IN-Silico trials for treatment of acute Ischemic STroke

Rezultaty

Final public version of the population model

First version of a virtual population of stroke patients (Module I)
Final Statistical model that relates images features of clot to clot characteristics

Final statistical model that relates images features of clot to clot characteristics

Final statistical model (Module III)

Final statistical model (Module III) that relates image outcome (revascularisation, reperfusion) to clinical outcome

Periodic reporting period 3

Periodic technical reports and periodic financial and ethical reports for the ECMonth 54 is Period end report is due month 56

Outcome of in silico trials
Final report on all available models with full validation data for thrombosis and thrombolysis including the description of the increased understanding of the pathophysiological aspects of thrombosis and thrombolysis

Final report on all available models with full validation data for thrombosis and thrombolysis including the description of the increased understanding of the pathophysiological aspects of thrombosis and thrombolysisThis deliverables is not just a report but will also deliver the associated models as simulation software eg to WP6

Periodic report period 2

Periodic technical reports and periodic financial and ethical reports for the EC Report is due month 38

Validated in silico trial platform
Implementation of full 3D characterized models
Initial integration of all models
Finite element meshes of patient specific clot and vessel geometries
Second report on models for advanced versions thrombosis and thrombolysis and combined model including validation and the formal VVUQ and reports on the experiments carried out during the second 18 months of the project

Second report on models for advanced versions thrombosis and thrombolysis and combined model including validation and the formal VVUQ and reports on the experiments carried out during the second 18 months of the project. This deliverables is not just a report, but will also deliver the associated models as simulation software (e.g. to WP6).

Implementation of individual models of interaction
Quality Assurance Plan

Quality Assurance Plan to manage the quality control including a detailed risk analysis and contingency planning

In silico model for mechanical performance of thrombectomy devices
Project Handbook

Project Handbook to ensure consistent implementation of the management

Implementation of model of microvascular damage
Data Management Plan template
Validation of models with clinical data
Data base of composition-specific clot mechanical properties and a new constitutive law for clots
Modelling platform for simulation of thrombectomy performance in patient specific models
First public version of a population model to generate virtual populations
Initial report on dissemination, exploitation and sustainability plan

Initial report on dissemination, exploitation and sustainability plan with a detailed plan and schedule for all dissemination, communication, and exploitation activities. The plan will be delivered in M3, and updated to coincide with reporting period Note: All the tasks and deliverables depicted in this WP will be implemented taking into account the best practices in Data Management (WP1) and the template for Data Management Plan (D1.6)

Periodic reporting

Periodic technical reports and periodic financial and ethical reports for the EC. Report is due month 20

Implementation of VVUQ procedures and initial validation exercises on integrated models
An in silico clinical stroke trial computing environment
First report on models for thrombosis and thrombolysis and combined model describing the models and performed experiments

First report on models for thrombosis and thrombolysis and combined model describing the models and performed experiments. This deliverables is not just a report, but will also deliver the associated models as simulation software (e.g. to WP6).

Consortium Agreement

Second report on dissemination, communication and sustainability

Second dissemination, communication and sustainability report. Note: All the tasks and deliverables depicted in this WP will be implemented taking into account the best practices in Data Management (WP1) and the template for Data Management Plan (D1.6)

First report on dissemination, communication and sustainability

First dissemination, communication and sustainability report, with a review of events dissemination, communication, and exploitation results including an update of dissemination, communication, and exploitation action plan Note: All the tasks and deliverables depicted in this WP will be implemented taking into account the best practices in Data Management (WP1) and the template for Data Management Plan (D1.6)

Final dissemination, communication and sustainability report

Final dissemination communication and sustainability report with a review of the events and dissemination communication and exploitation results and reports on postproject plans for exploitations of INSIST M54Note All the tasks and deliverables depicted in this WP will be implemented taking into account the best practices in Data Management WP1 and the template for Data Management Plan D16

Publikacje

Early recanalization in large-vessel occlusion stroke patients transferred for endovascular treatment

Autorzy: Nerea Arrarte Terreros, Agnetha A E Bruggeman, Isabella S J Swijnenburg, Laura C C van Meenen, Adrien E Groot, Jonathan M Coutinho, Yvo B W E M Roos, Bart J Emmer, Ludo F M Beenen, Ed van Bavel, Henk A Marquering, Charles B L M Majoie
Opublikowane w: Journal of NeuroInterventional Surgery, 2021, Strona(/y) neurintsurg-2021-017441, ISSN 1759-8478
Wydawca: BMJ Publishing Group
DOI: 10.1136/neurintsurg-2021-017441

Extravasation of biodegradable microspheres in the rat brain.

