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Personalised Postoperative Immunotherapy To Improving Cancer Outcome and improving quality of life


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Established network organisation and management structure

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Annual gender equality monitoring

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Po-260 deep phenotyping of colorectal cancers by high-dimensional mass cytometry reveals tumor-specific immune landscapes

Author(s): N De Vries, V Van Unen, T Abdelaal, M Van Herk, R Van der Breggen, A Farina Sarasqueta, T Höllt, B Lelieveldt, F Koning, N De Miranda
Published in: Tumour Microenvironment, 02018, Page(s) A328.2-A329
DOI: 10.1136/esmoopen-2018-EACR25.775

Perivascular macrophages in health and disease

Author(s): Antonio Lapenna, Michele De Palma, Claire E. Lewis
Published in: Nature Reviews Immunology, 2018, ISSN 1474-1733
DOI: 10.1038/s41577-018-0056-9

Diverse Functions of Macrophages in Different Tumor Microenvironments

Author(s): Ming Yang, Daniel McKay, Jeffrey W. Pollard, Claire E. Lewis
Published in: Cancer Research, Issue 78/19, 2018, Page(s) 5492-5503, ISSN 0008-5472
DOI: 10.1158/0008-5472.CAN-18-1367

Combinatory therapy adopting nanoparticle-based cancer vaccination with immune checkpoint blockade for treatment of post-surgical tumor recurrences

Author(s): Chih Kit Chung, C.G. Da Silva, Dana Kralisch, Alan Chan, Ferry Ossendorp, Luis J. Cruz
Published in: Journal of Controlled Release, Issue 285, 2018, Page(s) 56-66, ISSN 0168-3659
DOI: 10.1016/j.jconrel.2018.07.011

Opportunities of bacterial cellulose to treat epithelial tissues

Author(s): Irene Anton-Sales, Uwe Beekmann, Anna Laromaine, Anna Roig, Dana Kralisch
Published in: Current Drug Targets, Issue 20, 2018, Page(s) 808-822, ISSN 1389-4501
DOI: 10.2174/1389450120666181129092144

pH-responsive poly(lactide-co-glycolide) nanoparticles containing near-infrared dye for visualization and hyaluronic acid for treatment of osteoarthritis

Author(s): L. Zerrillo, I. Que, O. Vepris, L.N. Morgado, A. Chan, K. Bierau, Y. Li, F. Galli, E. Bos, R. Censi, P. Di Martino, G.J.V.M. van Osch, L.J. Cruz
Published in: Journal of Controlled Release, Issue 309, 2019, Page(s) 265-276, ISSN 0168-3659
DOI: 10.1016/j.jconrel.2019.07.031

Effective chemoimmunotherapy by co-delivery of doxorubicin and immune adjuvants in biodegradable nanoparticles

Author(s): Candido G. Da Silva, Marcel G.M. Camps, Tracy M.W.Y. Li, Luana Zerrillo, Clemens W. Löwik, Ferry Ossendorp, Luis J. Cruz
Published in: Theranostics, Issue 9/22, 2019, Page(s) 6485-6500, ISSN 1838-7640
DOI: 10.7150/thno.34429

Hot Melt Extrusion: Highlighting Physicochemical Factors to Be Investigated While Designing and Optimizing a Hot Melt Extrusion Process

Author(s): Roberta Censi, Maria Gigliobianco, Cristina Casadidio, Piera Di Martino
Published in: Pharmaceutics, Issue 10/3, 2018, Page(s) 89, ISSN 1999-4923
DOI: 10.3390/pharmaceutics10030089

Optical imaging and pH-awakening therapy of deep tissue cancer based on specific upconversion nanophotosensitizers

Author(s): Yansong Feng, Haoran Chen, Yanni Wu, Ivo Que, Filippo Tamburini, Fabio Baldazzi, Yulei Chang, Hong Zhang
Published in: Biomaterials, Issue 230, 2020, Page(s) 119637, ISSN 0142-9612
DOI: 10.1016/j.biomaterials.2019.119637

Co-delivery of immunomodulators in biodegradable nanoparticles improves therapeutic efficacy of cancer vaccines

Author(s): C.G. Da Silva, M.G.M. Camps, T.M.W.Y. Li, A.B. Chan, F. Ossendorp, L.J. Cruz
Published in: Biomaterials, Issue 220, 2019, Page(s) 119417, ISSN 0142-9612
DOI: 10.1016/j.biomaterials.2019.119417

Assembly of upconversion nanophotosensitizer in vivo to achieve scatheless real-time imaging and selective photodynamic therapy

Author(s): Yansong Feng, Yanni Wu, Jing Zuo, Langping Tu, Ivo Que, Yulei Chang, Luis J. Cruz, Alan Chan, Hong Zhang
Published in: Biomaterials, Issue 201, 2019, Page(s) 33-41, ISSN 0142-9612
DOI: 10.1016/j.biomaterials.2019.02.015

Irradiation-free photodynamic therapy in vivo induced by enhanced deep red afterglow within NIR-I bio-window

