrugge, Robert van; van der Lugt, Aad; Dippel, Diederik; Roos, Yvo; Bot, Joost; Majoie, Charles; Marquering, Henk
Publié dans: Frontiers in Neurology, Numéro 8, 2021, ISSN 1664-2295
Éditeur: Frontiers Research Foundation
DOI: 10.3389/fneur.2021.705221

Self-expandable stent for thrombus removal modeling: Solid or beam finite elements?

Auteurs: Giulia Luraghi; Sara Bridio; Francesco Migliavacca; Jose Felix Rodriguez Matas
Publié dans: Med Eng Phys, Numéro 106, 2022, Page(s) 103836, ISSN 1751-6161
Éditeur: Elsevier BV
DOI: 10.1016/j.medengphy.2022.103836

Investigating the two regimes of fibrin clot lysis: an experimental and computational approach

Auteurs: Franck Raynaud, Alexandre Rousseau, Daniel Monteyne, David Perez-Morga, Karim Zouaoui Boudjeltia, Bastien Chopard
Publié dans: Biophysical Journal, Numéro 120/18, 2021, Page(s) 4091-4106, ISSN 0006-3495
Éditeur: Biophysical Society
DOI: 10.1016/j.bpj.2021.08.005

A low dimensional surrogate model for a fast estimation of strain in the thrombus during a thrombectomy procedure.

Auteurs: Sara Bridio; Giulia Luraghi; Francesco Migliavacca; Sanjay Pant; Alberto García-González; Jose F. Rodriguez Matas
Publié dans: Med Eng Phys, Numéro 106, 2022, Page(s) 103836, ISSN 1751-6161
Éditeur: Elsevier BV
DOI: 10.1016/j.jmbbm.2022.105577

Modelling the effects of cerebral microthrombi on tissue oxygenation and cell death

Auteurs: Yidan Xue, Wahbi K. El-Bouri, Tamás I. Józsa, Stephen J. Payne
Publié dans: Journal of Biomechanics, Numéro 127, 2021, ISSN 0021-9290
Éditeur: Elsevier BV
DOI: 10.1016/j.jbiomech.2021.110705

Blood pressure during endovascular treatment under conscious sedation or local anesthesia

Auteurs: Noor Samuels, Rob A. van de Graaf, Carlijn A.L. van den Berg, Daan Nieboer, Ismail Eralp, Kilian M. Treurniet, Bart J. Emmer, Rogier V. Immink, Charles B.L.M. Majoie, Wim H. van Zwam, Reinoud P.H. Bokkers, Maarten Uyttenboogaart, Boudewijn A.A.M. van Hasselt, Jörg Mühling, James F. Burke, Bob Roozenbeek, Aad van der Lugt, Diederik W.J. Dippel, Hester F. Lingsma, Adriaan C.G.M. van Es
Publié dans: Neurology, 2020, Page(s) 10.1212/WNL.0000000000011006, ISSN 0028-3878
Éditeur: Lippincott Williams & Wilkins Ltd.
DOI: 10.1212/wnl.0000000000011006

similarities and interdependence

Auteurs: Terreros, N.A.; Bruggeman, A.A.E.; Kappelhof, M.; Tolhuisen, M.L.; Brouwer, J.; Hoving, J.W.; Konduri, P.R.; Kranendonk, K.R. van; Dutra, B.G.; Alves, H.C.B.R.; Dippel, D.W.J.; Zwam, W.H. van; Beenen, L.F.M.; Yo, L.S.F.; Bavel, E. van; Majoie, C.B.L.M.; Marquering, H.A.; MR CLEAN Registry Investigators
Publié dans: Journal of Neurointerventional Surgery, Numéro 6, 2022, ISSN 1759-8478
Éditeur: BMJ Publishing Group
DOI: 10.1136/jnis-2022-019134

Development of a patient-specific cerebral vasculature fluid–structure-interaction model

Auteurs: Kevin M. Moerman; Praneeta Konduri; Behrooz Fereidoonnezhad; Henk Marquering; Aad van der Lugt; Giulia Luraghi; Sara Bridio; Francesco Migliavacca; Jose F. Rodriguez Matas; Patrick McGarry
Publié dans: Journal of Biomechanics, Numéro 133, 2022, Page(s) 110896, ISSN 0021-9290
Éditeur: Elsevier BV
DOI: 10.1016/j.jbiomech.2021.110896

Coupling one-dimensional arterial blood flow to three-dimensional tissue perfusion models for in silico trials of acute ischaemic stroke