Autorzy: van der Wijk AE, Georgakopoulou T, Steendam R, Zuidema J, Hordijk PL, Bakker ENTP, van Bavel E.
Opublikowane w: Drug Deliv., Numer Dec;30(1), 2023, Strona(/y) 2194579, ISSN 2155-4277
Wydawca: Taylor & Francis online
DOI: 10.1080/10717544.2023.2194579

A porous circulation model of the human brain for in silico clinical trials in ischaemic stroke

Autorzy: T. I. Józsa, R. M. Padmos, N. Samuels, W. K. El-Bouri, A. G. Hoekstra, S. J. Payne
Opublikowane w: Interface Focus, Numer 11/1, 2021, Strona(/y) 20190127, ISSN 2042-8898
Wydawca: Royal Society Publishing
DOI: 10.1098/rsfs.2019.0127

Impact of the Internal Carotid Artery Morphology on in silico Stent-Retriever Thrombectomy Outcome

Autorzy: Sara Bridio, Giulia Luraghi, Jose F. Rodriguez Matas, Gabriele Dubini, Giorgia G. Giassi, Greta Maggio, Julia N. Kawamoto, Kevin M. Moerman, Patrick McGarry, Praneeta R. Konduri, Nerea Arrarte Terreros, Henk A. Marquering, Ed van Bavel, Charles B. L. M. Majoie, Francesco Migliavacca
Opublikowane w: Frontiers in Medical Technology, Numer 3, 2021, ISSN 2673-3129
Wydawca: Frontiers Media SA
DOI: 10.3389/fmedt.2021.719909

Blood clot fracture properties are dependent on red blood cell and fibrin content

Autorzy: B. Fereidoonnezhad; Anushree Dwivedi; Sarah E. Johnson; Ray McCarthy; Patrick McGarry
Opublikowane w: Acta Biomaterialia, Numer 7, 2021, Strona(/y) 213-228, ISSN 1742-7061
Wydawca: Elsevier BV
DOI: 10.1101/2020.10.05.326165

Bifurcation occlusions and endovascular treatment outcome in acute ischemic stroke

Autorzy: Nerea Arrarte Terreros, Agnetha A E Bruggeman, Henk van Voorst, Praneeta R Konduri, Ivo G H Jansen, Manon Kappelhof, Manon L Tolhuisen, Nikki Boodt, Diederik W J Dippel, Aad van der Lugt, Wim H van Zwam, Robert J van Oostenbrugge, H. Bart van der Worp, Bart J Emmer, Frederick J A Meijer, Yvo B W E M Roos, Ed van Bavel, Henk A Marquering, Charles B L M Majoie MR CLEAN Registry investigators
Opublikowane w: journal of NeuroInterventional Surgery, 2022, ISSN 1759-8486
Wydawca: BMJ
DOI: 10.1136/neurintsurg-2021-018560

In silico thrombectomy trials for acute ischemic stroke.

Autorzy: Miller C, Konduri P, Bridio S, Luraghi G, Arrarte Terreros N, Boodt N, Samuels N, Rodriguez Matas JF, Migliavacca F, Lingsma H, van der Lugt A, Roos Y, Dippel D, Marquering H, Majoie C, Hoekstra A.
Opublikowane w: Comput Methods Programs Biomed, Numer Jan;228, 2023, Strona(/y) 107244, ISSN 0169-2607
Wydawca: Elsevier BV
DOI: 10.1016/j.cmpb.2022.107244

Redistribution of TPA Fluxes in the Presence of PAI-1 Regulates Spatial Thrombolysis

Autorzy: Alexey M. Shibeko, Bastien Chopard, Alfons G. Hoekstra, Mikhail A. Panteleev
Opublikowane w: Biophysical Journal, Numer 119/3, 2020, Strona(/y) 638-651, ISSN 0006-3495
Wydawca: Biophysical Society
DOI: 10.1016/j.bpj.2020.06.020

Mechanical Characterization of Thrombi Retrieved With Endovascular Thrombectomy in Patients With Acute Ischemic Stroke

