Objective
Strongly associated with the epidemics of obesity and type 2 diabetes that are testing healthcare systems worldwide, Non-Alcoholic Fatty Liver Disease (NAFLD) is an increasingly common cause of advanced liver disease that is characterized by substantial inter-patient variability in severity and rate of progression. It is currently assessed by liver biopsy, an invasive, costly and risky procedure. The lack of noninvasive biomarkers has hampered patient care and impeded drug development by complicating conduct of clinical trials.The overarching aim of LITMUS is to develop, robustly validate and advance towards regulatory qualification biomarkers that diagnose, risk stratify and/or monitor NAFLD/NASH progression and fibrosis stage. This will be achieved through a goal-oriented, tri-partite collaboration delivering a definitive and impartial evaluation platform for biomarkers, bringing together: (i) End-users of biomarker technologies (clinicians with expertise in NAFLD and the pharmaceutical industry)? (ii) Independent academics with expertise in the evaluation of medical test/biomarker performance? and (iii) Biomarker researchers and developers (academic or commercial).
LITMUS has the demonstrable capability to fulfil the IMI call remit. Built upon foundations laid by the EU-funded FLIP/EPoS projects and long-established, successful scientific collaborations amongst many of Europe’s leading clinical-academic centres, LITMUS is at a unique advantage due to its existing large-scale patient cohorts, bioresources and multi-omics datasets. Consortium members are internationally recognised experts with substantial relevant expertise supporting the program’s clear focus on biomarker identification, validation and accelerating EMA/FDA qualification. Thus, LITMUS is powered to provide clarity on biomarker validity for NAFLD at scale and pace: supporting drug development and the targeting of medical care and limited healthcare resources to those at greatest need.
Fields of science
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques.
Keywords
Programme(s)
Funding Scheme
RIA - Research and Innovation actionCoordinator
NE1 7RU Newcastle Upon Tyne
United Kingdom
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Participants (59)
1081 HV Amsterdam
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75013 Paris
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Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.
75006 Paris
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75012 Paris
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55131 Mainz
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CB2 1TN Cambridge
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70182 Orebro
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48160 DERIO VIZCAYA
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3012 Bern
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OX1 2JD Oxford
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OX4 2LL Oxford
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
41071 SEVILLA
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2730 Herlev
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
1445 Strassen
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10124 Torino
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Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.
50121 Florence
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Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.
00185 Roma
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49035 Angers Cedex 01
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2650 Edegem
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581 83 Linkoping
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00014 HELSINGIN YLIOPISTO
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3584 CX Utrecht
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10561 Athina
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1649-028 Lisboa
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20122 Milano
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90133 Palermo
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20123 Milano
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97080 Wurzburg
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52074 Aachen
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NG7 2RD Nottingham
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Participation ended
1090 Wien
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431 53 MOLNDAL
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
B15 2TT Birmingham
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TW1 4JX Twickenham Middlesex
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
1649-003 Lisboa
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1203 Geneve
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59120 Loos
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
BS2 0ZX Bristol
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48160 Derio Bizkaia
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
Participation ended
7177872 MODIIN
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
RG21 4FA Basingstoke
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CT13 9NJ Sandwich
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55218 Ingelheim
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80301 Boulder Colorado
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
2880 Bagsvaerd
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65929 Frankfurt Am Main
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4261 Dalmose
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
4056 Basel
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WC2B 4AE London
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151 85 Sodertaelje
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75014 Paris
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55902 Rochester
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10154 New York
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139955 Singapore
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Participation ended
Marlow
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94404 Foster City Ca
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27709 Research Triangle Park
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8152 Glattpark
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60064 North Chicago Il
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