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Liver Investigation: Testing Marker Utility in Steatohepatitis

Objective

Strongly associated with the epidemics of obesity and type 2 diabetes that are testing healthcare systems worldwide, Non-Alcoholic Fatty Liver Disease (NAFLD) is an increasingly common cause of advanced liver disease that is characterized by substantial inter-patient variability in severity and rate of progression. It is currently assessed by liver biopsy, an invasive, costly and risky procedure. The lack of noninvasive biomarkers has hampered patient care and impeded drug development by complicating conduct of clinical trials.The overarching aim of LITMUS is to develop, robustly validate and advance towards regulatory qualification biomarkers that diagnose, risk stratify and/or monitor NAFLD/NASH progression and fibrosis stage. This will be achieved through a goal-oriented, tri-partite collaboration delivering a definitive and impartial evaluation platform for biomarkers, bringing together: (i) End-users of biomarker technologies (clinicians with expertise in NAFLD and the pharmaceutical industry)? (ii) Independent academics with expertise in the evaluation of medical test/biomarker performance? and (iii) Biomarker researchers and developers (academic or commercial).

LITMUS has the demonstrable capability to fulfil the IMI call remit. Built upon foundations laid by the EU-funded FLIP/EPoS projects and long-established, successful scientific collaborations amongst many of Europe’s leading clinical-academic centres, LITMUS is at a unique advantage due to its existing large-scale patient cohorts, bioresources and multi-omics datasets. Consortium members are internationally recognised experts with substantial relevant expertise supporting the program’s clear focus on biomarker identification, validation and accelerating EMA/FDA qualification. Thus, LITMUS is powered to provide clarity on biomarker validity for NAFLD at scale and pace: supporting drug development and the targeting of medical care and limited healthcare resources to those at greatest need.

Call for proposal

H2020-JTI-IMI2-2016-09-two-stage
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Coordinator

UNIVERSITY OF NEWCASTLE UPON TYNE
Address
Kings Gate
NE1 7RU Newcastle Upon Tyne
United Kingdom
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 2 938 036,25

Participants (55)

ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM
Netherlands
EU contribution
€ 1 180 910
Address
Meibergdreef 15
1105AZ Amsterdam
Activity type
Higher or Secondary Education Establishments
INST CARDIOMETABOLISME NUTRITION ICAN
France
EU contribution
€ 684 250
Address
Boulevard De L'hopital 47-83
75013 Paris
Activity type
Research Organisations
ASSISTANCE PUBLIQUE HOPITAUX DE PARIS
France
EU contribution
€ 260 500
Address
3 Avenue Victoria
75000 Paris
Activity type
Research Organisations
UNIVERSITAETSMEDIZIN DER JOHANNES GUTENBERG-UNIVERSITAET MAINZ
Germany
EU contribution
€ 1 073 015
Address
Langenbeckstrasse 1
55131 Mainz
Activity type
Higher or Secondary Education Establishments
THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
United Kingdom
EU contribution
€ 598 005
Address
Trinity Lane The Old Schools
CB2 1TN Cambridge
Activity type
Higher or Secondary Education Establishments
OREBRO UNIVERSITY
Sweden
EU contribution
€ 312 500
Address
Fakultetsgatan 1
70182 Orebro
Activity type
Higher or Secondary Education Establishments
ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOCIENCIAS
Spain
EU contribution
€ 403 017,50
Address
Parque Tecnologico Edificio 801 A
48160 Derio Vizcaya
Activity type
Research Organisations
UNIVERSITAET BERN
Switzerland
EU contribution
€ 435 000
Address
Hochschulstrasse 6
3012 Bern
Activity type
Higher or Secondary Education Establishments
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
United Kingdom
EU contribution
€ 1 818 750
Address
Wellington Square University Offices
OX1 2JD Oxford
Activity type
Higher or Secondary Education Establishments
PERSPECTUM LTD
United Kingdom
EU contribution
€ 250 000
Address
Gemini One, 5520 John Smith Drive Oxford Business Park South
OX4 2LL Oxford
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Private for-profit entities (excluding Higher or Secondary Education Establishments)
SERVICIO ANDALUZ DE SALUD
Spain
EU contribution
€ 601 250
Address
Avenida De La Constitucion 18
41071 Sevilla
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
NORDIC BIOSCIENCE A/S
Denmark
EU contribution
€ 1 427 093
Address
Herlev Hovedgade 205-207
2730 Herlev
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
LUXEMBOURG INSTITUTE OF HEALTH
Luxembourg
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€ 540 033,75
Address
Val Fleuri 84
1526 Luxembourg
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Research Organisations
UNIVERSITA DEGLI STUDI DI TORINO
Italy
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€ 365 160,75
Address
Via Giuseppe Verdi 8
10124 Torino
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Higher or Secondary Education Establishments
UNIVERSITE D'ANGERS
France
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€ 122 500
Address
Rue De Rennes 40
49035 Angers Cedex 01
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Higher or Secondary Education Establishments
UNIVERSITAIR ZIEKENHUIS ANTWERPEN
Belgium
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€ 167 100
Address
Drie Eikenstraat 655
2650 Edegem
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Research Organisations
LINKOPINGS UNIVERSITET
Sweden
EU contribution
€ 99 600
Address
Campus Valla
581 83 Linkoping
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Higher or Secondary Education Establishments
HELSINGIN YLIOPISTO
Finland
EU contribution
€ 202 500
Address
Yliopistonkatu 3
00014 Helsingin Yliopisto
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Higher or Secondary Education Establishments
UNIVERSITAIR MEDISCH CENTRUM UTRECHT
Netherlands
EU contribution
€ 273 328,75
Address
Heidelberglaan 100
3584 CX Utrecht
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Higher or Secondary Education Establishments
ETHNIKO KAI KAPODISTRIAKO PANEPISTIMIO ATHINON
Greece
EU contribution
€ 118 350
Address
6 Christou Lada Str
10561 Athina
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Higher or Secondary Education Establishments
FACULDADE DE MEDICINA DA UNIVERSIDADE DE LISBOA
Portugal
EU contribution
€ 78 487,50
Address
Avenida Professor Egas Moniz, Edificio Hospital Santa Maria
1649-028 Lisboa
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Higher or Secondary Education Establishments
UNIVERSITA DEGLI STUDI DI MILANO
Italy
EU contribution
€ 80 722,50
Address
Via Festa Del Perdono 7
20122 Milano
Activity type
Higher or Secondary Education Establishments
UNIVERSITA DEGLI STUDI DI PALERMO
Italy
EU contribution
€ 105 081,25
Address
Piazza Marina 61
90133 Palermo
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Higher or Secondary Education Establishments
UNIVERSITA CATTOLICA DEL SACRO CUORE
Italy
EU contribution
€ 80 653,75
Address
Largo Gemelli 1
20123 Milano
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UNIVERSITAETSKLINIKUM WUERZBURG - KLINIKUM DER BAYERISCHEN JULIUS-MAXIMILIANS-UNIVERSITAT
Germany
EU contribution
€ 406 206,25
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Josef-schneider-strasse 2
97080 Wurzburg
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UNIVERSITAETSKLINIKUM AACHEN
Germany
EU contribution
€ 248 076,25
Address
Pauwelsstrasse 30
52074 Aachen
Activity type
Higher or Secondary Education Establishments
THE UNIVERSITY OF NOTTINGHAM
United Kingdom
EU contribution
€ 118 115
Address
University Park
NG7 2RD Nottingham
Activity type
Higher or Secondary Education Establishments
MEDIZINISCHE UNIVERSITAET WIEN
Austria
EU contribution
€ 54 075
Address
Spitalgasse 23
1090 Wien
Activity type
Higher or Secondary Education Establishments
ANTAROS MEDICAL AB
Sweden
EU contribution
€ 231 275
Address
Bioventure Hub Pepparedsleden 1
431 83 Molndal
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
THE UNIVERSITY OF BIRMINGHAM
United Kingdom
EU contribution
€ 61 263,75
Address
Edgbaston
B15 2TT Birmingham
Activity type
Higher or Secondary Education Establishments
IXSCIENT LIMITED
United Kingdom
EU contribution
€ 344 375
Address
Popes Grove 76
TW1 4JX Twickenham Middlesex
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Private for-profit entities (excluding Higher or Secondary Education Establishments)
Faculdade de Farmácia da Universidade de Lisboa
Portugal
EU contribution
€ 56 968,75
Address
Av. Prof. Gama Pinto
1649-003 Lisboa
Activity type
Higher or Secondary Education Establishments
EUROPEAN ASSOCIATION FOR THE STUDYOF THE LIVER
Switzerland
EU contribution
€ 61 680
Address
Rue Daubin 7
1203 Geneve
Activity type
Other
GENFIT
France
EU contribution
€ 0
Address
885 Avenue Eugene Avinee Parc Eurosante
59120 Loos
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INTERCEPT PHARMA EUROPE LTD
United Kingdom
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€ 0
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One, Glass Wharf
BS2 0ZX Bristol
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ONE WAY LIVER SL
Spain
EU contribution
€ 1
Address
Parque Tecnologico De Bizkaia Edif 502
48160 Derio Bizkaia
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Private for-profit entities (excluding Higher or Secondary Education Establishments)
EXALENZ BIOSCIENCE LTD