Autorzy: Nikki Boodt, Philip R.W. Snouckaert van Schauburg, Hajo M. Hund, Behrooz Fereidoonnezhad, J. Patrick McGarry, Ali C. Akyildiz, Adriaan C.G.M. van Es, Simon F. De Meyer, Diederik W.J. Dippel, Hester F. Lingsma, Heleen M.M. van Beusekom, Aad van der Lugt, Frank J.H. Gijsen
Opublikowane w: Stroke, Numer 52/8, 2021, Strona(/y) 2510-2517, ISSN 0039-2499
Wydawca: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/strokeaha.120.033527

Red blood cell and platelet diffusivity and margination in the presence of cross-stream gradients in blood flows

Autorzy: Gábor Závodszky, Britt van Rooij, Ben Czaja, Victor Azizi, David de Kanter, Alfons G. Hoekstra
Opublikowane w: Physics of Fluids, Numer 31/3, 2019, Strona(/y) 031903, ISSN 1070-6631
Wydawca: American Institute of Physics
DOI: 10.1063/1.5085881

Investigating the Mechanical Behavior of Clot Analogues Through Experimental and Computational Analysis

Autorzy: Sarah Johnson, Ray McCarthy, Michael Gilvarry, Peter E. McHugh, J. Patrick McGarry
Opublikowane w: Annals of Biomedical Engineering, Numer 49/1, 2021, Strona(/y) 420-431, ISSN 0090-6964
Wydawca: Kluwer Academic Publishers
DOI: 10.1007/s10439-020-02570-5

Structural analysis of ischemic stroke thrombi: histological indications for therapy resistance

Autorzy: Senna Staessens, Frederik Denorme, Olivier Francois, Linda Desender, Tom Dewaele, Peter Vanacker, Hans Deckmyn, Karen Vanhoorelbeke, Tommy Andersson, Simon F. De Meyer
Opublikowane w: Haematologica, Numer 105/2, 2020, Strona(/y) 498-507, ISSN 0390-6078
Wydawca: Ferrata Storti Foundation
DOI: 10.3324/haematol.2019.219881

Occult blood flow patterns distal to an occluded artery in acute ischemic stroke

Autorzy: Nerea Arrarte Terreros; Bettine G. van Willigen; Wera S. Niekolaas; Manon L. Tolhuisen; Josje Brouwer; Jonathan M. Coutinho; Ludo F. M. Beenen; Charles B. L. Majoie; Ed van Bavel; Henk A. Marquering
Opublikowane w: J Cereb Blood Flow Metab., Numer 42, 2022, Strona(/y) 292-302, ISSN 0271-678X
Wydawca: Lippincott Williams & Wilkins Ltd.
DOI: 10.1177/0271678x211044941

Applicability analysis to evaluate credibility of an in silico thrombectomy procedure

Autorzy: Giulia Luraghi, Sara Bridio, Claire Miller, Alfons Hoekstra, Jose Felix Rodriguez Matas, Francesco Migliavacca
Opublikowane w: Journal of Biomechanics, Numer 126, 2021, Strona(/y) 110631, ISSN 0021-9290
Wydawca: Elsevier BV
DOI: 10.1016/j.jbiomech.2021.110631

Modelling the leptomeningeal collateral circulation during acute ischaemic stroke

Autorzy: Raymond M. Padmos, Nerea Arrarte Terreros, Tamás I. Józsa, Gábor Závodszky, Henk A. Marquering, Charles B.L.M. Majoie, Alfons G. Hoekstra
Opublikowane w: Medical Engineering & Physics, Numer 91, 2021, Strona(/y) 1-11, ISSN 1350-4533
Wydawca: Elsevier BV
DOI: 10.1016/j.medengphy.2021.03.003

The Ageing Brain: Investigating the Role of Age in Changes to the Human Cerebral Microvasculature With an in silico Model

Autorzy: Barnaby J. Graff; Stephen J. Payne; Wahbi K. El-Bouri; Wahbi K. El-Bouri; Wahbi K. El-Bouri
Opublikowane w: Frontiers in Aging Neuroscience, Numer 8, 2021, ISSN 1663-4365
Wydawca: Frontiers Research Foundation
DOI: 10.3389/fnagi.2021.632521

The first virtual patient-specific thrombectomy procedure

Autorzy: Giulia Luraghi, Sara Bridio, Jose Felix Rodriguez Matas, Gabriele Dubini, Nikki Boodt, Frank J.H. Gijsen, Aad van der Lugt, Behrooz Fereidoonnezhad, Kevin M. Moerman, Patrick McGarry, Praneeta R. Konduri, Nerea Arrarte Terreros, Henk A. Marquering, Charles B.L.M. Majoie, Francesco Migliavacca
Opublikowane w: Journal of Biomechanics, Numer 126, 2021, Strona(/y) 110622, ISSN 0021-9290
Wydawca: Elsevier BV
DOI: 10.1016/j.jbiomech.2021.110622