Author(s): Jian Yang, Yangyang Zhao, Yangqi Meng, Hancheng Zhu, Duanting Yan, Chunguang Liu, Changshan Xu, Hong Zhang, Lin Xu, Yuxin Li, Yuxue Liu
Published in: Chemical Engineering Journal, Issue 387, 2020, Page(s) 124067, ISSN 1385-8947
DOI: 10.1016/j.cej.2020.124067

Effect of Oxaliplatin-Loaded Poly (d,l-Lactide-co-Glycolic Acid) (PLGA) Nanoparticles Combined with Retinoic Acid and Cholesterol on Apoptosis, Drug Resistance, and Metastasis Factors of Colorectal Cancer

Author(s): Ana Luiza C. de S. L. Oliveira, Raimundo Fernandes de Araújo Júnior, Thaís Gomes de Carvalho, Alan B. Chan, Timo Schomann, Filippo Tamburini, Lioe-Fee de Geus-Oei, Luis J. Cruz
Published in: Pharmaceutics, Issue 12/2, 2020, Page(s) 193, ISSN 1999-4923
DOI: 10.3390/pharmaceutics12020193

Redox-Sensitive and Hyaluronic Acid-Functionalized Nanoparticles for Improving Breast Cancer Treatment by Cytoplasmic 17α-Methyltestosterone Delivery

Author(s): Somayeh Rezaei, Soheila Kashanian, Yadollah Bahrami, Luis J. Cruz, Marjan Motiei
Published in: Molecules, Issue 25/5, 2020, Page(s) 1181, ISSN 1420-3049
DOI: 10.3390/molecules25051181

Targeting Ephrin Receptor Tyrosine Kinase A2 with a Selective Aptamer for Glioblastoma Stem Cells

Author(s): Alessandra Affinito, Cristina Quintavalle, Carla Lucia Esposito, Giuseppina Roscigno, Catello Giordano, Silvia Nuzzo, Lucia Ricci-Vitiani, Iolanda Scognamiglio, Zoran Minic, Roberto Pallini, Maxim V. Berezovski, Vittorio de Francisis, Gerolama Condorelli
Published in: Molecular Therapy - Nucleic Acids, Issue 20, 2020, Page(s) 176-185, ISSN 2162-2531
DOI: 10.1016/j.omtn.2020.02.005

miR-216a Acts as a Negative Regulator of Breast Cancer by Modulating Stemness Properties and Tumor Microenvironment

Author(s): Giuseppina Roscigno, Assunta Cirella, Alessandra Affinito, Cristina Quintavalle, Iolanda Scognamiglio, Francesco Palma, Francesco Ingenito, Silvia Nuzzo, Francesca De Micco, Antonio Cuccuru, Renato Thomas, Gerolama Condorelli
Published in: International Journal of Molecular Sciences, Issue 21/7, 2020, Page(s) 2313, ISSN 1422-0067
DOI: 10.3390/ijms21072313

Thermosensitive hydrogels as sustained drug delivery system for CTLA-4 checkpoint blocking antibodies

Author(s): Chih Kit Chung, Marieke F. Fransen, Koen van der Maaden, Yaima Campos, Jomarien García-Couce, Dana Kralisch, Alan Chan, Ferry Ossendorp, Luis J. Cruz
Published in: Journal of Controlled Release, 2020, ISSN 0168-3659
DOI: 10.1016/j.jconrel.2020.03.050

Polymeric Nanocapsules as Nanotechnological Alternative for Drug Delivery System: Current Status, Challenges and Opportunities

Author(s): Siyuan Deng, Maria Rosa Gigliobianco, Roberta Censi, Piera Di Martino
Published in: Nanomaterials, Issue 10/5, 2020, Page(s) 847, ISSN 2079-4991
DOI: 10.3390/nano10050847

Doxorubicin Loaded Poloxamer Thermosensitive Hydrogels: Chemical, Pharmacological and Biological Evaluation

Author(s): Chih Kit Chung, Jomarien García-Couce, Yaima Campos, Dana Kralisch, Katja Bierau, Alan Chan, Ferry Ossendorp, Luis Javier Cruz
Published in: Molecules, Issue 25/9, 2020, Page(s) 2219, ISSN 1420-3049
DOI: 10.3390/molecules25092219

Similarities in the General Chemical Composition of Colon Cancer Cells and Their Microvesicles Investigated by Spectroscopic Methods-Potential Clinical Relevance

Author(s): Joanna Depciuch, Bartosz Klębowski, Małgorzata Stec, Rafał Szatanek, Kazimierz Węglarczyk, Monika Baj-Krzyworzeka, Magdalena Parlińska-Wojtan, Jarek Baran
Published in: International Journal of Molecular Sciences, Issue 21/5, 2020, Page(s) 1826, ISSN 1422-0067
DOI: 10.3390/ijms21051826

Ceramide and palmitic acid inhibit macrophage-mediated epithelial–mesenchymal transition in colorectal cancer