Participation ended

Israel
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4 Ha'maayan Str
7177872 Modiin
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ELI LILLY AND COMPANY LTD
United Kingdom
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Lilly House Basingview
RG21 4FA Basingstoke
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PFIZER LIMITED
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Ramsgate Road
CT13 9NJ Sandwich
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BOEHRINGER INGELHEIM INTERNATIONALGMBH
Germany
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€ 0
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Binger Strasse
55218 Ingelheim
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SOMALOGIC INC
United States
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€ 0
Address
Wilderness Place 2945
80301 Boulder Colorado
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NOVO NORDISK A/S
Denmark
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€ 0
Address
Novo Alle 1
2880 Bagsvaerd
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SANOFI-AVENTIS DEUTSCHLAND GMBH

Participation ended

Germany
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€ 0
Address
Bruningstrasse 50
65929 Frankfurt Am Main
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ELLEGAARD GOTTINGEN MINIPIGS AS
Denmark
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€ 0
Address
Soro Landevej 302 Hove
4261 Dalmose
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NOVARTIS PHARMA AG
Switzerland
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€ 0
Address
Lichtstrasse 35
4056 Basel
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TAKEDA DEVELOPMENT CENTRE EUROPE LTD

Participation ended

United Kingdom
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€ 0
Address
Aldwych 61
WC2B 4AE London
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
ASTRAZENECA AB
Sweden
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€ 0
Address
Vastra Maelarhamnen
151 85 Sodertaelje
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Private for-profit entities (excluding Higher or Secondary Education Establishments)
ECHOSENS
France
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€ 0
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Rue Ferrus 6
75014 Paris
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RESOUNDANT, INC.
United States
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421 1St Avenue Sw Ste 204W
55902 Rochester
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BRISTOL-MYERS SQUIBB COMPANY CORP
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€ 0
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Park Avenue 345
10154 New York
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HISTOINDEX PTE LTD
Singapore
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€ 0
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79 Ayer Rajah Crescent 04-05 Jtc Launchpad
139955 Singapore
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Private for-profit entities (excluding Higher or Secondary Education Establishments)
ALLERGAN LIMITED
United Kingdom
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€ 0
Address
1St Floor Marlow International The Parkway
Marlow
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Private for-profit entities (excluding Higher or Secondary Education Establishments)
GILEAD SCIENCES INC
United States
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€ 0
Address
Lakeside Drive 333
94404 Foster City Ca
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RESEARCH TRIANGLE INSTITUTE
United States
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€ 0
Address
Cornwallis Road 3040
27709 Research Triangle Park
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Research Organisations
TAKEDA PHARMACEUTICALS INTERNATIONAL AG
Switzerland
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€ 0
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Thurgauerstrasse 130
8152 Glattpark
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