In vitro and in silico modeling of endovascular stroke treatments for acute ischemic stroke

Autorzy: Giulia Luraghi, Rachel M.E. Cahalane, Emma van de Ven, Serena C.M. Overschie, Frank J.H. Gijsen, Ali C. Akyildiz
Opublikowane w: Journal of Biomechanics, Numer 127, 2021, Strona(/y) 110693, ISSN 0021-9290
Wydawca: Elsevier BV
DOI: 10.1016/j.jbiomech.2021.110693

A new constitutive model for permanent deformation of blood clots with application to simulation of aspiration thrombectomy

Autorzy: Behrooz Fereidoonnezhad, Patrick McGarry
Opublikowane w: Journal of Biomechanics, Numer 130, 2022, ISSN 0021-9290
Wydawca: Elsevier BV
DOI: 10.1016/j.jbiomech.2021.110865

Is modeling stents still an important issue?

Autorzy: Francesco Migliavacca
Opublikowane w: Procedia Structural Integrity, Numer 15, 2019, Strona(/y) 46-50, ISSN 2452-3216
Wydawca: Elsevier
DOI: 10.1016/j.prostr.2019.07.009

Association between thrombus composition and stroke etiology in the MR CLEAN Registry biobank

Autorzy: Hajo M. Hund, Nikki Boodt, Daniel Hansen, Willem A. Haffmans, Geert J. Lycklama à Nijeholt, Jeannette Hofmeijer, Diederik W. J. Dippel, Aad van der Lugt, Adriaan C. G. M. van Es, Heleen M. M. van Beusekom, on behalf of the MR CLEAN Registry Investigators
Opublikowane w: Neuroradiology, Numer 65, 2023, Strona(/y) 933–943, ISSN 1476-4687
Wydawca: Springer Nature
DOI: 10.1007/s00234-023-03115-y

A new anisotropic soft tissue model for elimination of unphysical auxetic behaviour

Autorzy: B. Fereidoonnezhad, C. O’Connor, J.P. McGarry
Opublikowane w: Journal of Biomechanics, Numer 111, 2020, Strona(/y) 110006, ISSN 0021-9290
Wydawca: Elsevier BV
DOI: 10.1016/j.jbiomech.2020.110006

A review on the association of thrombus composition with mechanical and radiological imaging characteristics in acute ischemic stroke.

Autorzy: Rachel Cahalane, Nikki Boodt, Ali Cagdas Akyildiz, Jo-anne Giezen, Manouk Mondeel, Aad van der Lugt, Henk Marquering, Frank Gijsen.
Opublikowane w: Journal of Biomechanics, Numer 129, 2021, ISSN 0021-9290
Wydawca: Elsevier BV
DOI: 10.1016/j.jbiomech.2021.110816

Recovery of Hypoxic Regions in a Rat Model of Microembolism

Autorzy: Theodosia Georgakopoulou, Anne-Eva van der Wijk, Erik N.T.P. Bakker, Ed vanBavel
Opublikowane w: Journal of Stroke and Cerebrovascular Diseases, Numer 30/6, 2021, Strona(/y) 105739, ISSN 1052-3057
Wydawca: W. B. Saunders Co., Ltd.
DOI: 10.1016/j.jstrokecerebrovasdis.2021.105739

Reliable Numerical Models of Nickel-Titanium Stents: How to Deduce the Specific Material Properties from Testing Real Devices

Autorzy: Francesca Berti; Sara Bridio; Giulia Luraghi; Sanjay Pant; Dario Allegretti; Giancarlo Pennati; Lorenza Petrini
Opublikowane w: Ann Biomed Eng., Numer 00906964, 2022, Strona(/y) 467-481, ISSN 0090-6964
Wydawca: Kluwer Academic Publishers
DOI: 10.1007/s10439-022-02932-1

Perivascular clearance of blood proteins after blood-brain barrier disruption in a rat modelof microinfarcts.