Auteurs: Raymond M. Padmos, Tamás I. Józsa, Wahbi K. El-Bouri, Praneeta R. Konduri, Stephen J. Payne, Alfons G. Hoekstra
Publié dans: Interface Focus, Numéro 11/1, 2021, Page(s) 20190125, ISSN 2042-8898
Éditeur: Royal Society Publishing
DOI: 10.1098/rsfs.2019.0125

In silico trials for treatment of acute ischemic stroke: Design and implementation

Auteurs: Claire Miller, Raymond M. Padmos, Max van der Kolk, Tamás I. Józsa, Noor Samuels, Yidan Xue, Stephen J. Payne, Alfons G. Hoekstra
Publié dans: Computers in Biology and Medicine, Numéro 137, 2021, Page(s) 104802, ISSN 0010-4825
Éditeur: Pergamon Press Ltd.
DOI: 10.1016/j.compbiomed.2021.104802

Applicability assessment of a stent-retriever thrombectomy finite-element model

Auteurs: Giulia Luraghi, Jose Felix Rodriguez Matas, Gabriele Dubini, Francesca Berti, Sara Bridio, Sharon Duffy, Anushree Dwivedi, Ray McCarthy, Behrooz Fereidoonnezhad, Patrick McGarry, Charles B. L. M. Majoie, Francesco Migliavacca
Publié dans: Interface Focus, Numéro 11/1, 2021, Page(s) 20190123, ISSN 2042-8898
Éditeur: Royal Society Publishing
DOI: 10.1098/rsfs.2019.0123

Microembolus clearance through angiophagy is an auxiliary mechanism preserving tissue perfusion in the rat brain

Auteurs: Anne-Eva van der Wijk, Theodosia Georgakopoulou, Jisca Majolée, Jan S. M. van Bezu, Miesje M. van der Stoel, Bert J. van het Hof, Helga E. de Vries, Stephan Huveneers, Peter L. Hordijk, Erik N. T. P. Bakker, Ed van Bavel
Publié dans: Acta Neuropathologica Communications, Numéro 8/1, 2020, ISSN 2051-5960
Éditeur: BioMed Central
DOI: 10.1186/s40478-020-01071-9

Quantification of hypoxic regions distant from occlusions in cerebral penetrating arteriole trees.

Auteurs: Xue Y, Georgakopoulou T, van der Wijk AE, Józsa TI, van Bavel E, Payne SJ.
Publié dans: PLoS Comput Biol., Numéro Aug 5;18(8), 2022, Page(s) e1010166, ISSN 1553-734X
Éditeur: Public Library of Science
DOI: 10.1371/journal.pcbi.1010166

Microcatheter tracking in thrombectomy procedures: A finite-element simulation study

Auteurs: Nerea Arrarte Terreros, Silvia Renon, Francesca Zucchelli, Sara Bridio, Jose Felix Rodriguez Matas, Gabriele Dubini, Praneeta R. Konduri, Miou S. Koopman, Wim H. van Zwam, Lonneke S.F. Yo, Rob H. Lo, Henk A. Marquering, Ed van Bavel, Charles B.L.M. Majoie, Francesco Migliavacca, Giulia Luraghi.
Publié dans: Computer Methods and Programs in Biomedicine, Numéro Volume 234, 2023, Page(s) 107515, ISSN 1751-6161
Éditeur: Elsevier BV
DOI: 10.1016/j.cmpb.2023.107515

sj-pdf-2-wso-10.1177_1747493019884527 - Supplemental material for Histological stroke clot analysis after thrombectomy: Technical aspects and recommendations

Auteurs: S Staessens; S Fitzgerald; T Andersson; F Clarençon; F Denorme; MJ Gounis; W Hacke; DS Liebeskind; I Szikora; ACGM Van Es; W Brinjikji; KM Doyle; SF De Meyer
Publié dans: International journal of stroke, Numéro 11, 2020, ISSN 1747-4930
Éditeur: Blackwell
DOI: 10.25384/sage.12325865

Novel hyperelastic models for large volumetric deformations

Auteurs: Kevin M. Moerman; Behrooz Fereidoonnezhad; J. Patrick McGarry
Publié dans: Numéro 1, 2019
Éditeur: Engxriv
DOI: 10.31224/OSF.IO/CFXDR

Thrombus mechanics: How can we contribute to improve diagnostics and treatment?

