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Personalised Medicine by Predictive Modeling in Stroke for better Quality of Life

Objective

Stroke is one of the most severe medical problems with far-reaching public health and socio-economic impact, gathering momentum in an ageing society. PRECISE4Q sets out to minimise the burden of stroke for the individual and for society. It will create multi-dimensional data-driven predictive simulation computer models enabling – for the first time – personalised stroke treatment, addressing patient’s needs in four stages: prevention, acute treatment, rehabilitation and reintegration.
Heterogeneous data from multidisciplinary sources will be integrated: genomics, microbiomics, biochemical; imaging including mechanistic biophysiological models of brain perfusion/function; social, lifestyle, gender; economic and worklife, requiring substantial efforts for information extraction, semantic labelling and standardisation.
Novel hybrid model architectures, structured prediction models, complex deep-learning and gradient boosting models will form the Digital Stroke Patient Platform including a Stroke Risk CDSS (Clinical Decision Support System), Treatment Outcomes CDSS, Rehab Programme, Socio-Economic Planning Tool and New QvidLab. The decision support will be tailored to the patient's current life stage thus enabling clinicians to optimise prevention and treatment strategies over time, and will include personalised coping strategies, support of well-being and reintegration into social life and work.
The predictive capability and clinical precision will be validated with real clinical data generated by (i) prospective clinical studies and (ii) retrospective analyses of big data sets: health registries, cohort studies, health insurance data, electronic health records.
PRECISE4Q will have a clinically measurable and sustainable impact leading to better understanding of risk, health and resilience factors. In contrast to current schematic therapy guidelines, it will support patients throughout their life-long journey by personalised strategies for their specific needs.

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Keywords

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Programme(s)

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Topic(s)

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RIA - Research and Innovation action

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Call for proposal

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(opens in new window) H2020-SC1-2016-2017

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Coordinator

CHARITE - UNIVERSITAETSMEDIZIN BERLIN
Net EU contribution

Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.

€ 1 316 250,00
Address
Chariteplatz 1
10117 Berlin
Germany

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Region
Berlin Berlin Berlin
Activity type
Higher or Secondary Education Establishments
Links
Total cost

The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.

€ 1 316 250,00

Participants (12)

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