Autorzy: Georgakopoulou T, van der Wijk AE, van Bavel E, Bakker ENTP.
Opublikowane w: Microvasc Res., Numer Mar 7;148, 2023, Strona(/y) 104515, ISSN 1751-6161
Wydawca: Elsevier BV
DOI: 10.1016/j.mvr.2023.104515

Stroke Etiology and Thrombus Computed Tomography Characteristics in Patients With Acute Ischemic Stroke

Autorzy: Nikki Boodt, Kars C.J. Compagne, Bruna G. Dutra, Noor Samuels, Manon L. Tolhuisen, Heitor C.B.R. Alves, Manon Kappelhof, Geert J. Lycklama à Nijeholt, Henk. A. Marquering, Charles B.L.M. Majoie, Hester F. Lingsma, Diederik W.J. Dippel, Aad van der Lugt, Yvo Roos, Robert van Oostenbrugge, Wim van Zwam, Jelis Boiten, Jan Albert Vos, Ivo Jansen, Maxim Mulder, Robert-Jan Goldhoorn, Wouter Schonewille
Opublikowane w: Stroke, Numer 51/6, 2020, Strona(/y) 1727-1735, ISSN 0039-2499
Wydawca: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/strokeaha.119.027749

Blood Pressure in the First 6 Hours Following Endovascular Treatment for Ischemic Stroke Is Associated With Outcome

Autorzy: Samuels N, van de Graaf RA, van den Berg CAL, Uniken Venema SM, Bala K, van Doormaal PJ, van der Steen W, Witvoet E, Boiten J, den Hertog H, Schonewille WJ, Hofmeijer J, Schreuder F, Schreuder TAHCML, van der Worp HB, Roos YBWEM, Majoie CBLM, Burke JF, van Es ACGM, van der Lugt A, Roozenbeek B, Lingsma HF, Dippel DWJ; MR CLEAN Registry Investigators.
Opublikowane w: Stroke., Numer 20479980, 2021, Strona(/y) 3514-3522, ISSN 2047-9980
Wydawca: Wiley-Blackwell
DOI: 10.1161/strokeaha.120.033657

Perivascular Clearance of Blood Proteins after Blood-Brain Barrier Disruption in a Rat Model of Micro-Infarcts

Autorzy: Theodosia Georgakopoulou; Anne-Eva van der Wijk; Ed van Bavel; Erik N.T.P. Bakker
Opublikowane w: Microvascular research, Numer Volume 148, July 2023, 2023, Strona(/y) 104515, ISSN 1751-6161
Wydawca: Elsevier BV
DOI: 10.2139/ssrn.4292893

Automated final lesion segmentation in posterior circulation acute ischemic stroke using deep learning

Autorzy: Riaan Zoetmulder; Praneeta R Konduri; Iris V Obdeijn; Efstratios Gavves; Ivana Išgum; Charles B. L. M. Majoie; Diederik W.J. Dippel; Yvo B.W.E.M. Roos; Mayank Goyal; Mayank Goyal; Peter Mitchell; Bruce C.V. Campbell; Demetrius K. Lopes; Gernot Reimann; Tudor G Jovin; Jeffrey L. Saver; Keith W. Muir; Phil White; Serge Bracard; Bailiang Chen; Scott Brown; Wouter J. Schonewille; Erik J.R.J. van der
Opublikowane w: Diagnostics, Numer Sep 4;11(9), 2021, Strona(/y) 1621, ISSN 2075-4418
Wydawca: MDPI
DOI: 10.3390/diagnostics11091621

Modelling collateral flow and thrombus permeability during acute ischaemic stroke

Autorzy: Raymond M. Padmos; Nerea Arrarte Terreros; Tamás I. Józsa; Gábor Závodszky; Henk A. Marquering; Charles B. L. M. Majoie; Stephen J. Payne; Alfons G. Hoekstra
Opublikowane w: Journal of the Royal Society, Interface, Numer vol. 19 , no. 195, 2022, Strona(/y) 20220649, ISSN 1742-5662
Wydawca: The royal society publishing
DOI: 10.1098/rsif.2022.0649

Thrombolysis: Observations and numerical models

Autorzy: Remy Petkantchin; Raymond Padmos; Karim Zouaoui Boudjeltia; Franck Raynaud; Bastien Chopard
Opublikowane w: Journal of Biomechanics, 132:110902. Elsevier, Numer 9, 2022, ISSN 0021-9290
Wydawca: Elsevier BV
DOI: 10.1016/j.jbiomech.2021.110902

Combined stent-retriever and aspiration intra-arterial thrombectomy performance for fragmentable blood clots: A proof-of-concept computational study

Autorzy: Giulia Luraghi, Sara Bridio, Vittorio Lissoni, Gabriele Dubini, Anushree Dwivedi, Ray McCarthy, Behrooz Fereidoonnezhad, Patrick McGarry, Frank J.H. Gijsen, Jose Felix Rodriguez Matas, Francesco Migliavacca
Opublikowane w: Journal of the Mechanical Behavior of Biomedical Materials, Numer Volume 135, 2022, Strona(/y) 105462, ISSN 1751-6161
Wydawca: Elsevier BV
DOI: 10.1016/j.jmbbm.2022.105462

Studying Stroke Thrombus Composition After Thrombectomy: What Can We Learn?