Author(s): Raimundo Fernandes de Araujo Junior, Christina Eich, Carla Jorquera, Timo Schomann, Fabio Baldazzi, Alan B. Chan, Luis J. Cruz
Published in: Molecular and Cellular Biochemistry, Issue 468/1-2, 2020, Page(s) 153-168, ISSN 0300-8177
DOI: 10.1007/s11010-020-03719-5

Cholesterol-functionalized carvedilol-loaded PLGA nanoparticles: anti-inflammatory, antioxidant, and antitumor effects

Author(s): Ana Luiza C. de S. L. Oliveira, Alaine M. dos Santos-Silva, Arnóbio A. da Silva-Júnior, Vinícius B. Garcia, Aurigena A. de Araújo, Lioe-Fee de Geus-Oei, Alan B. Chan, Luis J. Cruz, Raimundo F. de Araújo Júnior
Published in: Journal of Nanoparticle Research, Issue 22/5, 2020, ISSN 1388-0764
DOI: 10.1007/s11051-020-04832-8

The level of myeloid derived-suppressor cells in peripheral blood of patients with prostate cancerafter various types of therapy

Author(s): Izabela Siemińska, Edyta Rychlicka-Buniowska, Janusz Jaszczyński, Mikołaj Palaczyński, Karolina Bukowska-Strakova, Janusz Ryś, Jan Dumański, Maciej Siedlar, Jarosław Baran
Published in: Polish Journal of Pathology, Issue 71/1, 2020, Page(s) 46-54, ISSN 1233-9687
DOI: 10.5114/pjp.2020.95415

Compensate for or Minimize Matrix Effects? Strategies for Overcoming Matrix Effects in Liquid Chromatography-Mass Spectrometry Technique: A Tutorial Review

Author(s): Manuela Cortese, Maria Rosa Gigliobianco, Federico Magnoni, Roberta Censi, Piera Di Martino
Published in: Molecules, Issue 25/13, 2020, Page(s) 3047, ISSN 1420-3049
DOI: 10.3390/molecules25133047

Recent Advances in Rare-Earth-Doped Nanoparticles for NIR-II Imaging and Cancer Theranostics

Author(s): Zhenfeng Yu, Christina Eich, Luis J. Cruz
Published in: Frontiers in Chemistry, Issue 8, 2020, ISSN 2296-2646
DOI: 10.3389/fchem.2020.00496

Glycan-Based Near-infrared Fluorescent (NIRF) Imaging of Gastrointestinal Tumors: a Preclinical Proof-of-Concept In Vivo Study

Author(s): Ruben D. Houvast, Victor M. Baart, Shadhvi S. Bhairosingh, Robert A. Cordfunke, Jia Xin Chua, Mireille Vankemmelbeke, Tina Parsons, Peter J. K. Kuppen, Lindy G. Durrant, Alexander L. Vahrmeijer, Cornelis F. M. Sier
Published in: Molecular Imaging and Biology, Issue Aug 11, 2020, 2020, ISSN 1536-1632
DOI: 10.1007/s11307-020-01522-8

Quantification of phenolic compounds in different types of crafts beers, worts, starting and spent ingredients by liquid chromatography-tandem mass spectrometry

Author(s): Manuela Cortese, Maria Rosa Gigliobianco, Dolores Vargas Peregrina, Gianni Sagratini, Roberta Censi, Piera Di Martino
Published in: Journal of Chromatography A, 2019, Page(s) 460622, ISSN 0021-9673
DOI: 10.1016/j.chroma.2019.460622

Potential and Challenges of Aptamers as Specific Carriers of Therapeutic Oligonucleotides for Precision Medicine in Cancer

Author(s): Silvia Nuzzo, Giuseppina Roscigno, Alessandra Affinito, Francesco Ingenito, Cristina Quintavalle, Gerolama Condorelli
Published in: Cancers, Issue 11/10, 2019, Page(s) 1521, ISSN 2072-6694
DOI: 10.3390/cancers11101521

Applications of Noble Metal-Based Nanoparticles in Medicine

Author(s): Bartosz Klębowski, Joanna Depciuch, Magdalena Parlińska-Wojtan, Jarek Baran
Published in: International Journal of Molecular Sciences, Issue 19/12, 2018, Page(s) 4031, ISSN 1422-0067
DOI: 10.3390/ijms19124031

ICAM3-Fc Outperforms Receptor-Specific Antibodies Targeted Nanoparticles to Dendritic Cells for Cross-Presentation

Author(s): Luis J. Cruz, Paul J. Tacken, Johan M.S. van der Schoot, Felix Rueda, Ruurd Torensma, Carl G. Figdor
Published in: Molecules, Issue 24/9, 2019, Page(s) 1825, ISSN 1420-3049
DOI: 10.3390/molecules24091825

Construction and Optimization of Biofunctional Upconversion Nanoplatforms

Author(s): Yadan Ding
Published in: 2018

Bacterial cellulose product design towards biomedical and diagnostic applications

Author(s): Dana Kralisch, Uwe Beekmann
Published in: 2019