Auteurs: Migliavacca F, Luraghi G, Akyildiz AC, Gijsen FJH.
Publié dans: J Biomech., Numéro 132, 2022, Page(s) 110935, ISSN 0021-9290
Éditeur: Elsevier BV
DOI: 10.1016/j.jbiomech.2021.110935

sj-pdf-1-wso-10.1177_1747493019884527 - Supplemental material for Histological stroke clot analysis after thrombectomy: Technical aspects and recommendations

Auteurs: S Staessens; S Fitzgerald; T Andersson; F Clarençon; F Denorme; MJ Gounis; W Hacke; DS Liebeskind; I Szikora; ACGM Van Es; W Brinjikji; KM Doyle; SF De Meyer
Publié dans: International journal of stroke, Numéro 4, 2020, ISSN 1747-4930
Éditeur: Blackwell
DOI: 10.25384/sage.10253195.v2

Additional file 9 of Microembolus clearance through angiophagy is an auxiliary mechanism preserving tissue perfusion in the rat brain

Auteurs: Wijk, Anne-Eva Van Der; Georgakopoulou, Theodosia; Majolée, Jisca; Bezu, Jan S. M. Van; Stoel, Miesje M. Van Der; Hof, Bert J. Van Het; Vries, Helga E. De; Huveneers, Stephan; Hordijk, Peter L.; Bakker, Erik N. T. P.; Bavel, Ed Van
Publié dans: Acta Neuropathologica Communications, Numéro 8/1, 2020, ISSN 2051-5960
Éditeur: BioMed Central
DOI: 10.6084/m9.figshare.13250804.v1

Additional file 4 of Microembolus clearance through angiophagy is an auxiliary mechanism preserving tissue perfusion in the rat brain

Additional file 1 of Microembolus clearance through angiophagy is an auxiliary mechanism preserving tissue perfusion in the rat brain

sj-pdf-2-wso-10.1177_1747493019884527 - Supplemental material for Histological stroke clot analysis after thrombectomy: Technical aspects and recommendations

Auteurs: S Staessens; S Fitzgerald; T Andersson; F Clarençon; F Denorme; MJ Gounis; W Hacke; DS Liebeskind; I Szikora; ACGM Van Es; W Brinjikji; KM Doyle; SF De Meyer
Publié dans: International jounral of stroke, Numéro 10, 2020, ISSN 1747-4930
Éditeur: Blackwell publishing
DOI: 10.25384/sage.12325865.v1

Uncertainty Quantification of Coupled 1D Arterial Blood Flow and 3D Tissue Perfusion Models Using the INSIST Framework

Auteurs: Claire Miller, Max van der Kolk, Raymond Padmos, Tamás Józsa, Alfons Hoekstra
Publié dans: Computational Science – ICCS 2021 - 21st International Conference, Krakow, Poland, June 16–18, 2021, Proceedings, Part VI, Numéro 12747, 2021, Page(s) 691-697, ISBN 978-3-030-77979-5
Éditeur: Springer International Publishing
DOI: 10.1007/978-3-030-77980-1_52

Two-Way Coupling Between 1D Blood Flow and 3D Tissue Perfusion Models

Auteurs: Raymond M. Padmos, Tamás I. Józsa, Wahbi K. El-Bouri, Gábor Závodszky, Stephen J. Payne, Alfons G. Hoekstra
Publié dans: Computational Science – ICCS 2021 - 21st International Conference, Krakow, Poland, June 16–18, 2021, Proceedings, Part III, Numéro 12744, 2021, Page(s) 670-683, ISBN 978-3-030-77966-5
Éditeur: Springer International Publishing
DOI: 10.1007/978-3-030-77967-2_56

des-ist: A Simulation Framework to Streamline Event-Based In Silico Trials

Auteurs: Max van der Kolk, Claire Miller, Raymond Padmos, Victor Azizi, Alfons Hoekstra
Publié dans: Computational Science – ICCS 2021 - 21st International Conference, Krakow, Poland, June 16–18, 2021, Proceedings, Part III, Numéro 12744, 2021, Page(s) 648-654, ISBN 978-3-030-77966-5
Éditeur: Springer International Publishing
DOI: 10.1007/978-3-030-77967-2_53

INSIST - IN SILICO TRIALS FOR TREATMENT OF ACUTE ISCHEMIC STROKE

Auteurs: Konduri, Praneeta
Publié dans: Numéro 3, 2018
Éditeur: Moressier
DOI: 10.26226/morressier.5aeac941521e300021137ff8

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