Autorzy: Senna Staessens, Olivier François, Waleed Brinjikji, Karen M. Doyle, Peter Vanacker, Tommy Andersson and Simon F. De Meyer
Opublikowane w: Stroke, Numer 20479980, 2021, Strona(/y) 3718–3727, ISSN 2047-9980
Wydawca: Wiley-Blackwell
DOI: 10.1161/strokeaha.121.034289

From perviousness to permeability, modelling and measuring intra-thrombus flow in acute ischemic stroke

Autorzy: Nerea Arrarte Terreros, Manon L. Tolhuisen, Edwin Bennink, Hugo W.A.M. de Jong, Ludo F.M. Beenen, Charles B.L.M. Majoie, Ed van Bavel, Henk A. Marquering
Opublikowane w: Journal of Biomechanics, Numer 111, 2020, Strona(/y) 110001, ISSN 0021-9290
Wydawca: Elsevier BV
DOI: 10.1016/j.jbiomech.2020.110001

Quantification of hypoxic regions distant from occlusions in cerebral penetrating arteriole trees

Autorzy: Yidan Xue; Theodosia Georgakopoulou; Anne-Eva van der Wijk; Tamás I. Józsa; Ed van Bavel; Stephen J. Payne
Opublikowane w: PLoS Computational Biology, Numer 18, 2022, ISSN 1553-734X
Wydawca: Public Library of Science
DOI: 10.1101/2022.05.06.490869

Measuring the effect of thrombosis, thrombus maturation and thrombolysis on clot mechanical properties in an in-vitro model.

Autorzy: Anushree Dwivedi; Aoife Glynn; Sarah Johnson; Sarah Johnson; Sharon Duffy; Sharon Duffy; Behrooz Fereidoonnezhad; Patrick McGarry; Michael Gilvarry; Ray McCarthy
Opublikowane w: Journal of Biomechanics, Numer 129, 2021, ISSN 0021-9290
Wydawca: Elsevier BV
DOI: 10.1016/j.jbiomech.2021.110731

A new compressible hyperelastic model for the multi-axial deformation of blood clot occlusions in vessels

Autorzy: Behrooz Fereidoonnezhad, Kevin M. Moerman, Sarah Johnson, Ray McCarthy, Patrick J. McGarry
Opublikowane w: Biomechanics and Modeling in Mechanobiology, 2021, ISSN 1617-7959
Wydawca: Springer Verlag
DOI: 10.1007/s10237-021-01446-4

Extravasation of Microspheres in a Rat Model of Silent Brain Infarcts

Autorzy: Anne-Eva van der Wijk, Nadia Lachkar, Judith de Vos, Anita E. Grootemaat, Nicole N. van der Wel, Peter L. Hordijk, Erik N.T.P. Bakker, Ed vanBavel
Opublikowane w: Stroke, Numer 50/6, 2019, Strona(/y) 1590-1594, ISSN 0039-2499
Wydawca: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/strokeaha.119.024975

Quantitative 3D analysis of tissue damage in a rat model of microembolization

Autorzy: Georgakopoulou T, van der Wijk AE, Bakker ENTP, vanBavel E; INSIST investigators.
Opublikowane w: J Biomech., Numer 128, 2021, Strona(/y) 110723, ISSN 0021-9290
Wydawca: Elsevier BV
DOI: 10.1016/j.jbiomech.2021.110723

On the Sensitivity Analysis of Porous Finite Element Models for Cerebral Perfusion Estimation

Autorzy: T. I. Józsa, R. M. Padmos, W. K. El-Bouri, A. G. Hoekstra, S. J. Payne
Opublikowane w: Annals of Biomedical Engineering, 2021, ISSN 0090-6964
Wydawca: Kluwer Academic Publishers
DOI: 10.1007/s10439-021-02808-w

Modelling the impact of clot fragmentation on the microcirculation after thrombectomy

Autorzy: Wahbi K. El-Bouri, Andrew MacGowan, Tamás I. Józsa, Matthew J. Gounis, Stephen J. Payne
Opublikowane w: PLOS Computational Biology, Numer 17/3, 2021, Strona(/y) e1008515, ISSN 1553-7358
Wydawca: PLOS
DOI: 10.1371/journal.pcbi.1008515

