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Personalised Postoperative Immunotherapy To Improving Cancer Outcome and improving quality of life

Objective

During this RISE project we aim to develop nanoparticle-based encapsulated libraries of different immunotherapeutic
biomolecules for treatment after surgery as part of a novel cancer management strategy. The current state-of-art for the
management of cancer starts with surgery, after identification of an accessible tumour mass. Surgery remains an effective
treatment option for many types of cancer today and it is considered curative treatment for most solid tumours. It forms part
of a multidisciplinary approach used in conjunction with radiotherapy or chemotherapy. These approaches, however, have
several limitations, including inability of surgical resection to affect distal metastatic disease, toxicity to healthy tissues with
chemotherapy and lack of effectiveness of radiation therapy in more aggressive tumours. The observation that cancer can
relapse months or years after initial surgery implies that micrometastases still resides within the body in a latent state. Our
proposal is to take cancer therapy to beyond state-of-art by implementing techniques which will take us into new directions.
This includes a) new methods to identify immune gene profiles and biomarkers b) transgenic mouse models where the
complex interactions that underlie immune function can be visualised as multiplexed events in real time and c) the use of
nanoparticle-based libraries of immune modulating reagent combinations. There are three key objectives within this project:
i) to use immune gene signatures to monitor disease progression and therapeutic efficacy of immunotherapy combinations
on nanoparticle-based platforms, ii) to optimise the platform to encapsulate libraries of immune components for more
personalised, accurate and timely delivery of the payload to its intended target and iii) to optimise the overall cancer
management process of image-guided surgery followed by postoperative immunotherapy so that we can ultimately provide a
lifetime of protection against cancer.

Call for proposal

H2020-MSCA-RISE-2017
See other projects for this call

Coordinator

PERCUROS BV
Address
Eerbeeklaan 42
2573 HT 'S-gravenhage
Netherlands
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
EU contribution
€ 378 000

Participants (18)

ACADEMISCH ZIEKENHUIS LEIDEN
Netherlands
EU contribution
€ 162 000
Address
Albinusdreef 2
2333 ZA Leiden
Activity type
Higher or Secondary Education Establishments
ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM
Netherlands
EU contribution
€ 108 000
Address
Dr Molewaterplein 40
3015 GD Rotterdam
Activity type
Higher or Secondary Education Establishments
TECHNISCHE UNIVERSITEIT DELFT
Netherlands
EU contribution
€ 108 000
Address
Stevinweg 1
2628 CN Delft
Activity type
Higher or Secondary Education Establishments
UNIVERSITA DEGLI STUDI DI CAMERINO
Italy
EU contribution
€ 108 000
Address
Piazza Cavour 19F
62032 Camerino
Activity type
Higher or Secondary Education Establishments
TECOBIOSCIENCES GMBH
Germany
EU contribution
€ 162 000
Address
Bussardstrasse 35
84036 Landshut
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
UNIVERSITEIT VAN AMSTERDAM
Netherlands
EU contribution
€ 108 000
Address
Spui 21
1012WX Amsterdam
Activity type
Higher or Secondary Education Establishments
THE UNIVERSITY OF SHEFFIELD
United Kingdom
EU contribution
€ 108 000
Address
Firth Court Western Bank
S10 2TN Sheffield
Activity type
Higher or Secondary Education Establishments
UNIVERSITEIT MAASTRICHT
Netherlands
EU contribution
€ 108 000
Address
Minderbroedersberg 4
6200 MD Maastricht
Activity type
Higher or Secondary Education Establishments
JENACELL GMBH
Germany
EU contribution
€ 108 000
Address
Goschwitzer Str. 22
07745 Jena
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
MEDRES-MEDICAL RESEARCH GMBH
Germany
EU contribution
€ 108 000
Address
Gleueler Strasse 50
50931 Koln
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
AUGEAS ASSOCIAZIONE DI SPORT PROMOZIONE E TURISMO
Italy
EU contribution
€ 108 000
Address
Via Della Resistenza 35
00045 Genzano Di Roma
Activity type
Other
PROGREDUM GMBH
Germany
EU contribution
€ 108 000
Address
Otterberger Strasse 73
67659 Kaiserslautern
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
ASSOCIAZIONE CULTURALE CASTELLI ROMANI GREEN TOUR
Italy
EU contribution
€ 54 000
Address
Via Del Parco 3
00072 Ariccia
Activity type
Other
BOSCHIVA MELCHIORRI SRL
Italy
EU contribution
€ 108 000
Address
Via Di Barbarossa 18
00040 Rocca Di Papa
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
HELRIK AND LOUW COMPANY LTD

Participation ended

United Kingdom
EU contribution
€ 0
Address
72 Great Suffolk Street
SE1 0BL London
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
UNIWERSYTET JAGIELLONSKI
Poland
EU contribution
€ 108 000
Address
Ul. Golebia 24
31007 Krakow
Activity type
Higher or Secondary Education Establishments
ASSOCIAZIONE HAND IN HAND
Italy
EU contribution
€ 216 000
Address
Via Vittorio Emanuele 32
00074 Nemi
Activity type
Other
HELRIK AND LOUW AND PARTNERS COMPANY LTD
United Kingdom
EU contribution
€ 162 000
Address
72 Great Suffolk Street
SE1 0BL London
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)