In-Silico Trials for Treatment of Acute Ischemic Stroke

Autorzy: Praneeta R. Konduri, Henk A. Marquering, Ed E. van Bavel, Alfons Hoekstra, Charles B. L. M. Majoie
Opublikowane w: Frontiers in Neurology, Numer 11, 2020, ISSN 1664-2295
Wydawca: Frontiers Research Foundation
DOI: 10.3389/fneur.2020.558125

Novel hyperelastic models for large volumetric deformations

Autorzy: Kevin M. Moerman, Behrooz Fereidoonnezhad, J. Patrick McGarry
Opublikowane w: International Journal of Solids and Structures, Numer 193-194, 2020, Strona(/y) 474-491, ISSN 0020-7683
Wydawca: Pergamon Press Ltd.
DOI: 10.1016/j.ijsolstr.2020.01.019

Histological stroke clot analysis after thrombectomy: Technical aspects and recommendations

Autorzy: S Staessens, S Fitzgerald, T Andersson, F Clarençon, F Denorme, MJ Gounis, W Hacke, DS Liebeskind, I Szikora, ACGM van Es, W Brinjikji, KM Doyle, SF De Meyer
Opublikowane w: International Journal of Stroke, Numer 15/5, 2020, Strona(/y) 467-476, ISSN 1747-4930
Wydawca: Blackwell
DOI: 10.1177/1747493019884527

Detailed histological analysis of a thrombectomy-resistant ischemic stroke thrombus: a case report

Autorzy: Senna Staessens, Olivier François, Linda Desender, Peter Vanacker, Tom Dewaele, Raf Sciot, Karen Vanhoorelbeke, Tommy Andersson, Simon F. De Meyer
Opublikowane w: Thrombosis Journal, Numer 19/1, 2021, ISSN 1477-9560
Wydawca: BioMed Central
DOI: 10.1186/s12959-021-00262-1

Thrombus heterogeneity in ischemic stroke

Autorzy: Senna Staessens, Simon F. De Meyer
Opublikowane w: Platelets, 2020, Strona(/y) 1-9, ISSN 0953-7104
Wydawca: Taylor & Francis
DOI: 10.1080/09537104.2020.1748586

Quantitative thrombus characteristics on thin-slice computed tomography improve prediction of thrombus histopathology: results of the MR CLEAN Registry.

Autorzy: Hund H, Boodt N, Arrarte Terreros N, Taha A, Marquering HA, van Es ACGM, Bokkers RPH, Lycklama À Nijeholt GJ, Majoie CBLM, Dippel DWJ, Lingsma HF, van Beusekom HMM, van der Lugt A;MR CLEAN Registry Investigators.
Opublikowane w: European Radiology, 2022, ISSN 0938-7994
Wydawca: Springer Verlag
DOI: 10.1007/s00330-022-08762-y

The Role of Edema in Subacute Lesion Progression After Treatment of Acute Ischemic Stroke

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Self-expandable stent for thrombus removal modeling: Solid or beam finite elements?

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Investigating the two regimes of fibrin clot lysis: an experimental and computational approach

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A low dimensional surrogate model for a fast estimation of strain in the thrombus during a thrombectomy procedure.

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Opublikowane w: Med Eng Phys, Numer 106, 2022, Strona(/y) 103836, ISSN 1751-6161
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Modelling the effects of cerebral microthrombi on tissue oxygenation and cell death

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Blood pressure during endovascular treatment under conscious sedation or local anesthesia

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similarities and interdependence

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Development of a patient-specific cerebral vasculature fluid–structure-interaction model

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Coupling one-dimensional arterial blood flow to three-dimensional tissue perfusion models for in silico trials of acute ischaemic stroke

Autorzy: Raymond M. Padmos, Tamás I. Józsa, Wahbi K. El-Bouri, Praneeta R. Konduri, Stephen J. Payne, Alfons G. Hoekstra
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In silico trials for treatment of acute ischemic stroke: Design and implementation

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Applicability assessment of a stent-retriever thrombectomy finite-element model

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Microembolus clearance through angiophagy is an auxiliary mechanism preserving tissue perfusion in the rat brain

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Quantification of hypoxic regions distant from occlusions in cerebral penetrating arteriole trees.

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Microcatheter tracking in thrombectomy procedures: A finite-element simulation study

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sj-pdf-2-wso-10.1177_1747493019884527 - Supplemental material for Histological stroke clot analysis after thrombectomy: Technical aspects and recommendations

Autorzy: S Staessens; S Fitzgerald; T Andersson; F Clarençon; F Denorme; MJ Gounis; W Hacke; DS Liebeskind; I Szikora; ACGM Van Es; W Brinjikji; KM Doyle; SF De Meyer
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Novel hyperelastic models for large volumetric deformations

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Thrombus mechanics: How can we contribute to improve diagnostics and treatment?

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sj-pdf-1-wso-10.1177_1747493019884527 - Supplemental material for Histological stroke clot analysis after thrombectomy: Technical aspects and recommendations

Autorzy: S Staessens; S Fitzgerald; T Andersson; F Clarençon; F Denorme; MJ Gounis; W Hacke; DS Liebeskind; I Szikora; ACGM Van Es; W Brinjikji; KM Doyle; SF De Meyer
Opublikowane w: International journal of stroke, Numer 4, 2020, ISSN 1747-4930
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Additional file 9 of Microembolus clearance through angiophagy is an auxiliary mechanism preserving tissue perfusion in the rat brain

Autorzy: Wijk, Anne-Eva Van Der; Georgakopoulou, Theodosia; Majolée, Jisca; Bezu, Jan S. M. Van; Stoel, Miesje M. Van Der; Hof, Bert J. Van Het; Vries, Helga E. De; Huveneers, Stephan; Hordijk, Peter L.; Bakker, Erik N. T. P.; Bavel, Ed Van
Opublikowane w: Acta Neuropathologica Communications, Numer 8/1, 2020, ISSN 2051-5960
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DOI: 10.6084/m9.figshare.13250804.v1

Additional file 4 of Microembolus clearance through angiophagy is an auxiliary mechanism preserving tissue perfusion in the rat brain

Additional file 1 of Microembolus clearance through angiophagy is an auxiliary mechanism preserving tissue perfusion in the rat brain

sj-pdf-2-wso-10.1177_1747493019884527 - Supplemental material for Histological stroke clot analysis after thrombectomy: Technical aspects and recommendations

Autorzy: S Staessens; S Fitzgerald; T Andersson; F Clarençon; F Denorme; MJ Gounis; W Hacke; DS Liebeskind; I Szikora; ACGM Van Es; W Brinjikji; KM Doyle; SF De Meyer
Opublikowane w: International jounral of stroke, Numer 10, 2020, ISSN 1747-4930
Wydawca: Blackwell publishing
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Uncertainty Quantification of Coupled 1D Arterial Blood Flow and 3D Tissue Perfusion Models Using the INSIST Framework

Autorzy: Claire Miller, Max van der Kolk, Raymond Padmos, Tamás Józsa, Alfons Hoekstra
Opublikowane w: Computational Science – ICCS 2021 - 21st International Conference, Krakow, Poland, June 16–18, 2021, Proceedings, Part VI, Numer 12747, 2021, Strona(/y) 691-697, ISBN 978-3-030-77979-5
Wydawca: Springer International Publishing
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Two-Way Coupling Between 1D Blood Flow and 3D Tissue Perfusion Models

Autorzy: Raymond M. Padmos, Tamás I. Józsa, Wahbi K. El-Bouri, Gábor Závodszky, Stephen J. Payne, Alfons G. Hoekstra
Opublikowane w: Computational Science – ICCS 2021 - 21st International Conference, Krakow, Poland, June 16–18, 2021, Proceedings, Part III, Numer 12744, 2021, Strona(/y) 670-683, ISBN 978-3-030-77966-5
Wydawca: Springer International Publishing
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des-ist: A Simulation Framework to Streamline Event-Based In Silico Trials

Autorzy: Max van der Kolk, Claire Miller, Raymond Padmos, Victor Azizi, Alfons Hoekstra
Opublikowane w: Computational Science – ICCS 2021 - 21st International Conference, Krakow, Poland, June 16–18, 2021, Proceedings, Part III, Numer 12744, 2021, Strona(/y) 648-654, ISBN 978-3-030-77966-5
Wydawca: Springer International Publishing
DOI: 10.1007/978-3-030-77967-2_53

INSIST - IN SILICO TRIALS FOR TREATMENT OF ACUTE ISCHEMIC STROKE

Autorzy: Konduri, Praneeta
Opublikowane w: Numer 3, 2018
Wydawca: Moressier
DOI: 10.26226/morressier.5aeac941521e300021137ff8

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